Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect

While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Biochimica et biophysica acta. Reviews on cancer Jg. 1870; H. 1; S. 51 - 66
Hauptverfasser: Sun, Linchong, Suo, Caixia, Li, Shi-ting, Zhang, Huafeng, Gao, Ping
Format: Journal Article
Sprache:Englisch
Veröffentlicht: Netherlands Elsevier B.V 01.08.2018
Schlagworte:
Amino Acids, Branched-Chain - metabolism
Biomass synthesis
Cell Proliferation
Humans
Immune cells
Metabolic reprogramming
Microbiota
Neoplasms - metabolism
Nutrients
Pentose Phosphate Pathway
Serine - biosynthesis
Tumor Microenvironment
Microbiota
Biomass synthesis
Metabolic reprogramming
Tumor microenvironment
Immune cells
ISSN:0304-419X, 1879-2561, 1879-2561
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Abstract While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.
AbstractList While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.
While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via aerobic glycolysis, the so-called Warburg Effect, the progress in the following areas during the past several years has substantially advanced our understanding of the rewired metabolic network in cancer cells that is intertwined with oncogenic signaling. First, in addition to the major nutrient substrates glucose and glutamine, cancer cells have been discovered to utilize a variety of unconventional nutrient sources for survival. Second, the deregulated biomass synthesis is intertwined with cell cycle progression to coordinate the accelerated progression of cancer cells. Third, the reciprocal regulation of cancer cell's metabolic alterations and the microenvironment, involving extensive host immune cells and microbiota, have come into view as critical mechanisms to regulate cancer progression. These and other advances are shaping the current and future paradigm of cancer metabolism.
Author Sun, Linchong
Gao, Ping
Suo, Caixia
Li, Shi-ting
Zhang, Huafeng
Author_xml – sequence: 1
  givenname: Linchong
  surname: Sun
  fullname: Sun, Linchong
  organization: Laboratory of Cancer and Stem Cell metabolism, Guangzhou First Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China
– sequence: 2
  givenname: Caixia
  surname: Suo
  fullname: Suo, Caixia
  organization: Laboratory of Cancer and Stem Cell metabolism, Guangzhou First Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China
– sequence: 3
  givenname: Shi-ting
  surname: Li
  fullname: Li, Shi-ting
  organization: Laboratory of Cancer and Stem Cell metabolism, Guangzhou First Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China
– sequence: 4
  givenname: Huafeng
  surname: Zhang
  fullname: Zhang, Huafeng
  email: hzhang22@ustc.edu.cn
  organization: CAS Key Laboratory of Innate Immunity and Chronic Disease, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China
– sequence: 5
  givenname: Ping
  surname: Gao
  fullname: Gao, Ping
  email: pgao2@ustc.edu.cn
  organization: Laboratory of Cancer and Stem Cell metabolism, Guangzhou First Hospital, School of Medicine, South China University of Technology, Guangzhou 510006, China
BackLink https://www.ncbi.nlm.nih.gov/pubmed/29959989$$D View this record in MEDLINE/PubMed
BookMark eNqFkE1rFTEUhoO02Nurv0CQLN3MmEzm6wgubKmt0NJNRVeGJHNyzWUmqUluof_eXG914UIhcBZ53pdznlNy5INHQl5xVnPG-7fbWmujfN0wPtasrxnrnpEVHweomq7nR2TFBGurlsPXE3Ka0pYx3gnRPycnDUAHMMKKfLvBrHSYnaER72PYRLUszm-oDZGWdoNl4DwnqvxE83d0kS7OxID-wcXgF_T5HT3Dx3D4pl9U1Lu4oRfWoskvyLFVc8KXT3NNPn-8uDu_qq5vLz-df7iujOggV0ILxnlnrZhaqxVXpm3sAMAGwGEUCAbAAvBCaRgNaOiG8hCmRjUtMrEmbw695YQfO0xZLi7t91Yewy7JhvXNKHooZWvy-gnd6QUneR_douKj_O2kAOIAlCtTimj_IJzJvXm5lb_My715yXpZzJcU_JUyLqvsgs9Rufk_2feHLBZFDw6jTMZhcT-5WCTKKbh_5n8Ctlqf7g
CitedBy_id crossref_primary_10_3389_fphys_2023_1129889
crossref_primary_10_1186_s12943_025_02379_7
crossref_primary_10_3390_metabo13050618
crossref_primary_10_3390_cancers14215196
crossref_primary_10_3389_fneur_2023_1104738
crossref_primary_10_1016_j_bioorg_2024_107160
crossref_primary_10_1111_cas_14361
crossref_primary_10_3390_pharmaceutics14061303
crossref_primary_10_1038_s41420_025_02390_3
crossref_primary_10_1155_2022_3846010
crossref_primary_10_1016_j_apsb_2025_03_026
crossref_primary_10_3390_cancers12071822
crossref_primary_10_1016_j_biochi_2019_06_013
crossref_primary_10_1038_s41416_019_0644_x
crossref_primary_10_1371_journal_pbio_3002854
crossref_primary_10_3389_fimmu_2019_01399
crossref_primary_10_1016_j_biopha_2022_113345
crossref_primary_10_3389_fonc_2023_1291033
crossref_primary_10_1371_journal_pgen_1009201
crossref_primary_10_4252_wjsc_v14_i4_267
crossref_primary_10_37188_lam_2025_049
crossref_primary_10_1002_mco2_218
crossref_primary_10_1038_s42003_024_06801_6
crossref_primary_10_3389_fonc_2022_1004850
crossref_primary_10_3390_molecules28031441
crossref_primary_10_1186_s13046_023_02834_7
crossref_primary_10_3389_fimmu_2022_966167
crossref_primary_10_1002_advs_202202993
crossref_primary_10_3389_fimmu_2022_872910
crossref_primary_10_1111_cas_15468
crossref_primary_10_1002_cac2_12403
crossref_primary_10_3389_fmolb_2021_691795
crossref_primary_10_1038_s41598_021_98381_2
crossref_primary_10_1186_s10020_022_00516_2
crossref_primary_10_1186_s12885_025_13984_6
crossref_primary_10_3390_cancers13081973
crossref_primary_10_3748_wjg_v25_i16_1936
crossref_primary_10_1038_s41392_020_00326_0
crossref_primary_10_1155_2022_3983637
crossref_primary_10_1007_s13402_023_00812_x
crossref_primary_10_3390_cancers15245727
crossref_primary_10_1186_s12964_024_01624_8
crossref_primary_10_1016_j_tiv_2024_105785
crossref_primary_10_1038_s42003_023_05282_3
crossref_primary_10_1155_2022_6766787
crossref_primary_10_3390_ani13172757
crossref_primary_10_3389_fimmu_2023_1307228
crossref_primary_10_1186_s12885_023_11182_w
crossref_primary_10_1515_med_2022_0586
crossref_primary_10_3390_v14030602
crossref_primary_10_1097_JN9_0000000000000008
crossref_primary_10_3389_fimmu_2022_951137
crossref_primary_10_1038_s41698_024_00627_5
crossref_primary_10_3390_biomedicines10020428
crossref_primary_10_3389_fonc_2022_881252
crossref_primary_10_1186_s12967_020_02267_2
crossref_primary_10_3389_fonc_2022_1060495
crossref_primary_10_1038_s41598_024_74281_z
crossref_primary_10_3389_fphar_2022_1020343
crossref_primary_10_1038_s41419_024_06490_3
crossref_primary_10_1186_s12944_022_01651_9
crossref_primary_10_1186_s12885_020_07345_8
crossref_primary_10_1111_imm_13574
crossref_primary_10_3389_fmolb_2021_645084
crossref_primary_10_1371_journal_pone_0263693
crossref_primary_10_1007_s00210_025_03985_4
crossref_primary_10_1186_s40364_021_00345_1
crossref_primary_10_3389_fendo_2023_1090906
crossref_primary_10_3390_ijms24087076
crossref_primary_10_1016_j_phrs_2022_106081
crossref_primary_10_3389_fimmu_2025_1575452
crossref_primary_10_3389_fimmu_2024_1424237
crossref_primary_10_3390_biom11070926
crossref_primary_10_3390_jcm8050753
crossref_primary_10_1055_a_1816_8903
crossref_primary_10_14814_phy2_15137
crossref_primary_10_1002_jcla_24189
crossref_primary_10_1186_s40164_022_00326_6
crossref_primary_10_1016_j_metabol_2022_155194
crossref_primary_10_3389_fimmu_2021_692004
crossref_primary_10_3390_ijms26189092
crossref_primary_10_1002_1878_0261_12860
crossref_primary_10_1016_j_molmet_2022_101478
crossref_primary_10_1515_hsz_2019_0413
crossref_primary_10_1002_advs_202508878
crossref_primary_10_1089_bioe_2019_0017
crossref_primary_10_1016_j_biopha_2023_114963
crossref_primary_10_1016_j_jtemb_2023_127147
crossref_primary_10_3390_cancers13174281
crossref_primary_10_1016_j_cbi_2023_110568
crossref_primary_10_1111_jcmm_15254
crossref_primary_10_1371_journal_pgen_1009117
crossref_primary_10_2147_CMAR_S314502
crossref_primary_10_15252_embr_201948483
crossref_primary_10_3390_cells8091055
crossref_primary_10_1186_s40170_024_00349_z
crossref_primary_10_1016_j_canlet_2022_215921
crossref_primary_10_1007_s12072_022_10459_9
crossref_primary_10_1155_2022_5946670
crossref_primary_10_1016_j_jtemb_2025_127750
crossref_primary_10_3390_ijms24065162
crossref_primary_10_1007_s41061_025_00497_w
crossref_primary_10_1186_s40170_024_00348_0
crossref_primary_10_1016_j_foodchem_2021_131860
crossref_primary_10_1038_s41598_023_42992_4
crossref_primary_10_3892_ol_2025_14873
crossref_primary_10_1016_j_heliyon_2024_e38718
crossref_primary_10_1111_jcmm_18406
crossref_primary_10_1155_2022_6454482
crossref_primary_10_1038_s44286_024_00116_3
crossref_primary_10_1097_CAD_0000000000001643
crossref_primary_10_3389_fonc_2022_1024789
crossref_primary_10_3389_fgene_2021_703210
crossref_primary_10_1097_SHK_0000000000001931
crossref_primary_10_3390_cancers16051057
crossref_primary_10_1016_j_cej_2023_143244
crossref_primary_10_1016_j_pharmthera_2022_108298
crossref_primary_10_1016_j_jrras_2023_100614
crossref_primary_10_1038_s42003_024_07051_2
crossref_primary_10_1186_s40164_022_00292_z
crossref_primary_10_1186_s12911_021_01634_3
crossref_primary_10_1038_s41419_021_04342_y
crossref_primary_10_2174_1381612828666220922111342
crossref_primary_10_1155_2021_4731349
crossref_primary_10_1016_j_biopha_2023_114546
crossref_primary_10_1016_j_canlet_2022_215798
crossref_primary_10_3390_cancers14215228
crossref_primary_10_3389_fmolb_2022_1003227
crossref_primary_10_3892_ol_2024_14396
crossref_primary_10_1038_s41417_022_00470_5
crossref_primary_10_1038_s42003_023_04924_w
crossref_primary_10_1042_BSR20220395
crossref_primary_10_1002_cbin_11182
crossref_primary_10_1007_s10555_025_10264_4
crossref_primary_10_1016_j_lfs_2019_116730
crossref_primary_10_1155_2019_1253727
crossref_primary_10_1038_s41556_024_01549_x
crossref_primary_10_3390_cancers14122964
crossref_primary_10_1186_s13045_022_01359_4
crossref_primary_10_3390_ijms22042217
crossref_primary_10_3390_ijms25010342
crossref_primary_10_1016_j_semcancer_2022_07_003
crossref_primary_10_1186_s12967_023_04167_7
crossref_primary_10_1038_s41467_019_13601_8
crossref_primary_10_1016_j_jaci_2024_01_032
crossref_primary_10_3390_ijms24031992
crossref_primary_10_1007_s11306_024_02114_1
crossref_primary_10_3389_fcell_2023_1275543
crossref_primary_10_1186_s12920_022_01417_3
crossref_primary_10_1007_s10142_024_01521_w
crossref_primary_10_1016_j_metabol_2024_155794
crossref_primary_10_1186_s12964_023_01116_1
crossref_primary_10_1002_bies_202300166
crossref_primary_10_1016_j_ejphar_2021_174365
crossref_primary_10_1093_toxres_tfae169
crossref_primary_10_1016_j_cbi_2024_110926
crossref_primary_10_3892_ijo_2023_5604
crossref_primary_10_1016_j_apsb_2023_12_003
crossref_primary_10_26508_lsa_202302285
crossref_primary_10_3389_fphar_2025_1598978
crossref_primary_10_1007_s44337_024_00131_6
crossref_primary_10_3389_fgene_2023_1094838
crossref_primary_10_1016_j_isci_2024_111359
crossref_primary_10_1097_JP9_0000000000000146
crossref_primary_10_3390_biom15030356
crossref_primary_10_1007_s10142_024_01497_7
crossref_primary_10_1002_mef2_12
crossref_primary_10_1016_j_molstruc_2024_140570
crossref_primary_10_1016_j_heliyon_2023_e22201
crossref_primary_10_1016_j_omto_2021_06_012
crossref_primary_10_3390_ijms22179118
crossref_primary_10_1002_cam4_5682
crossref_primary_10_13005_bpj_2250
crossref_primary_10_1002_advs_202402809
crossref_primary_10_1002_bies_202000058
crossref_primary_10_1016_j_ijbiomac_2020_09_096
crossref_primary_10_1016_j_jlr_2021_100154
crossref_primary_10_1016_j_biopha_2022_113376
crossref_primary_10_3389_fimmu_2021_635738
crossref_primary_10_1038_s41419_025_07975_5
crossref_primary_10_3390_ijms24087463
crossref_primary_10_1016_j_compbiomed_2023_106957
crossref_primary_10_1007_s00018_023_04810_y
crossref_primary_10_1016_j_semcancer_2023_12_001
crossref_primary_10_3389_fbioe_2022_822835
crossref_primary_10_1016_j_carbpol_2022_119464
crossref_primary_10_1002_kjm2_12299
crossref_primary_10_3389_fonc_2021_676562
crossref_primary_10_1007_s13402_023_00852_3
crossref_primary_10_1016_j_biomaterials_2023_122409
crossref_primary_10_1016_j_apsb_2021_07_008
crossref_primary_10_3389_fonc_2020_00317
crossref_primary_10_1158_0008_5472_CAN_23_1344
crossref_primary_10_3389_fphar_2022_855488
crossref_primary_10_3390_ijms26125435
crossref_primary_10_1016_j_semcancer_2020_12_002
crossref_primary_10_4251_wjgo_v16_i7_3241
crossref_primary_10_1007_s00262_024_03702_9
crossref_primary_10_1007_s11306_019_1483_8
crossref_primary_10_1038_s41598_023_34728_1
crossref_primary_10_3389_fonc_2019_00145
crossref_primary_10_1038_s41598_024_51406_y
crossref_primary_10_2147_OTT_S270688
crossref_primary_10_3390_ijms241512397
crossref_primary_10_1016_j_phrs_2020_105159
crossref_primary_10_3389_fcell_2021_633259
crossref_primary_10_3389_fonc_2021_758336
crossref_primary_10_3389_fonc_2023_1328827
crossref_primary_10_1186_s12894_023_01317_3
crossref_primary_10_1016_j_envpol_2021_118708
crossref_primary_10_1002_jcp_31495
crossref_primary_10_1158_0008_5472_CAN_22_0917
crossref_primary_10_3390_biom14040412
crossref_primary_10_1016_j_scitotenv_2023_165348
crossref_primary_10_1186_s13048_020_00762_0
crossref_primary_10_3389_fmolb_2022_834976
crossref_primary_10_3389_fonc_2022_860932
crossref_primary_10_1016_j_heliyon_2024_e35158
crossref_primary_10_1016_j_canlet_2024_217082
crossref_primary_10_1038_s41420_024_02061_9
crossref_primary_10_3390_ijms242317060
crossref_primary_10_1016_j_canlet_2025_217808
crossref_primary_10_1111_jcmm_16879
crossref_primary_10_1007_s12307_019_00226_0
crossref_primary_10_1038_s41598_020_75862_4
crossref_primary_10_1002_ctm2_70045
crossref_primary_10_3390_life14010124
crossref_primary_10_1016_j_biopha_2022_112864
crossref_primary_10_1155_2022_4525540
crossref_primary_10_3389_fonc_2023_1272305
crossref_primary_10_1007_s10815_023_02769_0
crossref_primary_10_1002_jcla_24005
crossref_primary_10_3390_molecules27238250
crossref_primary_10_3389_fonc_2024_1305684
crossref_primary_10_1080_07853890_2023_2283160
crossref_primary_10_1016_j_bbcan_2023_188861
Cites_doi 10.1038/sj.cdd.4400935
10.1194/jlr.R900007-JLR200
10.4161/cc.9.19.13302
10.3748/wjg.15.3329
10.1126/science.1160809
10.3389/fimmu.2017.00093
10.1038/sj.onc.1205729
10.1146/annurev.bi.15.070146.001205
10.1038/nature12040
10.1126/science.1240537
10.1038/s41467-017-01647-5
10.1016/j.cmet.2013.11.004
10.1016/j.cmet.2016.12.011
10.1126/science.aar2946
10.1074/jbc.M008782200
10.1016/S0753-3322(03)00043-X
10.4049/jimmunol.0903670
10.1038/nri.2016.103
10.1016/j.metabol.2012.07.007
10.1016/j.pharmthera.2010.03.005
10.1158/0008-5472.CAN-14-2211
10.1016/j.cmet.2016.06.007
10.1016/j.immuni.2017.01.005
10.1158/0008-5472.CAN-07-0389
10.1016/j.chembiol.2012.07.021
10.1073/pnas.1311939110
10.1016/0092-8674(95)90530-8
10.1073/pnas.1521548113
10.1016/j.cmet.2011.08.004
10.1038/nm.3217
10.1016/j.tcb.2016.08.009
10.1158/2159-8290.CD-14-1228
10.1039/C6FO00105J
10.1016/j.chom.2015.03.005
10.1194/jlr.R054114
10.1093/jn/134.10.2837S
10.1016/j.chembiol.2016.11.013
10.1016/j.cmet.2016.12.022
10.1016/j.cell.2013.04.023
10.1073/pnas.94.13.6658
10.1038/ng.890
10.1016/j.immuni.2011.09.021
10.3748/wjg.v17.i12.1519
10.1038/nrc2819
10.1006/mgme.1999.2857
10.1016/j.cmet.2015.12.006
10.1158/0008-5472.CAN-11-1457
10.1126/science.aan3706
10.1016/j.cell.2013.05.016
10.1038/nature22797
10.1172/JCI105650
10.1620/tjem.215.227
10.1038/nature10350
10.1016/j.cmet.2011.12.009
10.1096/fj.03-0374fje
10.1038/ncb3124
10.1194/jlr.R500013-JLR200
10.1001/jama.2016.4059
10.1016/S0021-9258(17)31580-6
10.1016/j.immuni.2015.09.001
10.1126/science.aao3290
10.1038/bjc.2012.409
10.3109/10428194.2016.1144879
10.1038/ng.3421
10.1038/nm.4243
10.1158/2159-8290.CD-14-0250
10.1016/0016-5085(87)90430-6
10.4161/onci.27360
10.1042/bj20031327
10.1097/MCO.0b013e32835665fa
10.1038/nri2378
10.1038/srep04548
10.1126/science.aan4236
10.1016/j.apsb.2015.01.006
10.1074/jbc.M802671200
10.1016/j.cell.2015.08.015
10.1016/j.mam.2017.04.002
10.1016/j.ccr.2005.09.008
10.1038/nrd2619
10.1074/jbc.271.51.32529
10.1016/j.molmed.2015.11.003
10.1016/j.atherosclerosis.2016.07.899
10.1038/nm.4222
10.1038/nchembio.2070
10.1016/j.chom.2016.03.004
10.1016/j.cell.2014.11.020
10.1371/journal.pone.0005839
10.1016/j.ceb.2013.07.002
10.1074/jbc.M004160200
10.1042/bj20021785
10.1074/jbc.M111.333120
10.1016/j.ymgme.2009.10.012
10.1038/nature12347
10.1016/j.radonc.2009.11.007
10.1126/science.aad1329
10.1038/cddis.2017.161
10.1016/j.ccell.2014.12.006
10.1038/nm.3473
10.1126/science.123.3191.309
10.3109/10408368209085073
10.1016/j.semcdb.2012.02.002
10.1016/j.cell.2016.05.041
10.1053/jhep.2000.7877
10.1016/j.cmet.2007.10.002
10.1172/JCI7199
10.1126/science.aaq1070
10.1038/cr.2016.110
10.1158/0008-5472.CAN-16-1730
10.1203/00006450-199710000-00013
10.1016/j.cell.2014.11.025
10.1038/nrc.2016.71
10.1111/j.1755-148X.2011.00919.x
10.1136/gutjnl-2011-300784
10.4049/jimmunol.0903586
10.1126/science.1218595
10.1038/nature17412
10.1016/j.bbalip.2009.08.007
10.1038/nrc.2016.87
10.1016/j.cmet.2013.01.012
10.1126/science.aac4255
10.1111/j.1365-2672.2007.03322.x
10.1002/mc.20008
10.1016/j.cell.2015.12.034
10.1038/onc.2008.271
10.1038/msb4100153
10.1016/S0027-5107(01)00195-6
10.1038/ncb1975
10.1038/nrmicro3344
10.1016/j.cell.2017.09.019
10.1128/MCB.19.1.1
10.1038/ncb2789
10.1111/cas.13244
10.1097/MCO.0000000000000430
10.1146/annurev-cellbio-092910-154010
10.1038/145627a0
10.1016/j.ccell.2014.12.002
10.1093/jn/134.10.2791S
10.1016/j.ccr.2013.02.003
10.1158/0008-5472.CAN-04-0465
10.1016/S1499-3872(14)60307-6
10.1093/clinids/20.Supplement_2.S111
10.1152/ajpgi.00360.2012
10.1038/nrc1454
10.1016/j.ccell.2017.08.004
10.1016/j.immuni.2016.09.009
10.1158/0008-5472.CAN-17-1589
10.1016/j.ccr.2014.05.004
10.1073/pnas.1712726114
10.1158/2159-8290.CD-14-0501
10.4049/jimmunol.0803978
10.1038/cddis.2013.393
10.1126/science.1164097
10.1016/j.ccr.2012.11.020
10.1016/S0009-2797(97)00146-4
10.1158/0008-5472.CAN-14-1491
10.1126/science.aad7706
10.1152/ajpheart.00646.2012
10.1016/j.cmet.2016.03.016
10.1038/nature17310
10.1038/cr.2016.109
10.1093/jn/137.6.1681S
10.1016/0026-0495(92)90130-3
10.1038/nrgastro.2013.121
10.1002/ijc.10645
10.1158/0008-5472.CAN-17-0165
10.1182/blood-2006-07-035972
10.1016/j.chom.2014.07.011
10.1038/onc.2013.456
10.1016/j.cell.2017.04.004
10.1038/nature22314
10.1016/j.molcel.2017.12.015
10.1016/j.freeradbiomed.2009.12.022
10.1007/s00204-011-0648-7
10.1046/j.1365-2567.2002.01526.x
10.1016/j.tibs.2014.02.004
10.1073/pnas.1113873109
10.1073/pnas.0808567105
10.1371/journal.pone.0002722
10.1182/blood-2005-05-1795
10.1158/2326-6066.CIR-13-0120-T
10.1038/bjc.1988.15
10.1016/j.ccr.2012.02.014
10.1038/nature12138
10.1038/nm.3686
10.1038/ncb2172
10.1038/nature13267
10.1016/j.cell.2012.12.028
10.1126/science.aam9305
10.1016/j.molcel.2005.03.027
10.1038/nature10491
10.1126/science.1223813
10.5306/wjco.v7.i2.200
10.1038/nature13490
10.1371/journal.pone.0023652
10.1038/nature18309
10.1073/pnas.1406199111
10.1128/MCB.24.13.5923-5936.2004
10.1016/j.chom.2012.09.009
10.1038/srep04202
10.1016/j.cell.2012.03.003
10.1016/j.cell.2016.09.031
10.1016/j.mrrev.2004.08.001
10.1038/nature11743
10.1016/j.bbadis.2011.04.005
10.1158/0008-5472.CAN-16-0530
10.1074/jbc.M307265200
10.1016/j.devcel.2014.03.012
10.1038/cr.2015.33
10.1016/j.cmet.2015.04.011
10.4049/jimmunol.1101029
10.1016/j.cell.2015.08.016
10.1016/j.immuni.2016.10.007
10.21037/tcr.2017.05.13
10.1016/j.cmet.2017.11.005
10.1084/jem.20151159
10.1016/S0021-9258(18)69735-2
10.1126/science.aaf5171
10.1016/j.cbi.2010.03.035
10.1136/gutjnl-2015-310101
10.1007/BF02049993
10.1016/j.cell.2015.08.012
10.1126/science.1240527
10.1194/jlr.R900010-JLR200
10.1038/nrd4591
10.1016/j.celrep.2014.08.028
10.1111/j.1600-065X.2008.00608.x
10.1038/nchembio.2172
10.1158/0008-5472.CAN-12-3709
10.2174/187152008784533008
10.1073/pnas.1204176109
10.1038/nrendo.2014.171
10.1007/978-3-642-10858-7_4
10.1016/j.immuni.2016.03.016
10.1038/nrgastro.2017.119
10.1016/j.ccell.2015.11.010
10.1074/jbc.R112.357194
10.1016/j.cmet.2016.08.011
10.1091/mbc.e13-07-0408
10.1038/nature21052
10.1038/nrmicro.2017.44
10.1002/ijc.2910590115
10.1038/nature11540
10.1056/NEJMoa1414428
10.1016/j.tem.2013.09.002
10.1038/nrc3557
10.1126/science.aai7629
10.1016/j.cell.2015.06.017
10.1002/iub.230
10.1152/jappl.2000.89.1.169
10.1016/j.neurobiolaging.2015.03.012
10.1016/j.ccr.2011.12.004
10.1038/nature24057
10.1016/j.cmet.2016.10.011
10.1016/j.cmet.2006.02.002
10.1186/s12885-016-2376-0
10.1158/0008-5472.CAN-08-1921
ContentType Journal Article
Copyright 2018 Elsevier B.V.
