Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma
The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear. We retrospectively evaluated 236 patients who underwent radical resection for perihilar cholangiocarcinoma from September 2002 to December 2020. The cachexia index was calculated a...
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| Vydáno v: | Surgery Ročník 182; s. 109344 |
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01.06.2025
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| Abstract | The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.
We retrospectively evaluated 236 patients who underwent radical resection for perihilar cholangiocarcinoma from September 2002 to December 2020. The cachexia index was calculated as follows: (skeletal muscle index × albumin level)/neutrophil-to-lymphocyte ratio, with sex-specific cutoff values determined via receiver operating characteristic curves on the basis of 3-year survival data. Clinicopathologic characteristics and survival outcomes were compared between the low-cachexia index (n = 95) and high-cachexia index (n = 141) groups. Multivariable analyses were performed to identify prognostic factors for overall survival and relapse-free survival.
The low-cachexia index group was characterized by greater carbohydrate antigen 19–9 level (56 vs 31 U/mL, P = .024) and greater proportion of preoperative biliary drainage (84% vs 70%, P = .013). The low-cachexia index group underwent vascular resection and reconstruction more frequently (47% vs 29%, P = .006) and had a greater rate of lymph node metastasis (54% vs 35%, P = .005). The median overall survival and relapse-free survival times of the low-cachexia index group were significantly worse than those of the high-cachexia index group (overall survival, 29.0 vs 47.4 months, P < .001; relapse-free survival, 17.2 vs 33.1 months, P < .001). Multivariable analysis revealed that a preoperative cachexia index (hazard ratio for overall survival, 0.95, P = .008; hazard ratio for relapse-free survival, 0.95, P = .017) and high preoperative carbohydrate antigen 19-9 level (hazard ratio for overall survival, 1.01, P = .002; hazard ratio for relapse-free survival, 1.01, P = .012) were prognostic factors.
The cachexia index may be a useful biomarker for the prediction of tumor aggressiveness and prognosis before perihilar cholangiocarcinoma resection.
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| AbstractList | The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.
We retrospectively evaluated 236 patients who underwent radical resection for perihilar cholangiocarcinoma from September 2002 to December 2020. The cachexia index was calculated as follows: (skeletal muscle index × albumin level)/neutrophil-to-lymphocyte ratio, with sex-specific cutoff values determined via receiver operating characteristic curves on the basis of 3-year survival data. Clinicopathologic characteristics and survival outcomes were compared between the low-cachexia index (n = 95) and high-cachexia index (n = 141) groups. Multivariable analyses were performed to identify prognostic factors for overall survival and relapse-free survival.
The low-cachexia index group was characterized by greater carbohydrate antigen 19-9 level (56 vs 31 U/mL, P = .024) and greater proportion of preoperative biliary drainage (84% vs 70%, P = .013). The low-cachexia index group underwent vascular resection and reconstruction more frequently (47% vs 29%, P = .006) and had a greater rate of lymph node metastasis (54% vs 35%, P = .005). The median overall survival and relapse-free survival times of the low-cachexia index group were significantly worse than those of the high-cachexia index group (overall survival, 29.0 vs 47.4 months, P < .001; relapse-free survival, 17.2 vs 33.1 months, P < .001). Multivariable analysis revealed that a preoperative cachexia index (hazard ratio for overall survival, 0.95, P = .008; hazard ratio for relapse-free survival, 0.95, P = .017) and high preoperative carbohydrate antigen 19-9 level (hazard ratio for overall survival, 1.01, P = .002; hazard ratio for relapse-free survival, 1.01, P = .012) were prognostic factors.
