Pedigree analysis of lumbar developmental spinal stenosis: Determination of potential inheritance patterns
Lumbar developmental spinal stenosis (DSS) refers to multilevel pre‐existing narrowed spinal canals, which predispose to neural compromise. The objective of this study is to identify any inheritance pattern of DSS by utilizing pedigree charts. This was a case series of 13 families with a total of 80...
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| Vydané v: | Journal of orthopaedic research Ročník 39; číslo 8; s. 1763 - 1776 |
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| Hlavní autori: | , , , , |
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| Jazyk: | English |
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01.08.2021
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| ISSN: | 0736-0266, 1554-527X, 1554-527X |
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| Abstract | Lumbar developmental spinal stenosis (DSS) refers to multilevel pre‐existing narrowed spinal canals, which predispose to neural compromise. The objective of this study is to identify any inheritance pattern of DSS by utilizing pedigree charts. This was a case series of 13 families with a total of 80 subjects having magnetic resonance imaging (MRI) from L1 to S1. Cases (subjects with DSS) or controls (subjects without DSS) were identified by measuring their anteroposterior (AP) vertebral canal diameters. Multilevel model analyses were also performed to evaluate whether there is substantial clustering of observations within the families, and the effect of multilevel DSS. The intraclass correlation coefficient (ICC) and Akaike information criteria (AIC) were compared between models. Correlations between subject demographics and AP vertebral canal diameter were statistically insignificant at all levels. Only vertebral canal cross‐sectional area, and axial and sagittal vertebral canal diameter were found to be statistically different between cases and controls at all levels (all p < .05). Both males and females were affected by DSS and there was no skipping of generation, which highly suggested DSS followed an autosomal dominant inheritance pattern. After accounting for multilevel DSS, there was a drop of more than 10 in AIC and some variances were also explained within families. This is the first study that suggests multilevel lumbar DSS to have an autosomal dominant inheritance pattern. Within families with a background of DSS, subjects had a smaller canal size, contributed by shortened axial and sagittal AP vertebral canal diameter, and smaller canal cross‐sectional area. |
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| AbstractList | Lumbar developmental spinal stenosis (DSS) refers to multilevel pre-existing narrowed spinal canals, which predispose to neural compromise. The objective of this study is to identify any inheritance pattern of DSS by utilizing pedigree charts. This was a case series of 13 families with a total of 80 subjects having magnetic resonance imaging (MRI) from L1 to S1. Cases (subjects with DSS) or controls (subjects without DSS) were identified by measuring their anteroposterior (AP) vertebral canal diameters. Multilevel model analyses were also performed to evaluate whether there is substantial clustering of observations within the families, and the effect of multilevel DSS. The intraclass correlation coefficient (ICC) and Akaike information criteria (AIC) were compared between models. Correlations between subject demographics and AP vertebral canal diameter were statistically insignificant at all levels. Only vertebral canal cross-sectional area, and axial and sagittal vertebral canal diameter were found to be statistically different between cases and controls at all levels (all p < .05). Both males and females were affected by DSS and there was no skipping of generation, which highly suggested DSS followed an autosomal dominant inheritance pattern. After accounting for multilevel DSS, there was a drop of more than 10 in AIC and some variances were also explained within families. This is the first study that suggests multilevel lumbar DSS to have an autosomal dominant inheritance pattern. Within families with a background of DSS, subjects had a smaller canal size, contributed by shortened axial and sagittal AP vertebral canal diameter, and smaller