Molecular mechanisms of ROS production and oxidative stress in diabetes
Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associat...
Gespeichert in:
| Veröffentlicht in: | Biochemical journal Jg. 473; H. 24; S. 4527 |
|---|---|
| Hauptverfasser: | , , , , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
England
15.12.2016
|
| Schlagworte: | |
| ISSN: | 1470-8728, 1470-8728 |
| Online-Zugang: | Weitere Angaben |
| Tags: |
Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
|
| Abstract | Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associated reactive oxygen species (ROS). One outcome of excessive levels of ROS is the modification of the structure and function of cellular proteins and lipids, leading to cellular dysfunction including impaired energy metabolism, altered cell signalling and cell cycle control, impaired cell transport mechanisms and overall dysfunctional biological activity, immune activation and inflammation. Nutritional stress, such as that caused by excess high-fat and/or carbohydrate diets, promotes oxidative stress as evident by increased lipid peroxidation products, protein carbonylation and decreased antioxidant status. In obesity, chronic oxidative stress and associated inflammation are the underlying factors that lead to the development of pathologies such as insulin resistance, dysregulated pathways of metabolism, diabetes and cardiovascular disease through impaired signalling and metabolism resulting in dysfunction to insulin secretion, insulin action and immune responses. However, exercise may counter excessive levels of oxidative stress and thus improve metabolic and inflammatory outcomes. In the present article, we review the cellular and molecular origins and significance of ROS production, the molecular targets and responses describing how oxidative stress affects cell function including mechanisms of insulin secretion and action, from the point of view of possible application of novel diabetic therapies based on redox regulation. |
|---|---|
| AbstractList | Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associated reactive oxygen species (ROS). One outcome of excessive levels of ROS is the modification of the structure and function of cellular proteins and lipids, leading to cellular dysfunction including impaired energy metabolism, altered cell signalling and cell cycle control, impaired cell transport mechanisms and overall dysfunctional biological activity, immune activation and inflammation. Nutritional stress, such as that caused by excess high-fat and/or carbohydrate diets, promotes oxidative stress as evident by increased lipid peroxidation products, protein carbonylation and decreased antioxidant status. In obesity, chronic oxidative stress and associated inflammation are the underlying factors that lead to the development of pathologies such as insulin resistance, dysregulated pathways of metabolism, diabetes and cardiovascular disease through impaired signalling and metabolism resulting in dysfunction to insulin secretion, insulin action and immune responses. However, exercise may counter excessive levels of oxidative stress and thus improve metabolic and inflammatory outcomes. In the present article, we review the cellular and molecular origins and significance of ROS production, the molecular targets and responses describing how oxidative stress affects cell function including mechanisms of insulin secretion and action, from the point of view of possible application of novel diabetic therapies based on redox regulation. Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associated reactive oxygen species (ROS). One outcome of excessive levels of ROS is the modification of the structure and function of cellular proteins and lipids, leading to cellular dysfunction including impaired energy metabolism, altered cell signalling and cell cycle control, impaired cell transport mechanisms and overall dysfunctional biological activity, immune activation and inflammation. Nutritional stress, such as that caused by excess high-fat and/or carbohydrate diets, promotes oxidative stress as evident by increased lipid peroxidation products, protein carbonylation and decreased antioxidant status. In obesity, chronic oxidative stress and associated inflammation are the underlying factors that lead to the development of pathologies such as insulin resistance, dysregulated pathways of metabolism, diabetes and cardiovascular disease through impaired signalling and metabolism resulting in dysfunction to insulin secretion, insulin action and immune responses. However, exercise may counter excessive levels of oxidative stress and thus improve metabolic and inflammatory outcomes. In the present article, we review the cellular and molecular origins and significance of ROS production, the molecular targets and responses describing how oxidative stress affects cell function including mechanisms of insulin secretion and action, from the point of view of possible application of novel diabetic therapies based on redox regulation.Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an imbalance between oxidative and antioxidative systems of cells and tissues, is a result of over production of oxidative-free radicals and associated reactive oxygen species (ROS). One outcome of excessive levels of ROS is the modification of the structure and function of cellular proteins and lipids, leading to cellular dysfunction including impaired energy metabolism, altered cell signalling and cell cycle control, impaired cell transport mechanisms and overall dysfunctional biological activity, immune activation and inflammation. Nutritional stress, such as that caused by excess high-fat and/or carbohydrate diets, promotes oxidative stress as evident by increased lipid peroxidation products, protein carbonylation and decreased antioxidant status. In obesity, chronic oxidative stress and associated inflammation are the underlying factors that lead to the development of pathologies such as insulin resistance, dysregulated pathways of metabolism, diabetes and cardiovascular disease through impaired signalling and metabolism resulting in dysfunction to insulin secretion, insulin action and immune responses. However, exercise may counter excessive levels of oxidative stress and thus improve metabolic and inflammatory outcomes. In the present article, we review the cellular and molecular origins and significance of ROS production, the molecular targets and responses describing how oxidative stress affects cell function including mechanisms of insulin secretion and action, from the point of view of possible application of novel diabetic therapies based on redox regulation. |
| Author | Newsholme, Philip Cruzat, Vinicius Fernandes Keane, Kevin Noel Carlessi, Rodrigo de Bittencourt, Jr, Paulo Ivo Homem |
| Author_xml | – sequence: 1 givenname: Philip surname: Newsholme fullname: Newsholme, Philip organization: School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Kent St., Bentley, Perth, Western Australia 6102, Australia – sequence: 2 givenname: Vinicius Fernandes surname: Cruzat fullname: Cruzat, Vinicius Fernandes organization: Department of Physiology and Biophysics, Institute of Biomedical Sciences, University of São Paulo (USP), São Paulo, SP, Brazil – sequence: 3 givenname: Kevin Noel surname: Keane fullname: Keane, Kevin Noel organization: School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Kent St., Bentley, Perth, Western Australia 6102, Australia – sequence: 4 givenname: Rodrigo surname: Carlessi fullname: Carlessi, Rodrigo organization: School of Biomedical Sciences, Curtin Health Innovation Research Institute, Curtin University, Kent St., Bentley, Perth, Western Australia 6102, Australia – sequence: 5 givenname: Paulo Ivo Homem surname: de Bittencourt, Jr fullname: de Bittencourt, Jr, Paulo Ivo Homem organization: Laboratory of Cellular Physiology, Institute of Basic Health Sciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27941030$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNj81LxDAUxIMo7ofePEuOXqrvJWmTHmXRVVhZ8ONcXtO3mKUfa9OK_vcuuIKnmYEfw8xMHLddy0JcIFwjGHVT-q0CzCAF7Y_EFI2FxFnljv_5iZjFuAVAAwZOxUTZ3CBomIrlU1ezH2vqZcP-ndoQmyi7jXxev8hd31WjH0LXSmor2X2FiobwyTIOPccoQyurQCUPHM_EyYbqyOcHnYu3-7vXxUOyWi8fF7erxOvUDglnlJNGbQAh9Vhqxxps6bwmqDxyTvvglKUMSWn0RtMG0BlDpnJlmau5uPrt3W_7GDkORROi57qmlrsxFuhSlWVoM7tHLw_oWDZcFbs-NNR_F3_n1Q_moFyN |
