Cognitive Function in People With Pediatric Multiple Sclerosis Over 2 Years
Pediatric multiple sclerosis (MS) affects children and adolescents at an important time for neurologic and cognitive development. Although cognitive impairment has been described, few longitudinal studies of cognitive functioning in pediatric MS with matched controls are available. Here, we report t...
Uloženo v:
| Vydáno v: | Neurology Ročník 105; číslo 8; s. e214142 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
21.10.2025
|
| Témata: | |
| ISSN: | 1526-632X, 1526-632X |
| On-line přístup: | Zjistit podrobnosti o přístupu |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Pediatric multiple sclerosis (MS) affects children and adolescents at an important time for neurologic and cognitive development. Although cognitive impairment has been described, few longitudinal studies of cognitive functioning in pediatric MS with matched controls are available. Here, we report the 2-year follow-up cognitive results of a cohort of participants with MS and healthy controls (HCs) recruited from multiple regions of the United States.
Three cohorts-participants with pediatric MS, age-matched pediatric HC, and adults with early-onset MS-were recruited across 7 sites through the United States Network of Pediatric MS Centers. Two cognitive batteries, Cogstate Brief Battery (CBB) and Brief International Cognition Assessment for MS (BICAMS), were administered at baseline and follow-up. The primary outcome was the change in CBB composite z-score compared between groups. Change in BICAMS composite z-score was also compared, as were change in z-scores of individual measures. Reliable change indices (RCIs) were calculated to determine meaningful change over time.
A total of 63/72 (87.5%) of participants with pediatric MS, 81/99 (81.8%) of pediatric controls, and 48/66 (72.7%) of adults with MS returned for follow-up a mean 2.15 ± 0.27 years later. Participants with pediatric MS were median 17.4 years [IQR 16.0-18.3] at time of follow-up with median disease duration of 3.9 years [IQR 2.8-5.6]. 71% were female. There were no significant differences in change in CBB composite z-scores among pediatric MS and pediatric HC groups (0.10 vs 0.31,
= 0.113) or between the pediatric and adult MS groups (0.10 vs 0.00,
= 0.987). Although on RCI of the CBB, 80% of participants with pediatric MS were either stable or improved, more of the pediatric MS group declined relative to the control group 19.7% vs 5.1%,
= 0.022.
Most individuals with pediatric MS early in their disease showed stable cognitive function over a 2-year period and had longitudinal changes that were largely similar to pediatric controls. A subset of participants with pediatric MS declined in cognitive processing speed relative to pediatric controls. |
|---|---|
| AbstractList | Pediatric multiple sclerosis (MS) affects children and adolescents at an important time for neurologic and cognitive development. Although cognitive impairment has been described, few longitudinal studies of cognitive functioning in pediatric MS with matched controls are available. Here, we report the 2-year follow-up cognitive results of a cohort of participants with MS and healthy controls (HCs) recruited from multiple regions of the United States.BACKGROUND AND OBJECTIVESPediatric multiple sclerosis (MS) affects children and adolescents at an important time for neurologic and cognitive development. Although cognitive impairment has been described, few longitudinal studies of cognitive functioning in pediatric MS with matched controls are available. Here, we report the 2-year follow-up cognitive results of a cohort of participants with MS and healthy controls (HCs) recruited from multiple regions of the United States.Three cohorts-participants with pediatric MS, age-matched pediatric HC, and adults with early-onset MS-were recruited across 7 sites through the United States Network of Pediatric MS Centers. Two cognitive batteries, Cogstate Brief Battery (CBB) and Brief International Cognition Assessment for MS (BICAMS), were administered at baseline and follow-up. The primary outcome was the change in CBB composite z-score compared between groups. Change in BICAMS composite z-score was also compared, as were change in z-scores of individual measures. Reliable change indices (RCIs) were calculated to determine meaningful change over time.METHODSThree cohorts-participants with pediatric MS, age-matched pediatric HC, and adults with early-onset MS-were recruited across 7 sites through the United States Network of Pediatric MS Centers. Two cognitive batteries, Cogstate Brief Battery (CBB) and Brief International Cognition Assessment for MS (BICAMS), were administered at baseline and follow-up. The primary outcome was the change in CBB composite z-score compared between groups. Change in BICAMS composite z-score was also compared, as were change in z-scores of individual measures. Reliable change indices (RCIs) were calculated to determine meaningful change over time.A total of 63/72 (87.5%) of participants with pediatric MS, 81/99 (81.8%) of pediatric controls, and 48/66 (72.7%) of adults with MS returned for follow-up a mean 2.15 ± 0.27 years later. Participants with pediatric MS were median 17.4 years [IQR 16.0-18.3] at time of follow-up with median disease duration of 3.9 years [IQR 2.8-5.6]. 71% were female. There were no significant differences in change in CBB composite z-scores among pediatric MS and pediatric HC groups (0.10 vs 0.31, p = 0.113) or between the pediatric and adult MS groups (0.10 vs 0.00, p = 0.987). Although on RCI of the CBB, 80% of participants with pediatric MS were either stable or improved, more of the pediatric MS group declined relative to the control group 19.7% vs 5.1%, p = 0.022.RESULTSA total of 63/72 (87.5%) of participants with pediatric MS, 81/99 (81.8%) of pediatric controls, and 48/66 (72.7%) of adults with MS returned for follow-up a mean 2.15 ± 0.27 years later. Participants with pediatric MS were median 17.4 years [IQR 16.0-18.3] at time of follow-up with median disease duration of 3.9 years [IQR 2.8-5.6]. 71% were female. There were no significant differences in change in CBB composite z-scores among pediatric MS and pediatric HC groups (0.10 vs 0.31, p = 0.113) or between the pediatric and adult MS groups (0.10 vs 0.00, p = 0.987). Although on RCI of the CBB, 80% of participants with pediatric MS were either stable or improved, more of the pediatric MS group declined relative to the control group 19.7% vs 5.1%, p = 0.022.Most individuals with pediatric MS early in their disease showed stable cognitive function over a 2-year period and had longitudinal changes that were largely similar to pediatric controls. A subset of participants with pediatric MS declined in cognitive processing speed relative to pediatric controls.DISCUSSIONMost individuals with pediatric MS early in their disease showed stable cognitive function over a 2-year period and had longitudinal changes that were largely similar to pediatric controls. A subset of participants with pediatric MS declined in cognitive processing speed relative to pediatric controls. Pediatric multiple sclerosis (MS) affects children and adolescents at an important time for neurologic and cognitive development. Although cognitive impairment has been described, few longitudinal studies of cognitive functioning in pediatric MS with