Identification and risk assessment of human and veterinary antibiotics in the wastewater treatment plants and the adjacent sea in Tunisia

In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UP...

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Veröffentlicht in:	Water science and technology Jg. 76; H. 11; S. 3000 - 3021
Hauptverfasser:	Tahrani, Leyla, Van Loco, Joris, Anthonissen, Roel, Verschaeve, Luc, Ben Mansour, Hedi, Reyns, Tim
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England IWA Publishing 01.12.2017
Schlagworte:	Animals Anti-Bacterial Agents - chemistry Antibiotics Assaying Batteries Chromatography Chromatography, Liquid - methods Drugs Ecosystems Genotoxicity Hepatocellular carcinoma Hepatocytes Human performance Humans Hypoxis Liquid chromatography Liver Liver cancer Mass spectrometry Mass spectroscopy Mediterranean Sea Metabolites Methods Neoplasms Organic compounds Pharmaceutical industry Power plants Quinolones Risk Assessment Salmonella Salmonella Typhimurium Scientific imaging Sulfonamides Tandem Mass Spectrometry - methods Tetracyclines Toxicity Tunisia Veterinary Drugs Veterinary medicine Waste Disposal Facilities Waste Disposal, Fluid Waste Water - analysis Wastewater Wastewater treatment Wastewater treatment plants Water Pollutants, Chemical - chemistry Water treatment
ISSN:	0273-1223, 1996-9732
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Abstract	In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples collected from four wastewater treatment plants and five coasts in Tunisia. Results showed the presence of high concentrations of antibiotics that ranged from 0.1 to 646 ng mL−1, which can induce many negative impacts on health and the environment. For this reason, we have opted to evaluate toxicity of wastewater samples using a battery of biotests. In fact, genotoxicity was assessed using three tests: Vitotox, comet and micronucleus assays. The input and output of wastewater treatment plants induced a strongly genotoxic effect on the Salmonella typhimurium TA104 prokaryotic Vitotox assay. This result was confirmed using the comet and the micronucleus assays performed on the human liver hepatocellular carcinoma cells. The genotoxic power of the tested wastewater treatment plants' samples could be attributed to the presence of the higher quantities of antibiotics that are detected in these samples and to the antibiotic and organic compound cocktails.
AbstractList	In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples collected from four wastewater treatment plants and five coasts in Tunisia. Results showed the presence of high concentrations of antibiotics that ranged from 0.1 to 646 ng mL , which can induce many negative impacts on health and the environment. For this reason, we have opted to evaluate toxicity of wastewater samples using a battery of biotests. In fact, genotoxicity was assessed using three tests: Vitotox, comet and micronucleus assays. The input and output of wastewater treatment plants induced a strongly genotoxic effect on the Salmonella typhimurium TA104 prokaryotic Vitotox assay. This result was confirmed using the comet and the micronucleus assays performed on the human liver hepatocellular carcinoma cells. The genotoxic power of the tested wastewater treatment plants' samples could be attributed to the presence of the higher quantities of antibiotics that are detected in these samples and to the antibiotic and organic compound cocktails. In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples collected from four wastewater treatment plants and five coasts in Tunisia. Results showed the presence of high concentrations of antibiotics that ranged from 0.1 to 646 ng mL-1, which can induce many negative impacts on health and the environment. For this reason, we have opted to evaluate toxicity of wastewater samples using a battery of biotests. In fact, genotoxicity was assessed using three tests: Vitotox, comet and micronucleus assays. The input and output of wastewater treatment plants induced a strongly genotoxic effect on the Salmonella typhimurium TA104 prokaryotic Vitotox assay. This result was confirmed using the comet and the micronucleus assays performed on the human liver hepatocellular carcinoma cells. The genotoxic power of the tested wastewater treatment plants' samples could be attributed to the presence of the higher quantities of antibiotics that are detected in these samples and to the antibiotic and organic compound cocktails.In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples collected from four wastewater treatment plants and five coasts in Tunisia. Results showed the presence of high concentrations of antibiotics that ranged from 0.1 to 646 ng mL-1, which can induce many negative impacts on health and the environment. For this reason, we have opted to evaluate toxicity of wastewater samples using a battery of