Radiation-induced upregulation of γ-glutamyltransferase in colon carcinoma cells is mediated through the Ras signal transduction pathway

The activity of γ-glutamyltransferase (GGT) is frequently upregulated in tumor cells after oxidative stress and may thus increase the availability of amino acids needed for biosynthesis of the antioxidant glutathione. As γ-radiation of tumor cells can result in oxidative stress, we investigated whet...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1760; no. 2; pp. 151 - 157
Main Authors:	Pankiv, Serhiy, Møller, Seila, Bjørkøy, Geir, Moens, Ugo, Huseby, Nils-Erik
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.02.2006
Subjects:	Animals Apoptosis - radiation effects Cell Line, Tumor Colon carcinoma cell Colonic Neoplasms - enzymology Extracellular Signal-Regulated MAP Kinases - physiology Gamma Rays gamma-Glutamyltransferase - biosynthesis gamma-Glutamyltransferase - radiation effects Glutathione Humans MAP Kinase Kinase Kinases - physiology Oxidative stress Phosphatidylinositol 3-Kinases - physiology Radioactive irradiation ras Proteins - physiology Rats Reactive Oxygen Species - antagonists & inhibitors Signal Transduction - physiology Up-Regulation - radiation effects γ-glutamyltransferase Oxidative stress PI-3K JNK MAPK Radioactive irradiation MEK GGT ROS γ-glutamyltransferase Colon carcinoma cell GSH ERK Glutathione
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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