| CitedBy_id | crossref_primary_10_3390_md23010009 crossref_primary_10_1007_s40995_020_01001_3 crossref_primary_10_1016_j_ecoenv_2023_114571 crossref_primary_10_1007_s11418_022_01675_6 crossref_primary_10_1039_D1QI01025E crossref_primary_10_3390_jcm8101659 crossref_primary_10_1016_j_biopha_2017_03_099 crossref_primary_10_1186_s13098_020_00525_3 crossref_primary_10_3389_fnut_2022_847966 crossref_primary_10_1089_ars_2019_7952 crossref_primary_10_3390_antiox11081553 crossref_primary_10_1111_apha_13351 crossref_primary_10_1016_j_compositesb_2024_111282 crossref_primary_10_1142_S0192415X18500611 crossref_primary_10_1016_j_anireprosci_2024_107453 crossref_primary_10_1016_j_fbio_2025_107265 crossref_primary_10_1016_j_ijbiomac_2023_123803 crossref_primary_10_3389_fendo_2024_1390351 crossref_primary_10_3389_fnmol_2025_1553308 crossref_primary_10_1007_s00592_024_02371_5 crossref_primary_10_1089_ars_2017_7158 crossref_primary_10_3389_fmolb_2024_1470711 crossref_primary_10_3389_fendo_2020_00400 crossref_primary_10_1016_j_jep_2024_118695 crossref_primary_10_1016_j_lfs_2020_117464 crossref_primary_10_1177_1934578X231177878 crossref_primary_10_3390_antiox9100920 crossref_primary_10_1093_rb_rbad096 crossref_primary_10_3390_ijms20246358 crossref_primary_10_1002_ptr_70028 crossref_primary_10_1016_j_fct_2020_111202 crossref_primary_10_1002_tcr_201600143 crossref_primary_10_1007_s00011_021_01529_z crossref_primary_10_1089_ars_2017_7390 crossref_primary_10_3390_ph16010050 crossref_primary_10_1016_j_ijheh_2018_01_011 crossref_primary_10_1016_j_envpol_2021_118763 crossref_primary_10_1016_j_maturitas_2020_12_005 crossref_primary_10_3390_jpm12122087 crossref_primary_10_3390_nu11091978 crossref_primary_10_1016_j_chemosphere_2021_131831 crossref_primary_10_1016_j_phymed_2024_155352 crossref_primary_10_1002_bab_2083 crossref_primary_10_1016_j_intimp_2021_108408 crossref_primary_10_3390_ijms21218204 crossref_primary_10_2174_0929867328666210810142527 crossref_primary_10_1016_j_xpro_2024_102964 crossref_primary_10_1155_2022_3959390 crossref_primary_10_3390_ijms242115728 crossref_primary_10_1007_s40122_022_00359_z crossref_primary_10_1007_s12291_022_01031_1 crossref_primary_10_1155_2020_9637365 crossref_primary_10_3389_fphys_2022_837926 crossref_primary_10_3390_antiox11010108 crossref_primary_10_3390_nu16111641 crossref_primary_10_3389_fgene_2022_848116 crossref_primary_10_1016_j_fsi_2023_109289 crossref_primary_10_4239_wjd_v15_i5_1021 crossref_primary_10_1016_j_cellsig_2025_111833 crossref_primary_10_1002_jcla_24966 crossref_primary_10_1016_j_clnesp_2022_01_022 crossref_primary_10_1007_s10719_022_10041_3 crossref_primary_10_3390_ani13182847 crossref_primary_10_3390_antiox12030658 crossref_primary_10_2174_0929867328666210902131021 crossref_primary_10_1016_j_fbio_2023_103376 crossref_primary_10_3390_brainsci12020250 crossref_primary_10_1093_burnst_tkae078 crossref_primary_10_1155_2022_4362317 crossref_primary_10_1016_j_molmet_2022_101577 crossref_primary_10_1016_j_foodres_2018_12_033 crossref_primary_10_1017_S0007114517003208 crossref_primary_10_4239_wjd_v11_i5_193 crossref_primary_10_2478_acve_2021_0024 crossref_primary_10_3390_molecules27051539 crossref_primary_10_1111_and_14424 crossref_primary_10_1007_s11010_022_04478_1 crossref_primary_10_1111_ijcp_14945 crossref_primary_10_1111_jfbc_14256 crossref_primary_10_3390_proteomes7040035 crossref_primary_10_4196_kjpp_24_182 crossref_primary_10_1080_09273948_2022_2081862 crossref_primary_10_1093_pm_pnz022 crossref_primary_10_1210_endocr_bqaa065 crossref_primary_10_1039_D1RA05819C crossref_primary_10_1038_s41585_022_00621_1 crossref_primary_10_3390_app132413112 crossref_primary_10_1007_s11010_020_03880_x crossref_primary_10_1016_j_jff_2024_106160 crossref_primary_10_1038_s41598_017_04283_7 crossref_primary_10_1016_j_lfs_2019_117184 crossref_primary_10_2174_0118715206354948250226103832 crossref_primary_10_3390_biom13091385 crossref_primary_10_1016_j_biochi_2019_10_015 crossref_primary_10_3390_molecules23061483 crossref_primary_10_1016_j_bbadis_2017_02_008 crossref_primary_10_1016_j_nutres_2025_06_009 crossref_primary_10_3390_molecules24173103 crossref_primary_10_1038_s41598_019_55329_x crossref_primary_10_1016_j_neuroscience_2024_10_048 crossref_primary_10_2147_JIR_S273446 crossref_primary_10_1042_BCJ20170042 crossref_primary_10_1007_s00217_021_03866_z crossref_primary_10_1016_j_envpol_2024_124633 crossref_primary_10_1016_j_freeradbiomed_2019_09_019 crossref_primary_10_3390_ijms21186644 crossref_primary_10_1016_j_ejphar_2021_174721 crossref_primary_10_1080_21655979_2022_2071021 crossref_primary_10_1016_j_jff_2021_104539 crossref_primary_10_1016_j_archoralbio_2022_105551 crossref_primary_10_3389_fendo_2020_00568 crossref_primary_10_1155_2019_5403761 crossref_primary_10_1007_s12035_019_01708_4 crossref_primary_10_3389_fcimb_2023_1276406 crossref_primary_10_1002_iid3_593 crossref_primary_10_1055_a_1910_3505 crossref_primary_10_1016_j_jtemb_2025_127635 crossref_primary_10_2174_0109298673275187231121054541 crossref_primary_10_1016_j_ijbiomac_2020_10_258 crossref_primary_10_3390_diagnostics15050568 crossref_primary_10_1016_j_biotechadv_2017_12_015 