The cachexia index may be a useful biomarker for the prediction of tumor aggressiveness and prognosis before perihilar cholangiocarcinoma resection. The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.BACKGROUNDThe prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.We retrospectively evaluated 236 patients who underwent radical resection for perihilar cholangiocarcinoma from September 2002 to December 2020. The cachexia index was calculated as follows: (skeletal muscle index × albumin level)/neutrophil-to-lymphocyte ratio, with sex-specific cutoff values determined via receiver operating characteristic curves on the basis of 3-year survival data. Clinicopathologic characteristics and survival outcomes were compared between the low-cachexia index (n = 95) and high-cachexia index (n = 141) groups. Multivariable analyses were performed to identify prognostic factors for overall survival and relapse-free survival.METHODSWe retrospectively evaluated 236 patients who underwent radical resection for perihilar cholangiocarcinoma from September 2002 to December 2020. The cachexia index was calculated as follows: (skeletal muscle index × albumin level)/neutrophil-to-lymphocyte ratio, with sex-specific cutoff values determined via receiver operating characteristic curves on the basis of 3-year survival data. Clinicopathologic characteristics and survival outcomes were compared between the low-cachexia index (n = 95) and high-cachexia index (n = 141) groups. Multivariable analyses were performed to identify prognostic factors for overall survival and relapse-free survival.The low-cachexia index group was characterized by greater carbohydrate antigen 19-9 level (56 vs 31 U/mL, P = .024) and greater proportion of preoperative biliary drainage (84% vs 70%, P = .013). The low-cachexia index group underwent vascular resection and reconstruction more frequently (47% vs 29%, P = .006) and had a greater rate of lymph node metastasis (54% vs 35%, P = .005). The median overall survival and relapse-free survival times of the low-cachexia index group were significantly worse than those of the high-cachexia index group (overall survival, 29.0 vs 47.4 months, P < .001; relapse-free survival, 17.2 vs 33.1 months, P < .001). Multivariable analysis revealed that a preoperative cachexia index (hazard ratio for overall survival, 0.95, P = .008; hazard ratio for relapse-free survival, 0.95, P = .017) and high preoperative carbohydrate antigen 19-9 level (hazard ratio for overall survival, 1.01, P = .002; hazard ratio for relapse-free survival, 1.01, P = .012) were prognostic factors.RESULTSThe low-cachexia index group was characterized by greater carbohydrate antigen 19-9 level (56 vs 31 U/mL, P = .024) and greater proportion of preoperative biliary drainage (84% vs 70%, P = .013). The low-cachexia index group underwent vascular resection and reconstruction more frequently (47% vs 29%, P = .006) and had a greater rate of lymph node metastasis (54% vs 35%, P = .005). The median overall survival and relapse-free survival times of the low-cachexia index group were significantly worse than those of the high-cachexia index group (overall survival, 29.0 vs 47.4 months, P < .001; relapse-free survival, 17.2 vs 33.1 months, P < .001). Multivariable analysis revealed that a preoperative cachexia index (hazard ratio for overall survival, 0.95, P = .008; hazard ratio for relapse-free survival, 0.95, P = .017) and high preoperative carbohydrate antigen 19-9 level (hazard ratio for overall survival, 1.01, P = .002; hazard ratio for relapse-free survival, 1.01, P = .012) were prognostic factors.The cachexia index may be a useful biomarker for the prediction of tumor aggressiveness and prognosis before perihilar cholangiocarcinoma resection.CONCLUSIONThe cachexia index may be a useful biomarker for the prediction of tumor aggressiveness and prognosis before perihilar cholangiocarcinoma resection. The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear. We