Copyright © 2018 Elsevier B.V. All rights reserved.
Copyright_xml – notice: 2018 Elsevier B.V.
– notice: Copyright © 2018 Elsevier B.V. All rights reserved.
DBID AAYXX
CITATION
CGR
CUY
CVF
ECM
EIF
NPM
7X8
DOI 10.1016/j.bbcan.2018.06.005
DatabaseName CrossRef
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
MEDLINE - Academic
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
MEDLINE - Academic
DatabaseTitleList MEDLINE - Academic

MEDLINE
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: 7X8
  name: MEDLINE - Academic
  url: https://search.proquest.com/medline
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Chemistry
Biology
EISSN 1879-2561
EndPage 66
ExternalDocumentID 29959989
10_1016_j_bbcan_2018_06_005
S0304419X18300350
Genre Research Support, Non-U.S. Gov't
Journal Article
Review
GroupedDBID ---
--K
--M
.~1
0R~
1B1
1RT
1~.
1~5
23N
3O-
4.4
457
4G.
53G
5GY
5RE
5VS
7-5
71M
8P~
9JM
AACTN
AAEDT
AAEDW
AAIAV
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AAXUO
ABBQC
ABEFU
ABFNM
ABGSF
ABLVK
ABMAC
ABMZM
ABUDA
ABXDB
ABYKQ
ACDAQ
ACIUM
ACRLP
ADBBV
ADEZE
ADMUD
ADUVX
AEBSH
AEHWI
AEKER
AFKWA
AFTJW
AFXIZ
AGHFR
AGRDE
AGUBO
AGYEJ
AHHHB
AIEXJ
AIKHN
AITUG
AJBFU
AJOXV
AJRQY
ALMA_UNASSIGNED_HOLDINGS
AMFUW
AMRAJ
ANZVX
ASPBG
AVWKF
AXJTR
AZFZN
BKOJK
BLXMC
BNPGV
CS3
DOVZS
EBS
EFJIC
EFLBG
EJD
EO8
EO9
EP2
EP3
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
G-2
G-Q
GBLVA
HED
HLW
HMK
HMO
HVGLF
HZ~
IHE
J1W
KOM
LCYCR
LX3
M29
M41
MO0
N9A
O-L
O9-
OAUVE
OZT
P-8
P-9
PC.
Q38
R2-
ROL
RPZ
SAE
SBG
SDF
SDG
SDP
SES
SEW
SPCBC
SSH
SSU
SSZ
T5K
UQL
WUQ
XJT
XPP
ZE2
~G-
9DU
AATTM
AAXKI
AAYWO
AAYXX
ABWVN
ACIEU
ACLOT
ACRPL
ACVFH
ADCNI
ADNMO
AEIPS
AEUPX
AFJKZ
AFPUW
AGQPQ
AIGII
AIIUN
AKBMS
AKRWK
AKYEP
ANKPU
APXCP
CITATION
EFKBS
~HD
CGR
CUY
CVF
ECM
EIF
NPM
7X8
ID FETCH-LOGICAL-c359t-3b30115ff3d4fba1ac42f799079e783e9c99f991301b98c9b957957e9d2a24e03
ISICitedReferencesCount 290
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000442974700007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0304-419X
1879-2561
IngestDate Sat Sep 27 20:11:42 EDT 2025
Wed Feb 19 02:36:34 EST 2025
Tue Nov 18 21:54:49 EST 2025
Sat Nov 29 01:33:11 EST 2025
Fri Feb 23 02:21:05 EST 2024
IsPeerReviewed true
IsScholarly true
Issue 1
Keywords Microbiota
Biomass synthesis
Metabolic reprogramming
Tumor microenvironment
Immune cells
Language English
License Copyright © 2018 Elsevier B.V. All rights reserved.
LinkModel OpenURL
MergedId FETCHMERGED-LOGICAL-c359t-3b30115ff3d4fba1ac42f799079e783e9c99f991301b98c9b957957e9d2a24e03
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
PMID 29959989
PQID 2062836978
PQPubID 23479
PageCount 16
ParticipantIDs proquest_miscellaneous_2062836978
pubmed_primary_29959989
crossref_primary_10_1016_j_bbcan_2018_06_005
crossref_citationtrail_10_1016_j_bbcan_2018_06_005
elsevier_sciencedirect_doi_10_1016_j_bbcan_2018_06_005
PublicationCentury 2000
PublicationDate August 2018
2018-08-00
20180801
PublicationDateYYYYMMDD 2018-08-01
PublicationDate_xml – month: 08
  year: 2018
  text: August 2018
PublicationDecade 2010
PublicationPlace Netherlands
PublicationPlace_xml – name: Netherlands
PublicationTitle Biochimica et biophysica acta. Reviews on cancer
PublicationTitleAlternate Biochim Biophys Acta Rev Cancer
PublicationYear 2018
Publisher Elsevier B.V
Publisher_xml – name: Elsevier B.V
References Jin, Li, Alesi, Fan, Kang, Lu, Boggon, Jin, Yi, Wright, Duong, Seyfried, Egnatchik, DeBerardinis, Magliocca, He, Arellano, Khoury, Shin, Khuri, Kang (bb0245) 2015; 27
Nicholson, Holmes, Kinross, Burcelin, Gibson, Jia, Pettersson (bb0875) 2012; 336
West, Powrie (bb1330) 2015; 28
Krajcovic, Krishna, Akkari, Joyce, Overholtzer (bb0280) 2013; 24
Zimber, Gespach (bb1115) 2008; 8
Tabatabaie, Klomp, Berger, de Koning (bb0360) 2010; 99
Bernstein, Bernstein, Payne, Dvorak (bb1045) 2009; 15
Brosnan, Brosnan (bb0730) 2004; 134
Coloff, Murphy, Braun, Harris, Shelton, Kami, Gygi, Selfors, Brugge (bb0230) 2016; 23
Viaud, Saccheri, Mignot, Yamazaki, Daillere, Hannani, Enot, Pfirschke, Engblom, Pittet, Schlitzer, Ginhoux, Apetoh, Chachaty, Woerther, Eberl, Berard, Ecobichon, Clermont, Bizet, Gaboriau-Routhiau, Cerf-Bensussan, Opolon, Yessaad, Vivier, Ryffel, Elson, Dore, Kroemer, Lepage, Boneca, Ghiringhelli, Zitvogel (bb1290) 2013; 342
Linsalata, Caruso, Leo, Guerra, D'Attoma, Di Leo (bb1160) 2002; 22
Warburg (bb0025) 1956; 123
Kamphorst, Nofal, Commisso, Hackett, Lu, Grabocka, Vander Heiden, Miller, Drebin, Bar-Sagi, Thompson, Rabinowitz (bb0265) 2015; 75
Pevsner-Fischer, Tuganbaev, Meijer, Zhang, Zeng, Chen, Elinav (bb0880) 2016; 7
Cook, Kennaway, Kennaway (bb1050) 1940; 145
Friberg, Jennings, Alsarraj, Dessureault, Cantor, Extermann, Mellor, Munn, Antonia (bb0800) 2002; 101
Anderson, Woeller, Chiang, Shane, Stover (bb0415) 2012; 287
Jobin (bb1350) 2018; 359
Valencia, Kim, Abu-Baker, Moscat-Pardos, Ahn, Reina-Campos, Duran, Castilla, Metallo, Diaz-Meco, Moscat (bb0630) 2014; 26
Ma, Bantug, Griss, Condotta, Johnson, Samborska, Mainolfi, Suri, Guak, Balmer, Verway, Raissi, Tsui, Boukhaled, da Costa, Frezza, Krawczyk, Friedman, Manfredi, Richer, Hess, Jones (bb0840) 2017; 25
Perez-Chacon, Astudillo, Balgoma, Balboa, Balsinde (bb0130) 2009; 1791
Rodriguez, Ochoa, Al-Khami (bb0740) 2017; 8
Adeva, Souto, Blanco, Donapetry (bb0215) 2012; 61
Dawson, Karpen (bb1080) 2015; 56
Lee, Finkel (bb0310) 2013; 25
Pacold, Brimacombe, Chan, Rohde, Lewis, Swier, Possemato, Chen, Sullivan, Fiske, Cho, Freinkman, Birsoy, Abu-Remaileh, Shaul, Liu, Zhou, Koh, Chung, Davidson, Luengo, Wang, Xu, Yasgar, Liu, Rai, Westover, Vander Heiden, Shen, Gray, Boxer, Sabatini (bb0445) 2016; 12
Hensley, Faubert, Yuan, Lev-Cohain, Jin, Kim, Jiang, Ko, Skelton, Loudat, Wodzak, Klimko, McMillan, Butt, Ni, Oliver, Torrealba, Malloy, Kernstine, Lenkinski, DeBerardinis (bb0075) 2016; 164
Cotter, Schugar, Crawford (bb0175) 2013; 304
Locasale, Grassian, Melman, Lyssiotis, Mattaini, Bass, Heffron, Metallo, Muranen, Sharfi, Sasaki, Anastasiou, Mullarky, Vokes, Sasaki, Beroukhim, Stephanopoulos, Ligon, Meyerson, Richardson, Chin, Wagner, Asara, Brugge, Cantley, Vander Heiden (bb0425) 2011; 43
Karin, Jobin, Balkwill (bb1305) 2014; 20
Louis, Hold, Flint (bb0985) 2014; 12
Mima, Nishihara, Qian, Cao, Sukawa, Nowak, Yang, Dou, Masugi, Song, Kostic, Giannakis, Bullman, Milner, Baba, Giovannucci, Garraway, Freeman, Dranoff, Garrett, Huttenhower, Meyerson, Meyerhardt, Chan, Fuchs, Ogino (bb0895) 2016; 65
Wu, Shi, Xu (bb0705) 2016; 16
Jones, Plas, Kubek, Buzzai, Mu, Xu, Birnbaum, Thompson (bb0305) 2005; 18
Cao, Feng, Zhang, Zhu, Jin (bb0780) 2016; 16
Hayes, Burns, Gilmour (bb1205) 2014; 3
Wang, Dillon, Shi, Milasta, Carter, Finkelstein, McCormick, Fitzgerald, Chi, Munger, Green (bb0825) 2011; 35
Galluzzi, Kroemer (bb0170) 2016; 26
Peters, Minton, Phanstiel Iv, Gilmour (bb1220) 2018; 6
Bernstein, Bernstein, Payne, Dvorakova, Garewal (bb1090) 2005; 589
Salazar-Roa, Malumbres (bb0300) 2017; 27
Vazquez, Lim, Chim, Bhalla, Girnun, Pierce, Clish, Granter, Widlund, Spiegelman, Puigserver (bb1215) 2013; 23
Townsend, Tew, Tapiero (bb0410) 2003; 57
Zhang, Kurupati, Liu, Zhou, Zhang, Hudaihed, Filisio, Giles-Davis, Xu, Karakousis, Schuchter, Xu, Amaravadi, Xiao, Sadek, Krepler, Herlyn, Freeman, Rabinowitz, Ertl (bb0725) 2017; 32
Johnson, Dejea, Edler, Hoang, Santidrian, Felding, Ivanisevic, Cho, Wick, Hechenbleikner, Uritboonthai, Goetz, Casero, Pardoll, White, Patti, Sears, Siuzdak (bb1230) 2015; 21
Ding, Li, Wang, Zhao, Choi, Yang, Zha, Dong, Huang, Asara, Cui, Ding (bb0480) 2013; 18
Vavassori, Mencarelli, Renga, Distrutti, Fiorucci (bb1130) 2009; 183
Cori, Cori (bb0035) 1946; 15
Aviles-Jimenez, Vazquez-Jimenez, Medrano-Guzman, Mantilla, Torres (bb0890) 2014; 4
Keku, Dulal, Deveaux, Jovov, Han (bb0955) 2015; 308
Dang (bb0050) 1999; 19
Rodriguez, Quiceno, Zabaleta, Ortiz, Zea, Piazuelo, Delgado, Correa, Brayer, Sotomayor, Antonia, Ochoa, Ochoa (bb0760) 2004; 64
Warburg, Posener, Negelein (bb0020) 1924; 152
Hatzivassiliou, Zhao, Bauer, Andreadis, Shaw, Dhanak, Hingorani, Tuveson, Thompson (bb0115) 2005; 8
MacFarlane, Liu, Perry, Flodby, Allen, Stabler, Stover (bb0350) 2008; 283
Wang, Liberti, Liu, Deng, Liu, Locasale, Lai (bb0450) 2017; 24
Koh, De Vadder, Kovatcheva-Datchary, Backhed (bb0910) 2016; 165
Ridlon, Bajaj (bb1120) 2015; 5
Bajaj, Kassam, Fagan, Gavis, Liu, Kheradman, Wang, Cox, Taylor-Robinson, Sikaroodi, Alm, Gurry, Smith, John, Heuman, Fuchs, Gillevet (bb1355) 2017; 152
DeBerardinis, Lum, Hatzivassiliou, Thompson (bb0640) 2008; 7
Lind (bb0745) 2004; 134
Mahoney, Rennert, Freeman (bb1280) 2015; 14
Ho, Bihuniak, Macintyre, Staron, Liu, Amezquita, Tsui, Cui, Micevic, Perales, Kleinstein, Abel, Insogna, Feske, Locasale, Bosenberg, Rathmell, Kaech (bb0655) 2015; 162
Amores-Sanchez, Medina (bb0395) 1999; 67
Geiger, Rieckmann, Wolf, Basso, Feng, Fuhrer, Kogadeeva, Picotti, Meissner, Mann, Zamboni, Sallusto, Lanzavecchia (bb0755) 2016; 167
Huang, Li, Wang, Zhang, Yan, Li, Xing, Wu, Hu, Jia, Lin, Dang, Song, Gao, Zhang (bb0205) 2016; 26
Shim, Dolde, Lewis, Wu, Dang, Jungmann, Dalla-Favera, Dang (bb0045) 1997; 94
Mullarky, Mattaini, Vander Heiden, Cantley, Locasale (bb0430) 2011; 24
Yang, Bai, Xiong, Zhang, Chen, Zheng, Meng, Li, Wang, Xu, Yan, Wang, Chang, Chang, Zhang, Zhou, Song, Liu, Sun, Liu, Li, Xu (bb0695) 2016; 531
Forman, Goode, Chen, Oro, Bradley, Perlmann, Noonan, Burka, Mcmorris, Lamph, Evans, Weinberger (bb1020) 1995; 81
Meyskens, Gerner (bb1195) 1999; 5
Thomas, Pellicciari, Pruzanski, Auwerx, Schoonjans (bb1040) 2008; 7
Zollner, Wagner, Trauner (bb1025) 2010; 126
Jan, Belzacq, Haouzi, Rouault, Metivier, Kroemer, Brenner (bb0930) 2002; 9
Rivera-Chavez, Zhang, Faber, Lopez, Byndloss, Olsan, Xu, Velazquez, Lebrilla, Winter, Baumler (bb0975) 2016; 19
Axelson, Ellis, Mork, Garmark, Abrahamsson, Bjorkhem, Ericzon, Einarsson (bb1000) 2000; 31
Zelenay, van der Veen, Bottcher, Snelgrove, Rogers, Acton, Chakravarty, Girotti, Marais, Quezada, Sahai, Sousa (bb0710) 2015; 162
Farrell, Zhang, Zhou, Chia, Elashoff, Akin, Paster, Joshipura, Wong (bb0885) 2012; 61
Hui, Ghergurovich, Morscher, Jang, Teng, Lu, Esparza, Reya, Zhan, Guo, White, Rabinowitz (bb0060) 2017; 551
Dang (bb0250) 2017; 358
Mora, Iwata, von Andrian (bb1030) 2008; 8
Gadaleta, Garcia-Irigoyen, Moschetta (bb1135) 2017; 56
Brooks, Hurley (bb0505) 2010; 9
Ridlon, Kang, Hylemon (bb1015) 2006; 47
Kim, Tchernyshyov, Semenza, Dang (bb0590) 2006; 3
Ye, Fan, Venneti, Wan, Pawel, Zhang, Finley, Lu, Lindsten, Cross, Qing, Liu, Simon, Rabinowitz, Thompson (bb0600) 2014; 4
Carmona-Fontaine, Bucci, Akkari, Deforet, Joyce, Xavier (bb0670) 2013; 110
Commisso, Davidson, Soydaner-Azeloglu, Parker, Kamphorst, Hackett, Grabocka, Nofal, Drebin, Thompson, Rabinowitz, Metallo, Vander Heiden, Bar-Sagi (bb0260) 2013; 497
Ma, Tao, Duran, Llado, Galvez, Barger, Castilla, Chen, Yajima, Porollo, Medvedovic, Brill, Plas, Riedl, Leitges, Diaz-Meco, Richardson, Moscat (bb0485) 2013; 152
Becciolini, Porciani, Lanini, Balzi, Cionini, Bandettini (bb1165) 1991; 34
Dejea, Wick, Hechenbleikner, White, Welch, Rossetti, Peterson, Snesrud, Borisy, Lazarev, Stein, Vadivelu, Roslani, Malik, Wanyiri, Goh, Thevambiga, Fu, Wan, Llosa, Housseau, Romans, Wu, McAllister, Wu, Vogelstein, Kinzler, Pardoll, Sears (bb1225) 2014; 111
Ward, Thompson (bb0010) 2012; 21
Stanimirov, Stankov, Mikov (bb1125) 2015; 14
Popovic, Zeh, Ochoa (bb0750) 2007; 137
Fletcher, Ramirez, Sierra, Raber, Thevenot, Al-Khami, Sanchez-Pino, Hernandez, Wyczechowska, Ochoa, Rodriguez (bb0770) 2015; 75
Haq, Shoag, Andreu-Perez, Yokoyama, Edelman, Rowe, Frederick, Hurley, Nellore, Kung, Wargo, Song, Fisher, Arany, Widlund (bb1210) 2013; 23
Sattler, Meyer, Quennet, Hoerner, Knoerzer, Fabian, Yaromina, Zips, Walenta, Baumann, Mueller-Klieser (bb0090) 2010; 94
Zimber, Chedeville, Abita, Barbu, Gespach (bb1110) 2000; 60
D.H. Russell, Clinical relevance of polyamines, Crit. Rev. Clin. Lab. Sci., 18 (1983) 261-311.