crossref_primary_10_3389_fbioe_2020_00880 crossref_primary_10_1016_j_biopha_2021_112179 crossref_primary_10_1111_odi_14292 crossref_primary_10_14814_phy2_16009 crossref_primary_10_3390_toxins16070285 crossref_primary_10_1007_s11696_022_02273_2 crossref_primary_10_1557_jmr_2020_96 crossref_primary_10_1016_j_jmb_2019_10_012 crossref_primary_10_1155_2020_2309437 crossref_primary_10_1002_cbin_11771 crossref_primary_10_1007_s12192_018_0943_9 crossref_primary_10_1155_2020_1720961 crossref_primary_10_1016_j_jbc_2024_107756 crossref_primary_10_1080_21655979_2021_1979914 crossref_primary_10_1016_j_cellimm_2025_104989 crossref_primary_10_12677_MD_2023_134067 crossref_primary_10_1016_j_lfs_2021_119511 crossref_primary_10_1007_s12519_023_00710_0 crossref_primary_10_1038_s41598_025_97964_7 crossref_primary_10_1016_j_biopha_2022_112636 crossref_primary_10_3390_antiox10020224 crossref_primary_10_1016_j_omtn_2020_12_008 crossref_primary_10_1016_j_nano_2023_102700 crossref_primary_10_3390_membranes13030306 crossref_primary_10_3390_nu12030806 crossref_primary_10_1007_s11010_022_04496_z crossref_primary_10_1055_s_0043_125148 crossref_primary_10_1007_s11011_021_00762_z crossref_primary_10_3390_md23060235 crossref_primary_10_3390_ijms23169081 crossref_primary_10_3390_nu15092105 crossref_primary_10_1016_j_jpba_2021_114271 crossref_primary_10_2147_DMSO_S395818 crossref_primary_10_1108_NFS_06_2021_0175 crossref_primary_10_3389_fendo_2020_00365 crossref_primary_10_1016_j_jbc_2023_104803 crossref_primary_10_3390_biom10030361 crossref_primary_10_1016_j_fitote_2023_105803 crossref_primary_10_1002_jcb_29845 crossref_primary_10_1016_j_nantod_2019_05_008 crossref_primary_10_1111_jdi_14147 crossref_primary_10_1155_2022_1373533 crossref_primary_10_1186_s43094_025_00844_0 crossref_primary_10_1007_s11695_020_05073_3 crossref_primary_10_4103_pm_pm_84_19 crossref_primary_10_1007_s11756_021_00925_4 crossref_primary_10_1016_j_ctim_2018_10_019 crossref_primary_10_1016_j_dci_2023_105116 crossref_primary_10_1111_jfbc_13337 crossref_primary_10_3390_nu14071522 crossref_primary_10_1177_0960327120909525 crossref_primary_10_1186_s13098_020_00528_0 crossref_primary_10_3390_antiox13040457 crossref_primary_10_1016_j_scitotenv_2022_160601 crossref_primary_10_1016_j_envpol_2024_123467 crossref_primary_10_3390_molecules25225342 crossref_primary_10_1016_j_optmat_2025_117089 crossref_primary_10_1155_2017_5716409 crossref_primary_10_1155_adpp_7285762 crossref_primary_10_2147_IJN_S292319 crossref_primary_10_3390_antiox11091657 crossref_primary_10_1021_acsfoodscitech_4c00916 crossref_primary_10_2337_db20_0207 crossref_primary_10_1016_j_ijbiomac_2024_138849 crossref_primary_10_1016_j_aquaculture_2023_739805 crossref_primary_10_3390_md18070357 crossref_primary_10_1016_j_tifs_2020_07_024 crossref_primary_10_1002_edm2_70037 crossref_primary_10_1016_j_bone_2022_116355 crossref_primary_10_1155_2021_3683796 crossref_primary_10_1016_j_cjca_2017_12_005 crossref_primary_10_3389_fchem_2020_00838 crossref_primary_10_1002_jbm_b_35458 crossref_primary_10_1016_j_heliyon_2023_e23894 crossref_primary_10_1021_acs_analchem_4c07070 crossref_primary_10_4103_ijp_ijp_671_22 crossref_primary_10_3390_foods12050981 crossref_primary_10_3390_jcm10122692 crossref_primary_10_1097_MD_0000000000013108 crossref_primary_10_1016_j_bbrep_2025_102069 crossref_primary_10_1155_2022_9012943 crossref_primary_10_1007_s12011_021_02882_0 crossref_primary_10_1093_humupd_dmx020 crossref_primary_10_3389_fpubh_2023_1248518 crossref_primary_10_20935_AcadBiol7453 crossref_primary_10_3390_md22100469 crossref_primary_10_1111_jch_70046 crossref_primary_10_1016_j_ctim_2021_102755 crossref_primary_10_1038_s41598_023_46431_2 crossref_primary_10_3390_cells10051251 crossref_primary_10_3390_antiox9060459 crossref_primary_10_1002_jbt_22764 crossref_primary_10_3390_brainsci10100742 crossref_primary_10_1016_j_jenvman_2024_120928 crossref_primary_10_1016_j_aquaculture_2021_737153 crossref_primary_10_1016_j_jtemb_2022_126952 crossref_primary_10_1038_s41419_020_2429_9 crossref_primary_10_3390_antiox11061196 crossref_primary_10_3390_biomedicines13020251 crossref_primary_10_1016_j_cej_2022_134970 crossref_primary_10_1002_ptr_7137 crossref_primary_10_3390_catal15070617 crossref_primary_10_1007_s11094_022_02759_z crossref_primary_10_2147_DMSO_S243560 crossref_primary_10_1111_1440_1681_13353 crossref_primary_10_3390_antiox10010112 crossref_primary_10_1007_s00253_019_10156_y crossref_primary_10_1096_fj_202201117 crossref_primary_10_1007_s12272_024_01490_5 