retrospectively evaluated 236 patients who underwent radical resection for perihilar cholangiocarcinoma from September 2002 to December 2020. The cachexia index was calculated as follows: (skeletal muscle index × albumin level)/neutrophil-to-lymphocyte ratio, with sex-specific cutoff values determined via receiver operating characteristic curves on the basis of 3-year survival data. Clinicopathologic characteristics and survival outcomes were compared between the low-cachexia index (n = 95) and high-cachexia index (n = 141) groups. Multivariable analyses were performed to identify prognostic factors for overall survival and relapse-free survival. The low-cachexia index group was characterized by greater carbohydrate antigen 19–9 level (56 vs 31 U/mL, P = .024) and greater proportion of preoperative biliary drainage (84% vs 70%, P = .013). The low-cachexia index group underwent vascular resection and reconstruction more frequently (47% vs 29%, P = .006) and had a greater rate of lymph node metastasis (54% vs 35%, P = .005). The median overall survival and relapse-free survival times of the low-cachexia index group were significantly worse than those of the high-cachexia index group (overall survival, 29.0 vs 47.4 months, P < .001; relapse-free survival, 17.2 vs 33.1 months, P < .001). Multivariable analysis revealed that a preoperative cachexia index (hazard ratio for overall survival, 0.95, P = .008; hazard ratio for relapse-free survival, 0.95, P = .017) and high preoperative carbohydrate antigen 19-9 level (hazard ratio for overall survival, 1.01, P = .002; hazard ratio for relapse-free survival, 1.01, P = .012) were prognostic factors. The cachexia index may be a useful biomarker for the prediction of tumor aggressiveness and prognosis before perihilar cholangiocarcinoma resection. [Display omitted] |
| ArticleNumber | 109344 |
| Author | Uesaka, Katsuhiko Ohgi, Katsuhisa Sugiura, Teiichi Kato, Yoshiyasu Dei, Hideyuki Otsuka, Shimpei Sakashita, Katsuya Notsu, Akifumi Ashida, Ryo |
| Author_xml | – sequence: 1 givenname: Katsuya orcidid: 0009-0005-5373-4563 surname: Sakashita fullname: Sakashita, Katsuya organization: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan – sequence: 2 givenname: Shimpei orcidid: 0000-0002-2450-3011 surname: Otsuka fullname: Otsuka, Shimpei email: sh.otsuka@scchr.jp organization: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan – sequence: 3 givenname: Ryo surname: Ashida fullname: Ashida, Ryo organization: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan – sequence: 4 givenname: Katsuhisa surname: Ohgi fullname: Ohgi, Katsuhisa organization: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan – sequence: 5 givenname: Yoshiyasu surname: Kato fullname: Kato, Yoshiyasu organization: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan – sequence: 6 givenname: Hideyuki surname: Dei fullname: Dei, Hideyuki organization: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan – sequence: 7 givenname: Akifumi surname: Notsu fullname: Notsu, Akifumi organization: Department of Biostatistics, Clinical Research Support Center, Shizuoka Cancer Center, Shizuoka, Japan – sequence: 8 givenname: Katsuhiko surname: Uesaka fullname: Uesaka, Katsuhiko organization: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan – sequence: 9 givenname: Teiichi surname: Sugiura fullname: Sugiura, Teiichi organization: Division of Hepato-Biliary-Pancreatic Surgery, Shizuoka Cancer Center, Shizuoka, Japan |
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| Cites_doi | 10.1002/bjs.10776 10.1159/000488779 10.4137/CMO.S30891 10.1038/s41571-023-00746-1 10.1007/s00268-018-4833-1 10.1111/hpb.12394 10.1002/ags3.12345 10.1097/HEP.0000000000000554 10.1002/bjs.5920 10.1016/S0140-6736(22)02038-4 10.1016/j.suronc.2022.101881 10.1016/S2468-1253(24)00095-5 10.1002/ags3.12669 10.4254/wjh.v6.i8.559 10.1016/j.surg.2010.12.002 10.1152/ajpendo.00520.2010 10.1002/bjs.7084 10.1007/s00595-023-02646-4 10.1097/01.sla.0000201482.11876.14 10.1093/bjsopen/zrab064 10.1016/j.surg.2010.10.001 10.1002/ags3.12578 10.3390/cancers16040698 10.1016/S1470-2045(18)30915-X 10.1016/j.suronc.2022.101825 10.1038/bmt.2012.244 10.1016/S0140-6736(21)00153-7 10.1002/sim.2331 10.1097/SLA.0000000000005103 10.1002/ags3.12686 10.1016/0002-9343(65)90178-6 10.1007/s00534-011-0474-6 |