canal cross-sectional area. Lumbar developmental spinal stenosis (DSS) refers to multilevel pre‐existing narrowed spinal canals, which predispose to neural compromise. The objective of this study is to identify any inheritance pattern of DSS by utilizing pedigree charts. This was a case series of 13 families with a total of 80 subjects having magnetic resonance imaging (MRI) from L1 to S1. Cases (subjects with DSS) or controls (subjects without DSS) were identified by measuring their anteroposterior (AP) vertebral canal diameters. Multilevel model analyses were also performed to evaluate whether there is substantial clustering of observations within the families, and the effect of multilevel DSS. The intraclass correlation coefficient (ICC) and Akaike information criteria (AIC) were compared between models. Correlations between subject demographics and AP vertebral canal diameter were statistically insignificant at all levels. Only vertebral canal cross‐sectional area, and axial and sagittal vertebral canal diameter were found to be statistically different between cases and controls at all levels (all p < .05). Both males and females were affected by DSS and there was no skipping of generation, which highly suggested DSS followed an autosomal dominant inheritance pattern. After accounting for multilevel DSS, there was a drop of more than 10 in AIC and some variances were also explained within families. This is the first study that suggests multilevel lumbar DSS to have an autosomal dominant inheritance pattern. Within families with a background of DSS, subjects had a smaller canal size, contributed by shortened axial and sagittal AP vertebral canal diameter, and smaller canal cross‐sectional area. Lumbar developmental spinal stenosis (DSS) refers to multilevel pre-existing narrowed spinal canals, which predispose to neural compromise. The objective of this study is to identify any inheritance pattern of DSS by utilizing pedigree charts. This was a case series of 13 families with a total of 80 subjects having magnetic resonance imaging (MRI) from L1 to S1. Cases (subjects with DSS) or controls (subjects without DSS) were identified by measuring their anteroposterior (AP) vertebral canal diameters. Multilevel model analyses were also performed to evaluate whether there is substantial clustering of observations within the families, and the effect of multilevel DSS. The intraclass correlation coefficient (ICC) and Akaike information criteria (AIC) were compared between models. Correlations between subject demographics and AP vertebral canal diameter were statistically insignificant at all levels. Only vertebral canal cross-sectional area, and axial and sagittal vertebral canal diameter were found to be statistically different between cases and controls at all levels (all p < .05). Both males and females were affected by DSS and there was no skipping of generation, which highly suggested DSS followed an autosomal dominant inheritance pattern. After accounting for multilevel DSS, there was a drop of more than 10 in AIC and some variances were also explained within families. This is the first study that suggests multilevel lumbar DSS to have an autosomal dominant inheritance pattern. Within families with a background of DSS, subjects had a smaller canal size, contributed by shortened axial and sagittal AP vertebral canal diameter, and smaller canal cross-sectional area.Lumbar developmental spinal stenosis (DSS) refers to multilevel pre-existing narrowed spinal canals, which predispose to neural compromise. The objective of this study is to identify any inheritance pattern of DSS by utilizing pedigree charts. This was a case series of 13 families with a total of 80 subjects having magnetic resonance imaging (MRI) from L1 to S1. Cases (subjects with DSS) or controls (subjects without DSS) were identified by measuring their anteroposterior (AP) vertebral canal diameters. Multilevel model analyses were also performed to evaluate whether there is substantial clustering of observations within the families, and the effect of multilevel DSS. The intraclass correlation coefficient (ICC) and Akaike information criteria (AIC) were compared between models. Correlations between subject demographics and AP vertebral canal diameter were statistically insignificant at all levels. Only vertebral canal cross-sectional