Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our...

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Published in:Biochimica et biophysica acta. Reviews on cancer Vol. 1870; no. 1; pp. 51 - 66
Main Authors: Sun, Linchong, Suo, Caixia, Li, Shi-ting, Zhang, Huafeng, Gao, Ping
Format: Journal Article
Language:English
Published: Netherlands Elsevier B.V 01.08.2018
Subjects:
Amino Acids, Branched-Chain - metabolism
Biomass synthesis
Cell Proliferation
Humans
Immune cells
Metabolic reprogramming
Microbiota
Neoplasms - metabolism
Nutrients
Pentose Phosphate Pathway
Serine - biosynthesis
Tumor Microenvironment
Microbiota
Biomass synthesis
Metabolic reprogramming
Tumor microenvironment
Immune cells
ISSN:0304-419X, 1879-2561, 1879-2561
Online Access:Get full text
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Summary:While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.
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ISSN:0304-419X
1879-2561
1879-2561
DOI:10.1016/j.bbcan.2018.06.005