crossref_primary_10_3390_fermentation9040332 crossref_primary_10_1002_tox_24220 crossref_primary_10_1016_j_fsi_2020_06_033 crossref_primary_10_1080_15321819_2020_1726774 crossref_primary_10_1016_j_ijbiomac_2024_134210 crossref_primary_10_1080_09513590_2019_1707797 crossref_primary_10_1002_ptr_7124 crossref_primary_10_1016_j_addr_2022_114456 crossref_primary_10_1177_1178630219839013 crossref_primary_10_1155_2020_6656033 crossref_primary_10_1016_j_cstres_2024_01_002 crossref_primary_10_1016_j_freeradbiomed_2020_08_024 crossref_primary_10_1111_1440_1681_13462 crossref_primary_10_1111_pai_13523 crossref_primary_10_1007_s00424_020_02417_x crossref_primary_10_1007_s12975_018_0652_9 crossref_primary_10_1038_s41598_024_75734_1 crossref_primary_10_1016_j_exer_2024_110216 crossref_primary_10_1080_13813455_2020_1733026 crossref_primary_10_1016_j_aquaculture_2021_737017 crossref_primary_10_3389_fphar_2021_578796 crossref_primary_10_3390_ijms21072427 crossref_primary_10_1002_adfm_202101611 crossref_primary_10_1016_j_molmet_2022_101515 crossref_primary_10_1016_j_atherosclerosis_2020_08_016 crossref_primary_10_12729_jbtr_2025_26_2_47 crossref_primary_10_1016_j_freeradbiomed_2022_03_019 crossref_primary_10_1016_j_tifs_2024_104677 crossref_primary_10_1016_j_envpol_2023_121911 crossref_primary_10_3390_nu11040794 crossref_primary_10_3389_fphar_2024_1344276 crossref_primary_10_1007_s12291_022_01105_0 crossref_primary_10_1007_s12011_019_01821_4 crossref_primary_10_3390_nu9040345 crossref_primary_10_1080_01913123_2022_2060395 crossref_primary_10_1080_15376516_2021_1941462 crossref_primary_10_3390_antiox11112274 crossref_primary_10_3390_ijms18040843 crossref_primary_10_1007_s00592_022_01883_2 crossref_primary_10_1002_ddr_21811 crossref_primary_10_1007_s13659_022_00347_y crossref_primary_10_1111_andr_12764 crossref_primary_10_1108_NFS_11_2020_0437 crossref_primary_10_1016_j_ajpath_2020_03_009 crossref_primary_10_1530_JOE_18_0131 crossref_primary_10_3390_ijerph19148276 crossref_primary_10_1016_j_ccr_2024_215942 crossref_primary_10_1016_j_jep_2024_117931 crossref_primary_10_2147_DMSO_S412747 crossref_primary_10_3390_antiox10081220 crossref_primary_10_1161_CIRCULATIONAHA_118_037398 crossref_primary_10_1111_jre_12570 crossref_primary_10_2147_DMSO_S286888 crossref_primary_10_3390_antiox8060169 crossref_primary_10_1016_j_biopha_2023_115236 crossref_primary_10_1080_07435800_2025_2511845 crossref_primary_10_1080_21655979_2021_2001911 crossref_primary_10_3390_molecules24091801 crossref_primary_10_3390_nu12072050 crossref_primary_10_3390_ijms22126530 crossref_primary_10_4274_BMB_galenos_2025_47955 crossref_primary_10_1080_14786419_2025_2478654 crossref_primary_10_1016_j_fct_2021_112124 crossref_primary_10_1038_s41598_025_89642_5 crossref_primary_10_3390_antiox12020249 crossref_primary_10_1038_s41598_023_44814_z crossref_primary_10_1016_j_orcp_2020_06_005 crossref_primary_10_1038_s41598_021_00108_w crossref_primary_10_1038_s41387_017_0009_6 crossref_primary_10_1007_s10068_018_00553_w crossref_primary_10_1016_j_ecoenv_2024_116364 crossref_primary_10_3390_ijms20153737 crossref_primary_10_1016_j_snb_2017_09_099 crossref_primary_10_3390_antiox13040400 crossref_primary_10_3892_mmr_2024_13256 crossref_primary_10_1016_j_carbpol_2022_120011 crossref_primary_10_1016_j_intimp_2025_114431 crossref_primary_10_1038_ejcn_2017_45 crossref_primary_10_1016_j_ijbiomac_2024_130175 crossref_primary_10_3390_ph17091135 crossref_primary_10_3389_fphar_2019_00909 crossref_primary_10_1209_0295_5075_acd80c crossref_primary_10_1016_j_sjbs_2021_06_063 crossref_primary_10_1111_jdi_13576 crossref_primary_10_3390_biomedicines9111645 crossref_primary_10_1111_1440_1681_13547 crossref_primary_10_1002_advs_202307342 crossref_primary_10_1016_j_intimp_2023_110747 crossref_primary_10_3390_nu10070948 crossref_primary_10_1089_dna_2019_5097 crossref_primary_10_3390_molecules25173970 crossref_primary_10_1016_j_foodres_2021_110414 crossref_primary_10_1089_ars_2021_0100 crossref_primary_10_3390_phycology5030036 crossref_primary_10_3390_antiox11040784 crossref_primary_10_1016_j_bbagen_2023_130538 crossref_primary_10_1016_j_rvsc_2023_105114 crossref_primary_10_1016_j_cej_2024_158962 crossref_primary_10_1177_17448069241252654 crossref_primary_10_1007_s13258_022_01250_z crossref_primary_10_3390_ijms21197062 crossref_primary_10_1016_j_freeradbiomed_2021_08_233 crossref_primary_10_1155_2019_9582714 crossref_primary_10_1016_j_mce_2019_04_013 crossref_primary_10_1590_0001_3765202120201925 crossref_primary_10_1080_13813455_2024_2406904 