Physiologically-Based Pharmacokinetic Predictions of the Effect of Curcumin on Metabolism of Imatinib and Bosutinib: In Vitro and In Vivo Disconnect

Purpose This study aimed to investigate the potential pharmacokinetic interactions between curcumin, imatinib and bosutinib, combining In Vitro and in silico methods. Methods In Vitro metabolism of imatinib and bosutinib were investigated in pooled human liver microsomes and recombinant CYP3A4 enzym...

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Bibliographic Details
Published in:	Pharmaceutical research Vol. 37; no. 7; p. 128
Main Authors:	Adiwidjaja, Jeffry, Boddy, Alan V, McLachlan, Andrew J
Format:	Journal Article
Language:	English
Published:	New York Springer US 01.07.2020 Springer Springer Nature B.V
Subjects:	Analysis Aniline Compounds - metabolism Bioavailability Biochemistry Biomedical and Life Sciences Biomedical Engineering and Bioengineering Biomedicine Bosutinib Chromatography, High Pressure Liquid Curcumin Curcumin - analogs & derivatives Curcumin - metabolism Curcumin - pharmacokinetics Cytochrome P-450 CYP2C8 - metabolism Cytochrome P-450 CYP3A - metabolism Cytochrome P-450 Enzyme Inhibitors - pharmacokinetics Cytochrome P450 Demethylation Drug Interactions Enzymes Glucuronides - metabolism Humans Hydroxylation Imatinib Imatinib Mesylate - metabolism Inhibitor drugs Liver Medical Law Metabolism Metabolites Microsomes Microsomes, Liver - metabolism Models, Biological Models, Molecular Nanoparticles Nitriles - metabolism Paclitaxel Paclitaxel - metabolism Pharmacokinetics Pharmacology/Toxicology Pharmacy Quinolines - metabolism Research Paper Simulation methods Tandem Mass Spectrometry physiologically-based pharmacokinetic (PBPK) imatinib modelling and simulation natural product-drug interactions bosutinib curcumin
ISSN:	0724-8741, 1573-904X, 1573-904X
Online Access:	Get full text
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