area, and axial and sagittal vertebral canal diameter were found to be statistically different between cases and controls at all levels (all p < .05). Both males and females were affected by DSS and there was no skipping of generation, which highly suggested DSS followed an autosomal dominant inheritance pattern. After accounting for multilevel DSS, there was a drop of more than 10 in AIC and some variances were also explained within families. This is the first study that suggests multilevel lumbar DSS to have an autosomal dominant inheritance pattern. Within families with a background of DSS, subjects had a smaller canal size, contributed by shortened axial and sagittal AP vertebral canal diameter, and smaller canal cross-sectional area. |
| Author | Samartzis, Dino Cheung, Prudence W. H. Lai, Marcus K. L. Song, You‐Qiang Cheung, Jason P. Y. |
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| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32902878$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.3349/ymj.2013.54.6.1498 10.1016/j.spinee.2013.08.054 10.1302/0301-620X.36B2.230 10.1016/S0140-6736(05)67570-8 10.1186/s12868-015-0228-5 10.1016/j.spinee.2013.09.012 10.1097/00007632-197812000-00004 10.1186/s13013-016-0088-5 10.1002/jor.23746 10.1302/0301-620X.101B2.BJJ-2018-1136.R2 10.1302/0301-620X.62B1.7351440 10.1097/00007632-198303000-00010 10.1097/BRS.0b013e31820e6282 10.1302/0301-620X.37B4.576 10.1002/jor.24221 10.1007/BF00266685 10.1002/art.33462 10.1097/BRS.0b013e3181d534f3 10.2106/JBJS.I.01568 10.1097/00007632-197612000-00006 10.1371/journal.pone.0190141 10.1097/BRS.0000000000000335 10.1177/0049124104268644 10.1136/ard.2003.008334 10.1007/s10897-008-9169-9 10.1002/(SICI)1098-2272(1997)14:4<365::AID-GEPI3>3.0.CO;2-2 10.1302/0301-620X.102B8.BJJ-2020-0528.R1 |
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| References | 1955; 37‐B 2015; 16 2010; 35 1995; 56 1981; 5 2019; 37 2008; 17 1983; 8 1978; 3 1976; 1 1980; 62‐B 2011; 36 1954; 36‐B 2016; 11 2004; 33 2013; 54 2020 2005; 366 2011; 93 1997; 14 2017; 12 2014; 14 2011; 69 2014; 39 2012; 24 2020; 102‐B 2003; 62 2019; 101‐B 2012; 64 2018; 36 2020; 29 e_1_2_9_30_1 e_1_2_9_31_1 e_1_2_9_11_1 e_1_2_9_10_1 e_1_2_9_32_1 e_1_2_9_12_1 e_1_2_9_33_1 Lai MKL (e_1_2_9_3_1) 2020; 29 e_1_2_9_15_1 e_1_2_9_14_1 e_1_2_9_17_1 e_1_2_9_16_1 e_1_2_9_19_1 e_1_2_9_18_1 Chatha DS (e_1_2_9_4_1) 2011; 69 e_1_2_9_20_1 e_1_2_9_22_1 e_1_2_9_21_1 e_1_2_9_24_1 e_1_2_9_23_1 e_1_2_9_8_1 e_1_2_9_7_1 e_1_2_9_6_1 e_1_2_9_5_1 Mukaka M (e_1_2_9_27_1) 2012; 24 e_1_2_9_2_1 e_1_2_9_9_1 Lai MKL (e_1_2_9_13_1) 2020 e_1_2_9_25_1 e_1_2_9_28_1 Bennett RL (e_1_2_9_26_1) 1995; 56 e_1_2_9_29_1 |
| References_xml | – volume: 29 start-page: 2187 issue: 2173 year: 2020 article-title: A systematic review of developmental lumbar spinal stenosis publication-title: Eur Spine J – volume: 36‐B start-page: 230 issue: 2 year: 1954 end-page: 237 article-title: A radicular syndrome from developmental narrowing of the lumbar vertebral canal publication-title: J Bone Joint Surg Br – volume: 39 start-page: 1067 issue: 13 year: 2014 end-page: 1076 article-title: Defining clinically relevant values for developmental spinal stenosis: a large‐scale magnetic resonance imaging study publication-title: Spine (Phila Pa 1976) – volume: 62 start-page: 1208 issue: 12 year: 2003 end-page: 1214 article-title: Sequence variations in the collagen IX and XI genes are associated with degenerative lumbar spinal stenosis publication-title: Ann Rheum Dis – volume: 56 start-page: 745 issue: 3 year: 1995 end-page: 752 article-title: Recommendations for standardized human pedigree nomenclature. Pedigree Standardization Task Force of the National Society of Genetic Counselors publication-title: Am J Hum Genet – volume: 366 start-page: 1397 issue: 9494 year: 2005 end-page: 1406 article-title: Population‐based family studies in genetic epidemiology publication-title: Lancet – volume: 12 issue: 12 year: 2017 article-title: An effective assessment method of spinal flexibility to predict the initial in‐orthosis correction on the patients with adolescent idiopathic scoliosis (AIS) publication-title: PLOS One – volume: 14 start-page: 808 issue: 5 year: 2014 end-page: 815 article-title: Anatomic radiological variations in developmental lumbar spinal stenosis: a prospective, control‐matched comparative analysis