crossref_primary_10_1016_j_lfs_2019_116796 crossref_primary_10_1007_s40200_021_00803_5 crossref_primary_10_1080_13543784_2020_1716216 crossref_primary_10_1155_2021_3314871 crossref_primary_10_2337_db21_0706 crossref_primary_10_1016_j_toxicon_2024_107724 crossref_primary_10_3389_fcvm_2021_649785 crossref_primary_10_1016_j_biopha_2020_111017 crossref_primary_10_3390_ijms18020413 crossref_primary_10_1016_j_bjorl_2022_02_004 crossref_primary_10_1002_jcp_27755 crossref_primary_10_46897_livestockstudies_1703717 crossref_primary_10_7717_peerj_8604 crossref_primary_10_3390_nu15245050 crossref_primary_10_1016_j_yexcr_2022_113340 crossref_primary_10_1039_C8FO02550A crossref_primary_10_1111_jpn_13328 crossref_primary_10_3389_fnut_2022_798708 crossref_primary_10_1080_10520295_2021_1954691 crossref_primary_10_1016_j_biopha_2019_108684 crossref_primary_10_1016_j_jep_2017_12_018 crossref_primary_10_1007_s11239_017_1594_x crossref_primary_10_1002_jcb_26089 crossref_primary_10_1016_j_freeradbiomed_2018_09_039 crossref_primary_10_1016_j_thromres_2017_04_018 crossref_primary_10_1007_s00726_023_03342_w crossref_primary_10_1016_j_jdiacomp_2020_107693 crossref_primary_10_1371_journal_pone_0199505 crossref_primary_10_1016_j_ecoenv_2021_112598 crossref_primary_10_1016_j_diabres_2018_07_007 crossref_primary_10_1016_j_scitotenv_2020_138821 crossref_primary_10_1016_j_apjtm_2017_10_017 crossref_primary_10_1080_10408398_2020_1822277 crossref_primary_10_3390_ijerph19127524 crossref_primary_10_1016_j_bbadis_2023_167007 crossref_primary_10_1016_j_bbrc_2018_04_027 crossref_primary_10_1210_clinem_dgad403 crossref_primary_10_1155_2018_8359013 crossref_primary_10_3390_antiox11122321 crossref_primary_10_1155_2022_4043105 crossref_primary_10_26599_FMH_2025_9420074 crossref_primary_10_3390_molecules30030505 crossref_primary_10_3390_ani13142300 crossref_primary_10_3390_molecules27092632 crossref_primary_10_3389_fphys_2021_700055 crossref_primary_10_1155_2020_7453406 crossref_primary_10_1038_s41419_021_03407_2 crossref_primary_10_3390_gidisord2040035 crossref_primary_10_1136_bmjopen_2024_092714 crossref_primary_10_3389_fphar_2023_1062664 crossref_primary_10_1097_CM9_0000000000000006 crossref_primary_10_3390_molecules27217612 crossref_primary_10_3390_ijms25010227 crossref_primary_10_1016_j_bbrc_2025_151825 crossref_primary_10_1016_j_jaim_2024_101038 crossref_primary_10_1371_journal_pone_0204173 crossref_primary_10_1111_ijfs_13597 crossref_primary_10_1038_s41598_020_79106_3 crossref_primary_10_3390_antiox9010022 crossref_primary_10_1002_cbf_3735 crossref_primary_10_1016_j_fsi_2023_108828 crossref_primary_10_1088_1742_6596_1655_1_012110 crossref_primary_10_1371_journal_pone_0187434 crossref_primary_10_3390_biomedicines9101437 crossref_primary_10_3390_jpm11020070 crossref_primary_10_1089_thy_2018_0549 crossref_primary_10_3389_fcvm_2021_703355 crossref_primary_10_3389_fmars_2023_1076870 crossref_primary_10_2337_db18_0223 crossref_primary_10_3390_antiox9080659 crossref_primary_10_1016_j_heliyon_2023_e21676 crossref_primary_10_3389_fphar_2022_984499 crossref_primary_10_1111_jcmm_17686 crossref_primary_10_1016_j_aquatox_2024_107003 crossref_primary_10_1016_j_drup_2018_11_001 crossref_primary_10_1016_j_colsurfb_2019_04_033 crossref_primary_10_1016_j_yexcr_2017_03_050 crossref_primary_10_1016_j_freeradbiomed_2020_06_014 crossref_primary_10_1371_journal_pone_0331077 crossref_primary_10_1016_j_intimp_2022_109323 crossref_primary_10_3390_antiox8060162 crossref_primary_10_3390_molecules26030631 crossref_primary_10_1016_j_fct_2023_114156 crossref_primary_10_1016_j_jep_2023_117255 crossref_primary_10_1002_jbio_202300198 crossref_primary_10_3390_obesities5030056 crossref_primary_10_3390_antiox14060731 crossref_primary_10_1111_and_14195 crossref_primary_10_1016_j_ijbiomac_2020_08_006 crossref_primary_10_1016_j_mcp_2020_101527 crossref_primary_10_3390_pharmaceutics12080708 crossref_primary_10_3390_antiox13010014 crossref_primary_10_1007_s11356_018_3265_7 crossref_primary_10_1016_j_jsps_2024_102106 crossref_primary_10_1007_s00210_020_02000_2 crossref_primary_10_3389_fphys_2022_707176 crossref_primary_10_1016_j_snb_2022_133253 crossref_primary_10_1016_j_fbio_2024_105644 crossref_primary_10_1155_2020_8396708 crossref_primary_10_1134_S0006350922040200 crossref_primary_10_1002_cbdv_202403059 crossref_primary_10_1111_jfb_15158 crossref_primary_10_1186_s12885_024_12511_3 crossref_primary_10_1016_j_sciaf_2024_e02419 crossref_primary_10_3390_cells12091223 crossref_primary_10_1186_s12929_017_0379_z