Protease activated receptor 4 limits bacterial growth and lung pathology during late stage Streptococcus pneumoniae induced pneumonia in mice

Streptococcus pneumoniae is a common causative pathogen of pneumonia and sepsis. Pneumonia and sepsis are associated with enhanced activation of coagulation, resulting in the production of several host-derived proteases at the primary site of infection and in the circulation. Serine proteases cleave...

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Bibliographic Details
Published in:	Thrombosis and haemostasis Vol. 110; no. 3; p. 582
Main Authors:	de Stoppelaar, S F, Van't Veer, C, van den Boogaard, F E, Nieuwland, R, Hoogendijk, A J, de Boer, O J, Roelofs, J J T H, van der Poll, T
Format:	Journal Article
Language:	English
Published:	Germany 01.09.2013
Subjects:	Animals Blood Platelets - metabolism Cytokines - metabolism Disease Models, Animal Humans Inflammation Liver - microbiology Lung - microbiology Lung - pathology Mice Mice, Inbred C57BL Mice, Transgenic Peptides - chemistry Pneumonia, Pneumococcal - metabolism Pneumonia, Pneumococcal - microbiology Pneumonia, Pneumococcal - pathology Receptors, Thrombin - metabolism Sepsis - metabolism Spleen - microbiology Stem Cells Streptococcus pneumoniae - growth & development Time Factors
ISSN:	0340-6245, 2567-689X, 2567-689X
Online Access:	Get more information
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