IFNγ‐mediated repression of system xc− drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells

IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in regulating tumor cell proliferation and apoptosis. However, few studies have examined its role in cell ferroptosis. Here, we found that IFNγ tr...

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Bibliographic Details
Published in:	Journal of leukocyte biology Vol. 110; no. 2; pp. 301 - 314
Main Authors:	Kong, Rui, Wang, Nan, Han, Wei, Bao, Wen, Lu, Jie
Format:	Journal Article
Language:	English
Published:	Bethesda Oxford University Press 01.08.2021
Subjects:	Apoptosis Cancer Cancer therapies CD8 antigen Cell cycle cell ferroptosis Cell proliferation Ferroptosis G1 phase Glutathione Hepatocellular carcinoma IFNγ JAK/STAT pathway Lipid peroxidation Lipids Liver cancer Lymphocytes Lymphocytes T Membrane potential mRNA Natural killer cells Peroxidation Reactive oxygen species system xc Transforming growth factor-b1 Tumor cell lines γ-Interferon
ISSN:	0741-5400, 1938-3673, 1938-3673
Online Access:	Get full text
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