Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops

Abstract Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis, therapy resistance and metastasis. Radiobiological hypoxia (<0.1% O2) is one of the few physiologically relevant stresses that activates both the replication stress/DNA damage response and the unfo...

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Bibliographic Details

Published in:	Nucleic acids research Vol. 51; no. 21; pp. 11584 - 11599
Main Authors:	Ma, Tiffany S, Worth, Katja R, Maher, Conor, Ng, Natalie, Beghè, Chiara, Gromak, Natalia, Rose, Anna M, Hammond, Ester M
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 27.11.2023
Subjects:	DNA, Ribosomal - genetics DNA, Ribosomal - metabolism Humans R-Loop Structures Reactive Oxygen Species - metabolism RNA Polymerase I - metabolism Transcription, Genetic Tumor Hypoxia
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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