Physiologically‐based pharmacokinetic model predictions of inter‐ethnic differences in imatinib pharmacokinetics and dosing regimens

Aims This study implements a physiologically‐based pharmacokinetic (PBPK) modelling approach to investigate inter‐ethnic differences in imatinib pharmacokinetics and dosing regimens. Methods A PBPK model of imatinib was built in the Simcyp Simulator (version 17) integrating in vitro drug metabolism...

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Bibliographic Details

Published in:	British journal of clinical pharmacology Vol. 88; no. 4; pp. 1735 - 1750
Main Authors:	Adiwidjaja, Jeffry, Gross, Annette S., Boddy, Alan V., McLachlan, Andrew J.
Format:	Journal Article
Language:	English
Published:	England 01.02.2022
Subjects:	ethnic differences imatinib physiologically‐based pharmacokinetic simulation imatinib physiologically-based pharmacokinetic simulation ethnic differences
ISSN:	0306-5251, 1365-2125, 1365-2125
Online Access:	Get full text
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