Mullarky, Lucki, Zavareh, Anglin, Gomes, Nicolay, Wong, Christen, Takahashi, Singh, Blenis, Warren, Fendt, Asara, DeNicola, Lyssiotis, Lairson, Cantley (bb0440) 2016; 113
Zimber, Chedeville, Gespach, Abita (bb1105) 1994; 59
van Riggelen, Yetil, Felsher (bb0500) 2010; 10
Fujino, Kondo, Ishikawa, Morikawa, Yamamoto (bb0125) 2001; 276
Lin, Zhang, Gao, Watts (bb0185) 2015; 36
Ray, microbiota (bb1055) 2013; 10
Anderson, Stover (bb0355) 2009; 4
Balmer, Ma, Bantug, Grahlert, Pfister, Glatter, Jauch, Dimeloe, Slack, Dehio, Krzyzaniak, King, Burgener, Fischer, Develioglu, Belle, Recher, Bonilla, Macpherson, Hapfelmeier, Jones, Hess (bb0850) 2016; 44
Vetizou, Pitt, Daillere, Lepage, Waldschmitt, Flament, Rusakiewicz, Routy, Roberti, Duong, Poirier-Colame, Roux, Becharef, Formenti, Golden, Cording, Eberl, Schlitzer, Ginhoux, Mani, Yamazaki, Jacquelot, Enot, Berard, Nigou, Opolon, Eggermont, Woerther, Chachaty, Chaput, Robert, Mateus, Kroemer, Raoult, Boneca, Carbonnel, Chamaillard, Zitvogel (bb1320) 2015; 350
Dustin (bb0700) 2016; 531
Yoshimoto, Loo, Atarashi, Kanda, Sato, Oyadomari, Iwakura, Oshima, Morita, Hattori, Honda, Ishikawa, Hara, Ohtani (bb1060) 2013; 499
Gerner, Meyskens (bb1185) 2004; 4
Mayers, Torrence, Danai, Papagiannakopoulos, Davidson, Bauer, Lau, Ji, Dixit, Hosios, Muir, Chin, Freinkman, Jacks, Wolpin, Vitkup, Vander Heiden (bb0555) 2016; 353
Martinez-Reyes, Chandel (bb0070) 2017; 26
Goetze, Walenta, Ksiazkiewicz, Kunz-Schughart, Mueller-Klieser (bb0080) 2011; 39
Yu, Song, Zhu, Huang, Xiao, Luo (bb0785) 20
Cai (10.1016/j.bbcan.2018.06.005_bb0295) 2012; 28
Kelly (10.1016/j.bbcan.2018.06.005_bb0970) 2015; 17
Babbar (10.1016/j.bbcan.2018.06.005_bb1270) 2011; 188
Mima (10.1016/j.bbcan.2018.06.005_bb0895) 2016; 65
Wallace (10.1016/j.bbcan.2018.06.005_bb1145) 2003; 376
Kung (10.1016/j.bbcan.2018.06.005_bb0465) 2012; 19
Owen (10.1016/j.bbcan.2018.06.005_bb0180) 1967; 46
Ivanov (10.1016/j.bbcan.2018.06.005_bb0870) 2012; 12
Palm (10.1016/j.bbcan.2018.06.005_bb0275) 2017; 114
Wang (10.1016/j.bbcan.2018.06.005_bb0720) 2016; 22
Ignatenko (10.1016/j.bbcan.2018.06.005_bb1155) 2004; 39
Schug (10.1016/j.bbcan.2018.06.005_bb0145) 2015; 27
Gadaleta (10.1016/j.bbcan.2018.06.005_bb1135) 2017; 56
Srere (10.1016/j.bbcan.2018.06.005_bb0100) 1959; 234
Wellen (10.1016/j.bbcan.2018.06.005_bb0105) 2009; 324
Lee (10.1016/j.bbcan.2018.06.005_bb0310) 2013; 25
DeBerardinis (10.1016/j.bbcan.2018.06.005_bb0435) 2011; 14
Iida (10.1016/j.bbcan.2018.06.005_bb1295) 2013; 342
Eisenberg (10.1016/j.bbcan.2018.06.005_bb1235) 2009; 11
Chen (10.1016/j.bbcan.2018.06.005_bb0040) 2016; 12
Anderson (10.1016/j.bbcan.2018.06.005_bb0355) 2009; 4
Meyskens (10.1016/j.bbcan.2018.06.005_bb1195) 1999; 5
de Koning (10.1016/j.bbcan.2018.06.005_bb0365) 2003; 371
Lynch (10.1016/j.bbcan.2018.06.005_bb0540) 2014; 10
Ron-Harel (10.1016/j.bbcan.2018.06.005_bb0845) 2016; 24
Wang (10.1016/j.bbcan.2018.06.005_bb0825) 2011; 35
Bernstein (10.1016/j.bbcan.2018.06.005_bb1070) 2011; 85
Beckers (10.1016/j.bbcan.2018.06.005_bb0110) 2007; 67
Snyder (10.1016/j.bbcan.2018.06.005_bb1325) 2015; 350
Mayers (10.1016/j.bbcan.2018.06.005_bb0555) 2016; 353
Valencia (10.1016/j.bbcan.2018.06.005_bb0630) 2014; 26
Csibi (10.1016/j.bbcan.2018.06.005_bb0240) 2013; 153
Lee (10.1016/j.bbcan.2018.06.005_bb0315) 2014; 510
Yang (10.1016/j.bbcan.2018.06.005_bb0695) 2016; 531
Samanta (10.1016/j.bbcan.2018.06.005_bb0605) 2016; 76
Maddocks (10.1016/j.bbcan.2018.06.005_bb0470) 2012; 493
Vazquez (10.1016/j.bbcan.2018.06.005_bb0385) 2012; 73
Le (10.1016/j.bbcan.2018.06.005_bb0835) 2012; 15
Hayes (10.1016/j.bbcan.2018.06.005_bb1200) 2014; 2
Perez-Chacon (10.1016/j.bbcan.2018.06.005_bb0130) 2009; 1791
Bernstein (10.1016/j.bbcan.2018.06.005_bb1045) 2009; 15
Karin (10.1016/j.bbcan.2018.06.005_bb1305) 2014; 20
Martinez-Reyes (10.1016/j.bbcan.2018.06.005_bb0620) 2014; 4
Wu (10.1016/j.bbcan.2018.06.005_bb0705) 2016; 16
Biswas (10.1016/j.bbcan.2018.06.005_bb0860) 2015; 43
Canizares (10.1016/j.bbcan.2018.06.005_bb1170) 1999; 5
Puchalska (10.1016/j.bbcan.2018.06.005_bb0160) 2017; 25
Commisso (10.1016/j.bbcan.2018.06.005_bb0260) 2013; 497
Ray (10.1016/j.bbcan.2018.06.005_bb1055) 2013; 10
Fujino (10.1016/j.bbcan.2018.06.005_bb0125) 2001; 276
Sun (10.1016/j.bbcan.2018.06.005_bb0530) 2015; 25
Samanta (10.1016/j.bbcan.2018.06.005_bb0610) 2016; 76
Cotter (10.1016/j.bbcan.2018.06.005_bb0175) 2013; 304
Yoshino (10.1016/j.bbcan.2018.06.005_bb0615) 2017; 77
Yoshimoto (10.1016/j.bbcan.2018.06.005_bb1060) 2013; 499
Vousden (10.1016/j.bbcan.2018.06.005_bb0560) 2016; 353
Ye (10.1016/j.bbcan.2018.06.005_bb0600) 2014; 4
Jia (10.1016/j.bbcan.2018.06.005_bb0995) 2018; 15
Ananieva (10.1016/j.bbcan.2018.06.005_bb0535) 2018; 21
Ho (10.1016/j.bbcan.2018.06.005_bb0655) 2015; 162
Newman (10.1016/j.bbcan.2018.06.005_bb0165) 2014; 25
Hayes (10.1016/j.bbcan.2018.06.005_bb1205) 2014; 3
Amores-Sanchez (10.1016/j.bbcan.2018.06.005_bb0395) 1999; 67
Lin (10.1016/j.bbcan.2018.06.005_bb0185) 2015; 36
Whiteside (10.1016/j.bbcan.2018.06.005_bb0585) 2008; 27
Yu (10.1016/j.bbcan.2018.06.005_bb0785) 2017
Brooks (10.1016/j.bbcan.2018.06.005_bb0505) 2010; 9
Friberg (10.1016/j.bbcan.2018.06.005_bb0800) 2002; 101
Zimber (10.1016/j.bbcan.2018.06.005_bb1105) 1994; 59
Amelio (10.1016/j.bbcan.2018.06.005_bb0490) 2014; 33
Linsalata (10.1016/j.bbcan.2018.06.005_bb1160) 2002; 22
Dawson (10.1016/j.bbcan.2018.06.005_bb1080) 2015; 56
Ma (10.1016/j.bbcan.2018.06.005_bb0840) 2017; 25
Matson (10.1016/j.bbcan.2018.06.005_bb1345) 2018; 359
Altman (10.1016/j.bbcan.2018.06.005_bb0210) 2016; 16
Jain (10.1016/j.bbcan.2018.06.005_bb0345) 2012; 336
Leonel (10.1016/j.bbcan.2018.06.005_bb0950) 2012; 15
Mondanelli (10.1016/j.bbcan.2018.06.005_bb0855) 2017; 46
Luong (10.1016/j.bbcan.2018.06.005_bb0135) 2000; 275
Mahoney (10.1016/j.bbcan.2018.06.005_bb1280) 2015; 14
Anderson (10.1016/j.bbcan.2018.06.005_bb0415) 2012; 287
Tavana (10.1016/j.bbcan.2018.06.005_bb0475) 2013; 17
Tabatabaie (10.1016/j.bbcan.2018.06.005_bb0360) 2010; 99
Mashimo (10.1016/j.bbcan.2018.06.005_bb0150) 2014; 159
Sattler (10.1016/j.bbcan.2018.06.005_bb0090) 2010; 94
Gadaleta (10.1016/j.bbcan.2018.06.005_bb1075) 2011; 1812
Ward (10.1016/j.bbcan.2018.06.005_bb0010) 2012; 21
Balmer (10.1016/j.bbcan.2018.06.005_bb0850) 2016; 44
Buck (10.1016/j.bbcan.2018.06.005_bb0805) 2015; 212
Becciolini (10.1016/j.bbcan.2018.06.005_bb1165) 1991; 34
Salazar-Roa (10.1016/j.bbcan.2018.06.005_bb0300) 2017; 27
Du (10.1016/j.bbcan.2018.06.005_bb0325) 2013; 15
Tedeschi (10.1016/j.bbcan.2018.06.005_bb0380) 2013; 4
Kalinski (10.1016/j.bbcan.2018.06.005_bb0690) 2012; 188
Cao (10.1016/j.bbcan.2018.06.005_bb0780) 2016; 16
Mora (10.1016/j.bbcan.2018.06.005_bb1030) 2008; 8
Dey (10.1016/j.bbcan.2018.06.005_bb0575) 2017; 542
Jin (10.1016/j.bbcan.2018.06.005_bb0245) 2015; 27
Wallace (10.1016/j.bbcan.2018.06.005_bb0820) 1992; 41
Shim (10.1016/j.bbcan.2018.06.005_bb0045) 1997; 94
Possemato (10.1016/j.bbcan.2018.06.005_bb0420) 2011; 476
Bindels (10.1016/j.bbcan.2018.06.005_bb0990) 2012; 107
Faubert (10.1016/j.bbcan.2018.06.005_bb0065) 2017; 171
Debruyne (10.1016/j.bbcan.2018.06.005_bb1095) 2001; 480
Ye (10.1016/j.bbcan.2018.06.005_bb0460) 2012; 109
Dang (10.1016/j.bbcan.2018.06.005_bb0510) 2012; 149
Cook (10.1016/j.bbcan.2018.06.005_bb1050) 1940; 145
Dejea (10.1016/j.bbcan.2018.06.005_bb1225) 2014; 111
Dustin (10.1016/j.bbcan.2018.06.005_bb0700) 2016; 531
Louis (10.1016/j.bbcan.2018.06.005_bb0920) 2007; 102
Jones (10.1016/j.bbcan.2018.06.005_bb0305) 2005; 18
Araya (10.1016/j.bbcan.2018.06.005_bb1310) 2016; 45
Ding (10.1016/j.bbcan.2018.06.005_bb0480) 2013; 18
Zhang (10.1016/j.bbcan.2018.06.005_bb0725) 2017; 32
Daye (10.1016/j.bbcan.2018.06.005_bb0635) 2012; 23
Adeva (10.1016/j.bbcan.2018.06.005_bb0215) 2012; 61
Zollner (10.1016/j.bbcan.2018.06.005_bb1025) 2010; 126
Mayers (10.1016/j.bbcan.2018.06.005_bb0550) 2014; 20
Thomas (10.1016/j.bbcan.2018.06.005_bb1005) 2008; 7
Hofmann (10.1016/j.bbcan.2018.06.005_bb1085) 1987; 93
10.1016/j.bbcan.2018.06.005_bb1180
Pavlova (10.1016/j.bbcan.2018.06.005_bb0015) 2016; 23
Ribas (10.1016/j.bbcan.2018.06.005_bb1285) 2016; 315
Vetizou (10.1016/j.bbcan.2018.06.005_bb1320) 2015; 350
Chang (10.1016/j.bbcan.2018.06.005_bb0650) 2015; 162
Vavassori (10.1016/j.bbcan.2018.06.005_bb1130) 2009; 183
Circu (10.1016/j.bbcan.2018.06.005_bb0400) 2010; 48
Pacold (10.1016/j.bbcan.2018.06.005_bb0445) 2016; 12
Hylemon (10.1016/j.bbcan.2018.06.005_bb1035) 2009; 50
Sivan (10.1016/j.bbcan.2018.06.005_bb1315) 2015; 350
Perry (10.1016/j.bbcan.2018.06.005_bb0915) 2016; 534
Locasale (10.1016/j.bbcan.2018.06.005_bb0425) 2011; 43
Heiden (10.1016/j.bbcan.2018.06.005_bb0005) 2009; 324
Ohashi (10.1016/j.bbcan.2018.06.005_bb0680) 2017; 108
Warburg (10.1016/j.bbcan.2018.06.005_bb0025) 1956; 123
Viaud (10.1016/j.bbcan.2018.06.005_bb1290) 2013; 342
Johnson (10.1016/j.bbcan.2018.06.005_bb1230) 2015; 21
Yang (10.1016/j.bbcan.2018.06.005_bb0220) 2016; 24
Haq (10.1016/j.bbcan.2018.06.005_bb1210) 2013; 23
Coloff (10.1016/j.bbcan.2018.06.005_bb0230) 2016; 23
Rodriguez (10.1016/j.bbcan.2018.06.005_bb0740) 2017; 8
Peters (10.1016/j.bbcan.2018.06.005_bb1220) 2018; 6
Warburg (10.1016/j.bbcan.2018.06.005_bb0020) 1924; 152
Wang (10.1016/j.bbcan.2018.06.005_bb0290) 2014; 29
Huang (10.1016/j.bbcan.2018.06.005_bb0205) 2016; 26
Tonjes (10.1016/j.bbcan.2018.06.005_bb0545) 2013; 19
Schug (10.1016/j.bbcan.2018.06.005_bb0155) 2016; 16
Spinelli (10.1016/j.bbcan.2018.06.005_bb0225) 2017; 358
Keku (10.1016/j.bbcan.2018.06.005_bb0955) 2015; 308
Colegio (10.1016/j.bbcan.2018.06.005_bb0675) 2014; 513
Forman (10.1016/j.bbcan.2018.06.005_bb1020) 1995; 81
Cori (10.1016/j.bbcan.2018.06.005_bb0035) 1946; 15
Grippo (10.1016/j.bbcan.2018.06.005_bb0565) 2017; 6
DeBerardinis (10.1016/j.bbcan.2018.06.005_bb0640) 2008; 7
Zitvogel (10.1016/j.bbcan.2018.06.005_bb0905) 2017; 15
Martin (10.1016/j.bbcan.2018.06.005_bb0900) 2007; 3
Coloff (10.1016/j.bbcan.2018.06.005_bb0255) 2018; 69
Eisenberg (10.1016/j.bbcan.2018.06.005_bb1240) 2016; 22
Kalhan (10.1016/j.bbcan.2018.06.005_bb0340) 2012; 287
Lind (10.1016/j.bbcan.2018.06.005_bb0745) 2004; 134
Rodriguez (10.1016/j.bbcan.2018.06.005_bb0765) 2009; 69
Liu (10.1016/j.bbcan.2018.06.005_bb0525) 2008; 3
Wang (10.1016/j.bbcan.2018.06.005_bb0330) 2017; 546
Galluzzi (10.1016/j.bbcan.2018.06.005_bb0170) 2016; 26
Fletcher (10.1016/j.bbcan.2018.06.005_bb0770) 2015; 75
Hui (10.1016/j.bbcan.2018.06.005_bb0060) 2017; 551
Jobin (10.1016/j.bbcan.2018.06.005_bb1350) 2018; 359
Quante (10.1016/j.bbcan.2018.06.005_bb1065) 2012; 21
Anderson (10.1016/j.bbcan.2018.06.005_bb0405) 1998; 111-112
Mullarky (10.1016/j.bbcan.2018.06.005_bb0440) 2016; 113
Semenza (10.1016/j.bbcan.2018.06.005_bb0055) 1996; 271
Yang (10.1016/j.bbcan.2018.06.005_bb1265) 2017; 8
Gopalakrishnan (10.1016/j.bbcan.2018.06.005_bb1340) 2018; 359
Stolzing (10.1016/j.bbcan.2018.06.005_bb0285) 2004; 18
Comerford (10.1016/j.bbcan.2018.06.005_bb0140) 2014; 159
Debruyne (10.1016/j.bbcan.2018.06.005_bb1100) 2002; 21
Carr (10.1016/j.bbcan.2018.06.005_bb0830) 2010; 185
Thomas (10.1016/j.bbcan.2018.06.005_bb1040) 2008; 7
Kibe (10.1016/j.bbcan.2018.06.005_bb1255) 2014; 4
Michiels (10.1016/j.bbcan.2018.06.005_bb1260) 2016; 251
Vazquez (10.1016/j.bbcan.2018.06.005_bb1215) 2013; 23
Postow (10.1016/j.bbcan.2018.06.005_bb1275) 2015; 372
Fukao (10.1016/j.bbcan.2018.06.005_bb0190) 1997; 42
Chang (10.1016/j.bbcan.2018.06.005_bb0645) 2013; 153
Axelson (10.1016/j.bbcan.2018.06.005_bb1000) 2000; 31
Gutierrez-Diaz (10.1016/j.bbcan.2018.06.005_bb0980) 2016; 7
Routy (10.1016/j.bbcan.2018.06.005_bb1335) 2018; 359
Townsend (10.1016/j.bbcan.2018.06.005_bb0410) 2003; 57
Ridlon (10.1016/j.bbcan.2018.06.005_bb1015) 2006; 47
Martinez-Reyes (10.1016/j.bbcan.2018.06.005_bb0070) 2017; 26
Buck (10.1016/j.bbcan.2018.06.005_bb0865)
References_xml – volume: 546
  start-page: 426
  year: 2017
  end-page: 430
  ident: bb0330
  article-title: The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival
  publication-title: Nature
– volume: 107
  start-page: 1337
  year: 2012
  end-page: 1344
  ident: bb0990
  article-title: Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
  publication-title: Br. J. Cancer
– volume: 499
  start-page: 97
  year: 2013
  end-page: 101
  ident: bb1060
  article-title: Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
  publication-title: Nature
– volume: 167
  start-page: 829
  year: 2016
  end-page: 842
  ident: bb0755
  article-title: L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity
  publication-title: Cell
– volume: 35
  start-page: 871
  year: 2011
  end-page: 882
  ident: bb0825
  article-title: The transcription factor myc controls metabolic reprogramming upon T lymphocyte activation
  publication-title: Immunity
– volume: 4
  start-page: 781
  year: 2004
  end-page: 792
  ident: bb1185
  article-title: Polyamines and cancer: old molecules, new understanding
  publication-title: Nat. Rev. Cancer
– volume: 9
  start-page: 179
  year: 2002
  end-page: 188
  ident: bb0930
  article-title: Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria
  publication-title: Cell Death Differ.
– volume: 15
  start-page: 110
  year: 2012
  end-page: 121
  ident: bb0835
  article-title: Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
  publication-title: Cell Metab.
– volume: 75
  start-page: 275
  year: 2015
  end-page: 283
  ident: bb0770
  article-title: L-arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells
  publication-title: Cancer Res.
– volume: 7
  start-page: 678
  year: 2008
  end-page: 693
  ident: bb1040
  article-title: Targeting bile-acid signalling for metabolic diseases
  publication-title: Nat. Rev. Drug Discov.
