AIM2-driven inflammasome activation in heart failure

Abstract Aims Interleukin-1β (IL-1β) is an important pathogenic factor in cardiovascular diseases including chronic heart failure (HF). The CANTOS trial highlighted that inflammasomes as primary sources of IL-1 β are promising new therapeutic targets in cardiovascular diseases. Therefore, we aimed t...

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Bibliographic Details
Published in:	Cardiovascular research Vol. 117; no. 13; pp. 2639 - 2651
Main Authors:	Onódi, Zsófia, Ruppert, Mihály, Kucsera, Dániel, Sayour, Alex Ali, Tóth, Viktória E, Koncsos, Gábor, Novák, Julianna, Brenner, Gábor B, Makkos, András, Baranyai, Tamás, Giricz, Zoltán, Görbe, Anikó, Leszek, Przemyslaw, Gyöngyösi, Mariann, Horváth, Iván G, Schulz, Rainer, Merkely, Béla, Ferdinandy, Péter, Radovits, Tamás, Varga, Zoltán V
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 22.11.2021
Subjects:	Adolescent Adult Aged Animals Calcium-Binding Proteins - genetics Calcium-Binding Proteins - immunology Calcium-Binding Proteins - metabolism CARD Signaling Adaptor Proteins - genetics CARD Signaling Adaptor Proteins - immunology CARD Signaling Adaptor Proteins - metabolism Case-Control Studies Connexins - antagonists & inhibitors Connexins - metabolism Disease Models, Animal DNA-Binding Proteins - genetics DNA-Binding Proteins - immunology DNA-Binding Proteins - metabolism Female Heart Failure - drug therapy Heart Failure - immunology Heart Failure - metabolism Heart Failure - physiopathology Humans Inflammasomes - immunology Inflammasomes - metabolism Male Middle Aged Myocytes, Cardiac - drug effects Myocytes, Cardiac - immunology Myocytes, Cardiac - metabolism Nerve Tissue Proteins - antagonists & inhibitors Nerve Tissue Proteins - metabolism Probenecid - pharmacology Rats Rats, Wistar Receptors, Cell Surface - genetics Receptors, Cell Surface - immunology Receptors, Cell Surface - metabolism Signal Transduction Sus scrofa THP-1 Cells Ventricular Function, Left Young Adult Heart failure Drug repurposing Inflammation Canakinumab Cardiomyopathy Probenecid
ISSN:	0008-6363, 1755-3245, 1755-3245
Online Access:	Get full text
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