P2X7 receptor contributes to DNA damage repair and acquisition of malignant phenotypes in irradiated human glioblastoma cells

Radiation therapy for cancer takes advantage of the higher sensitivity of tumor cells to radiation compared to normal tissue, but some cancers, such as glioblastoma (GBM) and malignant melanoma, acquire radiation resistance (radioresistance), rendering treatment ineffective. Radioresistance is chara...

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Bibliographic Details
Published in:	Biochimica et biophysica acta. General subjects Vol. 1869; no. 12; p. 130873
Main Authors:	Seki, Hiromu, Kitabatake, Kazuki, Uchiumi, Fumiaki, Tanuma, Sei-ichi, Tsukimoto, Mitsutoshi
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.12.2025
Subjects:	Adenosine Triphosphate - metabolism Brain Neoplasms - genetics Brain Neoplasms - metabolism Brain Neoplasms - pathology Cell Line, Tumor Cell migration Cell Movement - drug effects Cell Movement - radiation effects DNA Damage - radiation effects DNA repair DNA Repair - radiation effects Gamma Rays Glioblastoma Glioblastoma - genetics Glioblastoma - metabolism Glioblastoma - pathology Glioblastoma - radiotherapy HMGB1 HMGB1 Protein - metabolism Humans P2X7 receptor Phenotype Purinergic P2X Receptor Antagonists - pharmacology Radiation Radiation Tolerance Receptors, Purinergic P2X7 - genetics Receptors, Purinergic P2X7 - metabolism HMGB1 DNA repair P2X7 receptor Cell migration Glioblastoma Radiation
ISSN:	0304-4165, 1872-8006, 1872-8006
Online Access:	Get full text
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