Immunogenicity, including vitiligo, and feasibility of vaccination with autologous GM-CSF-transduced tumor cells in metastatic melanoma patients

To determine the feasibility, toxicity, and immunologic effects of vaccination with autologous tumor cells retrovirally transduced with the GM-CSF gene, we performed a phase I/II vaccination study in stage IV metastatic melanoma patients. Sixty-four patients were randomly assigned to receive three v...

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Bibliographic Details
Published in:	Journal of clinical oncology Vol. 23; no. 35; p. 8978
Main Authors:	Luiten, Rosalie M, Kueter, Esther W M, Mooi, Wolter, Gallee, Maarten P W, Rankin, Elaine M, Gerritsen, Winald R, Clift, Shirley M, Nooijen, Willem J, Weder, Pauline, van de Kasteele, Willeke F, Sein, Johan, van den Berk, Paul C M, Nieweg, Omgo E, Berns, Anton M, Spits, Hergen, de Gast, Gijsbert C
Format:	Journal Article
Language:	English
Published:	United States 10.12.2005
Subjects:	Adjuvants, Immunologic Adult Aged Antigens, Neoplasm - immunology Autoimmune Diseases - etiology Cancer Vaccines - adverse effects Cancer Vaccines - immunology Cancer Vaccines - therapeutic use Cytotoxicity, Immunologic Drug Administration Schedule Feasibility Studies Female Granulocyte-Macrophage Colony-Stimulating Factor - adverse effects Granulocyte-Macrophage Colony-Stimulating Factor - immunology Granulocyte-Macrophage Colony-Stimulating Factor - therapeutic use Humans Male Melanoma - drug therapy Melanoma - immunology Middle Aged Neoplasm Proteins - immunology Peptide Fragments - immunology T-Lymphocytes - immunology Vitiligo - etiology
ISSN:	0732-183X
Online Access:	Get more information
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