– volume: 107
  start-page: 452
  year: 2002
  end-page: 460
  ident: bb0795
  article-title: Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division
  publication-title: Immunology
– volume: 113
  start-page: 1778
  year: 2016
  end-page: 1783
  ident: bb0440
  article-title: Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 109
  start-page: 6904
  year: 2012
  end-page: 6909
  ident: bb0460
  article-title: Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 350
  start-page: 1031
  year: 2015
  end-page: 1032
  ident: bb1325
  article-title: Could microbial therapy boost cancer immunotherapy?
  publication-title: Science
– volume: 371
  start-page: 653
  year: 2003
  end-page: 661
  ident: bb0365
  article-title: L-serine in disease and development
  publication-title: Biochem. J.
– volume: 11
  start-page: 1305
  year: 2009
  end-page: 1314
  ident: bb1235
  article-title: Induction of autophagy by spermidine promotes longevity
  publication-title: Nat. Cell Biol.
– volume: 14
  start-page: 561
  year: 2015
  end-page: 584
  ident: bb1280
  article-title: Combination cancer immunotherapy and new immunomodulatory targets
  publication-title: Nat. Rev. Drug Discov.
– volume: 6
  year: 2011
  ident: bb1250
  article-title: Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production
  publication-title: PLoS One
– volume: 15
  start-page: 3329
  year: 2009
  end-page: 3340
  ident: bb1045
  article-title: Bile acids as endogenous etiologic agents in gastrointestinal cancer
  publication-title: World J. Gastroenterol.
– volume: 4
  start-page: 1371
  year: 2014
  end-page: 1373
  ident: bb0620
  article-title: Mitochondrial one-carbon metabolism maintains redox balance during hypoxia
  publication-title: Cancer Discov.
– volume: 534
  start-page: 213
  year: 2016
  end-page: 217
  ident: bb0915
  article-title: Acetate mediates a microbiome-brain-beta-cell axis to promote metabolic syndrome
  publication-title: Nature
– volume: 45
  start-page: 714
  year: 2016
  end-page: 716
  ident: bb1310
  article-title: Two bugs a NOD away from improving cancer therapy efficacy
  publication-title: Immunity
– volume: 134
  start-page: 2837s
  year: 2004
  end-page: 2841s
  ident: bb0745
  article-title: Arginine and cancer
  publication-title: J. Nutr.
– volume: 50
  start-page: 6146
  year: 1990
  end-page: 6153
  ident: bb1175
  article-title: Two chromosomal locations for human ornithine decarboxylase gene sequences and elevated expression in colorectal neoplasia
  publication-title: Cancer Res.
– volume: 3
  year: 2008
  ident: bb0525
  article-title: Global Regulation of Nucleotide Biosynthetic Genes by c-Myc
  publication-title: PLoS One
– volume: 497
  start-page: 633
  year: 2013
  end-page: 637
  ident: bb0260
  article-title: Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
  publication-title: Nature
– volume: 20
  start-page: 126
  year: 2014
  end-page: 127
  ident: bb1305
  article-title: Chemotherapy, immunity and microbiota--a new triumvirate?
  publication-title: Nat. Med.
– volume: 287
  start-page: 7051
  year: 2012
  end-page: 7062
  ident: bb0415
  article-title: Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis
  publication-title: J. Biol. Chem.
– volume: 23
  start-page: 362
  year: 2012
  end-page: 369
  ident: bb0635
  article-title: Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
  publication-title: Semin. Cell Dev. Biol.
– volume: 16
  start-page: 343
  year: 2016
  ident: bb0780
  article-title: L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo
  publication-title: BMC Cancer
– volume: 45
  start-page: 931
  year: 2016
  end-page: 943
  ident: bb1300
  article-title: Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
  publication-title: Immunity
– volume: 491
  start-page: 458
  year: 2012
  end-page: 462
  ident: bb0455
  article-title: Serine is a natural ligand and allosteric activator of pyruvate kinase M2
  publication-title: Nature
– volume: 10
  start-page: 442
  year: 2013
  ident: bb1055
  article-title: Obesity-induced microbial metabolite promotes HCC
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
– volume: 108
  start-page: 1128
  year: 2017
  end-page: 1134
  ident: bb0680
  article-title: M2-like macrophage polarization in high lactic acid-producing head and neck cancer
  publication-title: Cancer Sci.
– volume: 8
  year: 2017
  ident: bb0740
  article-title: Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity
  publication-title: Front. Immunol.
– start-page: 34
  year: 2017
  ident: bb0785
  article-title: Targeting TDO in cancer immunotherapy
  publication-title: Med. Oncol.
– volume: 336
  start-page: 1262
  year: 2012
  end-page: 1267
  ident: bb0875
  article-title: Host-gut microbiota metabolic interactions
  publication-title: Science
– volume: 25
  start-page: 262
  year: 2017
  end-page: 284
  ident: bb0160
  article-title: Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics
  publication-title: Cell Metab.
– volume: 39
  start-page: 221
  year: 2004
  end-page: 233
  ident: bb1155
  article-title: The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells
  publication-title: Mol. Carcinog.
– volume: 37
  start-page: 214
  year: 1977
  end-page: 221
  ident: bb1190
  article-title: Polyamines as Markers of Response and Disease Activity in Cancer Chemotherapy
  publication-title: Cancer Res.
– volume: 23
  start-page: 867
  year: 2016
  end-page: 880
  ident: bb0230
  article-title: Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells
  publication-title: Cell Metab.
– volume: 353
  start-page: 1095
  year: 2016
  end-page: 1096
  ident: bb0560
  article-title: Location, location, location
  publication-title: Science
– volume: 32
  start-page: 377
  year: 2017
  end-page: 391
  ident: bb0725
  article-title: Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
  publication-title: Cancer Cell
– volume: 342
  start-page: 967
  year: 2013
  end-page: 970
  ident: bb1295
  article-title: Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
  publication-title: Science
– volume: 287
  start-page: 19786
  year: 2012
  end-page: 19791
  ident: bb0340
  article-title: Resurgence of serine: an often neglected but indispensable amino acid
  publication-title: J. Biol. Chem.
– volume: 188
  start-page: 49
  year: 2011
  end-page: 64
  ident: bb1270
  article-title: Targeting Polyamines and Inflammation for Cancer Prevention
  publication-title: Rec. Res. Cancer
– volume: 61
  start-page: 1495
  year: 2012
  end-page: 1511
  ident: bb0215
  article-title: Ammonium metabolism in humans
  publication-title: Metabolism
– volume: 18
  start-page: 283
  year: 2005
  end-page: 293
  ident: bb0305
  article-title: AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
  publication-title: Mol. Cell
– volume: 18
  start-page: 743
  year: 2004
  end-page: 745
  ident: bb0285
  article-title: Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells
  publication-title: FASEB J.
– volume: 359
  start-page: 97
  year: 2018
  end-page: 103
  ident: bb1340
  article-title: Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
  publication-title: Science
– volume: 39
  start-page: 191
  year: 2014
  end-page: 198
  ident: bb0390
  article-title: Serine and glycine metabolism in cancer
  publication-title: Trends Biochem. Sci.
– volume: 6
  start-page: S585
  year: 2017
  end-page: S586
  ident: bb0565
  article-title: Targeting cancer with tumor-specific therapeutic strategies-metabolic reprogramming beyond the Warburg effect
  publication-title: Trans. Cancer Res.
– volume: 111
  start-page: 18321
  year: 2014
  end-page: 18326
  ident: bb1225
  article-title: Microbiota organization is a distinct feature of proximal colorectal cancers
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 324
  start-page: 1076
  year: 2009
  end-page: 1080
  ident: bb0105
  article-title: ATP-citrate lyase links cellular metabolism to histone acetylation
  publication-title: Science
– volume: 20
  start-page: S111
  year: 1995
  ident: bb0030
  article-title: Pasteur - the anaerobic life and the anaerobes
  publication-title: Clin. Infect. Dis.
– volume: 15
  start-page: 991
  year: 2013
  end-page: 1000
  ident: bb0325
  article-title: TAp73 enhances the pentose phosphate pathway and supports cell proliferation
  publication-title: Nat. Cell Biol.
– volume: 10
  start-page: 301
  year: 2010
  end-page: 309
  ident: bb0500
  article-title: MYC as a regulator of ribosome biogenesis and protein synthesis
  publication-title: Nat. Rev. Cancer
– volume: 94
  start-page: 6658
  year: 1997
  end-page: 6663
  ident: bb0045
  article-title: c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 24
  start-page: 55
  year: 2017
  end-page: 65
  ident: bb0450
  article-title: Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity
  publication-title: Cell Chem. Biol.
– volume: 12
  start-page: 622
  year: 2015
  ident: bb0715
  article-title: Immunotherapy: Evading immune escape: synergy of COX and immune-checkpoint inhibitors
  publication-title: Nat. Rev. Clin. Oncol.
– volume: 27
  start-page: 69
  year: 2017
  end-page: 81
  ident: bb0300
  article-title: Fueling the Cell Division Cycle
  publication-title: Trends Cell Biol.
– volume: 41
  start-page: 1016
  year: 1992
  end-page: 1020
  ident: bb0820
  article-title: Glutamine and Macrophage Function
  publication-title: Metabolism
– volume: 7
  start-page: 2347
  year: 2016
  end-page: 2356
  ident: bb0980
  article-title: Mediterranean diet and faecal microbiota: a transversal study
  publication-title: Food Funct.
– volume: 342
  start-page: 971
  year: 2013
  end-page: 976
  ident: bb1290
  article-title: The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide
  publication-title: Science
– volume: 56
  start-page: 66
  year: 2017
  end-page: 74
  ident: bb1135
  article-title: Bile acids and colon cancer: is FXR the solution of the conundrum?
  publication-title: Mol. Asp. Med.
– volume: 105
  start-page: 16767
  year: 2008
  end-page: 16772
  ident: bb0925
  article-title: Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
  publication-title: Proc. Nat. Acad. Sci. USA
– volume: 531
  start-page: 651
  year: 2016
  end-page: 655
  ident: bb0695
  article-title: Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism
  publication-title: Nature
– volume: 152
  start-page: 309
  year: 1924
  end-page: 344
  ident: bb0020
  article-title: On the metabolism of carcinoma cells
  publication-title: Biochem. Z.
– volume: 67
  start-page: 8180
  year: 2007
  end-page: 8187
  ident: bb0110
  article-title: Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
  publication-title: Cancer Res.
– volume: 22
  start-page: 1389
  year: 2016
  end-page: 1390
  ident: bb1245
  article-title: Spermidine to the rescue for an aging heart
  publication-title: Nat. Med.
– volume: 102
  start-page: 1197
  year: 2007
  end-page: 1208
  ident: bb0920
  article-title: Understanding the effects of diet on bacterial metabolism in the large intestine
  publication-title: J. Appl. Microbiol.
– volume: 17
  start-page: 662
  year: 2015
  end-page: 671
  ident: bb0970
  article-title: Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial hif augments tissue barrier function
  publication-title: Cell Host Microbe
– volume: 185
  start-page: 1037
  year: 2010
  end-page: 1044
  ident: bb0830
  article-title: Glutamine uptake and metabolism are coordinately Regulated by ERK/MAPK during T lymphocyte activation
  publication-title: J. Immunol.
– volume: 21
  start-page: 64
  year: 2018
  end-page: 70
  ident: bb0535
  article-title: Branched-chain amino acid metabolism in cancer
  publication-title: Curr. Opin. Clin. Nutr. Metab. Care
– volume: 7
  start-page: 11
  year: 2008
  end-page: 20
  ident: bb0640
  article-title: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
  publication-title: Cell Metab.
– volume: 26
  start-page: 1077
  year: 2016
  end-page: 1078
  ident: bb0170
  article-title: Aberrant ketolysis fuels hepatocellular cancer progression
  publication-title: Cell Res.
– volume: 304
  start-page: H1060
  year: 2013
  end-page: H1076
  ident: bb0175
  article-title: Ketone body metabolism and cardiovascular disease
  publication-title: Am. J. Physiol-Heart C
– volume: 126
  start-page: 228
  year: 2010
  end-page: 243
  ident: bb1025
  article-title: Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity
  publication-title: Pharmacol. Ther.
– volume: 24
  start-page: 3736
  year: 2013
  end-page: 3745
  ident: bb0280
  article-title: mTOR regulates phagosome and entotic vacuole fission
  publication-title: Mol. Biol. Cell
– volume: 17
  start-page: 159
  year: 2013
  end-page: 161
  ident: bb0475
  article-title: The Hunger games: p53 regulates metabolism upon serine starvation
  publication-title: Cell Metab.
– volume: 114
  start-page: E8628
  year: 2017
  end-page: E8636
  ident: bb0275
  article-title: Critical role for PI3-kinase in regulating the use of proteins as an amino acid source
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 153
  start-page: 1239
  year: 2013
  end-page: 1251
  ident: bb0645
  article-title: Posttranscriptional control of T Cell effector function by aerobic glycolysis
  publication-title: Cell
– volume: 44
  start-page: 1312
  year: 2016
  end-page: 1324
  ident: bb0850
  article-title: Memory CD8(+) T cells require Increased concentrations of acetate induced by stress for optimal function
  publication-title: Immunity
– volume: 21
  start-page: 891
  year: 2015
  end-page: 897
  ident: bb1230
  article-title: Metabolism Links Bacterial Biofilms and Colon Carcinogenesis
  publication-title: Cell Metab.
– volume: 24
  start-page: 5923
  year: 2004
  end-page: 5936
  ident: bb0520
  article-title: Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays
  publication-title: Mol. Cell. Biol.
– volume: 17
  start-page: 351
  year: 2015
  end-page: 359
  ident: bb0625
  article-title: Metabolic pathways promoting cancer cell survival and growth
  publication-title: Nat. Cell Biol.
– volume: 69
  start-page: 1553
  year: 2009
  end-page: 1560
  ident: bb0765
  article-title: Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
  publication-title: Cancer Res.
– volume: 24
  start-page: 685
  year: 2016
  end-page: 700
  ident: bb0220
  article-title: Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth
  publication-title: Cell Metab.
– volume: 28
  start-page: 59
  year: 2012
  end-page: 87
  ident: bb0295
  article-title: Driving the Cell Cycle Through Metabolism
  publication-title: Ann. Rev. Cell Dev. B
– volume: 185
  start-page: 174
  year: 2010
  end-page: 181
  ident: bb0940
  article-title: Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells
  publication-title: Chem. Biol. Interact.
– volume: 77
  start-page: 6321
  year: 2017
  end-page: 6329
  ident: bb0615
  article-title: PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2 alpha-Targeting Therapy for Renal Cell Carcinoma
  publication-title: Cancer Res.
– volume: 152
  start-page: 599
  year: 2013
  end-page: 611
  ident: bb0485
  article-title: Control of nutrient stress-induced metabolic reprogramming by PKCzeta in tumorigenesis
  publication-title: Cell
– volume: 9
  start-page: 3884
  year: 2010
  end-page: 3886
  ident: bb0515
  article-title: Glutaminolysis: Supplying carbon or nitrogen, or both for cancer cells?
  publication-title: Cell Cycle
– volume: 50
  start-page: 1955
  year: 2009
  end-page: 1966
  ident: bb1010
  article-title: Bile acids: regulation of synthesis
  publication-title: J. Lipid Res.
– volume: 145
  start-page: 627
  year: 1940
  ident: bb1050
  article-title: Production of tumours in mice by deoxycholic acid
  publication-title: Nature
– volume: 57
  start-page: 145
  year: 2003
  end-page: 155
  ident: bb0410
  article-title: The importance of glutathione in human disease
  publication-title: Biomed Pharmacother
– volume: 46
  start-page: 233
  year: 2017
  end-page: 244
  ident: bb0855
  article-title: A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells
  publication-title: Immunity
– volume: 8
  start-page: 1506
  year: 2017
  ident: bb0335
  article-title: Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
  publication-title: Nat. Commun.
– volume: 101
  start-page: 151
  year: 2002
  end-page: 155
  ident: bb0800
  article-title: Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
  publication-title: Int. J. Cancer
– volume: 17
  start-page: 1519
  year: 2011
  end-page: 1528
  ident: bb0945
  article-title: Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
  publication-title: World J. Gastroenterol.
– volume: 251
  start-page: 319
  year: 2016
  end-page: 327
  ident: bb1260
  article-title: Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy
  publication-title: Atherosclerosis
– volume: 276
  start-page: 11420
  year: 2001
  end-page: 11426
  ident: bb0125
  article-title: Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate
  publication-title: J. Biol. Chem.
– volume: 12
  start-page: 452
  year: 2016
  end-page: 458
  ident: bb0445
  article-title: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
  publication-title: Nat. Chem. Biol.
– volume: 15
  start-page: 193
  year: 1946
  end-page: 218
  ident: bb0035
  article-title: Carbohydrate metabolism
  publication-title: Annu. Rev. Biochem.
– volume: 28
  start-page: 687
  year: 2015
  end-page: 689
  ident: bb1330
  article-title: Immunotherapy not working? Check your microbiota
  publication-title: Cancer Cell
– volume: 358
  start-page: 941
  year: 2017
  end-page: 946
  ident: bb0225
  article-title: Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
  publication-title: Science
– volume: 215
  start-page: 227
  year: 2008
  end-page: 236
  ident: bb0195
  article-title: Liver-specific silencing of the human gene encoding succinyl-CoA : 3-ketoacid CoA transferase
  publication-title: Tohoku J. Exp. Med.
– volume: 353
  start-page: 1161
  year: 2016
  end-page: 1165
  ident: bb0555
  article-title: Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
  publication-title: Science
– volume: 22
  start-page: 2465
  year: 2002
  end-page: 2469
  ident: bb1160
  article-title: Prognostic value of tissue polyamine levels in human colorectal carcinoma
  publication-title: Anticancer Res.
– volume: 36
  start-page: 2296
  year: 2015
  end-page: 2303
  ident: bb0185
  article-title: Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain
  publication-title: Neurobiol. Aging
– volume: 89
  start-page: 169
  year: 2000
  end-page: 175
  ident: bb0095
  article-title: Free radical scavenging and antioxidant effects of lactate ion: an in vitro study
  publication-title: J. Appl. Physiol.
– volume: 21
  start-page: 36
  year: 2012
  end-page: 51
  ident: bb1065
  article-title: Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
  publication-title: Cancer Cell
– volume: 350
  start-page: 1079
  year: 2015
  end-page: 1084
  ident: bb1320
  article-title: Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
  publication-title: Science
– volume: 4
  start-page: e877
  year: 2013
  ident: bb0380
  article-title: Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
  publication-title: Cell Death Dis.
– volume: 493
  start-page: 542
  year: 2012
  end-page: 546
  ident: bb0470
  article-title: Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
  publication-title: Nature
– volume: 476
  start-page: 346
  year: 2011
  end-page: 350
  ident: bb0420
  article-title: Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
  publication-title: Nature
– volume: 315
  start-page: 1600
  year: 2016
  end-page: 1609
  ident: bb1285
  article-title: Association of pembrolizumab with tumor response and survival among patients with advanced melanoma
  publication-title: Jama-J. Am. Med. Assoc.
– volume: 47
  start-page: 1475
  year: 2015
  end-page: 1481
  ident: bb0495
  article-title: NRF2 regulates serine biosynthesis in non-small cell lung cancer
  publication-title: Nat. Genet.
– volume: 589
  start-page: 47
  year: 2005
  end-page: 65
  ident: bb1090
  article-title: Bile acids as carcinogens in human gastrointestinal cancers
  publication-title: Mutat. Res-Rev. Mutat.
– volume: 34
  start-page: 167
  year: 1991
  end-page: 173
  ident: bb1165
  article-title: Polyamine Levels in Healthy and Tumor-Tissues of Patients with Colon Adenocarcinoma
  publication-title: Dis. Colon Rectum
– volume: 7
  start-page: 154
  year: 2012
  end-page: 167
  ident: bb0120
  article-title: ATP citrate lyase inhibitors as novel cancer therapeutic agents
  publication-title: Rec. Pat Anti-Can.
– volume: 513
  start-page: 559
  year: 2014
  end-page: 563
  ident: bb0675
  article-title: Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
  publication-title: Nature
– volume: 15
  start-page: 474
  year: 2012
  end-page: 479
  ident: bb0950
  article-title: Butyrate: implications for intestinal function
  publication-title: Curr. Opin. Clin. Nutr. Metab. Care
– volume: 169
  start-page: 570
  year: 2017
  end-page: 586
  ident: bb0865
  article-title: Metabolic instruction of immunity
  publication-title: Cell
– volume: 24
  start-page: 1112
  year: 2011
  end-page: 1115
  ident: bb0430
  article-title: PHGDH amplification and altered glucose metabolism in human melanoma
  publication-title: Pig. Cell Melan. Res.
– volume: 29
  start-page: 217
  year: 2014
  end-page: 232
  ident: bb0290
  article-title: Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression
  publication-title: Dev. Cell
– volume: 75
  start-page: 544
  year: 2015
  end-page: 553
  ident: bb0265
  article-title: Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
  publication-title: Cancer Res.
– volume: 278
  start-page: 47762
  year: 2003
  end-page: 47775
  ident: bb1150
  article-title: Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer
  publication-title: J. Biol. Chem.
– volume: 5
  start-page: 2035
  year: 1999
  end-page: 2041
  ident: bb1170
  article-title: Prognostic value of ornithine decarboxylase and polyamines in human breast cancer: Correlation with clinicopathologic parameters
  publication-title: Clin. Cancer Res.
– volume: 76
  start-page: 4430
  year: 2016
  end-page: 4442
  ident: bb0605
  article-title: PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis
  publication-title: Cancer Res.
– volume: 376
  start-page: 1
  year: 2003
  end-page: 14
  ident: bb1145
  article-title: A perspective of polyamine metabolism
  publication-title: Biochem. J.
– volume: 27
  start-page: 257
  year: 2015
  end-page: 270
  ident: bb0245
  article-title: Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth
  publication-title: Cancer Cell
– volume: 137
  start-page: 1681S
  year: 2007
  end-page: 1686S
  ident: bb0750
  article-title: Arginine and immunity
  publication-title: J. Nutr.
