Inhibition of human colon carcinoma cell growth by ammonia: a non-cytotoxic process associated with polyamine synthesis reduction

Ammonia, produced by bacterial degradation of unabsorbed and endogenous nitrogenous compounds, is found to be present at millimolar concentrations in the colon lumen. From in vivo animal experiments, this metabolite has been shown to alter colonic epithelial cell morphology and to increase compensat...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1624; no. 1; pp. 88 - 97
Main Authors:	Mouillé, Béatrice, Delpal, Serge, Mayeur, Camille, Blachier, François
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 05.12.2003
Subjects:	Ammonia Ammonia - metabolism Ammonium Chloride - pharmacology Biogenic Polyamines - biosynthesis Cell Cycle - drug effects Cell Differentiation - drug effects Cell Division - drug effects Colon carcinoma cell Colonic Neoplasms - drug therapy Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Glutamine - metabolism HT29 Cells Humans Metabolism Polyamine Proliferation Protein Biosynthesis Putrescine - pharmacology Ammonia Polyamine Proliferation Colon carcinoma cell Metabolism
ISSN:	0304-4165, 0006-3002, 1872-8006
Online Access:	Get full text
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