biotests. In fact, genotoxicity was assessed using three tests: Vitotox, comet and micronucleus assays. The input and output of wastewater treatment plants induced a strongly genotoxic effect on the Salmonella typhimurium TA104 prokaryotic Vitotox assay. This result was confirmed using the comet and the micronucleus assays performed on the human liver hepatocellular carcinoma cells. The genotoxic power of the tested wastewater treatment plants' samples could be attributed to the presence of the higher quantities of antibiotics that are detected in these samples and to the antibiotic and organic compound cocktails. In the following study, we came up with and validated a prompt, sensitive and precise method for the simultaneous determination of 56 antimicrobial drugs (tetracyclines, sulfonamides, β-lactams, macrolides and quinolones) using the ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS). This method was implemented with success to determine antibiotics in samples collected from four wastewater treatment plants and five coasts in Tunisia. Results showed the presence of high concentrations of antibiotics that ranged from 0.1 to 646 ng mL−1, which can induce many negative impacts on health and the environment. For this reason, we have opted to evaluate toxicity of wastewater samples using a battery of biotests. In fact, genotoxicity was assessed using three tests: Vitotox, comet and micronucleus assays. The input and output of wastewater treatment plants induced a strongly genotoxic effect on the Salmonella typhimurium TA104 prokaryotic Vitotox assay. This result was confirmed using the comet and the micronucleus assays performed on the human liver hepatocellular carcinoma cells. The genotoxic power of the tested wastewater treatment plants' samples could be attributed to the presence of the higher quantities of antibiotics that are detected in these samples and to the antibiotic and organic compound cocktails.
Author	Verschaeve, Luc Reyns, Tim Van Loco, Joris Tahrani, Leyla Ben Mansour, Hedi Anthonissen, Roel
Author_xml	– sequence: 1 givenname: Leyla surname: Tahrani fullname: Tahrani, Leyla organization: Research Unit of Analysis and Process Applied to the Environment-APAE UR17ES32 Higher Institute of Applied Sciences and Technology, University of Monastir, Mahdia 5100, Tunisia, Laboratory of Chemical Residues and Contaminants, Direction of Food Medicines and Consumer Safety, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, Brussels 1050, Belgium, Laboratory of Toxicology, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, Brussels 1050, Belgium – sequence: 2 givenname: Joris surname: Van Loco fullname: Van Loco, Joris organization: Laboratory of Chemical Residues and Contaminants, Direction of Food Medicines and Consumer Safety, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, Brussels 1050, Belgium – sequence: 3 givenname: Roel surname: Anthonissen fullname: Anthonissen, Roel organization: Laboratory of Toxicology, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, Brussels 1050, Belgium – sequence: 4 givenname: Luc surname: Verschaeve fullname: Verschaeve, Luc organization: Laboratory of Toxicology, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, Brussels 1050, Belgium, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium – sequence: 5 givenname: Hedi surname: Ben Mansour fullname: Ben Mansour, Hedi organization: Research Unit of Analysis and Process Applied to the Environment-APAE UR17ES32 Higher Institute of Applied Sciences and Technology, University of Monastir, Mahdia 5100, Tunisia – sequence: 6 givenname: Tim surname: Reyns fullname: Reyns, Tim organization: Laboratory of Chemical Residues and Contaminants, Direction of Food Medicines and Consumer Safety, Scientific Institute of Public Health, Juliette Wytsmanstraat 14, Brussels 1050, Belgium
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SubjectTerms	Animals Anti-Bacterial Agents - chemistry Antibiotics Assaying Batteries Chromatography Chromatography, Liquid - methods Drugs Ecosystems Genotoxicity Hepatocellular carcinoma Hepatocytes Human performance Humans Hypoxis Liquid chromatography Liver Liver cancer Mass spectrometry Mass spectroscopy Mediterranean Sea Metabolites Methods Neoplasms Organic compounds Pharmaceutical industry Power plants Quinolones Risk Assessment Salmonella Salmonella Typhimurium Scientific imaging Sulfonamides Tandem Mass Spectrometry - methods Tetracyclines Toxicity Tunisia Veterinary Drugs Veterinary medicine Waste Disposal Facilities Waste Disposal, Fluid Waste Water - analysis Wastewater Wastewater treatment Wastewater treatment plants Water Pollutants, Chemical - chemistry Water treatment
Title	Identification and risk assessment of human and veterinary antibiotics in the wastewater treatment plants and the adjacent sea in Tunisia
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