matched controls are available. Here, we report the 2-year follow-up cognitive results of a cohort of participants with MS and healthy controls (HCs) recruited from multiple regions of the United States. Three cohorts-participants with pediatric MS, age-matched pediatric HC, and adults with early-onset MS-were recruited across 7 sites through the United States Network of Pediatric MS Centers. Two cognitive batteries, Cogstate Brief Battery (CBB) and Brief International Cognition Assessment for MS (BICAMS), were administered at baseline and follow-up. The primary outcome was the change in CBB composite z-score compared between groups. Change in BICAMS composite z-score was also compared, as were change in z-scores of individual measures. Reliable change indices (RCIs) were calculated to determine meaningful change over time. A total of 63/72 (87.5%) of participants with pediatric MS, 81/99 (81.8%) of pediatric controls, and 48/66 (72.7%) of adults with MS returned for follow-up a mean 2.15 ± 0.27 years later. Participants with pediatric MS were median 17.4 years [IQR 16.0-18.3] at time of follow-up with median disease duration of 3.9 years [IQR 2.8-5.6]. 71% were female. There were no significant differences in change in CBB composite z-scores among pediatric MS and pediatric HC groups (0.10 vs 0.31, = 0.113) or between the pediatric and adult MS groups (0.10 vs 0.00, = 0.987). Although on RCI of the CBB, 80% of participants with pediatric MS were either stable or improved, more of the pediatric MS group declined relative to the control group 19.7% vs 5.1%, = 0.022. Most individuals with pediatric MS early in their disease showed stable cognitive function over a 2-year period and had longitudinal changes that were largely similar to pediatric controls. A subset of participants with pediatric MS declined in cognitive processing speed relative to pediatric controls. |
| Author | O'Neill, Kimberly A Casper, T Charles Schreiner, Teri George, Allan Chitnis, Tanuja Wheeler, Yolanda S Krupp, Lauren B Ness, Jayne M Waubant, Emmanuelle Charvet, Leigh Benson, Leslie A Gorman, Mark P Mar, Soe S Weinstock-Guttman, Bianca Rose, John W Virupakshaiah, Akash Waltz, Michael Abrams, Aaron W Rodriguez, Moses Tillema, Jan-Mendelt |
| Author_xml | – sequence: 1 givenname: Kimberly A surname: O'Neill fullname: O'Neill, Kimberly A organization: Department of Neurology, NYU Grossman School of Medicine, New York – sequence: 2 givenname: Leigh orcidid: 0000-0003-4429-9713 surname: Charvet fullname: Charvet, Leigh organization: Department of Neurology, NYU Grossman School of Medicine, New York – sequence: 3 givenname: Michael orcidid: 0009-0008-8859-0362 surname: Waltz fullname: Waltz, Michael organization: Department of Pediatrics, University of Utah, Salt Lake City – sequence: 4 givenname: Allan surname: George fullname: George, Allan organization: Department of Neurology, NYU Grossman School of Medicine, New York – sequence: 5 givenname: Leslie A orcidid: 0000-0002-1680-4834 surname: Benson fullname: Benson, Leslie A organization: Department of Neurology, Boston Children's Hospital, MA – sequence: 6 givenname: Mark P orcidid: 0000-0003-3694-8832 surname: Gorman fullname: Gorman, Mark P organization: Department of Neurology, Boston Children's Hospital, MA – sequence: 7 givenname: Soe S orcidid: 0000-0001-8449-2003 surname: Mar fullname: Mar, Soe S organization: Department of Neurology, Washington University in St. Louis School of Medicine, MO – sequence: 8 givenname: Jayne M orcidid: 0000-0001-8017-0138 surname: Ness fullname: Ness, Jayne M organization: Department of Neurology, University of Alabama at Birmingham – sequence: 9 givenname: Teri orcidid: 0000-0002-3816-812X