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| References | Shimagaki, Sugimachi, Mano (bib12) 2023; 7 Rahbari, Garden, Padbury (bib20) 2011; 149 Hamaguchi, Kaido, Okumura (bib27) 2019; 8 Akaoka, Haruki, Taniai (bib11) 2022; 45 Royston, Altman, Sauerbrei (bib28) 2006; 25 Hamura, Haruki, Shirai (bib13) 2022; 44 Ratti, Marino, Olthof (bib33) 2024; 79 Jafri, Previgliano, Khandelwal, Shi (bib25) 2015; 9 Pawaskar, Huang, Pham (bib31) 2024; 16 Oh, He, Bouattour (bib4) 2024; 9 Springfeld, Ferrone, Katz (bib5) 2023; 20 Valle, Kelley, Nervi, Oh, Zhu (bib2) 2021; 397 Sugiura, Uesaka, Okamura (bib17) 2021; 5 Primrose, Fox, Palmer (bib34) 2019; 20 Klatskin (bib1) 1965; 38 Sugiura, Okamura, Ito (bib16) 2019; 43 Sugiura, Uesaka, Okamura (bib24) 2020; 4 Kamada, Haruki, Nakashima (bib9) 2023; 53 Goenka, Goenka (bib32) 2014; 6 Hojman, Dethlefsen, Brandt, Hansen, Pedersen, Pedersen (bib30) 2011; 301 Nakashima, Haruki, Kamada (bib7) 2023; 7 Kanda (bib29) 2013; 48 Ebata, Hirano, Konishi (bib22) 2018; 105 Nagino, Kamiya, Nishio, Ebata, Arai, Nimura (bib14) 2006; 243 Yokoyama, Nishio, Ebata, Igami, Sugawara, Nagino (bib15) 2010; 97 Nakachi, Ikeda, Konishi (bib23) 2023; 401 (bib21) 2017 Tanji, Furukawa, Haruki (bib10) 2022; 6 Uesaka (bib18) 2012; 19 Noji, Kondo, Hirano, Tanaka, Suzuki, Shichinohe (bib6) 2008; 95 Brown, Thomson, Gardner (bib8) 2024; 111 Koch, Garden, Padbury (bib19) 2011; 149 Mueller, Breuer, Mizuno (bib3) 2021; 274 Coelen, Wiggers, Nio (bib26) 2015; 17 Jafri (10.1016/j.surg.2025.109344_bib25) 2015; 9 Noji (10.1016/j.surg.2025.109344_bib6) 2008; 95 Akaoka (10.1016/j.surg.2025.109344_bib11) 2022; 45 Uesaka (10.1016/j.surg.2025.109344_bib18) 2012; 19 Primrose (10.1016/j.surg.2025.109344_bib34) 2019; 20 Koch (10.1016/j.surg.2025.109344_bib19) 2011; 149 Kanda (10.1016/j.surg.2025.109344_bib29) 2013; 48 Coelen (10.1016/j.surg.2025.109344_bib26) 2015; 17 Goenka (10.1016/j.surg.2025.109344_bib32) 2014; 6 Ratti (10.1016/j.surg.2025.109344_bib33) 2024; 79 Nakashima (10.1016/j.surg.2025.109344_bib7) 2023; 7 Klatskin (10.1016/j.surg.2025.109344_bib1) 1965; 38 Nagino (10.1016/j.surg.2025.109344_bib14) 2006; 243 Ebata (10.1016/j.surg.2025.109344_bib22) 2018; 105 Sugiura (10.1016/j.surg.2025.109344_bib17) 2021; 5 Nakachi (10.1016/j.surg.2025.109344_bib23) 2023; 401 Sugiura (10.1016/j.surg.2025.109344_bib24) 2020; 4 Sugiura (10.1016/j.surg.2025.109344_bib16) 2019; 43 Valle (10.1016/j.surg.2025.109344_bib2) 2021; 397 Springfeld (10.1016/j.surg.2025.109344_bib5) 2023; 20 Hojman (10.1016/j.surg.2025.109344_bib30) 2011; 301 (10.1016/j.surg.2025.109344_bib21) 2017 Royston (10.1016/j.surg.2025.109344_bib28) 2006; 25 Pawaskar (10.1016/j.surg.2025.109344_bib31) 2024; 16 Brown (10.1016/j.surg.2025.109344_bib8) 2024; 111 Shimagaki (10.1016/j.surg.2025.109344_bib12) 2023; 7 Mueller (10.1016/j.surg.2025.109344_bib3) 2021; 274 Oh (10.1016/j.surg.2025.109344_bib4) 2024; 9 Kamada (10.1016/j.surg.2025.109344_bib9) 2023; 53 Hamaguchi (10.1016/j.surg.2025.109344_bib27) 2019; 8 Yokoyama (10.1016/j.surg.2025.109344_bib15) 2010; 97 Rahbari (10.1016/j.surg.2025.109344_bib20) 2011; 149 Tanji (10.1016/j.surg.2025.109344_bib10) 2022; 6 Hamura (10.1016/j.surg.2025.109344_bib13) 2022; 44 |
