Nerve-tumor crosstalk in tumor microenvironment: From tumor initiation and progression to clinical implications

The autonomic nerve system (ANS) innervates organs and tissues throughout the body and maintains functional balance among various systems. Further investigations have shown that excessive activation of ANS not only causes disruption of homeostasis, but also may promote tumor formation. In addition,...

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Veröffentlicht in:Biochimica et biophysica acta. Reviews on cancer Jg. 1879; H. 4; S. 189121
Hauptverfasser: Zhang, Zheng, Lv, Zhen Gang, Lu, Miao, Li, Haifeng, Zhou, Jiahua
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.07.2024
Schlagworte:
Animals
Cancer Pain - metabolism
Cancer Pain - pathology
Carcinogenesis - pathology
Crosstalk
Disease Progression
Humans
Neoplasm Invasiveness
Neoplasms - pathology
Nerve
Tumor
Tumor Microenvironment
Crosstalk
SACC
6-OHDA
PNI
ADM
Nerve
TDO2
Tumor
NK1R
SCs
HCC
IPMN
Ems
NGF
CSF-1
EMT
MMP
MAG
PDAC
CAP
AAV
CGRP
COX-2
ANS
ADRB2
12/15-LOX
IMs
CSC
iCAFs
DCs
NCAM1
GC
PGE2
Tumor microenvironment
NSCLC
BDNF
Tregs
VEGF
Ach
TRPV1
TME
OTSCC
MDSCs
PIN
PSCs
PanIN
NMU
DRG
ZFP277
CHRM
ISSN:0304-419X, 1879-2561, 1879-2561
Online-Zugang:Volltext
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Zusammenfassung:The autonomic nerve system (ANS) innervates organs and tissues throughout the body and maintains functional balance among various systems. Further investigations have shown that excessive activation of ANS not only causes disruption of homeostasis, but also may promote tumor formation. In addition, the dynamic interaction between nerve and tumor cells in the tumor microenvironment also regulate tumor progression. On the one hand, nerves are passively invaded by tumor cells, that is, perineural invasion (PNI). On the other hand, compared with normal tissues, tumor tissues are subject to more abundant innervation, and nerves can influence tumor progression through regulating tumor proliferation, metastasis and drug resistance. A large number of studies have shown that nerve-tumor crosstalk, including PNI and innervation, is closely related to the prognosis of patients, and contributes to the formation of cancer pain, which significantly deteriorates the quality of life for patients. These findings suggest that nerve-tumor crosstalk represents a potential target for anti-tumor therapies and the management of cancer pain in the future. In this review, we systematically describe the mechanism by which nerve-tumor crosstalk regulates tumorigenesis and progression.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:0304-419X
1879-2561
1879-2561
DOI:10.1016/j.bbcan.2024.189121