– volume: 16
  start-page: 690
  year: 2016
  end-page: 701
  ident: bb0705
  article-title: Regulation of T cell signalling by membrane lipids
  publication-title: Nat. Rev. Immunol.
– volume: 64
  start-page: 5839
  year: 2004
  end-page: 5849
  ident: bb0760
  article-title: Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
  publication-title: Cancer Res.
– volume: 25
  start-page: 724
  year: 2013
  end-page: 729
  ident: bb0310
  article-title: Metabolic regulation of the cell cycle
  publication-title: Curr. Opin. Cell Biol.
– volume: 13
  start-page: 572
  year: 2013
  end-page: 583
  ident: bb0375
  article-title: Serine, glycine and one-carbon units: cancer metabolism in full circle
  publication-title: Nat. Rev. Cancer
– volume: 31
  start-page: 1305
  year: 2000
  end-page: 1312
  ident: bb1000
  article-title: Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid
  publication-title: Hepatology
– volume: 510
  start-page: 547
  year: 2014
  end-page: 551
  ident: bb0315
  article-title: Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression
  publication-title: Nature
– volume: 43
  start-page: 435
  year: 2015
  end-page: 449
  ident: bb0860
  article-title: Metabolic reprogramming of immune cells in cancer progression
  publication-title: Immunity
– volume: 1791
  start-page: 1103
  year: 2009
  end-page: 1113
  ident: bb0130
  article-title: Control of free arachidonic acid levels by phospholipases A(2) and lysophospholipid acyltransferases
  publication-title: Bba-Mol. Cell Biol. L
– volume: 234
  start-page: 2544
  year: 1959
  end-page: 2547
  ident: bb0100
  article-title: The citrate cleavage enzyme. I. Distribution and purification
  publication-title: J. Biol. Chem.
– volume: 336
  start-page: 1040
  year: 2012
  end-page: 1044
  ident: bb0345
  article-title: Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
  publication-title: Science
– volume: 10
  start-page: 723
  year: 2014
  end-page: 736
  ident: bb0540
  article-title: Branched-chain amino acids in metabolic signalling and insulin resistance
  publication-title: Nat. Rev. Endocrinol.
– volume: 93
  start-page: 693
  year: 1987
  end-page: 709
  ident: bb1085
  article-title: Simulation of the Metabolism and Enterohepatic Circulation of Endogenous Deoxycholic-Acid in Humans Using a Physiological Pharmacokinetic Model for Bile-Acid Metabolism
  publication-title: Gastroenterology
– volume: 359
  start-page: 104
  year: 2018
  end-page: 108
  ident: bb1345
  article-title: The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
  publication-title: Science
– volume: 4
  start-page: 4202
  year: 2014
  ident: bb0890
  article-title: Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer
  publication-title: Sci. Rep.
– volume: 94
  start-page: 102
  year: 2010
  end-page: 109
  ident: bb0090
  article-title: Glycolytic metabolism and tumour response to fractionated irradiation
  publication-title: Radiother. Oncol.
– volume: 109
  start-page: 2497
  year: 2012
  end-page: 2502
  ident: bb0790
  article-title: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 39
  start-page: 453
  year: 2011
  end-page: 463
  ident: bb0080
  article-title: Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
  publication-title: Int. J. Oncol.
– volume: 107
  start-page: 2013
  year: 2006
  end-page: 2021
  ident: bb0660
  article-title: Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
  publication-title: Blood
– volume: 359
  start-page: 32
  year: 2018
  end-page: 34
  ident: bb1350
  article-title: Precision medicine using microbiota
  publication-title: Science
– volume: 308
  start-page: G351
  year: 2015
  end-page: G363
  ident: bb0955
  article-title: The gastrointestinal microbiota and colorectal cancer
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
– volume: 3
  year: 2007
  ident: bb0900
  article-title: A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model
  publication-title: Mol. Syst. Biol.
– volume: 165
  start-page: 1332
  year: 2016
  end-page: 1345
  ident: bb0910
  article-title: From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites
  publication-title: Cell
– volume: 4
  start-page: 1387
  year: 2014
  end-page: 1397
  ident: bb0960
  article-title: A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner
  publication-title: Cancer Discov.
– volume: 8
  start-page: e2738
  year: 2017
  ident: bb1265
  article-title: Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage
  publication-title: Cell Death Dis.
– volume: 162
  start-page: 1229
  year: 2015
  end-page: 1241
  ident: bb0650
  article-title: Metabolic competition in the tumor microenvironment is a driver of cancer progression
  publication-title: Cell
– volume: 8
  start-page: 311
  year: 2005
  end-page: 321
  ident: bb0115
  article-title: ATP citrate lyase inhibition can suppress tumor cell growth
  publication-title: Cancer Cell
– volume: 57
  start-page: 2401
  year: 2016
  end-page: 2408
  ident: bb0935
  article-title: Butyrate production from high-fiber diet protects against lymphoma tumor
  publication-title: Leuk. Lymphoma
– volume: 26
  start-page: 121
  year: 2014
  end-page: 135
  ident: bb0630
  article-title: Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes Inflammation and tumorigenesis
  publication-title: Cancer Cell
– reference: D.H. Russell, Clinical relevance of polyamines, Crit. Rev. Clin. Lab. Sci., 18 (1983) 261-311.
– volume: 162
  start-page: 1257
  year: 2015
  end-page: 1270
  ident: bb0710
  article-title: Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
  publication-title: Cell
– volume: 61
  start-page: 582
  year: 2012
  end-page: 588
  ident: bb0885
  article-title: Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer
  publication-title: Gut
– volume: 71
  start-page: 6921
  year: 2011
  end-page: 6925
  ident: bb0085
  article-title: Lactate: A Metabolic Key Player in Cancer
  publication-title: Cancer Res.
– volume: 24
  start-page: 657
  year: 2016
  end-page: 671
  ident: bb0685
  article-title: LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
  publication-title: Cell Metab.
– volume: 358
  start-page: 862
  year: 2017
  end-page: 863
  ident: bb0250
  article-title: Feeding frenzy for cancer cells Cancer cells rewire metabolism to scavenge nutrients and waste products
  publication-title: Science
– volume: 19
  start-page: 901
  year: 2013
  end-page: 908
  ident: bb0545
  article-title: BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
  publication-title: Nat. Med.
– volume: 12
  start-page: 937
  year: 2016
  end-page: 943
  ident: bb0040
  article-title: Lactate metabolism is associated with mammalian mitochondria
  publication-title: Nat. Chem. Biol.
– volume: 7
  start-page: 200
  year: 2016
  end-page: 213
  ident: bb0880
  article-title: Role of the microbiome in non-gastrointestinal cancers
  publication-title: World J. Clin. Oncol.
– volume: 25
  start-page: 429
  year: 2015
  end-page: 444
  ident: bb0530
  article-title: cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
  publication-title: Cell Res.
– volume: 73
  start-page: 478
  year: 2012
  end-page: 482
  ident: bb0385
  article-title: Overexpression of the Mitochondrial Folate and Glycine-Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors
  publication-title: Cancer Res.
– volume: 24
  start-page: 104
  year: 2016
  end-page: 117
  ident: bb0845
  article-title: Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation
  publication-title: Cell Metab.
– volume: 8
  start-page: 685
  year: 2008
  end-page: 698
  ident: bb1030
  article-title: Vitamin effects on the immune system: vitamins A and D take centre stage
  publication-title: Nat. Rev. Immunol.
– volume: 23
  start-page: 302
  year: 2013
  end-page: 315
  ident: bb1210
  article-title: Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF
  publication-title: Cancer Cell
– volume: 105
  start-page: 1217
  year: 2000
  end-page: 1225
  ident: bb0735
  article-title: Arginine, citrulline, and nitric oxide metabolism in. end-stage renal disease patients
  publication-title: J. Clin. Invest.
– volume: 212
  start-page: 1345
  year: 2015
  end-page: 1360
  ident: bb0805
  article-title: T cell metabolism drives immunity
  publication-title: J. Exp. Med.
– volume: 8
  start-page: 540
  year: 2008
  end-page: 563
  ident: bb1115
  article-title: Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: Role in health and disease and their therapeutic potential
  publication-title: Anti-Can. Agent M.
– volume: 77
  start-page: 3131
  year: 2017
  end-page: 3134
  ident: bb0570
  article-title: Nature and nurture: what determines tumor metabolic phenotypes?
  publication-title: Cancer Res.
– volume: 14
  start-page: 18
  year: 2015
  end-page: 33
  ident: bb1125
  article-title: Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases
  publication-title: Hepatob. Pancreat Dis.
– volume: 26
  start-page: 803
  year: 2017
  end-page: 804
  ident: bb0070
  article-title: Waste Not, want not: lactate oxidation fuels the TCA cycle
  publication-title: Cell Metab.
– volume: 9
  start-page: 949
  year: 2010
  ident: bb0505
  article-title: The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
  publication-title: Nat. Rev. Cancer
– volume: 15
  start-page: 465
  year: 2017
  end-page: 478
  ident: bb0905
  article-title: Anticancer effects of the microbiome and its products
  publication-title: Nat. Rev. Microbiol.
– volume: 4
  start-page: 4548
  year: 2014
  ident: bb1255
  article-title: Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
  publication-title: Sci. Rep.
– volume: 46
  start-page: 1589
  year: 1967
  end-page: 1595
  ident: bb0180
  article-title: Brain Metabolism during Fasting
  publication-title: J. Clin. Invest.
– volume: 531
  start-page: 583
  year: 2016
  end-page: 584
  ident: bb0700
  article-title: Cancer immunotherapy: Killers on sterols
  publication-title: Nature
– volume: 1812
  start-page: 851
  year: 2011
  end-page: 858
  ident: bb1075
  article-title: Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-kappa B signaling in the intestine
  publication-title: Bba-Mol. Basis Dis.
– volume: 25
  start-page: 345
  year: 2017
  end-page: 357
  ident: bb0840
  article-title: Serine Is an Essential Metabolite for Effector T Cell Expansion
  publication-title: Cell Metab.
– volume: 25
  start-page: 42
  year: 2014
  end-page: 52
  ident: bb0165
  article-title: Ketone bodies as signaling metabolites
  publication-title: Trends Endocrinol. Metab.
– volume: 7
  start-page: 678
  year: 2008
  end-page: 693
  ident: bb1005
  article-title: Targeting bile-acid signalling for metabolic diseases
  publication-title: Nat. Rev. Drug Discov.
– volume: 269
  start-page: 23757
  year: 1994
  end-page: 23763
  ident: bb0595
  article-title: Transcriptional Regulation of Genes Encoding Glycolytic-Enzymes by Hypoxia-Inducible Factor-1
  publication-title: J. Biol. Chem.
– volume: 324
  start-page: 1029
  year: 2009
  end-page: 1033
  ident: bb0005
  article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation
  publication-title: Science
– volume: 16
  start-page: 619
  year: 2016
  end-page: 634
  ident: bb0210
  article-title: From Krebs to clinic: glutamine metabolism to cancer therapy
  publication-title: Nat. Rev. Cancer
– volume: 3
  year: 2014
  ident: bb1205
  article-title: Polyamine blockade promotes antitumor immunity
  publication-title: Oncoimmunology
– volume: 275
  start-page: 26458
  year: 2000
  end-page: 26466
  ident: bb0135
  article-title: Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins
  publication-title: J. Biol. Chem.
– volume: 6
  year: 2018
  ident: bb1220
  article-title: A novel polyamine-targeted therapy for BRAF mutant melanoma tumors
  publication-title: Med. Sci.
– volume: 14
  start-page: 285
  year: 2011
  end-page: 286
  ident: bb0435
  article-title: Serine metabolism: some tumors take the road less traveled
  publication-title: Cell Metab.
– volume: 111-112
  start-page: 1
  year: 1998
  end-page: 14
  ident: bb0405
  article-title: Glutathione: an overview of biosynthesis and modulation
  publication-title: Chem. Biol. Interact.
– volume: 545
  start-page: 500
  year: 2017
  end-page: 504
  ident: bb0580
  article-title: Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
  publication-title: Nature
– volume: 59
  start-page: 71
  year: 1994
  end-page: 77
  ident: bb1105
  article-title: Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro
  publication-title: Int. J. Cancer
– volume: 183
  start-page: 6251
  year: 2009
  end-page: 6261
  ident: bb1130
  article-title: The bile acid receptor FXR is a modulator of intestinal innate immunity
  publication-title: J. Immunol.
– volume: 48
  start-page: 749
  year: 2010
  end-page: 762
  ident: bb0400
  article-title: Reactive oxygen species, cellular redox systems, and apoptosis
  publication-title: Free Radic. Biol. Med.
– volume: 85
  start-page: 863
  year: 2011
  end-page: 871
  ident: bb1070
  article-title: Carcinogenicity of deoxycholate, a secondary bile acid
  publication-title: Arch. Toxicol.
– volume: 47
  start-page: 241
  year: 2006
  end-page: 259
  ident: bb1015
  article-title: Bile salt biotransformations by human intestinal bacteria
  publication-title: J. Lipid Res.
– volume: 283
  start-page: 25846
  year: 2008
  end-page: 25853
  ident: bb0350
  article-title: Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice
  publication-title: J. Biol. Chem.
– volume: 81
  start-page: 687
  year: 1995
  end-page: 693
  ident: bb1020
  article-title: Identification of a Nuclear Receptor That Is Activated by Farnesol Metabolites
  publication-title: Cell
– volume: 16
  start-page: 143
  year: 2014
  end-page: 145
  ident: bb0965
  article-title: Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?
  publication-title: Cell Host Microbe
– volume: 153
  start-page: 840
  year: 2013
  end-page: 854
  ident: bb0240
  article-title: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4
  publication-title: Cell
– volume: 5
  start-page: 945
  year: 1999
  end-page: 951
  ident: bb1195
  article-title: Development of difluoromethylornithine (DFMO) as a chemoprevention agent
  publication-title: Clin. Cancer Res.
– volume: 222
  start-page: 180
  year: 2008
  end-page: 191
  ident: bb0775
  article-title: Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives
  publication-title: Immunol. Rev.
– volume: 359
  start-page: 91
  year: 2018
  end-page: 97
  ident: bb1335
  article-title: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
  publication-title: Science
– volume: 67
  start-page: 100
  year: 1999
  end-page: 105
  ident: bb0395
  article-title: Glutamine, as a precursor of glutathione, and oxidative stress
  publication-title: Mol. Genet. Metab.
– volume: 188
  start-page: 21
  year: 2012
  end-page: 28
  ident: bb0690
  article-title: Regulation of immune responses by prostaglandin E2
  publication-title: J. Immunol.
– volume: 159
  start-page: 1591
  year: 2014
  end-page: 1602
  ident: bb0140
  article-title: Acetate dependence of tumors
  publication-title: Cell
– volume: 19
  start-page: 443
  year: 2016
  end-page: 454
  ident: bb0975
  article-title: Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella
  publication-title: Cell Host Microbe
– volume: 18
  start-page: 896
  year: 2013
  end-page: 907
  ident: bb0480
  article-title: The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
  publication-title: Cell Metab.
– volume: 20
  start-page: 1193
  year: 2014
  end-page: 1198
  ident: bb0550
  article-title: Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
  publication-title: Nat. Med.
– volume: 159
  start-page: 1603
  year: 2014
  end-page: 1614
  ident: bb0150
  article-title: Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
  publication-title: Cell
– volume: 350
  start-page: 1084
  year: 2015
  end-page: 1089
  ident: bb1315
  article-title: Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
  publication-title: Science
– volume: 19
  start-page: 1
  year: 1999
  end-page: 11
  ident: bb0050
  article-title: c-Myc target genes involved in cell growth, apoptosis, and metabolism
  publication-title: Mol. Cell. Biol.
– volume: 43
  start-page: 869
  year: 2011
  end-page: 874
  ident: bb0425
  article-title: Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
  publication-title: Nat. Genet.
– volume: 26
  start-page: 1112
  year: 2016
  end-page: 1130
  ident: bb0205
  article-title: Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress
  publication-title: Cell Res.
– volume: 27
  start-page: 5904
  year: 2008
  end-page: 5912
  ident: bb0585
  article-title: The tumor microenvironment and its role in promoting tumor growth
  publication-title: Oncogene
– volume: 50
  start-page: 1509
  year: 2009
  end-page: 1520
  ident: bb1035
  article-title: Bile acids as regulatory molecules
  publication-title: J. Lipid Res.
– volume: 372
  start-page: 2006
  year: 2015
  end-page: 2017
  ident: bb1275
  article-title: Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
  publication-title: New Engl. J. Med.
– volume: 271
  start-page: 32529
  year: 1996
  end-page: 32537
  ident: bb0055
  article-title: Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
  publication-title: J. Biol. Chem.
– volume: 99
  start-page: 256
  year: 2010
  end-page: 262
  ident: bb0360
  article-title: L-serine synthesis in the central nervous system: a review on serine deficiency disorders
  publication-title: Mol. Genet. Metab.
– volume: 110
  start-page: 19402
  year: 2013
  end-page: 19407
  ident: bb0670
  article-title: Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
– volume: 152
  start-page: S906
  year: 2017
  ident: bb1355
  article-title: Fecal Microbiota Transplant Using a Precision Medicine Approach Is Safe, Associated with Lower Hospitalization Risk and Improved Cognitive Function in Recurrent Hepatic Encephalopathy
  publication-title: Gastroenterology
– volume: 551
  start-page: 115
  year: 2017
  end-page: 118
  ident: bb0060
  article-title: Glucose feeds the TCA cycle via circulating lactate
  publication-title: Nature
– volume: 164
  start-page: 681
  year: 2016
  end-page: 694
  ident: bb0075
  article-title: Metabolic heterogeneity in human lung tumors
  publication-title: Cell
– volume: 162
  start-page: 1217
  year: 2015
  end-page: 1228
  ident: bb0655
  article-title: Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
  publication-title: Cell
– volume: 109
  start-page: 3812
  year: 2007
  end-page: 3819
  ident: bb0665
  article-title: Inhibitory effect of tumor cell-derived lactic acid on human T cells
  publication-title: Blood
– volume: 480
  start-page: 359
  year: 2001
  end-page: 369
  ident: bb1095
  article-title: The role of bile acids in carcinogenesis
  publication-title: Mutat. Res-Fund Mol. M.
– volume: 123
  start-page: 309
  year: 1956
  end-page: 314
  ident: bb0025
  article-title: Origin of cancer cells
  publication-title: Science
– volume: 4
  year: 2009
  ident: bb0355
  article-title: SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis
  publication-title: PLoS One
– volume: 42
  start-page: 498
  year: 1997
  end-page: 502
  ident: bb0190
  article-title: Enzymes of ketone body utilization in human tissues: Protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases
  publication-title: Pediatr. Res.
– volume: 478
  start-page: 197
  year: 2011
  end-page: 203
  ident: bb0810
  article-title: An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
  publication-title: Nature
– volume: 56
  start-page: 1085
  year: 2015
  end-page: 1099
  ident: bb1080
  article-title: Thematic Review Series: Intestinal Lipid Metabolism: New Developments and Current Insights Intestinal transport and metabolism of bile acids
  publication-title: J. Lipid Res.
– volume: 496
  start-page: 101
  year: 2013
  end-page: 105
  ident: bb0235
  article-title: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
  publication-title: Nature
– volume: 57
  start-page: 87
  year: 1988
  end-page: 90
  ident: bb0370
  article-title: Enzymic imbalance in serine metabolism in human-colon carcinoma and rat sarcoma
  publication-title: Br. J. Cancer
– volume: 27
  start-page: 57
  year: 2015
  end-page: 71
  ident: bb0145
  article-title: Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer Cell growth under metabolic stress
  publication-title: Cancer Cell
– volume: 16
  start-page: 708
  year: 2016
  end-page: 717
  ident: bb0155
  article-title: The metabolic fate of acetate in cancer
  publication-title: Nat. Rev. Cancer
– volume: 65
  start-page: 1973
  year: 2016
  end-page: 1980
  ident: bb0895
  article-title: Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
  publication-title: Gut
– volume: 13
  start-page: U278
  year: 2011
  end-page: U310
  ident: bb0320
  article-title: p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
  publication-title: Nat. Cell Biol.
– volume: 12
  start-page: 661
  year: 2014
  end-page: 672
  ident: bb0985
  article-title: The gut microbiota, bacterial metabolites and colorectal cancer
  publication-title: Nat. Rev. Microbiol.
– volume: 33
  start-page: 5039
  year: 2014
  end-page: 5046
  ident: bb0490
  article-title: p73 regulates serine biosynthesis in cancer
  publication-title: Oncogene
– volume: 22
  start-page: 1
  year: 2016
  end-page: 3
  ident: bb0720
  article-title: The Role of Prostaglandin E-2 in Tumor-Associated Immunosuppression
  publication-title: Trends Mol. Med.
– volume: 2
  start-page: 274
  year: 2014
  end-page: 285
  ident: bb1200
  article-title: Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment
  publication-title: Cancer Immunol. Res.
– volume: 21
  start-page: 297
  year: 2012
  end-page: 308
  ident: bb0010
  article-title: Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
  publication-title: Cancer Cell
– volume: 23
  start-page: 287
  year: 2013
  end-page: 301
  ident: bb1215
  article-title: PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress
  publication-title: Cancer Cell
– volume: 76
  start-page: 6458
  year: 2016
  end-page: 6462
  ident: bb0610
  article-title: Serine synthesis helps hypoxic cancer stem cells regulate redox
  publication-title: Cancer Res.
– volume: 61
  start-page: 880
  year: 2009
  end-page: 894
  ident: bb1140
  article-title: Mammalian Polyamine Metabolism and Function
  publication-title: IUBMB Life
– volume: 171
  start-page: 358
  year: 2017
  end-page: 371
  ident: bb0065
  article-title: Lactate metabolism in human lung tumors
  publication-title: Cell
– volume: 23
  start-page: 27
  year: 2016
  end-page: 47
  ident: bb0015
  article-title: The emerging hallmarks of cancer metabolism
  publication-title: Cell Metab.
