Mitochondrial transcription in mammalian cells

As a consequence of recent discoveries of intimate involvement of mitochondria with key cellular processes, there has been a resurgence of interest in all aspects of mitochondrial biology, including the intricate mechanisms of mitochondrial DNA maintenance and expression. Despite four decades of res...

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Bibliographic Details
Published in:Frontiers in bioscience (Landmark. Print) Vol. 22; no. 5; p. 835
Main Authors: Shokolenko, Inna N, Alexeyev, Mikhail F
Format: Journal Article
Language:English
Published: Singapore 01.01.2017
Subjects:
Adenosine Triphosphate - metabolism
Animals
DNA, Mitochondrial - genetics
DNA, Mitochondrial - metabolism
DNA-Directed RNA Polymerases - metabolism
Humans
Mitochondria - metabolism
Mitochondrial Proteins - metabolism
Models, Biological
Promoter Regions, Genetic
RNA - genetics
RNA - metabolism
RNA Processing, Post-Transcriptional
RNA, Mitochondrial
Transcription Factors - metabolism
Transcription, Genetic
Transcriptome
ISSN:2768-6698, 2768-6698
Online Access:Get more information
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Summary:As a consequence of recent discoveries of intimate involvement of mitochondria with key cellular processes, there has been a resurgence of interest in all aspects of mitochondrial biology, including the intricate mechanisms of mitochondrial DNA maintenance and expression. Despite four decades of research, there remains a lot to be learned about the processes that enable transcription of genetic information from mitochondrial DNA to RNA, as well as their regulation. These processes are vitally important, as evidenced by the lethality of inactivating the central components of mitochondrial transcription machinery. Here, we review the current understanding of mitochondrial transcription and its regulation in mammalian cells. We also discuss key theories in the field and highlight controversial subjects and future directions as we see them.
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ISSN:2768-6698
2768-6698
DOI:10.2741/4520