surname: Schreiner fullname: Schreiner, Teri organization: Department of Neurology, University of Colorado, Aurora – sequence: 10 givenname: Emmanuelle orcidid: 0000-0001-5188-0157 surname: Waubant fullname: Waubant, Emmanuelle organization: Department of Neurology, University of California San Francisco – sequence: 11 givenname: Bianca orcidid: 0000-0001-6732-151X surname: Weinstock-Guttman fullname: Weinstock-Guttman, Bianca organization: Department of Neurology, University of Buffalo, NY – sequence: 12 givenname: Yolanda S orcidid: 0000-0003-1391-4496 surname: Wheeler fullname: Wheeler, Yolanda S organization: Department of Neurology, University of Alabama at Birmingham – sequence: 13 givenname: Aaron W orcidid: 0000-0002-4607-5740 surname: Abrams fullname: Abrams, Aaron W organization: Department of Neurology, Cleveland Clinic, OH – sequence: 14 givenname: Tanuja orcidid: 0000-0002-9897-4422 surname: Chitnis fullname: Chitnis, Tanuja organization: Department of Pediatric Neurology, Massachusetts General Hospital, Mass General Brigham, Boston – sequence: 15 givenname: Moses orcidid: 0000-0001-6328-6497 surname: Rodriguez fullname: Rodriguez, Moses organization: Department of Neurology, Mayo Clinic, Rochester, MN – sequence: 16 givenname: John W orcidid: 0000-0003-2382-5921 surname: Rose fullname: Rose, John W organization: Department of Neurology, University of Utah, Salt Lake City – sequence: 17 givenname: Jan-Mendelt orcidid: 0000-0001-6933-8913 surname: Tillema fullname: Tillema, Jan-Mendelt organization: Department of Neurology, Mayo Clinic, Rochester, MN – sequence: 18 givenname: Akash orcidid: 0000-0003-2624-9974 surname: Virupakshaiah fullname: Virupakshaiah, Akash organization: Department of Neurology, University of California San Francisco – sequence: 19 givenname: T Charles orcidid: 0000-0001-7512-1294 surname: Casper fullname: Casper, T Charles organization: Department of Pediatrics, University of Utah, Salt Lake City – sequence: 20 givenname: Lauren B orcidid: 0000-0001-7003-807X surname: Krupp fullname: Krupp, Lauren B organization: Department of Neurology, NYU Grossman School of Medicine, New York |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/40966491$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNUF9LwzAcDDJxf_QbiOTRl87klzZdHmU4FacTVKZPpU1-1UiX1qQd-O2tOMV7ueM4Du7GZOBqh4QcczblwOFsfbecsj8Aj3kMe2TEE5CRFPA8-KeHZBzCO2O9kaoDMoyZkjJWfERu5vWrs63dIl10Tre2dtQ6eo91UyFd2_at18bmrbea3nZVa7_9B12hr4MNdLVFT4G-YO7DIdkv8yrg0Y4n5Glx8Ti_ipary-v5-TLSIplBJDkwbrhBxqVQyIwsVKmERFCQzsAILFLJi6IsjUnVLMWExZrHrOgHGo0MJuT0p7fx9UeHoc02Nmisqtxh3YVMQAIAQjDZR0920a7YoMkabze5_8x-D4AvvXFegw |
| CitedBy_id | crossref_primary_10_1212_WNL_0000000000214244 |
| ContentType | Journal Article |
| CorporateAuthor | US Network of Pediatric MS Centers |
| CorporateAuthor_xml | – name: US Network of Pediatric MS Centers |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1212/WNL.0000000000214142 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic MEDLINE |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1526-632X |
| ExternalDocumentID | 40966491 |
| Genre | Multicenter Study Journal Article |
| GroupedDBID | --- -~X .XZ .Z2 01R 0R~ 123 1J1 354 3PY 4Q1 4Q2 4Q3 5RE 5VS 6PF 77Y AAAXR AAGIX AAHPQ AAIQE AAJCS AAMOA AAMTA AAQKA AARTV AASCR AASOK AASXQ AAWTL AAXQO AAYEP ABBLC ABIVO ABJNI ABOCM ABPXF ABVCZ ABXYN ABZZY ACDDN ACGFS ACILI ACLDA ACOAL ACWRI ACXJB ACZKN ADGGA ADKSD ADSXY AE6 AEBDS AENEX AFDTB AFEXH AFNMH AFUWQ AGINI AHOMT AHQNM AHQVU AHVBC AIJEX AJCLO AKCTQ AKULP AKWKN ALMA_UNASSIGNED_HOLDINGS AMJPA AMKUR AMNEI AOHHW BOYCO BQLVK BYPQX C45 CGR CS3 CUY CVF DIWNM DU5 E.X EBS ECM EIF EJD ERAAH EX3 F2K F2L F2M F2N F5P FCALG GQDEL HZ~ IKYAY IN~ IPNFZ JF7 KD2 KMI L-C L7B N9A NPM N~7 N~B O9- OAG OAH OBH ODMTH OHH OHYEH OL1 OLB OLH OLU OLV OLY OLZ OPX OVD OVDNE OVIDH OVLEI OWU OWV OWW OWX OWY OWZ OXXIT P2P RLZ RXW SJN TEORI V2I VVN W3M WH7 WOQ WOW XSW XXN XYM XYN YBU YFH ~9M 7X8 |