– volume: 162
  start-page: 259
  year: 2015
  end-page: 270
  ident: bb0270
  article-title: The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1
  publication-title: Cell
– volume: 542
  start-page: 119
  year: 2017
  end-page: 123
  ident: bb0575
  article-title: Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
  publication-title: Nature
– volume: 21
  start-page: 6740
  year: 2002
  end-page: 6750
  ident: bb1100
  article-title: Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways
  publication-title: Oncogene
– volume: 60
  start-page: 672
  year: 2000
  end-page: 678
  ident: bb1110
  article-title: Functional interactions between bile acids, all-trans retinoic acid, and 1,25-dihydroxy-vitamin D-3 on monocytic differentiation and myeloblastin gene down-regulation in HL60 and THP-1 human leukemia cells
  publication-title: Cancer Res.
– volume: 149
  start-page: 22
  year: 2012
  end-page: 35
  ident: bb0510
  article-title: MYC on the Path to Cancer
  publication-title: Cell
– volume: 4
  start-page: 1406
  year: 2014
  end-page: 1417
  ident: bb0600
  article-title: Serine catabolism regulates mitochondrial redox control during hypoxia
  publication-title: Cancer Discov.
– volume: 15
  start-page: 111
  year: 2018
  end-page: 128
  ident: bb0995
  article-title: Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
– volume: 22
  start-page: 1428
  year: 2016
  end-page: 1438
  ident: bb1240
  article-title: Cardioprotection and lifespan extension by the natural polyamine spermidine
  publication-title: Nat. Med.
– volume: 69
  start-page: 1
  year: 2018
  end-page: 2
  ident: bb0255
  article-title: Glutamate Dehydrogenase to the Rescue
  publication-title: Mol. Cell
– volume: 19
  start-page: 1187
  year: 2012
  end-page: 1198
  ident: bb0465
  article-title: Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy
  publication-title: Chem. Biol.
– volume: 134
  start-page: 2791s
  year: 2004
  end-page: 2795s
  ident: bb0730
  article-title: Renal arginine metabolism
  publication-title: J. Nutr.
– volume: 185
  start-page: 3190
  year: 2010
  end-page: 3198
  ident: bb0815
  article-title: An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
  publication-title: J. Immunol.
– volume: 3
  start-page: 177
  year: 2006
  end-page: 185
  ident: bb0590
  article-title: HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
  publication-title: Cell Metab.
– volume: 5
  start-page: 99
  year: 2015
  end-page: 105
  ident: bb1120
  article-title: The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics
  publication-title: Acta Pharm. Sin. B
– volume: 8
  start-page: 1930
  year: 2014
  end-page: 1942
  ident: bb0200
  article-title: HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
  publication-title: Cell Rep.
– volume: 12
  start-page: 496
  year: 2012
  end-page: 508
  ident: bb0870
  article-title: Intestinal commensal microbes as immune modulators
  publication-title: Cell Host Microbe
– volume: 9
  start-page: 179
  year: 2002
  ident: 10.1016/j.bbcan.2018.06.005_bb0930
  article-title: Propionibacteria induce apoptosis of colorectal carcinoma cells via short-chain fatty acids acting on mitochondria
  publication-title: Cell Death Differ.
  doi: 10.1038/sj.cdd.4400935
– volume: 50
  start-page: 1509
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb1035
  article-title: Bile acids as regulatory molecules
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R900007-JLR200
– volume: 9
  start-page: 3884
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0515
  article-title: Glutaminolysis: Supplying carbon or nitrogen, or both for cancer cells?
  publication-title: Cell Cycle
  doi: 10.4161/cc.9.19.13302
– volume: 15
  start-page: 3329
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb1045
  article-title: Bile acids as endogenous etiologic agents in gastrointestinal cancer
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.15.3329
– volume: 324
  start-page: 1029
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb0005
  article-title: Understanding the Warburg effect: the metabolic requirements of cell proliferation
  publication-title: Science
  doi: 10.1126/science.1160809
– volume: 8
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0740
  article-title: Arginine Metabolism in Myeloid Cells Shapes Innate and Adaptive Immunity
  publication-title: Front. Immunol.
  doi: 10.3389/fimmu.2017.00093
– volume: 21
  start-page: 6740
  year: 2002
  ident: 10.1016/j.bbcan.2018.06.005_bb1100
  article-title: Bile acids stimulate invasion and haptotaxis in human colorectal cancer cells through activation of multiple oncogenic signaling pathways
  publication-title: Oncogene
  doi: 10.1038/sj.onc.1205729
– volume: 15
  start-page: 193
  year: 1946
  ident: 10.1016/j.bbcan.2018.06.005_bb0035
  article-title: Carbohydrate metabolism
  publication-title: Annu. Rev. Biochem.
  doi: 10.1146/annurev.bi.15.070146.001205
– volume: 496
  start-page: 101
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0235
  article-title: Glutamine supports pancreatic cancer growth through a KRAS-regulated metabolic pathway
  publication-title: Nature
  doi: 10.1038/nature12040
– volume: 342
  start-page: 971
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb1290
  article-title: The Intestinal Microbiota Modulates the Anticancer Immune Effects of Cyclophosphamide
  publication-title: Science
  doi: 10.1126/science.1240537
– volume: 8
  start-page: 1506
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0335
  article-title: Polo-like kinase 1 coordinates biosynthesis during cell cycle progression by directly activating pentose phosphate pathway
  publication-title: Nat. Commun.
  doi: 10.1038/s41467-017-01647-5
– volume: 18
  start-page: 896
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0480
  article-title: The histone H3 methyltransferase G9A epigenetically activates the serine-glycine synthesis pathway to sustain cancer cell survival and proliferation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.11.004
– volume: 25
  start-page: 345
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0840
  article-title: Serine Is an Essential Metabolite for Effector T Cell Expansion
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.12.011
– volume: 359
  start-page: 32
  year: 2018
  ident: 10.1016/j.bbcan.2018.06.005_bb1350
  article-title: Precision medicine using microbiota
  publication-title: Science
  doi: 10.1126/science.aar2946
– volume: 276
  start-page: 11420
  year: 2001
  ident: 10.1016/j.bbcan.2018.06.005_bb0125
  article-title: Acetyl-CoA synthetase 2, a mitochondrial matrix enzyme involved in the oxidation of acetate
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M008782200
– volume: 57
  start-page: 145
  year: 2003
  ident: 10.1016/j.bbcan.2018.06.005_bb0410
  article-title: The importance of glutathione in human disease
  publication-title: Biomed Pharmacother
  doi: 10.1016/S0753-3322(03)00043-X
– volume: 185
  start-page: 3190
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0815
  article-title: An Interaction between Kynurenine and the Aryl Hydrocarbon Receptor Can Generate Regulatory T Cells
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0903670
– volume: 16
  start-page: 690
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0705
  article-title: Regulation of T cell signalling by membrane lipids
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri.2016.103
– volume: 61
  start-page: 1495
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0215
  article-title: Ammonium metabolism in humans
  publication-title: Metabolism
  doi: 10.1016/j.metabol.2012.07.007
– volume: 126
  start-page: 228
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb1025
  article-title: Nuclear receptors as drug targets in cholestasis and drug-induced hepatotoxicity
  publication-title: Pharmacol. Ther.
  doi: 10.1016/j.pharmthera.2010.03.005
– volume: 75
  start-page: 544
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0265
  article-title: Human pancreatic cancer tumors are nutrient poor and tumor cells actively scavenge extracellular protein
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-2211
– volume: 24
  start-page: 104
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0845
  article-title: Mitochondrial biogenesis and proteome remodeling promote one-carbon metabolism for T cell activation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.06.007
– volume: 46
  start-page: 233
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0855
  article-title: A relay pathway between arginine and tryptophan metabolism confers immunosuppressive properties on dendritic cells
  publication-title: Immunity
  doi: 10.1016/j.immuni.2017.01.005
– volume: 67
  start-page: 8180
  year: 2007
  ident: 10.1016/j.bbcan.2018.06.005_bb0110
  article-title: Chemical inhibition of acetyl-CoA carboxylase induces growth arrest and cytotoxicity selectively in cancer cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-07-0389
– volume: 19
  start-page: 1187
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0465
  article-title: Small Molecule Activation of PKM2 in Cancer Cells Induces Serine Auxotrophy
  publication-title: Chem. Biol.
  doi: 10.1016/j.chembiol.2012.07.021
– volume: 9
  start-page: 949
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0505
  article-title: The role of supercoiling in transcriptional control of MYC and its importance in molecular therapeutics
  publication-title: Nat. Rev. Cancer
– volume: 110
  start-page: 19402
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0670
  article-title: Emergence of spatial structure in the tumor microenvironment due to the Warburg effect
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1311939110
– volume: 81
  start-page: 687
  year: 1995
  ident: 10.1016/j.bbcan.2018.06.005_bb1020
  article-title: Identification of a Nuclear Receptor That Is Activated by Farnesol Metabolites
  publication-title: Cell
  doi: 10.1016/0092-8674(95)90530-8
– volume: 113
  start-page: 1778
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0440
  article-title: Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1521548113
– volume: 14
  start-page: 285
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0435
  article-title: Serine metabolism: some tumors take the road less traveled
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2011.08.004
– volume: 19
  start-page: 901
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0545
  article-title: BCAT1 promotes cell proliferation through amino acid catabolism in gliomas carrying wild-type IDH1
  publication-title: Nat. Med.
  doi: 10.1038/nm.3217
– volume: 27
  start-page: 69
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0300
  article-title: Fueling the Cell Division Cycle
  publication-title: Trends Cell Biol.
  doi: 10.1016/j.tcb.2016.08.009
– volume: 4
  start-page: 1371
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0620
  article-title: Mitochondrial one-carbon metabolism maintains redox balance during hypoxia
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-14-1228
– volume: 7
  start-page: 2347
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0980
  article-title: Mediterranean diet and faecal microbiota: a transversal study
  publication-title: Food Funct.
  doi: 10.1039/C6FO00105J
– volume: 17
  start-page: 662
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0970
  article-title: Crosstalk between microbiota-derived short-chain fatty acids and intestinal epithelial hif augments tissue barrier function
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2015.03.005
– volume: 56
  start-page: 1085
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1080
  article-title: Thematic Review Series: Intestinal Lipid Metabolism: New Developments and Current Insights Intestinal transport and metabolism of bile acids
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R054114
– volume: 134
  start-page: 2837s
  year: 2004
  ident: 10.1016/j.bbcan.2018.06.005_bb0745
  article-title: Arginine and cancer
  publication-title: J. Nutr.
  doi: 10.1093/jn/134.10.2837S
– volume: 24
  start-page: 55
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0450
  article-title: Rational Design of Selective Allosteric Inhibitors of PHGDH and Serine Synthesis with Anti-tumor Activity
  publication-title: Cell Chem. Biol.
  doi: 10.1016/j.chembiol.2016.11.013
– volume: 25
  start-page: 262
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0160
  article-title: Multi-dimensional roles of ketone bodies in fuel metabolism, signaling, and therapeutics
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.12.022
– volume: 153
  start-page: 840
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0240
  article-title: The mTORC1 pathway stimulates glutamine metabolism and cell proliferation by repressing SIRT4
  publication-title: Cell
  doi: 10.1016/j.cell.2013.04.023
– volume: 94
  start-page: 6658
  year: 1997
  ident: 10.1016/j.bbcan.2018.06.005_bb0045
  article-title: c-Myc transactivation of LDH-A: implications for tumor metabolism and growth
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.94.13.6658
– volume: 43
  start-page: 869
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0425
  article-title: Phosphoglycerate dehydrogenase diverts glycolytic flux and contributes to oncogenesis
  publication-title: Nat. Genet.
  doi: 10.1038/ng.890
– volume: 35
  start-page: 871
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0825
  article-title: The transcription factor myc controls metabolic reprogramming upon T lymphocyte activation
  publication-title: Immunity
  doi: 10.1016/j.immuni.2011.09.021
– volume: 17
  start-page: 1519
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0945
  article-title: Potential beneficial effects of butyrate in intestinal and extraintestinal diseases
  publication-title: World J. Gastroenterol.
  doi: 10.3748/wjg.v17.i12.1519
– volume: 10
  start-page: 301
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0500
  article-title: MYC as a regulator of ribosome biogenesis and protein synthesis
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc2819
– volume: 67
  start-page: 100
  year: 1999
  ident: 10.1016/j.bbcan.2018.06.005_bb0395
  article-title: Glutamine, as a precursor of glutathione, and oxidative stress
  publication-title: Mol. Genet. Metab.
  doi: 10.1006/mgme.1999.2857
– volume: 23
  start-page: 27
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0015
  article-title: The emerging hallmarks of cancer metabolism
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.12.006
– volume: 71
  start-page: 6921
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0085
  article-title: Lactate: A Metabolic Key Player in Cancer
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-11-1457
– volume: 359
  start-page: 91
  year: 2018
  ident: 10.1016/j.bbcan.2018.06.005_bb1335
  article-title: Gut microbiome influences efficacy of PD-1-based immunotherapy against epithelial tumors
  publication-title: Science
  doi: 10.1126/science.aan3706
– volume: 153
  start-page: 1239
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0645
  article-title: Posttranscriptional control of T Cell effector function by aerobic glycolysis
  publication-title: Cell
  doi: 10.1016/j.cell.2013.05.016
– volume: 546
  start-page: 426
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0330
  article-title: The metabolic function of cyclin D3-CDK6 kinase in cancer cell survival
  publication-title: Nature
  doi: 10.1038/nature22797
– volume: 46
  start-page: 1589
  year: 1967
  ident: 10.1016/j.bbcan.2018.06.005_bb0180
  article-title: Brain Metabolism during Fasting
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI105650
– volume: 215
  start-page: 227
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb0195
  article-title: Liver-specific silencing of the human gene encoding succinyl-CoA : 3-ketoacid CoA transferase
  publication-title: Tohoku J. Exp. Med.
  doi: 10.1620/tjem.215.227
– volume: 476
  start-page: 346
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0420
  article-title: Functional genomics reveal that the serine synthesis pathway is essential in breast cancer
  publication-title: Nature
  doi: 10.1038/nature10350
– volume: 15
  start-page: 110
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0835
  article-title: Glucose-independent glutamine metabolism via TCA cycling for proliferation and survival in B cells
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2011.12.009
– volume: 5
  start-page: 2035
  year: 1999
  ident: 10.1016/j.bbcan.2018.06.005_bb1170
  article-title: Prognostic value of ornithine decarboxylase and polyamines in human breast cancer: Correlation with clinicopathologic parameters
  publication-title: Clin. Cancer Res.
– volume: 18
  start-page: 743
  year: 2004
  ident: 10.1016/j.bbcan.2018.06.005_bb0285
  article-title: Neuronal apoptotic bodies: phagocytosis and degradation by primary microglial cells
  publication-title: FASEB J.
  doi: 10.1096/fj.03-0374fje
– volume: 17
  start-page: 351
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0625
  article-title: Metabolic pathways promoting cancer cell survival and growth
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb3124
– volume: 47
  start-page: 241
  year: 2006
  ident: 10.1016/j.bbcan.2018.06.005_bb1015
  article-title: Bile salt biotransformations by human intestinal bacteria
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R500013-JLR200
– volume: 315
  start-page: 1600
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb1285
  article-title: Association of pembrolizumab with tumor response and survival among patients with advanced melanoma
  publication-title: Jama-J. Am. Med. Assoc.
  doi: 10.1001/jama.2016.4059
– volume: 269
  start-page: 23757
  year: 1994
  ident: 10.1016/j.bbcan.2018.06.005_bb0595
  article-title: Transcriptional Regulation of Genes Encoding Glycolytic-Enzymes by Hypoxia-Inducible Factor-1
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(17)31580-6
– volume: 43
  start-page: 435
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0860
  article-title: Metabolic reprogramming of immune cells in cancer progression
  publication-title: Immunity
  doi: 10.1016/j.immuni.2015.09.001
– volume: 359
  start-page: 104
  year: 2018
  ident: 10.1016/j.bbcan.2018.06.005_bb1345
  article-title: The commensal microbiome is associated with anti-PD-1 efficacy in metastatic melanoma patients
  publication-title: Science
  doi: 10.1126/science.aao3290
– volume: 107
  start-page: 1337
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0990
  article-title: Gut microbiota-derived propionate reduces cancer cell proliferation in the liver
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.2012.409
– volume: 57
  start-page: 2401
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0935
  article-title: Butyrate production from high-fiber diet protects against lymphoma tumor
  publication-title: Leuk. Lymphoma
  doi: 10.3109/10428194.2016.1144879
– volume: 47
  start-page: 1475
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0495
  article-title: NRF2 regulates serine biosynthesis in non-small cell lung cancer
  publication-title: Nat. Genet.
  doi: 10.1038/ng.3421
– volume: 22
  start-page: 1389
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb1245
  article-title: Spermidine to the rescue for an aging heart
  publication-title: Nat. Med.
  doi: 10.1038/nm.4243
– volume: 4
  start-page: 1406
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0600
  article-title: Serine catabolism regulates mitochondrial redox control during hypoxia
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-14-0250
– volume: 93
  start-page: 693
  year: 1987
  ident: 10.1016/j.bbcan.2018.06.005_bb1085
  article-title: Simulation of the Metabolism and Enterohepatic Circulation of Endogenous Deoxycholic-Acid in Humans Using a Physiological Pharmacokinetic Model for Bile-Acid Metabolism
  publication-title: Gastroenterology
  doi: 10.1016/0016-5085(87)90430-6
– volume: 3
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb1205
  article-title: Polyamine blockade promotes antitumor immunity
  publication-title: Oncoimmunology
  doi: 10.4161/onci.27360
– volume: 5
  start-page: 945
  year: 1999
  ident: 10.1016/j.bbcan.2018.06.005_bb1195
  article-title: Development of difluoromethylornithine (DFMO) as a chemoprevention agent
  publication-title: Clin. Cancer Res.
– volume: 376
  start-page: 1
  year: 2003
  ident: 10.1016/j.bbcan.2018.06.005_bb1145
  article-title: A perspective of polyamine metabolism
  publication-title: Biochem. J.
  doi: 10.1042/bj20031327
– volume: 15
  start-page: 474
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0950
  article-title: Butyrate: implications for intestinal function
  publication-title: Curr. Opin. Clin. Nutr. Metab. Care
  doi: 10.1097/MCO.0b013e32835665fa
– volume: 8
  start-page: 685
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb1030
  article-title: Vitamin effects on the immune system: vitamins A and D take centre stage
  publication-title: Nat. Rev. Immunol.
  doi: 10.1038/nri2378
– volume: 4
  start-page: 4548
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb1255
  article-title: Upregulation of colonic luminal polyamines produced by intestinal microbiota delays senescence in mice
  publication-title: Sci. Rep.
  doi: 10.1038/srep04548
– volume: 359
  start-page: 97
  year: 2018
  ident: 10.1016/j.bbcan.2018.06.005_bb1340
  article-title: Gut microbiome modulates response to anti-PD-1 immunotherapy in melanoma patients
  publication-title: Science
  doi: 10.1126/science.aan4236
– volume: 5
  start-page: 99
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1120
  article-title: The human gut sterolbiome: bile acid-microbiome endocrine aspects and therapeutics
  publication-title: Acta Pharm. Sin. B
  doi: 10.1016/j.apsb.2015.01.006
– volume: 283
  start-page: 25846
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb0350
  article-title: Cytoplasmic serine hydroxymethyltransferase regulates the metabolic partitioning of methylenetetrahydrofolate but is not essential in mice
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M802671200
– volume: 162
  start-page: 1257
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0710
  article-title: Cyclooxygenase-Dependent Tumor Growth through Evasion of Immunity
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.015
– volume: 56
  start-page: 66
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb1135
  article-title: Bile acids and colon cancer: is FXR the solution of the conundrum?
  publication-title: Mol. Asp. Med.
  doi: 10.1016/j.mam.2017.04.002
– volume: 8
  start-page: 311
  year: 2005
  ident: 10.1016/j.bbcan.2018.06.005_bb0115
  article-title: ATP citrate lyase inhibition can suppress tumor cell growth
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2005.09.008
– volume: 7
  start-page: 678
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb1005
  article-title: Targeting bile-acid signalling for metabolic diseases
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd2619
– volume: 271
  start-page: 32529
  year: 1996
  ident: 10.1016/j.bbcan.2018.06.005_bb0055
  article-title: Hypoxia response elements in the aldolase A, enolase 1, and lactate dehydrogenase A gene promoters contain essential binding sites for hypoxia-inducible factor 1
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.271.51.32529
– volume: 22
  start-page: 1
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0720
  article-title: The Role of Prostaglandin E-2 in Tumor-Associated Immunosuppression
  publication-title: Trends Mol. Med.
  doi: 10.1016/j.molmed.2015.11.003
– volume: 22
  start-page: 2465
  year: 2002
  ident: 10.1016/j.bbcan.2018.06.005_bb1160
  article-title: Prognostic value of tissue polyamine levels in human colorectal carcinoma
  publication-title: Anticancer Res.
– volume: 251
  start-page: 319
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb1260
  article-title: Spermidine reduces lipid accumulation and necrotic core formation in atherosclerotic plaques via induction of autophagy
  publication-title: Atherosclerosis
  doi: 10.1016/j.atherosclerosis.2016.07.899
– volume: 22
  start-page: 1428
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb1240
  article-title: Cardioprotection and lifespan extension by the natural polyamine spermidine
  publication-title: Nat. Med.
  doi: 10.1038/nm.4222
– volume: 152
  start-page: S906
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb1355
  article-title: Fecal Microbiota Transplant Using a Precision Medicine Approach Is Safe, Associated with Lower Hospitalization Risk and Improved Cognitive Function in Recurrent Hepatic Encephalopathy
  publication-title: Gastroenterology
– volume: 12
  start-page: 452
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0445
  article-title: A PHGDH inhibitor reveals coordination of serine synthesis and one-carbon unit fate
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.2070
– volume: 19
  start-page: 443
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0975
  article-title: Depletion of Butyrate-Producing Clostridia from the Gut Microbiota Drives an Aerobic Luminal Expansion of Salmonella
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2016.03.004
– volume: 159
  start-page: 1591
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0140
  article-title: Acetate dependence of tumors
  publication-title: Cell
  doi: 10.1016/j.cell.2014.11.020
– start-page: 34
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0785
  article-title: Targeting TDO in cancer immunotherapy
  publication-title: Med. Oncol.