crossref_primary_10_1016_j_indcrop_2019_111641 crossref_primary_10_1002_wsbm_1462 crossref_primary_10_1016_j_chroma_2024_464757 crossref_primary_10_1038_s41598_025_97578_z crossref_primary_10_3390_nu15234904 crossref_primary_10_1007_s11356_022_19876_7 crossref_primary_10_1039_C8FO01492B crossref_primary_10_59556_japi_73_0795 crossref_primary_10_1016_j_biopha_2021_111849 crossref_primary_10_1016_j_lfs_2019_117011 crossref_primary_10_1210_clinem_dgad634 crossref_primary_10_1002_pro_3425 crossref_primary_10_1016_j_lfs_2023_121612 crossref_primary_10_1007_s40122_020_00200_5 crossref_primary_10_1155_2022_9196232 crossref_primary_10_1007_s10787_021_00799_7 crossref_primary_10_1016_j_biopha_2020_110555 crossref_primary_10_1371_journal_pone_0321509 crossref_primary_10_2174_1570180819666220816115506 crossref_primary_10_1016_j_freeradbiomed_2022_09_031 crossref_primary_10_1002_fft2_399 crossref_primary_10_1016_j_fct_2018_12_040 crossref_primary_10_1016_j_heliyon_2024_e38505 crossref_primary_10_2174_1570180819666220616145558 crossref_primary_10_3390_cells10112841 crossref_primary_10_1002_jbt_22904 crossref_primary_10_3390_ijms241813833 crossref_primary_10_1136_bmjdrc_2020_002039 crossref_primary_10_1016_j_ijbiomac_2023_127126 crossref_primary_10_1039_D3FO05076A crossref_primary_10_1177_02676591211059901 crossref_primary_10_3389_fendo_2024_1440456 crossref_primary_10_3390_molecules29112597 crossref_primary_10_3390_plants10061103 crossref_primary_10_1016_j_lfs_2022_121326 crossref_primary_10_3390_cells11193060 crossref_primary_10_1016_j_ccr_2024_215672 crossref_primary_10_1002_tox_22901 crossref_primary_10_3390_cells10071763 crossref_primary_10_3390_antiox12010062 crossref_primary_10_1016_j_intimp_2020_106339 crossref_primary_10_1016_j_ceramint_2024_10_182 crossref_primary_10_1007_s00705_019_04406_7 crossref_primary_10_1016_j_ejps_2021_106013 crossref_primary_10_1093_micmic_ozad102 crossref_primary_10_3892_etm_2022_11338 crossref_primary_10_1016_j_fbio_2021_101473 crossref_primary_10_5812_ijpr_135315 crossref_primary_10_1080_10408398_2022_2025574 crossref_primary_10_33808_clinexphealthsci_1369239 crossref_primary_10_1088_1755_1315_948_1_012078 crossref_primary_10_1080_17512433_2017_1293521 crossref_primary_10_3390_antiox10050758 crossref_primary_10_3390_ijms21218108 crossref_primary_10_3390_medicina57101028 crossref_primary_10_1186_s12986_019_0335_x crossref_primary_10_1016_j_jep_2020_113641 crossref_primary_10_3390_nu13103575 crossref_primary_10_1016_j_biopha_2017_06_023 crossref_primary_10_1080_13880209_2021_1912117 crossref_primary_10_1016_j_mito_2020_11_011 crossref_primary_10_1016_j_phrs_2021_105783 crossref_primary_10_2903_sp_efsa_2024_EN_8661 crossref_primary_10_3390_antiox12111976 crossref_primary_10_1007_s10067_017_3746_y crossref_primary_10_1155_2022_7278064 crossref_primary_10_1016_j_neulet_2021_135845 crossref_primary_10_3389_fneur_2024_1344000 crossref_primary_10_1016_j_biopha_2023_115544 crossref_primary_10_1186_s13287_020_01700_z crossref_primary_10_1016_j_brainres_2022_148012 crossref_primary_10_1016_j_lfs_2020_117416 crossref_primary_10_1371_journal_pone_0281496 crossref_primary_10_3390_cimb46090619 crossref_primary_10_1007_s12011_022_03288_2 crossref_primary_10_1016_j_cca_2020_02_024 crossref_primary_10_1371_journal_pone_0311502 crossref_primary_10_1016_j_ecoenv_2021_112185 crossref_primary_10_1039_D0RA00343C crossref_primary_10_1371_journal_pone_0311501 crossref_primary_10_1016_j_ijbiomac_2021_01_197 crossref_primary_10_3390_ijms22147688 crossref_primary_10_1016_j_jep_2024_117718 crossref_primary_10_1017_S0967199420000520 crossref_primary_10_1089_ars_2017_7168 crossref_primary_10_1016_j_niox_2025_02_003 crossref_primary_10_1007_s11655_021_3309_6 crossref_primary_10_1186_s13765_021_00628_z crossref_primary_10_1016_j_freeradbiomed_2020_10_003 crossref_primary_10_3390_nu13020362 crossref_primary_10_1016_j_phymed_2022_154022 crossref_primary_10_3390_mps4040073 crossref_primary_10_1016_j_jep_2020_113667 crossref_primary_10_1016_j_mad_2023_111798 crossref_primary_10_3390_cancers13030576 crossref_primary_10_3390_foods10081854 crossref_primary_10_3390_antiox11071326 crossref_primary_10_1002_2211_5463_12370 crossref_primary_10_3389_fendo_2023_1076343 crossref_primary_10_3389_fphar_2018_00912 crossref_primary_10_2147_DDDT_S275336 crossref_primary_10_1016_j_intimp_2023_111423 crossref_primary_10_1155_2017_1378175 crossref_primary_10_3390_nu9070778 crossref_primary_10_1371_journal_pone_0271598 crossref_primary_10_1155_2021_6621568 crossref_primary_10_1007_s43450_023_00410_w crossref_primary_10_1007_s10753_020_01370_2 crossref_primary_10_1039_D4TB01778A crossref_primary_10_1080_15321819_2024_2312812 crossref_primary_10_3390_ijerph18020511 crossref_primary_10_1016_j_ecoenv_2021_113138 crossref_primary_10_3390_nu13103344 crossref_primary_10_1097_GME_0000000000001149 crossref_primary_10_1016_j_apsusc_2022_155622 crossref_primary_10_1155_2024_8520489 crossref_primary_10_1515_biol_2022_0974 |
