Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our...

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Vydáno v:Biochimica et biophysica acta. Reviews on cancer Ročník 1870; číslo 1; s. 51 - 66
Hlavní autoři: Sun, Linchong, Suo, Caixia, Li, Shi-ting, Zhang, Huafeng, Gao, Ping
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 01.08.2018
Témata:
Amino Acids, Branched-Chain - metabolism
Biomass synthesis
Cell Proliferation
Humans
Immune cells
Metabolic reprogramming
Microbiota
Neoplasms - metabolism
Nutrients
Pentose Phosphate Pathway
Serine - biosynthesis
Tumor Microenvironment
Microbiota
Biomass synthesis
Metabolic reprogramming
Tumor microenvironment
Immune cells
ISSN:0304-419X, 1879-2561, 1879-2561
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Shrnutí:While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.
Bibliografie:ObjectType-Article-1
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ISSN:0304-419X
1879-2561
1879-2561
DOI:10.1016/j.bbcan.2018.06.005