| References_xml | – volume: 243 start-page: 364 year: 2006 end-page: 372 ident: bib14 article-title: Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and long-term follow-up publication-title: Ann Surg – volume: 17 start-page: 520 year: 2015 end-page: 528 ident: bib26 article-title: Preoperative computed tomography assessment of skeletal muscle mass is valuable in predicting outcomes following hepatectomy for perihilar cholangiocarcinoma publication-title: HPB (Oxford) – volume: 149 start-page: 713 year: 2011 end-page: 724 ident: bib20 article-title: Posthepatectomy liver failure: a definition and grading by the international Study Group of Liver Surgery (ISGLS) publication-title: Surgery – volume: 9 start-page: 694 year: 2024 end-page: 704 ident: bib4 article-title: Durvalumab or placebo plus gemcitabine and cisplatin in participants with advanced biliary tract cancer (TOPAZ-1): updated overall survival from a randomised phase 3 study publication-title: Lancet Gastroenterol Hepatol – volume: 38 start-page: 241 year: 1965 end-page: 256 ident: bib1 article-title: Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis. An unusual tumor with distinctive clinical and pathological features publication-title: Am J Med – volume: 105 start-page: 192 year: 2018 end-page: 202 ident: bib22 article-title: Randomized clinical trial of adjuvant gemcitabine chemotherapy versus observation in resected bile duct cancer publication-title: Br J Surg – volume: 48 start-page: 452 year: 2013 end-page: 458 ident: bib29 article-title: Investigation of the freely available easy-to-use software 'EZR' for medical statistics publication-title: Bone Marrow Transpl – volume: 25 start-page: 127 year: 2006 end-page: 141 ident: bib28 article-title: Dichotomizing continuous predictors in multiple regression: a bad idea publication-title: Stat Med – volume: 8 start-page: 92 year: 2019 end-page: 109 ident: bib27 article-title: Preoperative visceral adiposity and muscularity predict poor outcomes after hepatectomy for hepatocellular carcinoma publication-title: Liver Cancer – year: 2017 ident: bib21 publication-title: TNM Classification of Malignant Tumours – volume: 397 start-page: 428 year: 2021 end-page: 444 ident: bib2 article-title: Biliary tract cancer publication-title: Lancet – volume: 274 start-page: 780 year: 2021 end-page: 788 ident: bib3 article-title: Perihilar cholangiocarcinoma—novel benchmark values for surgical and oncological outcomes from 24 expert centers publication-title: Ann Surg – volume: 301 start-page: E504 year: 2011 end-page: E510 ident: bib30 article-title: Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth publication-title: Am J Physiol Endocrinol Metab – volume: 44 year: 2022 ident: bib13 article-title: Preoperative cachexia index can predict the prognosis of extrahepatic biliary tract cancer after resection publication-title: Surg Oncol – volume: 149 start-page: 680 year: 2011 end-page: 688 ident: bib19 article-title: Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery publication-title: Surgery – volume: 43 start-page: 894 year: 2019 end-page: 901 ident: bib16 article-title: Left hepatectomy with combined resection and reconstruction of right hepatic artery for bismuth type I and II perihilar cholangiocarcinoma publication-title: World J Surg – volume: 9 start-page: 87 year: 2015 end-page: 93 ident: bib25 article-title: Cachexia index in advanced non–small-cell lung cancer patients publication-title: Clin Med Insights Oncol – volume: 20 start-page: 663 year: 2019 end-page: 673 ident: bib34 article-title: Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study publication-title: Lancet Oncol – volume: 97 start-page: 1260 year: 2010 end-page: 1268 ident: bib15 article-title: Value of indocyanine green clearance of the future liver remnant in predicting outcome after resection for biliary cancer publication-title: Br J Surg – volume: 6 start-page: 559 year: 2014 end-page: 569 ident: bib32 article-title: Palliation: hilar cholangiocarcinoma publication-title: World J Hepatol – volume: 53 start-page: 1064 year: 2023 end-page: 1072 ident: bib9 article-title: Prognostic significance of the cachexia index in patients with stage I-III colorectal cancer who underwent laparoscopic surgery publication-title: Surg Today – volume: 20 start-page: 318 year: 2023 end-page: 337 ident: bib5 article-title: Neoadjuvant therapy for pancreatic cancer publication-title: Nat Rev Clin Oncol – volume: 