| ContentType | Journal Article |
| Copyright | 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society. |
| Copyright_xml | – notice: 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society. |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1042/bcj20160503c |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Chemistry |
| EISSN | 1470-8728 |
| ExternalDocumentID | 27941030 |
| Genre | Journal Article Review |
| GroupedDBID | --- -DZ -~X 0R~ 23N 2WC 4.4 53G 5GY 5RE 6J9 79B A8Z AABGO AAHRG ABJNI ABPPZ ABRJW ACGFO ACGFS ACNCT ADBBV AEGXH AENEX AIAGR AIZAD ALMA_UNASSIGNED_HOLDINGS BAWUL CGR CS3 CUY CVF DU5 E3Z EBD EBS ECM EIF EJD EMOBN F5P H13 HH6 HZ~ K-O L7B ML- MV1 N9A NPM NTEUP O9- OK1 P2P RHI RNS RPM RPO SV3 TR2 TWZ WH7 XSW Y6R YNY ~02 ~KM 7X8 ESTFP |
| ID | FETCH-LOGICAL-c357t-e6a9a31340105c1b38e307b8c3a0dc1e9a7b8827a61a231c43af01844a4d8bb92 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 687 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000393762900002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1470-8728 |
| IngestDate | Mon Sep 08 06:42:08 EDT 2025 Wed Feb 19 02:42:17 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 24 |
| Keywords | insulin action metabolism insulin secretion oxidative stress pancreatic β cells reactive oxygen species |
| Language | English |
| License | 2016 The Author(s); published by Portland Press Limited on behalf of the Biochemical Society. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c357t-e6a9a31340105c1b38e307b8c3a0dc1e9a7b8827a61a231c43af01844a4d8bb92 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 |
| PMID | 27941030 |
| PQID | 1852661767 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1852661767 pubmed_primary_27941030 |
| PublicationCentury | 2000 |
| PublicationDate | 2016-12-15 |
| PublicationDateYYYYMMDD | 2016-12-15 |
| PublicationDate_xml | – month: 12 year: 2016 text: 2016-12-15 day: 15 |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | Biochemical journal |
| PublicationTitleAlternate | Biochem J |
| PublicationYear | 2016 |
| SSID | ssj0014040 |
| Score | 2.6745281 |
| SecondaryResourceType | review_article |
| Snippet | Oxidative stress and chronic inflammation are known to be associated with the development of metabolic diseases, including diabetes. Oxidative stress, an... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 4527 |
| SubjectTerms | Animals Diabetes Mellitus - metabolism Humans Insulin - metabolism Insulin-Secreting Cells - metabolism Oxidative Stress - physiology Reactive Oxygen Species - metabolism |
| Title | Molecular mechanisms of ROS production and oxidative stress in diabetes |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27941030 https://www.proquest.com/docview/1852661767 |
| Volume | 473 |
| WOSCitedRecordID | wos000393762900002&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFA7qBH3xsnmZNyKIb8UkzZrmSWZxirg5vLG3kqYp9GHttFP033vSC3sSBF8CeQi0J-ecnPuH0FnCaSIiD7wTpojDXa4dySgsMvKIBofFK1EUXu_FaORPJnJcB9yKuqyy0Ymloo5zbWPkF7bJF94S4YnL2ZtjUaNsdrWG0FhGLRdMGcvVYrLIInBSNURyQUDqmV8XvgOfXlwFd8wOV-sRN_jduCwfmcHmfz9vC23U5iXuV_ywjZZM1kadfgau9fQbn-Oy4LOMpLfRWtCAvXXQzbCBycVTY5uB02Ja4DzBjw9PeFZNhYUbxCqLcf6VxuW4cFw1muA0w00Idwe9DK6fg1unxlhwtNsTc8d4SiqgHbdImZpGrm9A6iNfu4rEmhqpYOMzoTyqwBTU3FUJAa-QKx77USTZLlrJ8szsI8y0FLHkRoGFwn1JpXC18SPKiJFCe6SLThvShfB3NjGhMpN_FOGCeF20V9E_nFXDNkIGCsNCoR384fQhWreXaqtNaO8ItRKQYHOMVvXnPC3eT0rmgHU0Hv4AtpDCOQ |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Molecular+mechanisms+of+ROS+production+and+oxidative+stress+in+diabetes&rft.jtitle=Biochemical+journal&rft.au=Newsholme%2C+Philip&rft.au=Cruzat%2C+Vinicius+Fernandes&rft.au=Keane%2C+Kevin+Noel&rft.au=Carlessi%2C+Rodrigo&rft.date=2016-12-15&rft.issn=1470-8728&rft.eissn=1470-8728&rft.volume=473&rft.issue=24&rft.spage=4527&rft_id=info:doi/10.1042%2FBCJ20160503C&rft.externalDBID=NO_FULL_TEXT |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1470-8728&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1470-8728&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1470-8728&client=summon |