Fibrous scaffolds fabricated by emulsion electrospinning: from hosting capacity to in vivo biocompatibility

Electrospinning is a versatile method for preparing functional three-dimensional scaffolds. Synthetic and natural polymers have been used to produce micro- and nanofibers that mimic extracellular matrices. Here, we describe the use of emulsion electrospinning to prepare blended fibers capable of hos...

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Published in:Nanoscale Vol. 8; no. 17; p. 9293
Main Authors: Spano, F, Quarta, A, Martelli, C, Ottobrini, L, Rossi, R M, Gigli, G, Blasi, L
Format: Journal Article
Language:English
Published: England 01.01.2016
ISSN:2040-3372, 2040-3372
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Abstract Electrospinning is a versatile method for preparing functional three-dimensional scaffolds. Synthetic and natural polymers have been used to produce micro- and nanofibers that mimic extracellular matrices. Here, we describe the use of emulsion electrospinning to prepare blended fibers capable of hosting aqueous species and releasing them in solution. The existence of an aqueous and a non-aqueous phase allows water-soluble molecules to be introduced without altering the structure and the degradation of the fibers, and means that their release properties under physiological conditions can be controlled. To demonstrate the loading capability and flexibility of the blend, various species were introduced, from magnetic nanoparticles and quantum rods to biological molecules. Cellular studies showed the spontaneous adhesion and alignment of cells along the fibers. Finally, in vivo experiments demonstrated the high biocompatibility and safety of the scaffolds up to 21 days post-implantation.
AbstractList Electrospinning is a versatile method for preparing functional three-dimensional scaffolds. Synthetic and natural polymers have been used to produce micro- and nanofibers that mimic extracellular matrices. Here, we describe the use of emulsion electrospinning to prepare blended fibers capable of hosting aqueous species and releasing them in solution. The existence of an aqueous and a non-aqueous phase allows water-soluble molecules to be introduced without altering the structure and the degradation of the fibers, and means that their release properties under physiological conditions can be controlled. To demonstrate the loading capability and flexibility of the blend, various species were introduced, from magnetic nanoparticles and quantum rods to biological molecules. Cellular studies showed the spontaneous adhesion and alignment of cells along the fibers. Finally, in vivo experiments demonstrated the high biocompatibility and safety of the scaffolds up to 21 days post-implantation.Electrospinning is a versatile method for preparing functional three-dimensional scaffolds. Synthetic and natural polymers have been used to produce micro- and nanofibers that mimic extracellular matrices. Here, we describe the use of emulsion electrospinning to prepare blended fibers capable of hosting aqueous species and releasing them in solution. The existence of an aqueous and a non-aqueous phase allows water-soluble molecules to be introduced without altering the structure and the degradation of the fibers, and means that their release properties under physiological conditions can be controlled. To demonstrate the loading capability and flexibility of the blend, various species were introduced, from magnetic nanoparticles and quantum rods to biological molecules. Cellular studies showed the spontaneous adhesion and alignment of cells along the fibers. Finally, in vivo experiments demonstrated the high biocompatibility and safety of the scaffolds up to 21 days post-implantation.
Electrospinning is a versatile method for preparing functional three-dimensional scaffolds. Synthetic and natural polymers have been used to produce micro- and nanofibers that mimic extracellular matrices. Here, we describe the use of emulsion electrospinning to prepare blended fibers capable of hosting aqueous species and releasing them in solution. The existence of an aqueous and a non-aqueous phase allows water-soluble molecules to be introduced without altering the structure and the degradation of the fibers, and means that their release properties under physiological conditions can be controlled. To demonstrate the loading capability and flexibility of the blend, various species were introduced, from magnetic nanoparticles and quantum rods to biological molecules. Cellular studies showed the spontaneous adhesion and alignment of cells along the fibers. Finally, in vivo experiments demonstrated the high biocompatibility and safety of the scaffolds up to 21 days post-implantation.
Author Rossi, R M
Blasi, L
Gigli, G
Martelli, C
Spano, F
Quarta, A
Ottobrini, L
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  surname: Spano
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  organization: Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Protection and Physiology, Lerchenfeldstrasse 5, CH-9014 St. Gallen, Switzerland and Center for Biomolecular Nanotechnologies (CBN) @UNILE, Istituto Italiano di Tecnologia (IIT), Via Barsanti, 73010 Arnesano (LE), Lecce, Italy
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  surname: Quarta
  fullname: Quarta, A
  email: alessandra.quarta@nanotec.cnr.it
  organization: Nanotechnology Institute (CNR-NANOTEC), Via Monteroni, 73100, Lecce, Italy. alessandra.quarta@nanotec.cnr.it
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  surname: Martelli
  fullname: Martelli, C
  organization: Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy
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  surname: Ottobrini
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  organization: Department of Pathophysiology and Transplantation, University of Milan, Milan, Italy and Institute of Molecular Bioimaging and Physiology (IBFM), National Researches Council (CNR), Segrate, Milan, Italy
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  email: alessandra.quarta@nanotec.cnr.it
  organization: Nanotechnology Institute (CNR-NANOTEC), Via Monteroni, 73100, Lecce, Italy. alessandra.quarta@nanotec.cnr.it
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  fullname: Blasi, L
  email: alessandra.quarta@nanotec.cnr.it
  organization: Center for Biomolecular Nanotechnologies (CBN) @UNILE, Istituto Italiano di Tecnologia (IIT), Via Barsanti, 73010 Arnesano (LE), Lecce, Italy and Nanotechnology Institute (CNR-NANOTEC), Via Monteroni, 73100, Lecce, Italy. alessandra.quarta@nanotec.cnr.it
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