401 start-page: 195 year: 2023 end-page: 203 ident: bib23 article-title: Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial publication-title: Lancet – volume: 4 start-page: 455 year: 2020 end-page: 463 ident: bib24 article-title: Adjuvant chemoradiotherapy for positive hepatic ductal margin on cholangiocarcinoma publication-title: Ann Gastroenterol Surg – volume: 111 year: 2024 ident: bib8 article-title: Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study publication-title: Br J Surg – volume: 6 start-page: 804 year: 2022 end-page: 812 ident: bib10 article-title: Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases publication-title: Ann Gastroenterol Surg – volume: 79 start-page: 341 year: 2024 end-page: 354 ident: bib33 article-title: Predicting futility of upfront surgery in perihilar cholangiocarcinoma: machine learning analytics model to optimize treatment allocation publication-title: Hepatology – volume: 95 start-page: 92 year: 2008 end-page: 96 ident: bib6 article-title: Computed tomography evaluation of regional lymph node metastases in patients with biliary cancer publication-title: Br J Surg – volume: 7 start-page: 733 year: 2023 end-page: 740 ident: bib7 article-title: Usefulness of the cachexia index as a prognostic indicator for patients with gastric cancer publication-title: Ann Gastroenterol Surg – volume: 45 year: 2022 ident: bib11 article-title: Clinical significance of cachexia index in patients with hepatocellular carcinoma after hepatic resection publication-title: Surg Oncol – volume: 7 start-page: 977 year: 2023 end-page: 986 ident: bib12 article-title: Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma publication-title: Ann Gastroenterol Surg – volume: 5 year: 2021 ident: bib17 article-title: Major hepatectomy with combined vascular resection for perihilar cholangiocarcinoma publication-title: BJS Open – volume: 19 start-page: 195 year: 2012 end-page: 202 ident: bib18 article-title: Left hepatectomy or left trisectionectomy with resection of the caudate lobe and extrahepatic bile duct for hilar cholangiocarcinoma (with video) publication-title: J Hepatobiliary Pancreat Sci – volume: 16 start-page: 698 year: 2024 ident: bib31 article-title: Systematic review of preoperative prognostic biomarkers in perihilar cholangiocarcinoma publication-title: Cancers (Basel) – volume: 105 start-page: 192 year: 2018 ident: 10.1016/j.surg.2025.109344_bib22 article-title: Randomized clinical trial of adjuvant gemcitabine chemotherapy versus observation in resected bile duct cancer publication-title: Br J Surg doi: 10.1002/bjs.10776 – volume: 8 start-page: 92 year: 2019 ident: 10.1016/j.surg.2025.109344_bib27 article-title: Preoperative visceral adiposity and muscularity predict poor outcomes after hepatectomy for hepatocellular carcinoma publication-title: Liver Cancer doi: 10.1159/000488779 – volume: 9 start-page: 87 year: 2015 ident: 10.1016/j.surg.2025.109344_bib25 article-title: Cachexia index in advanced non–small-cell lung cancer patients publication-title: Clin Med Insights Oncol doi: 10.4137/CMO.S30891 – volume: 20 start-page: 318 year: 2023 ident: 10.1016/j.surg.2025.109344_bib5 article-title: Neoadjuvant therapy for pancreatic cancer publication-title: Nat Rev Clin Oncol doi: 10.1038/s41571-023-00746-1 – volume: 43 start-page: 894 year: 2019 ident: 10.1016/j.surg.2025.109344_bib16 article-title: Left hepatectomy with combined resection and reconstruction of right hepatic artery for bismuth type I and II perihilar cholangiocarcinoma publication-title: World J Surg doi: 10.1007/s00268-018-4833-1 – volume: 17 start-page: 520 year: 2015 ident: 10.1016/j.surg.2025.109344_bib26 article-title: Preoperative computed tomography assessment of skeletal muscle mass is valuable in predicting outcomes following hepatectomy for perihilar cholangiocarcinoma publication-title: HPB (Oxford) doi: 10.1111/hpb.12394 – volume: 4 start-page: 455 year: 2020 ident: 10.1016/j.surg.2025.109344_bib24 article-title: Adjuvant chemoradiotherapy for positive hepatic ductal margin on cholangiocarcinoma publication-title: Ann Gastroenterol Surg doi: 10.1002/ags3.12345 – volume: 79 start-page: 341 year: 2024 ident: 10.1016/j.surg.2025.109344_bib33 article-title: Predicting futility of upfront surgery in perihilar cholangiocarcinoma: machine learning analytics model to optimize treatment allocation publication-title: Hepatology doi: 10.1097/HEP.0000000000000554 – volume: 95 start-page: 92 year: 2008 ident: 10.1016/j.surg.2025.109344_bib6 article-title: Computed tomography evaluation of regional lymph node metastases in patients with biliary cancer publication-title: Br J Surg doi: 10.1002/bjs.5920 – volume: 401 start-page: 195 year: 2023 ident: 10.1016/j.surg.2025.109344_bib23 article-title: Adjuvant S-1 compared with observation in resected biliary tract cancer (JCOG1202, ASCOT): a multicentre, open-label, randomised, controlled, phase 3 trial publication-title: Lancet doi: 10.1016/S0140-6736(22)02038-4 – volume: 45 year: 2022 ident: 10.1016/j.surg.2025.109344_bib11 article-title: Clinical significance of cachexia index in patients with hepatocellular carcinoma after hepatic resection publication-title: Surg Oncol doi: 10.1016/j.suronc.2022.101881 – volume: 9 start-page: 694 year: 2024 ident: 10.1016/j.surg.2025.109344_bib4 article-title: Durvalumab or placebo plus gemcitabine and cisplatin in participants with advanced biliary tract cancer (TOPAZ-1): updated overall survival from a randomised phase 3 study publication-title: Lancet Gastroenterol Hepatol doi: 10.1016/S2468-1253(24)00095-5 – volume: 7 start-page: 733 year: 2023 ident: 10.1016/j.surg.2025.109344_bib7 article-title: Usefulness of the cachexia index as a prognostic indicator for patients with gastric cancer publication-title: Ann Gastroenterol Surg doi: 10.1002/ags3.12669 – volume: 6 start-page: 559 year: 2014 ident: 10.1016/j.surg.2025.109344_bib32 article-title: Palliation: hilar cholangiocarcinoma publication-title: World J Hepatol doi: 10.4254/wjh.v6.i8.559 – volume: 149 start-page: 680 year: 2011 ident: 10.1016/j.surg.2025.109344_bib19 article-title: Bile leakage after hepatobiliary and pancreatic surgery: a definition and grading of severity by the International Study Group of Liver Surgery publication-title: Surgery doi: 10.1016/j.surg.2010.12.002 – volume: 301 start-page: E504 year: 2011 ident: 10.1016/j.surg.2025.109344_bib30 article-title: Exercise-induced muscle-derived cytokines inhibit mammary cancer cell growth publication-title: Am J Physiol Endocrinol Metab doi: 10.1152/ajpendo.00520.2010 – volume: 97 start-page: 1260 year: 2010 ident: 10.1016/j.surg.2025.109344_bib15 article-title: Value of indocyanine green clearance of the future liver remnant in predicting outcome after resection for biliary cancer publication-title: Br J Surg doi: 10.1002/bjs.7084 – volume: 53 start-page: 1064 year: 2023 ident: 10.1016/j.surg.2025.109344_bib9 article-title: Prognostic significance of the cachexia index in patients with stage I-III colorectal cancer who underwent laparoscopic surgery publication-title: Surg Today doi: 10.1007/s00595-023-02646-4 – volume: 243 start-page: 364 year: 2006 ident: 10.1016/j.surg.2025.109344_bib14 article-title: Two hundred forty consecutive portal vein embolizations before extended hepatectomy for biliary cancer: surgical outcome and long-term follow-up publication-title: Ann Surg doi: 10.1097/01.sla.0000201482.11876.14 – volume: 5 year: 2021 ident: 10.1016/j.surg.2025.109344_bib17 article-title: Major hepatectomy with combined vascular resection for perihilar cholangiocarcinoma publication-title: BJS Open doi: 10.1093/bjsopen/zrab064 – volume: 149 start-page: 713 year: 2011 ident: 10.1016/j.surg.2025.109344_bib20 article-title: Posthepatectomy liver failure: a definition and grading by the international Study Group of Liver Surgery (ISGLS) publication-title: Surgery doi: 10.1016/j.surg.2010.10.001 – volume: 111 year: 2024 ident: 10.1016/j.surg.2025.109344_bib8 