Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our...

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Veröffentlicht in:Biochimica et biophysica acta. Reviews on cancer Jg. 1870; H. 1; S. 51 - 66
Hauptverfasser: Sun, Linchong, Suo, Caixia, Li, Shi-ting, Zhang, Huafeng, Gao, Ping
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.08.2018
Schlagworte:
Amino Acids, Branched-Chain - metabolism
Biomass synthesis
Cell Proliferation
Humans
Immune cells
Metabolic reprogramming
Microbiota
Neoplasms - metabolism
Nutrients
Pentose Phosphate Pathway
Serine - biosynthesis
Tumor Microenvironment
Microbiota
Biomass synthesis
Metabolic reprogramming
Tumor microenvironment
Immune cells
ISSN:0304-419X, 1879-2561, 1879-2561
Online-Zugang:Volltext
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Abstract While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.
AbstractList While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.
While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.
Author Sun, Linchong
Gao, Ping
Suo, Caixia
Li, Shi-ting
Zhang, Huafeng
Author_xml – sequence: 1
  givenname: Linchong
  surname: Sun
  fullname: Sun, Linchong
  organization: Laboratory of Cancer and Stem Cell metabolism, Guangzhou First Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China
– sequence: 2
  givenname: Caixia
  surname: Suo
  fullname: Suo, Caixia
  organization: Laboratory of Cancer and Stem Cell metabolism, Guangzhou First Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China
– sequence: 3
  givenname: Shi-ting
  surname: Li
  fullname: Li, Shi-ting
  organization: Laboratory of Cancer and Stem Cell metabolism, Guangzhou First Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China
– sequence: 4
  givenname: Huafeng
  surname: Zhang
  fullname: Zhang, Huafeng
  email: hzhang22@ustc.edu.cn
  organization: CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
– sequence: 5
  givenname: Ping
  surname: Gao
  fullname: Gao, Ping
  email: pgao2@ustc.edu.cn
  organization: Laboratory of Cancer and Stem Cell metabolism, Guangzhou First Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29959989$$D View this record in MEDLINE/PubMed
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Keywords Microbiota
Biomass synthesis
Metabolic reprogramming
Tumor microenvironment
Immune cells
Language English
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Snippet While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via...
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SubjectTerms Amino Acids, Branched-Chain - metabolism
Biomass synthesis
Cell Proliferation
Humans
Immune cells
Metabolic reprogramming
Microbiota
Neoplasms - metabolism
Nutrients
Pentose Phosphate Pathway
Serine - biosynthesis
Tumor Microenvironment
Title Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
URI https://dx.doi.org/10.1016/j.bbcan.2018.06.005
https://www.ncbi.nlm.nih.gov/pubmed/29959989
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