Hypoxia-induced transcriptional stress is mediated by ROS-induced R-loops

Abstract Hypoxia is a common feature of solid tumors and is associated with poor patient prognosis, therapy resistance and metastasis. Radiobiological hypoxia (<0.1% O2) is one of the few physiologically relevant stresses that activates both the replication stress/DNA damage response and the unfo...

Ausführliche Beschreibung

Bibliographische Detailangaben

Veröffentlicht in:	Nucleic acids research Jg. 51; H. 21; S. 11584 - 11599
Hauptverfasser:	Ma, Tiffany S, Worth, Katja R, Maher, Conor, Ng, Natalie, Beghè, Chiara, Gromak, Natalia, Rose, Anna M, Hammond, Ester M
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	England Oxford University Press 27.11.2023
Schlagworte:	DNA, Ribosomal - genetics DNA, Ribosomal - metabolism Humans R-Loop Structures Reactive Oxygen Species - metabolism RNA Polymerase I - metabolism Transcription, Genetic Tumor Hypoxia
ISSN:	0305-1048, 1362-4962, 1362-4962
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!