article-title: Cachexia index for prognostication in surgical patients with locally advanced oesophageal or gastric cancer: multicentre cohort study publication-title: Br J Surg – volume: 6 start-page: 804 year: 2022 ident: 10.1016/j.surg.2025.109344_bib10 article-title: Significant impact of cachexia index on the outcomes after hepatic resection for colorectal liver metastases publication-title: Ann Gastroenterol Surg doi: 10.1002/ags3.12578 – year: 2017 ident: 10.1016/j.surg.2025.109344_bib21 – volume: 16 start-page: 698 year: 2024 ident: 10.1016/j.surg.2025.109344_bib31 article-title: Systematic review of preoperative prognostic biomarkers in perihilar cholangiocarcinoma publication-title: Cancers (Basel) doi: 10.3390/cancers16040698 – volume: 20 start-page: 663 year: 2019 ident: 10.1016/j.surg.2025.109344_bib34 article-title: Capecitabine compared with observation in resected biliary tract cancer (BILCAP): a randomised, controlled, multicentre, phase 3 study publication-title: Lancet Oncol doi: 10.1016/S1470-2045(18)30915-X – volume: 44 year: 2022 ident: 10.1016/j.surg.2025.109344_bib13 article-title: Preoperative cachexia index can predict the prognosis of extrahepatic biliary tract cancer after resection publication-title: Surg Oncol doi: 10.1016/j.suronc.2022.101825 – volume: 48 start-page: 452 year: 2013 ident: 10.1016/j.surg.2025.109344_bib29 article-title: Investigation of the freely available easy-to-use software 'EZR' for medical statistics publication-title: Bone Marrow Transpl doi: 10.1038/bmt.2012.244 – volume: 397 start-page: 428 year: 2021 ident: 10.1016/j.surg.2025.109344_bib2 article-title: Biliary tract cancer publication-title: Lancet doi: 10.1016/S0140-6736(21)00153-7 – volume: 25 start-page: 127 year: 2006 ident: 10.1016/j.surg.2025.109344_bib28 article-title: Dichotomizing continuous predictors in multiple regression: a bad idea publication-title: Stat Med doi: 10.1002/sim.2331 – volume: 274 start-page: 780 year: 2021 ident: 10.1016/j.surg.2025.109344_bib3 article-title: Perihilar cholangiocarcinoma—novel benchmark values for surgical and oncological outcomes from 24 expert centers publication-title: Ann Surg doi: 10.1097/SLA.0000000000005103 – volume: 7 start-page: 977 year: 2023 ident: 10.1016/j.surg.2025.109344_bib12 article-title: Cachexia index as a prognostic predictor after resection of pancreatic ductal adenocarcinoma publication-title: Ann Gastroenterol Surg doi: 10.1002/ags3.12686 – volume: 38 start-page: 241 year: 1965 ident: 10.1016/j.surg.2025.109344_bib1 article-title: Adenocarcinoma of the hepatic duct at its bifurcation within the porta hepatis. An unusual tumor with distinctive clinical and pathological features publication-title: Am J Med doi: 10.1016/0002-9343(65)90178-6 – volume: 19 start-page: 195 year: 2012 ident: 10.1016/j.surg.2025.109344_bib18 article-title: Left hepatectomy or left trisectionectomy with resection of the caudate lobe and extrahepatic bile duct for hilar cholangiocarcinoma (with video) publication-title: J Hepatobiliary Pancreat Sci doi: 10.1007/s00534-011-0474-6 |
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We retrospectively evaluated 236... The prognostic value of the preoperative cachexia index for patients with perihilar cholangiocarcinoma remains unclear.BACKGROUNDThe prognostic value of the... |
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| SubjectTerms | Adult Aged Bile Duct Neoplasms - blood Bile Duct Neoplasms - complications Bile Duct Neoplasms - mortality Bile Duct Neoplasms - pathology Bile Duct Neoplasms - surgery Cachexia - blood Cachexia - diagnosis Cachexia - etiology Cachexia - mortality Female Hepatectomy Humans Klatskin Tumor - blood Klatskin Tumor - complications Klatskin Tumor - mortality Klatskin Tumor - surgery Male Middle Aged Prognosis Retrospective Studies |
| Title | Prognostic significance of the cachexia index for patients with perihilar cholangiocarcinoma |
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