– volume: 4
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb0355
  article-title: SHMT1 and SHMT2 are functionally redundant in nuclear de novo thymidylate biosynthesis
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0005839
– volume: 25
  start-page: 724
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0310
  article-title: Metabolic regulation of the cell cycle
  publication-title: Curr. Opin. Cell Biol.
  doi: 10.1016/j.ceb.2013.07.002
– volume: 275
  start-page: 26458
  year: 2000
  ident: 10.1016/j.bbcan.2018.06.005_bb0135
  article-title: Molecular characterization of human acetyl-CoA synthetase, an enzyme regulated by sterol regulatory element-binding proteins
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M004160200
– volume: 371
  start-page: 653
  year: 2003
  ident: 10.1016/j.bbcan.2018.06.005_bb0365
  article-title: L-serine in disease and development
  publication-title: Biochem. J.
  doi: 10.1042/bj20021785
– volume: 287
  start-page: 7051
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0415
  article-title: Serine hydroxymethyltransferase anchors de novo thymidylate synthesis pathway to nuclear lamina for DNA synthesis
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M111.333120
– volume: 99
  start-page: 256
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0360
  article-title: L-serine synthesis in the central nervous system: a review on serine deficiency disorders
  publication-title: Mol. Genet. Metab.
  doi: 10.1016/j.ymgme.2009.10.012
– volume: 499
  start-page: 97
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb1060
  article-title: Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
  publication-title: Nature
  doi: 10.1038/nature12347
– volume: 6
  year: 2018
  ident: 10.1016/j.bbcan.2018.06.005_bb1220
  article-title: A novel polyamine-targeted therapy for BRAF mutant melanoma tumors
  publication-title: Med. Sci.
– volume: 94
  start-page: 102
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0090
  article-title: Glycolytic metabolism and tumour response to fractionated irradiation
  publication-title: Radiother. Oncol.
  doi: 10.1016/j.radonc.2009.11.007
– volume: 350
  start-page: 1079
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1320
  article-title: Anticancer immunotherapy by CTLA-4 blockade relies on the gut microbiota
  publication-title: Science
  doi: 10.1126/science.aad1329
– volume: 8
  start-page: e2738
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb1265
  article-title: Induction of autophagy by spermidine is neuroprotective via inhibition of caspase 3-mediated Beclin 1 cleavage
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2017.161
– volume: 27
  start-page: 257
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0245
  article-title: Glutamate dehydrogenase 1 signals through antioxidant glutathione peroxidase 1 to regulate redox homeostasis and tumor growth
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2014.12.006
– volume: 20
  start-page: 126
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb1305
  article-title: Chemotherapy, immunity and microbiota--a new triumvirate?
  publication-title: Nat. Med.
  doi: 10.1038/nm.3473
– volume: 123
  start-page: 309
  year: 1956
  ident: 10.1016/j.bbcan.2018.06.005_bb0025
  article-title: Origin of cancer cells
  publication-title: Science
  doi: 10.1126/science.123.3191.309
– volume: 37
  start-page: 214
  year: 1977
  ident: 10.1016/j.bbcan.2018.06.005_bb1190
  article-title: Polyamines as Markers of Response and Disease Activity in Cancer Chemotherapy
  publication-title: Cancer Res.
– ident: 10.1016/j.bbcan.2018.06.005_bb1180
  doi: 10.3109/10408368209085073
– volume: 7
  start-page: 154
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0120
  article-title: ATP citrate lyase inhibitors as novel cancer therapeutic agents
  publication-title: Rec. Pat Anti-Can.
– volume: 23
  start-page: 362
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0635
  article-title: Metabolic reprogramming in cancer: Unraveling the role of glutamine in tumorigenesis
  publication-title: Semin. Cell Dev. Biol.
  doi: 10.1016/j.semcdb.2012.02.002
– volume: 165
  start-page: 1332
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0910
  article-title: From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites
  publication-title: Cell
  doi: 10.1016/j.cell.2016.05.041
– volume: 31
  start-page: 1305
  year: 2000
  ident: 10.1016/j.bbcan.2018.06.005_bb1000
  article-title: Bile acid synthesis in cultured human hepatocytes: support for an alternative biosynthetic pathway to cholic acid
  publication-title: Hepatology
  doi: 10.1053/jhep.2000.7877
– volume: 7
  start-page: 11
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb0640
  article-title: The biology of cancer: metabolic reprogramming fuels cell growth and proliferation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2007.10.002
– volume: 105
  start-page: 1217
  year: 2000
  ident: 10.1016/j.bbcan.2018.06.005_bb0735
  article-title: Arginine, citrulline, and nitric oxide metabolism in. end-stage renal disease patients
  publication-title: J. Clin. Invest.
  doi: 10.1172/JCI7199
– volume: 358
  start-page: 862
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0250
  article-title: Feeding frenzy for cancer cells Cancer cells rewire metabolism to scavenge nutrients and waste products
  publication-title: Science
  doi: 10.1126/science.aaq1070
– volume: 26
  start-page: 1077
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0170
  article-title: Aberrant ketolysis fuels hepatocellular cancer progression
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.110
– volume: 76
  start-page: 6458
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0610
  article-title: Serine synthesis helps hypoxic cancer stem cells regulate redox
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-16-1730
– volume: 42
  start-page: 498
  year: 1997
  ident: 10.1016/j.bbcan.2018.06.005_bb0190
  article-title: Enzymes of ketone body utilization in human tissues: Protein and messenger RNA levels of succinyl-coenzyme A (CoA):3-ketoacid CoA transferase and mitochondrial and cytosolic acetoacetyl-CoA thiolases
  publication-title: Pediatr. Res.
  doi: 10.1203/00006450-199710000-00013
– volume: 159
  start-page: 1603
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0150
  article-title: Acetate is a bioenergetic substrate for human glioblastoma and brain metastases
  publication-title: Cell
  doi: 10.1016/j.cell.2014.11.025
– volume: 7
  start-page: 678
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb1040
  article-title: Targeting bile-acid signalling for metabolic diseases
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd2619
– volume: 16
  start-page: 619
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0210
  article-title: From Krebs to clinic: glutamine metabolism to cancer therapy
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.71
– volume: 24
  start-page: 1112
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0430
  article-title: PHGDH amplification and altered glucose metabolism in human melanoma
  publication-title: Pig. Cell Melan. Res.
  doi: 10.1111/j.1755-148X.2011.00919.x
– volume: 61
  start-page: 582
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0885
  article-title: Variations of oral microbiota are associated with pancreatic diseases including pancreatic cancer
  publication-title: Gut
  doi: 10.1136/gutjnl-2011-300784
– volume: 185
  start-page: 1037
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0830
  article-title: Glutamine uptake and metabolism are coordinately Regulated by ERK/MAPK during T lymphocyte activation
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0903586
– volume: 336
  start-page: 1040
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0345
  article-title: Metabolite profiling identifies a key role for glycine in rapid cancer cell proliferation
  publication-title: Science
  doi: 10.1126/science.1218595
– volume: 531
  start-page: 651
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0695
  article-title: Potentiating the antitumour response of CD8(+) T cells by modulating cholesterol metabolism
  publication-title: Nature
  doi: 10.1038/nature17412
– volume: 1791
  start-page: 1103
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb0130
  article-title: Control of free arachidonic acid levels by phospholipases A(2) and lysophospholipid acyltransferases
  publication-title: Bba-Mol. Cell Biol. L
  doi: 10.1016/j.bbalip.2009.08.007
– volume: 16
  start-page: 708
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0155
  article-title: The metabolic fate of acetate in cancer
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc.2016.87
– volume: 17
  start-page: 159
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0475
  article-title: The Hunger games: p53 regulates metabolism upon serine starvation
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2013.01.012
– volume: 350
  start-page: 1084
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1315
  article-title: Commensal Bifidobacterium promotes antitumor immunity and facilitates anti-PD-L1 efficacy
  publication-title: Science
  doi: 10.1126/science.aac4255
– volume: 102
  start-page: 1197
  year: 2007
  ident: 10.1016/j.bbcan.2018.06.005_bb0920
  article-title: Understanding the effects of diet on bacterial metabolism in the large intestine
  publication-title: J. Appl. Microbiol.
  doi: 10.1111/j.1365-2672.2007.03322.x
– volume: 39
  start-page: 221
  year: 2004
  ident: 10.1016/j.bbcan.2018.06.005_bb1155
  article-title: The chemopreventive agent alpha-difluoromethylornithine blocks Ki-ras-dependent tumor formation and specific gene expression in Caco-2 cells
  publication-title: Mol. Carcinog.
  doi: 10.1002/mc.20008
– volume: 164
  start-page: 681
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0075
  article-title: Metabolic heterogeneity in human lung tumors
  publication-title: Cell
  doi: 10.1016/j.cell.2015.12.034
– volume: 27
  start-page: 5904
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb0585
  article-title: The tumor microenvironment and its role in promoting tumor growth
  publication-title: Oncogene
  doi: 10.1038/onc.2008.271
– volume: 3
  year: 2007
  ident: 10.1016/j.bbcan.2018.06.005_bb0900
  article-title: A top-down systems biology view of microbiome-mammalian metabolic interactions in a mouse model
  publication-title: Mol. Syst. Biol.
  doi: 10.1038/msb4100153
– volume: 480
  start-page: 359
  year: 2001
  ident: 10.1016/j.bbcan.2018.06.005_bb1095
  article-title: The role of bile acids in carcinogenesis
  publication-title: Mutat. Res-Fund Mol. M.
  doi: 10.1016/S0027-5107(01)00195-6
– volume: 11
  start-page: 1305
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb1235
  article-title: Induction of autophagy by spermidine promotes longevity
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb1975
– volume: 12
  start-page: 661
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0985
  article-title: The gut microbiota, bacterial metabolites and colorectal cancer
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro3344
– volume: 171
  start-page: 358
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0065
  article-title: Lactate metabolism in human lung tumors
  publication-title: Cell
  doi: 10.1016/j.cell.2017.09.019
– volume: 19
  start-page: 1
  year: 1999
  ident: 10.1016/j.bbcan.2018.06.005_bb0050
  article-title: c-Myc target genes involved in cell growth, apoptosis, and metabolism
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.19.1.1
– volume: 15
  start-page: 991
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0325
  article-title: TAp73 enhances the pentose phosphate pathway and supports cell proliferation
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2789
– volume: 108
  start-page: 1128
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0680
  article-title: M2-like macrophage polarization in high lactic acid-producing head and neck cancer
  publication-title: Cancer Sci.
  doi: 10.1111/cas.13244
– volume: 21
  start-page: 64
  year: 2018
  ident: 10.1016/j.bbcan.2018.06.005_bb0535
  article-title: Branched-chain amino acid metabolism in cancer
  publication-title: Curr. Opin. Clin. Nutr. Metab. Care
  doi: 10.1097/MCO.0000000000000430
– volume: 28
  start-page: 59
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0295
  article-title: Driving the Cell Cycle Through Metabolism
  publication-title: Ann. Rev. Cell Dev. B
  doi: 10.1146/annurev-cellbio-092910-154010
– volume: 145
  start-page: 627
  year: 1940
  ident: 10.1016/j.bbcan.2018.06.005_bb1050
  article-title: Production of tumours in mice by deoxycholic acid
  publication-title: Nature
  doi: 10.1038/145627a0
– volume: 27
  start-page: 57
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0145
  article-title: Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer Cell growth under metabolic stress
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2014.12.002
– volume: 134
  start-page: 2791s
  year: 2004
  ident: 10.1016/j.bbcan.2018.06.005_bb0730
  article-title: Renal arginine metabolism
  publication-title: J. Nutr.
  doi: 10.1093/jn/134.10.2791S
– volume: 23
  start-page: 302
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb1210
  article-title: Oncogenic BRAF regulates oxidative metabolism via PGC1alpha and MITF
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2013.02.003
– volume: 64
  start-page: 5839
  year: 2004
  ident: 10.1016/j.bbcan.2018.06.005_bb0760
  article-title: Arginase I production in the tumor microenvironment by mature myeloid cells inhibits T-cell receptor expression and antigen-specific T-cell responses
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-04-0465
– volume: 14
  start-page: 18
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1125
  article-title: Bile acid signaling through farnesoid X and TGR5 receptors in hepatobiliary and intestinal diseases
  publication-title: Hepatob. Pancreat Dis.
  doi: 10.1016/S1499-3872(14)60307-6
– volume: 20
  start-page: S111
  year: 1995
  ident: 10.1016/j.bbcan.2018.06.005_bb0030
  article-title: Pasteur - the anaerobic life and the anaerobes
  publication-title: Clin. Infect. Dis.
  doi: 10.1093/clinids/20.Supplement_2.S111
– volume: 308
  start-page: G351
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0955
  article-title: The gastrointestinal microbiota and colorectal cancer
  publication-title: Am. J. Physiol. Gastrointest. Liver Physiol.
  doi: 10.1152/ajpgi.00360.2012
– volume: 4
  start-page: 781
  year: 2004
  ident: 10.1016/j.bbcan.2018.06.005_bb1185
  article-title: Polyamines and cancer: old molecules, new understanding
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc1454
– volume: 32
  start-page: 377
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0725
  article-title: Enhancing CD8(+) T Cell Fatty Acid Catabolism within a Metabolically Challenging Tumor Microenvironment Increases the Efficacy of Melanoma Immunotherapy
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2017.08.004
– volume: 45
  start-page: 931
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb1300
  article-title: Enterococcus hirae and Barnesiella intestinihominis Facilitate Cyclophosphamide-Induced Therapeutic Immunomodulatory Effects
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.09.009
– volume: 77
  start-page: 6321
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0615
  article-title: PHGDH as a Key Enzyme for Serine Biosynthesis in HIF2 alpha-Targeting Therapy for Renal Cell Carcinoma
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-17-1589
– volume: 26
  start-page: 121
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0630
  article-title: Metabolic reprogramming of stromal fibroblasts through p62-mTORC1 signaling promotes Inflammation and tumorigenesis
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2014.05.004
– volume: 39
  start-page: 453
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0080
  article-title: Lactate enhances motility of tumor cells and inhibits monocyte migration and cytokine release
  publication-title: Int. J. Oncol.
– volume: 114
  start-page: E8628
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0275
  article-title: Critical role for PI3-kinase in regulating the use of proteins as an amino acid source
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1712726114
– volume: 4
  start-page: 1387
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0960
  article-title: A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner
  publication-title: Cancer Discov.
  doi: 10.1158/2159-8290.CD-14-0501
– volume: 183
  start-page: 6251
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb1130
  article-title: The bile acid receptor FXR is a modulator of intestinal innate immunity
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.0803978
– volume: 4
  start-page: e877
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0380
  article-title: Contribution of serine, folate and glycine metabolism to the ATP, NADPH and purine requirements of cancer cells
  publication-title: Cell Death Dis.
  doi: 10.1038/cddis.2013.393
– volume: 324
  start-page: 1076
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb0105
  article-title: ATP-citrate lyase links cellular metabolism to histone acetylation
  publication-title: Science
  doi: 10.1126/science.1164097
– volume: 23
  start-page: 287
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb1215
  article-title: PGC1alpha expression defines a subset of human melanoma tumors with increased mitochondrial capacity and resistance to oxidative stress
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.11.020
– volume: 111-112
  start-page: 1
  year: 1998
  ident: 10.1016/j.bbcan.2018.06.005_bb0405
  article-title: Glutathione: an overview of biosynthesis and modulation
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/S0009-2797(97)00146-4
– volume: 75
  start-page: 275
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0770
  article-title: L-arginine depletion blunts antitumor T-cell responses by inducing myeloid-derived suppressor cells
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-14-1491
– volume: 350
  start-page: 1031
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1325
  article-title: Could microbial therapy boost cancer immunotherapy?
  publication-title: Science
  doi: 10.1126/science.aad7706
– volume: 304
  start-page: H1060
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0175
  article-title: Ketone body metabolism and cardiovascular disease
  publication-title: Am. J. Physiol-Heart C
  doi: 10.1152/ajpheart.00646.2012
– volume: 23
  start-page: 867
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0230
  article-title: Differential glutamate metabolism in proliferating and quiescent mammary epithelial cells
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.03.016
– volume: 531
  start-page: 583
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0700
  article-title: Cancer immunotherapy: Killers on sterols
  publication-title: Nature
  doi: 10.1038/nature17310
– volume: 26
  start-page: 1112
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0205
  article-title: Hepatocellular carcinoma redirects to ketolysis for progression under nutrition deprivation stress
  publication-title: Cell Res.
  doi: 10.1038/cr.2016.109
– volume: 137
  start-page: 1681S
  year: 2007
  ident: 10.1016/j.bbcan.2018.06.005_bb0750
  article-title: Arginine and immunity
  publication-title: J. Nutr.
  doi: 10.1093/jn/137.6.1681S
– volume: 41
  start-page: 1016
  year: 1992
  ident: 10.1016/j.bbcan.2018.06.005_bb0820
  article-title: Glutamine and Macrophage Function
  publication-title: Metabolism
  doi: 10.1016/0026-0495(92)90130-3
– volume: 10
  start-page: 442
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb1055
  article-title: Obesity-induced microbial metabolite promotes HCC
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2013.121
– volume: 101
  start-page: 151
  year: 2002
  ident: 10.1016/j.bbcan.2018.06.005_bb0800
  article-title: Indoleamine 2,3-dioxygenase contributes to tumor cell evasion of T cell-mediated rejection
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.10645
– volume: 77
  start-page: 3131
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0570
  article-title: Nature and nurture: what determines tumor metabolic phenotypes?
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-17-0165
– volume: 109
  start-page: 3812
  year: 2007
  ident: 10.1016/j.bbcan.2018.06.005_bb0665
  article-title: Inhibitory effect of tumor cell-derived lactic acid on human T cells
  publication-title: Blood
  doi: 10.1182/blood-2006-07-035972
– volume: 16
  start-page: 143
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0965
  article-title: Microbial-derived butyrate: an oncometabolite or tumor-suppressive metabolite?
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2014.07.011
– volume: 33
  start-page: 5039
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0490
  article-title: p73 regulates serine biosynthesis in cancer
  publication-title: Oncogene
  doi: 10.1038/onc.2013.456
– volume: 169
  start-page: 570
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0865
  article-title: Metabolic instruction of immunity
  publication-title: Cell
  doi: 10.1016/j.cell.2017.04.004
– volume: 545
  start-page: 500
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0580
  article-title: Cancer progression by reprogrammed BCAA metabolism in myeloid leukaemia
  publication-title: Nature
  doi: 10.1038/nature22314
– volume: 69
  start-page: 1
  year: 2018
  ident: 10.1016/j.bbcan.2018.06.005_bb0255
  article-title: Glutamate Dehydrogenase to the Rescue
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2017.12.015
– volume: 48
  start-page: 749
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0400
  article-title: Reactive oxygen species, cellular redox systems, and apoptosis
  publication-title: Free Radic. Biol. Med.
  doi: 10.1016/j.freeradbiomed.2009.12.022
– volume: 85
  start-page: 863
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb1070
  article-title: Carcinogenicity of deoxycholate, a secondary bile acid
  publication-title: Arch. Toxicol.
  doi: 10.1007/s00204-011-0648-7
– volume: 107
  start-page: 452
  year: 2002
  ident: 10.1016/j.bbcan.2018.06.005_bb0795
  article-title: Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division
  publication-title: Immunology
  doi: 10.1046/j.1365-2567.2002.01526.x
– volume: 12
  start-page: 622
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0715
  article-title: Immunotherapy: Evading immune escape: synergy of COX and immune-checkpoint inhibitors
  publication-title: Nat. Rev. Clin. Oncol.