| ID | FETCH-LOGICAL-c3582-61201d1de01639e0d6b9f936e292782d3eb761bbffdd7987e504c140b142dce02 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 1 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=001574602100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1526-632X |
| IngestDate | Fri Sep 19 21:04:10 EDT 2025 Sun Sep 21 01:51:06 EDT 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 8 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3582-61201d1de01639e0d6b9f936e292782d3eb761bbffdd7987e504c140b142dce02 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ORCID | 0000-0003-4429-9713 0000-0001-5188-0157 0000-0002-1680-4834 0009-0008-8859-0362 0000-0002-9897-4422 0000-0003-3694-8832 0000-0001-8017-0138 0000-0001-8449-2003 0000-0003-1391-4496 0000-0002-3816-812X 0000-0001-6328-6497 0000-0001-6933-8913 0000-0003-2624-9974 0000-0001-7512-1294 0000-0003-2382-5921 0000-0002-4607-5740 0000-0001-6732-151X 0000-0001-7003-807X |
| PMID | 40966491 |
| PQID | 3252223306 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_3252223306 pubmed_primary_40966491 |
| PublicationCentury | 2000 |
| PublicationDate | 2025-10-21 |
| PublicationDateYYYYMMDD | 2025-10-21 |
| PublicationDate_xml | – month: 10 year: 2025 text: 2025-10-21 day: 21 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States |
| PublicationTitle | Neurology |
| PublicationTitleAlternate | Neurology |
| PublicationYear | 2025 |
| SSID | ssj0015279 |
| Score | 2.4977384 |
| Snippet | Pediatric multiple sclerosis (MS) affects children and adolescents at an important time for neurologic and cognitive development. Although cognitive impairment... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | e214142 |
| SubjectTerms | Adolescent Adult Child Cognition - physiology Cognitive Dysfunction - etiology Cohort Studies Female Follow-Up Studies Humans Longitudinal Studies Male Multiple Sclerosis - complications Multiple Sclerosis - psychology Neuropsychological Tests Young Adult |
| Title | Cognitive Function in People With Pediatric Multiple Sclerosis Over 2 Years |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/40966491 https://www.proquest.com/docview/3252223306 |
| Volume | 105 |
| WOSCitedRecordID | wos001574602100001&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1LS8NAEB7Uinjx_agvVvAamt0km-5JpFgEbSyoNJ5Csw_MJamm-vudTbb2JAjmkJwSwuzOzDePnQ_gKqJaxMa2DfIwsmVG38slD7xQSs2UPfkZmYZsIk6SfpqKsUu41a6tcmETG0OtKmlz5L2ARdaVIcK9nr17ljXKVlcdhcYqdAKEMlYx43RZRYhYM2sPn9zjAUvd0Tm01r1J8tCOLmwuRkNqydp_A5mNsxlu__c3d2DLwUxy0-6LXVjR5R5sjFwhfR_uB4u2ITJEz2ZXhxQlGTf95GRSzN_ID4kHGbmmQ_KE30KvWtTkETWAMPKKelIfwMvw9nlw5zleBU_ac7EYLaLXV1RphHuB0L7iuTAi4JoJhoBBBTqPOc1zY5SKRT_WkR9KDMRsvkhJ7bNDWCurUh8DidFAaGFzR1MZ9kMtqMToHEGT4WpqjN-Fy4WYMty3thgxLXX1WWdLQXXhqJV1NmsHbGQYc3IeCnryh7dPYZNZSl50J4yeQceg1upzWJdf86L-uGg2BN6T8egbsrq8sQ |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Cognitive+Function+in+People+With+Pediatric+Multiple+Sclerosis+Over+2+Years&rft.jtitle=Neurology&rft.au=O%27Neill%2C+Kimberly+A&rft.au=Charvet%2C+Leigh&rft.au=Waltz%2C+Michael&rft.au=George%2C+Allan&rft.date=2025-10-21&rft.eissn=1526-632X&rft.volume=105&rft.issue=8&rft.spage=e214142&rft_id=info:doi/10.1212%2FWNL.0000000000214142&rft_id=info%3Apmid%2F40966491&rft_id=info%3Apmid%2F40966491&rft.externalDocID=40966491 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1526-632X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1526-632X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1526-632X&client=summon |