publication-title: Spine J – volume: 93 start-page: 662 issue: 7 year: 2011 end-page: 670 article-title: A population‐based study of juvenile disc degeneration and its association with overweight and obesity, low back pain, and diminished functional status publication-title: J Bone Joint Surg Am – volume: 69 start-page: 303 issue: 4 year: 2011 end-page: 307 article-title: MRI criteria of developmental lumbar spinal stenosis revisited publication-title: Bull NYU Hosp Jt Dis – volume: 17 start-page: 424 issue: 5 year: 2008 end-page: 433 article-title: Standardized human pedigree nomenclature: update and assessment of the recommendations of the National Society of Genetic Counselors publication-title: J Genet Couns – volume: 62‐B start-page: 78 issue: 1 year: 1980 end-page: 82 article-title: Computerised tomography in lumbar stenosis: a preliminary report publication-title: J Bone Joint Surg Br – volume: 36 start-page: 1273 issue: 16 year: 2011 end-page: 1278 article-title: A haplotype at the COL9A2 gene locus contributes to the genetic risk for lumbar spinal stenosis in the Korean population publication-title: Spine (Phila Pa 1976) – volume: 1 start-page: 217 year: 1976 end-page: 225 article-title: Fallacies of the present definition, nomenclature, and classification of the stenoses of the lumbar vertebral canal publication-title: Spine – volume: 33 start-page: 261 issue: 2 year: 2004 end-page: 304 article-title: Multimodel inference: understanding AIC and BIC in model selection publication-title: Sociol Methods Res – volume: 3 start-page: 319 issue: 4 year: 1978 end-page: 328 article-title: Pathology and pathogenesis of lumbar spondylosis and stenosis publication-title: Spine (Phila Pa 1976) – volume: 5 start-page: 209 issue: 3 year: 1981 end-page: 215 article-title: CT scanning versus myelography in the diagnosis of lumbar stenosis. A preliminary report publication-title: Int Orthop – volume: 35 start-page: 1944 issue: 21 year: 2010 end-page: 1952 article-title: ISSLS prize winner: prevalence, determinants, and association of Schmorl nodes of the lumbar spine with disc degeneration: a population‐based study of 2449 individuals publication-title: Spine (Phila Pa 1976) – year: 2020 article-title: Clinical implications of lumbar developmental spinal stenosis on back pain, radicular leg pain and disability publication-title: Bone Joint J – volume: 102‐B start-page: 1062 issue: 8 year: 2020 end-page: 1071 article-title: Predicting spondylolisthesis correction with prone traction radiographs publication-title: Bone Joint J – volume: 11 start-page: 26 issue: 1 year: 2016 article-title: The paradoxical relationship between ligamentum flavum hypertrophy and developmental lumbar spinal stenosis publication-title: Scoliosis Spinal Disord – volume: 14 start-page: 1476 issue: 8 year: 2014 end-page: 1483 article-title: Verification of measurements of lumbar spinal dimensions in T1‐ and T2‐weighted magnetic resonance imaging sequences publication-title: Spine J – volume: 37‐B start-page: 576 issue: 4 year: 1955 end-page: 583 article-title: Further experiences on the pathological influence of a developmental narrowness of the bony lumbar vertebral canal publication-title: J Bone Joint Surg Br – volume: 36 start-page: 1262 issue: 4 year: 2018 end-page: 1268 article-title: Etiology of developmental spinal stenosis: a genome‐wide association study publication-title: J Orthop Res – volume: 16 start-page: 94 year: 2015 article-title: Multilevel analysis quantifies variation in the experimental effect while optimizing power and preventing false positives publication-title: BMC Neurosci – volume: 14 start-page: 365 issue: 4 year: 1997 end-page: 388 article-title: Population‐based family study designs: an interdisciplinary research framework for genetic epidemiology publication-title: Genet Epidemiol – volume: 101‐B start-page: 154 issue: 2 year: 2019 end-page: 161 article-title: The influence of developmental spinal stenosis on the risk of re‐operation on an adjacent segment after decompression‐only surgery for lumbar spinal stenosis publication-title: Bone Joint J – volume: 64 start-page: 1488 issue: 5 year: 2012 end-page: 1496 article-title: The association of lumbar intervertebral disc degeneration on magnetic resonance imaging with body mass index in overweight and obese adults: a population‐based study publication-title: Arthritis Rheum – volume: 8 start-page: 187 issue: 2 year: 1983 end-page: 191 article-title: Lumbar vertebral canal morphometry for computerised tomography in spinal stenosis publication-title: Spine (Phila Pa 1976) – volume: 24 start-page: 69 issue: 3 year: 2012 end-page: 71 article-title: Statistics corner: a guide to appropriate use of correlation coefficient in medical research publication-title: Malawi Med J – volume: 37 start-page: 1090 issue: 5 year: 2019 end-page: 1100 article-title: Novel compression rat model for developmental spinal stenosis publication-title: J Orthop Res – volume: 54 start-page: 1498 issue: 6 year: 2013 end-page: 1504 article-title: Changes in spinal canal diameter and vertebral body height with age publication-title: Yonsei Med J – ident: e_1_2_9_30_1 doi: 10.3349/ymj.2013.54.6.1498 – ident: e_1_2_9_24_1 doi: 10.1016/j.spinee.2013.08.054 – year: 2020 ident: e_1_2_9_13_1 article-title: Clinical implications of lumbar developmental spinal stenosis on back pain, radicular leg pain and disability publication-title: Bone Joint J – ident: e_1_2_9_2_1 doi: 10.1302/0301-620X.36B2.230 – volume: 56 start-page: 745 issue: 3 year: 1995 ident: e_1_2_9_26_1 article-title: Recommendations for standardized human pedigree nomenclature. Pedigree Standardization Task Force of the National Society of Genetic Counselors publication-title: Am J Hum Genet – ident: e_1_2_9_31_1 doi: 10.1016/S0140-6736(05)67570-8 – ident: e_1_2_9_28_1 doi: 10.1186/s12868-015-0228-5 – volume: 24 start-page: 69 issue: 3 year: 2012 ident: e_1_2_9_27_1 article-title: Statistics corner: a guide to appropriate use of correlation coefficient in medical research publication-title: Malawi Med J – ident: e_1_2_9_7_1 doi: 10.1016/j.spinee.2013.09.012 – ident: e_1_2_9_17_1 doi: 10.1097/00007632-197812000-00004 – ident: e_1_2_9_11_1 doi: 10.1186/s13013-016-0088-5 – ident: e_1_2_9_10_1 doi: 10.1002/jor.23746 – ident: e_1_2_9_14_1 doi: 10.1302/0301-620X.101B2.BJJ-2018-1136.R2 – volume: 69 start-page: 303 issue: 4 year: 2011 ident: e_1_2_9_4_1 article-title: MRI criteria of developmental lumbar spinal stenosis revisited publication-title: Bull NYU Hosp Jt Dis – ident: e_1_2_9_8_1 doi: 10.1302/0301-620X.62B1.7351440 – ident: e_1_2_9_9_1 doi: 10.1097/00007632-198303000-00010 – ident: e_1_2_9_15_1 doi: 10.1097/BRS.0b013e31820e6282 – ident: e_1_2_9_18_1 doi: 10.1302/0301-620X.37B4.576 – ident: e_1_2_9_20_1 doi: 10.1002/jor.24221 – volume: 29 start-page: 2187 issue: 2173 year: 2020 ident: e_1_2_9_3_1 article-title: A systematic review of developmental lumbar spinal stenosis publication-title: Eur Spine J – ident: e_1_2_9_12_1 doi: 10.1007/BF00266685 – ident: e_1_2_9_21_1 doi: 10.1002/art.33462 – ident: e_1_2_9_22_1 doi: 10.1097/BRS.0b013e3181d534f3 – ident: e_1_2_9_23_1 doi: 10.2106/JBJS.I.01568 – ident: e_1_2_9_19_1 doi: 10.1097/00007632-197612000-00006 – ident: e_1_2_9_6_1 doi: 10.1371/journal.pone.0190141 – ident: e_1_2_9_5_1 doi: 10.1097/BRS.0000000000000335 – ident: e_1_2_9_29_1 doi: 10.1177/0049124104268644 – ident: e_1_2_9_16_1 doi: 10.1136/ard.2003.008334 – ident: e_1_2_9_25_1 doi: 10.1007/s10897-008-9169-9 – ident: e_1_2_9_32_1 doi: 10.1002/(SICI)1098-2272(1997)14:4<365::AID-GEPI3>3.0.CO;2-2 – ident: e_1_2_9_33_1 doi: 10.1302/0301-620X.102B8.BJJ-2020-0528.R1 |
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| Snippet | Lumbar developmental spinal stenosis (DSS) refers to multilevel pre‐existing narrowed spinal canals, which predispose to neural compromise. The objective of... Lumbar developmental spinal stenosis (DSS) refers to multilevel pre-existing narrowed spinal canals, which predispose to neural compromise. The objective of... Lumbar developmental spinal stenosis (DSS) refers to multilevel pre-existing narrowed spinal canals, which predispose to neural compromise. The objective of... |
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| SubjectTerms | developmental spinal stenosis family Female Humans Inheritance Patterns lumbar Lumbar Vertebrae - diagnostic imaging Lumbar Vertebrae - pathology Male Pedigree Spinal Canal - pathology Spinal Stenosis - diagnostic imaging Spinal Stenosis - genetics Spinal Stenosis - pathology |
| Title | Pedigree analysis of lumbar developmental spinal stenosis: Determination of potential inheritance patterns |
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