– volume: 39
  start-page: 191
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0390
  article-title: Serine and glycine metabolism in cancer
  publication-title: Trends Biochem. Sci.
  doi: 10.1016/j.tibs.2014.02.004
– volume: 109
  start-page: 2497
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0790
  article-title: Reversal of tumoral immune resistance by inhibition of tryptophan 2,3-dioxygenase
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1113873109
– volume: 105
  start-page: 16767
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb0925
  article-title: Effects of the gut microbiota on host adiposity are modulated by the short-chain fatty-acid binding G protein-coupled receptor, Gpr41
  publication-title: Proc. Nat. Acad. Sci. USA
  doi: 10.1073/pnas.0808567105
– volume: 3
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb0525
  article-title: Global Regulation of Nucleotide Biosynthetic Genes by c-Myc
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0002722
– volume: 107
  start-page: 2013
  year: 2006
  ident: 10.1016/j.bbcan.2018.06.005_bb0660
  article-title: Tumor-derived lactic acid modulates dendritic cell activation and antigen expression
  publication-title: Blood
  doi: 10.1182/blood-2005-05-1795
– volume: 2
  start-page: 274
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb1200
  article-title: Polyamine-Blocking Therapy Reverses Immunosuppression in the Tumor Microenvironment
  publication-title: Cancer Immunol. Res.
  doi: 10.1158/2326-6066.CIR-13-0120-T
– volume: 57
  start-page: 87
  year: 1988
  ident: 10.1016/j.bbcan.2018.06.005_bb0370
  article-title: Enzymic imbalance in serine metabolism in human-colon carcinoma and rat sarcoma
  publication-title: Br. J. Cancer
  doi: 10.1038/bjc.1988.15
– volume: 21
  start-page: 297
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0010
  article-title: Metabolic reprogramming: a cancer hallmark even warburg did not anticipate
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2012.02.014
– volume: 497
  start-page: 633
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0260
  article-title: Macropinocytosis of protein is an amino acid supply route in Ras-transformed cells
  publication-title: Nature
  doi: 10.1038/nature12138
– volume: 20
  start-page: 1193
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0550
  article-title: Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development
  publication-title: Nat. Med.
  doi: 10.1038/nm.3686
– volume: 13
  start-page: U278
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0320
  article-title: p53 regulates biosynthesis through direct inactivation of glucose-6-phosphate dehydrogenase
  publication-title: Nat. Cell Biol.
  doi: 10.1038/ncb2172
– volume: 510
  start-page: 547
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0315
  article-title: Cyclin D1-Cdk4 controls glucose metabolism independently of cell cycle progression
  publication-title: Nature
  doi: 10.1038/nature13267
– volume: 152
  start-page: 599
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0485
  article-title: Control of nutrient stress-induced metabolic reprogramming by PKCzeta in tumorigenesis
  publication-title: Cell
  doi: 10.1016/j.cell.2012.12.028
– volume: 358
  start-page: 941
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0225
  article-title: Metabolic recycling of ammonia via glutamate dehydrogenase supports breast cancer biomass
  publication-title: Science
  doi: 10.1126/science.aam9305
– volume: 18
  start-page: 283
  year: 2005
  ident: 10.1016/j.bbcan.2018.06.005_bb0305
  article-title: AMP-activated protein kinase induces a p53-dependent metabolic checkpoint
  publication-title: Mol. Cell
  doi: 10.1016/j.molcel.2005.03.027
– volume: 478
  start-page: 197
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb0810
  article-title: An endogenous tumour-promoting ligand of the human aryl hydrocarbon receptor
  publication-title: Nature
  doi: 10.1038/nature10491
– volume: 336
  start-page: 1262
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0875
  article-title: Host-gut microbiota metabolic interactions
  publication-title: Science
  doi: 10.1126/science.1223813
– volume: 7
  start-page: 200
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0880
  article-title: Role of the microbiome in non-gastrointestinal cancers
  publication-title: World J. Clin. Oncol.
  doi: 10.5306/wjco.v7.i2.200
– volume: 513
  start-page: 559
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0675
  article-title: Functional polarization of tumour-associated macrophages by tumour-derived lactic acid
  publication-title: Nature
  doi: 10.1038/nature13490
– volume: 6
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb1250
  article-title: Longevity in Mice Is Promoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production
  publication-title: PLoS One
  doi: 10.1371/journal.pone.0023652
– volume: 534
  start-page: 213
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0915
  article-title: Acetate mediates a microbiome-brain-beta-cell axis to promote metabolic syndrome
  publication-title: Nature
  doi: 10.1038/nature18309
– volume: 111
  start-page: 18321
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb1225
  article-title: Microbiota organization is a distinct feature of proximal colorectal cancers
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1406199111
– volume: 24
  start-page: 5923
  year: 2004
  ident: 10.1016/j.bbcan.2018.06.005_bb0520
  article-title: Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays
  publication-title: Mol. Cell. Biol.
  doi: 10.1128/MCB.24.13.5923-5936.2004
– volume: 12
  start-page: 496
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0870
  article-title: Intestinal commensal microbes as immune modulators
  publication-title: Cell Host Microbe
  doi: 10.1016/j.chom.2012.09.009
– volume: 4
  start-page: 4202
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0890
  article-title: Stomach microbiota composition varies between patients with non-atrophic gastritis and patients with intestinal type of gastric cancer
  publication-title: Sci. Rep.
  doi: 10.1038/srep04202
– volume: 149
  start-page: 22
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0510
  article-title: MYC on the Path to Cancer
  publication-title: Cell
  doi: 10.1016/j.cell.2012.03.003
– volume: 167
  start-page: 829
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0755
  article-title: L-arginine modulates T cell metabolism and enhances survival and anti-tumor activity
  publication-title: Cell
  doi: 10.1016/j.cell.2016.09.031
– volume: 589
  start-page: 47
  year: 2005
  ident: 10.1016/j.bbcan.2018.06.005_bb1090
  article-title: Bile acids as carcinogens in human gastrointestinal cancers
  publication-title: Mutat. Res-Rev. Mutat.
  doi: 10.1016/j.mrrev.2004.08.001
– volume: 493
  start-page: 542
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0470
  article-title: Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells
  publication-title: Nature
  doi: 10.1038/nature11743
– volume: 152
  start-page: 309
  year: 1924
  ident: 10.1016/j.bbcan.2018.06.005_bb0020
  article-title: On the metabolism of carcinoma cells
  publication-title: Biochem. Z.
– volume: 1812
  start-page: 851
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb1075
  article-title: Activation of bile salt nuclear receptor FXR is repressed by pro-inflammatory cytokines activating NF-kappa B signaling in the intestine
  publication-title: Bba-Mol. Basis Dis.
  doi: 10.1016/j.bbadis.2011.04.005
– volume: 76
  start-page: 4430
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0605
  article-title: PHGDH expression is required for mitochondrial redox homeostasis, breast cancer stem cell maintenance, and lung metastasis
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-16-0530
– volume: 278
  start-page: 47762
  year: 2003
  ident: 10.1016/j.bbcan.2018.06.005_bb1150
  article-title: Cyclooxygenase-independent induction of apoptosis by sulindac sulfone is mediated by polyamines in colon cancer
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.M307265200
– volume: 29
  start-page: 217
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0290
  article-title: Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle G2/M progression
  publication-title: Dev. Cell
  doi: 10.1016/j.devcel.2014.03.012
– volume: 25
  start-page: 429
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0530
  article-title: cMyc-mediated activation of serine biosynthesis pathway is critical for cancer progression under nutrient deprivation conditions
  publication-title: Cell Res.
  doi: 10.1038/cr.2015.33
– volume: 21
  start-page: 891
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1230
  article-title: Metabolism Links Bacterial Biofilms and Colon Carcinogenesis
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2015.04.011
– volume: 188
  start-page: 21
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0690
  article-title: Regulation of immune responses by prostaglandin E2
  publication-title: J. Immunol.
  doi: 10.4049/jimmunol.1101029
– volume: 162
  start-page: 1229
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0650
  article-title: Metabolic competition in the tumor microenvironment is a driver of cancer progression
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.016
– volume: 45
  start-page: 714
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb1310
  article-title: Two bugs a NOD away from improving cancer therapy efficacy
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.10.007
– volume: 6
  start-page: S585
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0565
  article-title: Targeting cancer with tumor-specific therapeutic strategies-metabolic reprogramming beyond the Warburg effect
  publication-title: Trans. Cancer Res.
  doi: 10.21037/tcr.2017.05.13
– volume: 26
  start-page: 803
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0070
  article-title: Waste Not, want not: lactate oxidation fuels the TCA cycle
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2017.11.005
– volume: 212
  start-page: 1345
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0805
  article-title: T cell metabolism drives immunity
  publication-title: J. Exp. Med.
  doi: 10.1084/jem.20151159
– volume: 234
  start-page: 2544
  year: 1959
  ident: 10.1016/j.bbcan.2018.06.005_bb0100
  article-title: The citrate cleavage enzyme. I. Distribution and purification
  publication-title: J. Biol. Chem.
  doi: 10.1016/S0021-9258(18)69735-2
– volume: 353
  start-page: 1161
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0555
  article-title: Tissue of origin dictates branched-chain amino acid metabolism in mutant Kras-driven cancers
  publication-title: Science
  doi: 10.1126/science.aaf5171
– volume: 185
  start-page: 174
  year: 2010
  ident: 10.1016/j.bbcan.2018.06.005_bb0940
  article-title: Butyrate induces cell apoptosis through activation of JNK MAP kinase pathway in human colon cancer RKO cells
  publication-title: Chem. Biol. Interact.
  doi: 10.1016/j.cbi.2010.03.035
– volume: 65
  start-page: 1973
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0895
  article-title: Fusobacterium nucleatum in colorectal carcinoma tissue and patient prognosis
  publication-title: Gut
  doi: 10.1136/gutjnl-2015-310101
– volume: 34
  start-page: 167
  year: 1991
  ident: 10.1016/j.bbcan.2018.06.005_bb1165
  article-title: Polyamine Levels in Healthy and Tumor-Tissues of Patients with Colon Adenocarcinoma
  publication-title: Dis. Colon Rectum
  doi: 10.1007/BF02049993
– volume: 162
  start-page: 1217
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0655
  article-title: Phosphoenolpyruvate Is a Metabolic Checkpoint of Anti-tumor T Cell Responses
  publication-title: Cell
  doi: 10.1016/j.cell.2015.08.012
– volume: 342
  start-page: 967
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb1295
  article-title: Commensal Bacteria Control Cancer Response to Therapy by Modulating the Tumor Microenvironment
  publication-title: Science
  doi: 10.1126/science.1240527
– volume: 50
  start-page: 1955
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb1010
  article-title: Bile acids: regulation of synthesis
  publication-title: J. Lipid Res.
  doi: 10.1194/jlr.R900010-JLR200
– volume: 14
  start-page: 561
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1280
  article-title: Combination cancer immunotherapy and new immunomodulatory targets
  publication-title: Nat. Rev. Drug Discov.
  doi: 10.1038/nrd4591
– volume: 8
  start-page: 1930
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0200
  article-title: HIF-1-Mediated Suppression of Acyl-CoA Dehydrogenases and Fatty Acid Oxidation Is Critical for Cancer Progression
  publication-title: Cell Rep.
  doi: 10.1016/j.celrep.2014.08.028
– volume: 222
  start-page: 180
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb0775
  article-title: Arginine regulation by myeloid derived suppressor cells and tolerance in cancer: mechanisms and therapeutic perspectives
  publication-title: Immunol. Rev.
  doi: 10.1111/j.1600-065X.2008.00608.x
– volume: 12
  start-page: 937
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0040
  article-title: Lactate metabolism is associated with mammalian mitochondria
  publication-title: Nat. Chem. Biol.
  doi: 10.1038/nchembio.2172
– volume: 73
  start-page: 478
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0385
  article-title: Overexpression of the Mitochondrial Folate and Glycine-Serine Pathway: A New Determinant of Methotrexate Selectivity in Tumors
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-12-3709
– volume: 8
  start-page: 540
  year: 2008
  ident: 10.1016/j.bbcan.2018.06.005_bb1115
  article-title: Bile acids and derivatives, their nuclear receptors FXR, PXR and ligands: Role in health and disease and their therapeutic potential
  publication-title: Anti-Can. Agent M.
  doi: 10.2174/187152008784533008
– volume: 109
  start-page: 6904
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0460
  article-title: Pyruvate kinase M2 promotes de novo serine synthesis to sustain mTORC1 activity and cell proliferation
  publication-title: Proc. Natl. Acad. Sci. U. S. A.
  doi: 10.1073/pnas.1204176109
– volume: 10
  start-page: 723
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0540
  article-title: Branched-chain amino acids in metabolic signalling and insulin resistance
  publication-title: Nat. Rev. Endocrinol.
  doi: 10.1038/nrendo.2014.171
– volume: 188
  start-page: 49
  year: 2011
  ident: 10.1016/j.bbcan.2018.06.005_bb1270
  article-title: Targeting Polyamines and Inflammation for Cancer Prevention
  publication-title: Rec. Res. Cancer
  doi: 10.1007/978-3-642-10858-7_4
– volume: 44
  start-page: 1312
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0850
  article-title: Memory CD8(+) T cells require Increased concentrations of acetate induced by stress for optimal function
  publication-title: Immunity
  doi: 10.1016/j.immuni.2016.03.016
– volume: 15
  start-page: 111
  year: 2018
  ident: 10.1016/j.bbcan.2018.06.005_bb0995
  article-title: Bile acid-microbiota crosstalk in gastrointestinal inflammation and carcinogenesis
  publication-title: Nat. Rev. Gastroenterol. Hepatol.
  doi: 10.1038/nrgastro.2017.119
– volume: 28
  start-page: 687
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1330
  article-title: Immunotherapy not working? Check your microbiota
  publication-title: Cancer Cell
  doi: 10.1016/j.ccell.2015.11.010
– volume: 287
  start-page: 19786
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0340
  article-title: Resurgence of serine: an often neglected but indispensable amino acid
  publication-title: J. Biol. Chem.
  doi: 10.1074/jbc.R112.357194
– volume: 24
  start-page: 657
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0685
  article-title: LDHA-Associated Lactic Acid Production Blunts Tumor Immunosurveillance by T and NK Cells
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.08.011
– volume: 24
  start-page: 3736
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0280
  article-title: mTOR regulates phagosome and entotic vacuole fission
  publication-title: Mol. Biol. Cell
  doi: 10.1091/mbc.e13-07-0408
– volume: 542
  start-page: 119
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0575
  article-title: Genomic deletion of malic enzyme 2 confers collateral lethality in pancreatic cancer
  publication-title: Nature
  doi: 10.1038/nature21052
– volume: 15
  start-page: 465
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0905
  article-title: Anticancer effects of the microbiome and its products
  publication-title: Nat. Rev. Microbiol.
  doi: 10.1038/nrmicro.2017.44
– volume: 59
  start-page: 71
  year: 1994
  ident: 10.1016/j.bbcan.2018.06.005_bb1105
  article-title: Inhibition of proliferation and induction of monocytic differentiation on HL60 human promyelocytic leukemia cells treated with bile acids in vitro
  publication-title: Int. J. Cancer
  doi: 10.1002/ijc.2910590115
– volume: 60
  start-page: 672
  year: 2000
  ident: 10.1016/j.bbcan.2018.06.005_bb1110
  article-title: Functional interactions between bile acids, all-trans retinoic acid, and 1,25-dihydroxy-vitamin D-3 on monocytic differentiation and myeloblastin gene down-regulation in HL60 and THP-1 human leukemia cells
  publication-title: Cancer Res.
– volume: 491
  start-page: 458
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb0455
  article-title: Serine is a natural ligand and allosteric activator of pyruvate kinase M2
  publication-title: Nature
  doi: 10.1038/nature11540
– volume: 50
  start-page: 6146
  year: 1990
  ident: 10.1016/j.bbcan.2018.06.005_bb1175
  article-title: Two chromosomal locations for human ornithine decarboxylase gene sequences and elevated expression in colorectal neoplasia
  publication-title: Cancer Res.
– volume: 372
  start-page: 2006
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb1275
  article-title: Nivolumab and ipilimumab versus ipilimumab in untreated melanoma
  publication-title: New Engl. J. Med.
  doi: 10.1056/NEJMoa1414428
– volume: 25
  start-page: 42
  year: 2014
  ident: 10.1016/j.bbcan.2018.06.005_bb0165
  article-title: Ketone bodies as signaling metabolites
  publication-title: Trends Endocrinol. Metab.
  doi: 10.1016/j.tem.2013.09.002
– volume: 13
  start-page: 572
  year: 2013
  ident: 10.1016/j.bbcan.2018.06.005_bb0375
  article-title: Serine, glycine and one-carbon units: cancer metabolism in full circle
  publication-title: Nat. Rev. Cancer
  doi: 10.1038/nrc3557
– volume: 353
  start-page: 1095
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0560
  article-title: Location, location, location
  publication-title: Science
  doi: 10.1126/science.aai7629
– volume: 162
  start-page: 259
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0270
  article-title: The Utilization of Extracellular Proteins as Nutrients Is Suppressed by mTORC1
  publication-title: Cell
  doi: 10.1016/j.cell.2015.06.017
– volume: 61
  start-page: 880
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb1140
  article-title: Mammalian Polyamine Metabolism and Function
  publication-title: IUBMB Life
  doi: 10.1002/iub.230
– volume: 89
  start-page: 169
  year: 2000
  ident: 10.1016/j.bbcan.2018.06.005_bb0095
  article-title: Free radical scavenging and antioxidant effects of lactate ion: an in vitro study
  publication-title: J. Appl. Physiol.
  doi: 10.1152/jappl.2000.89.1.169
– volume: 36
  start-page: 2296
  year: 2015
  ident: 10.1016/j.bbcan.2018.06.005_bb0185
  article-title: Caloric restriction increases ketone bodies metabolism and preserves blood flow in aging brain
  publication-title: Neurobiol. Aging
  doi: 10.1016/j.neurobiolaging.2015.03.012
– volume: 21
  start-page: 36
  year: 2012
  ident: 10.1016/j.bbcan.2018.06.005_bb1065
  article-title: Bile acid and inflammation activate gastric cardia stem cells in a mouse model of Barrett-like metaplasia
  publication-title: Cancer Cell
  doi: 10.1016/j.ccr.2011.12.004
– volume: 551
  start-page: 115
  year: 2017
  ident: 10.1016/j.bbcan.2018.06.005_bb0060
  article-title: Glucose feeds the TCA cycle via circulating lactate
  publication-title: Nature
  doi: 10.1038/nature24057
– volume: 24
  start-page: 685
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0220
  article-title: Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2016.10.011
– volume: 3
  start-page: 177
  year: 2006
  ident: 10.1016/j.bbcan.2018.06.005_bb0590
  article-title: HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia
  publication-title: Cell Metab.
  doi: 10.1016/j.cmet.2006.02.002
– volume: 16
  start-page: 343
  year: 2016
  ident: 10.1016/j.bbcan.2018.06.005_bb0780
  article-title: L-Arginine supplementation inhibits the growth of breast cancer by enhancing innate and adaptive immune responses mediated by suppression of MDSCs in vivo
  publication-title: BMC Cancer
  doi: 10.1186/s12885-016-2376-0
– volume: 69
  start-page: 1553
  year: 2009
  ident: 10.1016/j.bbcan.2018.06.005_bb0765
  article-title: Arginase I-producing myeloid-derived suppressor cells in renal cell carcinoma are a subpopulation of activated granulocytes
  publication-title: Cancer Res.
  doi: 10.1158/0008-5472.CAN-08-1921
SSID ssj0015336
Score 2.6457784
SecondaryResourceType review_article
Snippet While metabolic reprogramming of cancer cells has long been considered from the standpoint of how and why cancer cells preferentially utilize glucose via...
SourceID proquest
pubmed
crossref
elsevier
SourceType Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 51
SubjectTerms Amino Acids, Branched-Chain - metabolism
Biomass synthesis
Cell Proliferation
Humans
Immune cells
Metabolic reprogramming
Microbiota
Neoplasms - metabolism
Nutrients
Pentose Phosphate Pathway
Serine - biosynthesis
Tumor Microenvironment
Title Metabolic reprogramming for cancer cells and their microenvironment: Beyond the Warburg Effect
URI https://dx.doi.org/10.1016/j.bbcan.2018.06.005
https://www.ncbi.nlm.nih.gov/pubmed/29959989
https://www.proquest.com/docview/2062836978
Volume 1870
WOSCitedRecordID wos000442974700007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVESC
  databaseName: ScienceDirect database
  customDbUrl:
  eissn: 1879-2561
  dateEnd: 99991231
  omitProxy: false
  ssIdentifier: ssj0015336
  issn: 0304-419X
  databaseCode: AIEXJ
  dateStart: 19950728
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LbxMxELbSltcFQSkQHpWREJew1cYbxza3qkpVUBqQSEVOrOyNl26VbkIeVfgx_FfGrw2htCoHLptoYmc3_r7Y45nxDEKvYz0UOc_yiBCZRzDh8UglahhRyhLGcyqFjG2xCdbr8cFAfKrVfoazMBcjVpZ8uRST_wo1yABsc3T2H-CuvhQE8B5AhyvADtcbAX-s5wDsyKZm9tFX5yFcMjMYw4sejWYhdrKYNs5NVN5vR96MmcAfbTF66Rdphv5bw2U6XnMDF-PstDAZBxp63lDF2BlKpEnRIfe848E6JNydVy6o0hsEYPb1a6cVO8OtLJZFtVx0bbzB59Mi6herppWh-2ghc-3l3nrR5FXsXJhwORMRqF1OpP8iq2ZpV2BkjY9u0nUZay-tBc4scbanFPxEE8TnMrXGdLX0BXd_72N6eNLtpv3OoP9m8j0yRcmM895XaNlAW4RRAZPm1v77zuBD5aYCXdkeXwsPHNJa2QDCS_e9SvW5amtjVZz-A3Tf703wvuPUQ1TT5Ta67aqV_thGdw9CccBtdOfYx2Q8Ql8rwuE1wmEgHHawY0s4DITDlnD4T8K9w45u5mPs6YYd3XbQyWGnf3AU-aodUZZQMY8SZdYMmufJsJUr2ZRZi-QMlB4mNOOJFpkQOexKoJUSPBPKOIop02JIJGnpOHmMNstxqZ8iTCiJE0kIa-ohKFGxVLA55lms2hmjSuV1RMKApplPaW8qq4zSELt4lloUUoNCaiM4aR29rTpNXEaX65u3A1KpV0qdspkCz67v-CrgmgI4ZqBlqceLGTRqg1LfFozX0RMHePUkxOT_E1w8u0Hv5-je6i_1Am3Opwv9Et3KLubFbLqLNtiA73rG_gJjMcKx
linkProvider Elsevier
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Metabolic+reprogramming+for+cancer+cells+and+their+microenvironment%3A+Beyond+the+Warburg+Effect&rft.jtitle=Biochimica+et+biophysica+acta.+Reviews+on+cancer&rft.au=Sun%2C+Linchong&rft.au=Suo%2C+Caixia&rft.au=Li%2C+Shi-Ting&rft.au=Zhang%2C+Huafeng&rft.date=2018-08-01&rft.issn=1879-2561&rft.eissn=1879-2561&rft.volume=1870&rft.issue=1&rft.spage=51&rft_id=info:doi/10.1016%2Fj.bbcan.2018.06.005&rft.externalDBID=NO_FULL_TEXT
thumbnail_l http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0304-419X&client=summon
thumbnail_m http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0304-419X&client=summon
thumbnail_s http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0304-419X&client=summon