Associations of Immune Cell Subsets With Coronary Artery Calcium Incidence and Progression in the Multi‐Ethnic Study of Atherosclerosis

Limited data exist on associations of immune cell subsets with longitudinal changes in subclinical coronary artery disease. In the MESA (Multi-Ethnic Study of Atherosclerosis) study, we used a case-cohort approach to explore associations of 28 immune cell subsets measured at baseline (2000-2002) wit...

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Vydané v:Journal of the American Heart Association Ročník 14; číslo 19; s. e042502
Hlavní autori: Patel, Riddhi D., Buzkova, Petra, Huber, Sally, Landay, Alan, Budoff, Matthew, Bis, Joshua C., Olson, Nels, Rich, Stephen, Heckbert, Susan R., Manichaikul, Ani, Floyd, James, Tracy, Russell P., Psaty, Bruce M., Doyle, Margaret F., Sitlani, Colleen M, Delaney, Joseph A.C., Fohner, Alison E., Feinstein, Matthew J.
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England Wiley 07.10.2025
Predmet:
Aged
Coronary Angiography
coronary artery calcium
Coronary Artery Disease - diagnostic imaging
Coronary Artery Disease - epidemiology
Coronary Artery Disease - ethnology
Coronary Artery Disease - immunology
Coronary Vessels - diagnostic imaging
Disease Progression
Female
Humans
immune cells
Incidence
inflammation
Killer Cells, Natural - immunology
Male
Middle Aged
Monocytes - immunology
Prospective Studies
Risk Factors
subclinical atherosclerosis
United States - epidemiology
Vascular Calcification - diagnostic imaging
Vascular Calcification - epidemiology
Vascular Calcification - ethnology
Vascular Calcification - immunology
United States
immune cells
coronary artery calcium
inflammation
subclinical atherosclerosis
ISSN:2047-9980, 2047-9980
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Shrnutí:Limited data exist on associations of immune cell subsets with longitudinal changes in subclinical coronary artery disease. In the MESA (Multi-Ethnic Study of Atherosclerosis) study, we used a case-cohort approach to explore associations of 28 immune cell subsets measured at baseline (2000-2002) with longitudinal changes in coronary artery calcium (CAC). We examined incident CAC from examination 2 (2002-2004) through examination 5 (2010-2012) in participants with 0 CAC at baseline using multivariable-adjusted Cox regression. In participants with CAC >0 at baseline, we analyzed changes in CAC through examination 5 using multivariable-adjusted linear mixed models. Because no studies have investigated immune cells and longitudinal CAC changes, analyses were considered exploratory, with <0.05 as the threshold for possible significance. Of 975 participants with immune cells subsets and CAC measurements at baseline, 378 had CAC 0 at baseline (mean age, 58.4; 37.0% men) and 597 had CAC >0 at baseline (mean age, 65.7; 57.6% men). Natural killer cells were associated with higher incident CAC (hazard ratio [HR], 1.26 per SD higher natural killer cell proportion; =0.03), whereas T helper type cells were associated with lower incident CAC (HR, 0.81; =0.04). B cells were associated with CAC progression (β=53.1 Agatston units per SD higher B-cell proportion, =0.04), whereas CD14+CD16+ monocytes (β=-71.6; =0.03) and T regulatory cells (β=-61.9; =0.03) were associated with lower CAC progression. Natural killer cells may be associated with incident CAC and T regulatory cells may be associated with attenuated CAC progression, among other findings. These warrant replication and experimental investigation.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
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content type line 23
ISSN:2047-9980
2047-9980
DOI:10.1161/JAHA.125.042502