IFNγ‐mediated repression of system xc− drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells
IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in regulating tumor cell proliferation and apoptosis. However, few studies have examined its role in cell ferroptosis. Here, we found that IFNγ tr...
Uloženo v:
| Vydáno v: | Journal of leukocyte biology Ročník 110; číslo 2; s. 301 - 314 |
|---|---|
| Hlavní autoři: | , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
Bethesda
Oxford University Press
01.08.2021
|
| Témata: | |
| ISSN: | 0741-5400, 1938-3673, 1938-3673 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in regulating tumor cell proliferation and apoptosis. However, few studies have examined its role in cell ferroptosis. Here, we found that IFNγ treatment enhanced glutathione depletion, promoted cell cycle arrested in G0/G1 phase, increased lipid peroxidation, and sensitized cells to ferroptosis activators. Additionally, IFNγ down‐regulated the mRNA and protein levels of SLC3A2 and SLC7A11, two subunits of the glutamate‐cystine antiporter system xc− via activating the JAK/STAT pathway in hepatocellular carcinoma (HCC) cell lines. Furthermore, IFNγ increased reactive oxygen species levels and decreased mitochondiral membrane potential in Bel7402 and HepG2 cells. These changes were accompanied by decreased system xc− activity. Cancer cells exposed to TGFβ1 for 48 h showed sensitization to IFNγ + erastin‐induced ferroptosis, with decreased system xc− expression. In conclusion, IFNγ repressed system xc− activation via activating JAK/STAT signaling. Additionally, enhanced lipid peroxidation was associated with altered mitochondrial function in HCC cells. Our findings identified a role for IFNγ in sensitizing HCC cells to ferroptosis, which provided new insights for applying IFNγ as a cancer treatment.
Graphical
Shows IFN gamma is an effective modulator in inhibiting EMT‐associated growth of HCC via inducing ferroptosis, providing new insight into the use of IFN gamma for cancer treatment. |
|---|---|
| AbstractList | IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in regulating tumor cell proliferation and apoptosis. However, few studies have examined its role in cell ferroptosis. Here, we found that IFNγ treatment enhanced glutathione depletion, promoted cell cycle arrested in G0/G1 phase, increased lipid peroxidation, and sensitized cells to ferroptosis activators. Additionally, IFNγ down-regulated the mRNA and protein levels of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc− via activating the JAK/STAT pathway in hepatocellular carcinoma (HCC) cell lines. Furthermore, IFNγ increased reactive oxygen species levels and decreased mitochondiral membrane potential in Bel7402 and HepG2 cells. These changes were accompanied by decreased system xc− activity. Cancer cells exposed to TGFβ1 for 48 h showed sensitization to IFNγ + erastin-induced ferroptosis, with decreased system xc− expression. In conclusion, IFNγ repressed system xc− activation via activating JAK/STAT signaling. Additionally, enhanced lipid peroxidation was associated with altered mitochondrial function in HCC cells. Our findings identified a role for IFNγ in sensitizing HCC cells to ferroptosis, which provided new insights for applying IFNγ as a cancer treatment. IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in regulating tumor cell proliferation and apoptosis. However, few studies have examined its role in cell ferroptosis. Here, we found that IFNγ treatment enhanced glutathione depletion, promoted cell cycle arrested in G0/G1 phase, increased lipid peroxidation, and sensitized cells to ferroptosis activators. Additionally, IFNγ down-regulated the mRNA and protein levels of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc− via activating the JAK/STAT pathway in hepatocellular carcinoma (HCC) cell lines. Furthermore, IFNγ increased reactive oxygen species levels and decreased mitochondiral membrane potential in Bel7402 and HepG2 cells. These changes were accompanied by decreased system xc− activity. Cancer cells exposed to TGFβ1 for 48 h showed sensitization to IFNγ + erastin-induced ferroptosis, with decreased system xc− expression. In conclusion, IFNγ repressed system xc− activation via activating JAK/STAT signaling. Additionally, enhanced lipid peroxidation was associated with altered mitochondrial function in HCC cells. Our findings identified a role for IFNγ in sensitizing HCC cells to ferroptosis, which provided new insights for applying IFNγ as a cancer treatment. IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in regulating tumor cell proliferation and apoptosis. However, few studies have examined its role in cell ferroptosis. Here, we found that IFNγ treatment enhanced glutathione depletion, promoted cell cycle arrested in G0/G1 phase, increased lipid peroxidation, and sensitized cells to ferroptosis activators. Additionally, IFNγ down‐regulated the mRNA and protein levels of SLC3A2 and SLC7A11, two subunits of the glutamate‐cystine antiporter system xc− via activating the JAK/STAT pathway in hepatocellular carcinoma (HCC) cell lines. Furthermore, IFNγ increased reactive oxygen species levels and decreased mitochondiral membrane potential in Bel7402 and HepG2 cells. These changes were accompanied by decreased system xc− activity. Cancer cells exposed to TGFβ1 for 48 h showed sensitization to IFNγ + erastin‐induced ferroptosis, with decreased system xc− expression. In conclusion, IFNγ repressed system xc− activation via activating JAK/STAT signaling. Additionally, enhanced lipid peroxidation was associated with altered mitochondrial function in HCC cells. Our findings identified a role for IFNγ in sensitizing HCC cells to ferroptosis, which provided new insights for applying IFNγ as a cancer treatment. Graphical Shows IFN gamma is an effective modulator in inhibiting EMT‐associated growth of HCC via inducing ferroptosis, providing new insight into the use of IFN gamma for cancer treatment. IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in regulating tumor cell proliferation and apoptosis. However, few studies have examined its role in cell ferroptosis. Here, we found that IFNγ treatment enhanced glutathione depletion, promoted cell cycle arrested in G0/G1 phase, increased lipid peroxidation, and sensitized cells to ferroptosis activators. Additionally, IFNγ down-regulated the mRNA and protein levels of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc- via activating the JAK/STAT pathway in hepatocellular carcinoma (HCC) cell lines. Furthermore, IFNγ increased reactive oxygen species levels and decreased mitochondiral membrane potential in Bel7402 and HepG2 cells. These changes were accompanied by decreased system xc- activity. Cancer cells exposed to TGFβ1 for 48 h showed sensitization to IFNγ + erastin-induced ferroptosis, with decreased system xc- expression. In conclusion, IFNγ repressed system xc- activation via activating JAK/STAT signaling. Additionally, enhanced lipid peroxidation was associated with altered mitochondrial function in HCC cells. Our findings identified a role for IFNγ in sensitizing HCC cells to ferroptosis, which provided new insights for applying IFNγ as a cancer treatment.IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in regulating tumor cell proliferation and apoptosis. However, few studies have examined its role in cell ferroptosis. Here, we found that IFNγ treatment enhanced glutathione depletion, promoted cell cycle arrested in G0/G1 phase, increased lipid peroxidation, and sensitized cells to ferroptosis activators. Additionally, IFNγ down-regulated the mRNA and protein levels of SLC3A2 and SLC7A11, two subunits of the glutamate-cystine antiporter system xc- via activating the JAK/STAT pathway in hepatocellular carcinoma (HCC) cell lines. Furthermore, IFNγ increased reactive oxygen species levels and decreased mitochondiral membrane potential in Bel7402 and HepG2 cells. These changes were accompanied by decreased system xc- activity. Cancer cells exposed to TGFβ1 for 48 h showed sensitization to IFNγ + erastin-induced ferroptosis, with decreased system xc- expression. In conclusion, IFNγ repressed system xc- activation via activating JAK/STAT signaling. Additionally, enhanced lipid peroxidation was associated with altered mitochondrial function in HCC cells. Our findings identified a role for IFNγ in sensitizing HCC cells to ferroptosis, which provided new insights for applying IFNγ as a cancer treatment. |
| Author | Han, Wei Bao, Wen Wang, Nan Lu, Jie Kong, Rui |
| Author_xml | – sequence: 1 givenname: Rui surname: Kong fullname: Kong, Rui organization: Tongji University – sequence: 2 givenname: Nan surname: Wang fullname: Wang, Nan organization: Tongji University – sequence: 3 givenname: Wei surname: Han fullname: Han, Wei organization: Tongji University – sequence: 4 givenname: Wen surname: Bao fullname: Bao, Wen organization: Tongji University – sequence: 5 givenname: Jie surname: Lu fullname: Lu, Jie email: kennisren@hotmail.com organization: Tongji University |
| BookMark | eNqNkcFu1DAURS1UJKaFH2BliQ2blGc7cZJlqSgUTVtpBGvL2C_CVRIH22nJjiVLxK_0P_oR_RI8mll1gbry09U9z1fvHpKD0Y9IyGsGxwyAv_u8fn8sLk4Y51A0rNpsNs_IirWiKYSsxQFZQV2yoioBXpDDGK8BQHAJK7Kcn13e3z38-jOgdTqhpQGngDE6P1Lf0bjEhAP9aR5-_6U2uBuM9GbuRwz6m-tdWmjy1I12NhntMAQ_JR9dzBr9jpNO3mDfz70O1Ohg3OgHTbdSfEmed7qP-Gr_HpGvZx--nH4q1lcfz09P1oURVc0LaSwTRlsrJK-BVyCF1IJhk-MbjsyUYCzWwkrTStRaGkDshO3y3PLSiCPydrd3Cv7HjDGpwcVtAj2in6PiVVW1NW-hytY3j6zXfg5jTqcEL5sGGG_L7Gp2LhN8jAE7ZVzSKR8sBe16xUBtO1G5E7XvRO06ySh_hE7BDTos_4f2_926HpcnEFuJQdtw8Q9K-qfa |
| CitedBy_id | crossref_primary_10_1016_j_bbcan_2022_188848 crossref_primary_10_1016_j_intimp_2024_113416 crossref_primary_10_3892_or_2022_8308 crossref_primary_10_1016_j_cej_2025_162041 crossref_primary_10_1016_j_redox_2025_103788 crossref_primary_10_1038_s41392_024_02088_5 crossref_primary_10_1016_j_intimp_2024_113539 crossref_primary_10_3389_fimmu_2025_1524711 crossref_primary_10_1007_s12072_023_10593_y crossref_primary_10_3389_fimmu_2024_1511015 crossref_primary_10_1016_j_bbamcr_2022_119328 crossref_primary_10_1016_j_envpol_2025_126395 crossref_primary_10_1186_s12915_024_01931_z crossref_primary_10_3390_biom14111443 crossref_primary_10_3389_fimmu_2023_1294317 crossref_primary_10_3389_fonc_2023_1084289 crossref_primary_10_1007_s11864_024_01279_0 crossref_primary_10_3389_fonc_2024_1360638 crossref_primary_10_3390_cells11203301 crossref_primary_10_3390_biom13050820 crossref_primary_10_3389_fmolb_2022_1027912 crossref_primary_10_1007_s12032_024_02317_5 crossref_primary_10_3390_ijms23168862 crossref_primary_10_1038_s41420_024_02257_z crossref_primary_10_3390_cancers17091470 crossref_primary_10_1155_2022_3568597 crossref_primary_10_3390_immuno2010014 crossref_primary_10_7555_JBR_37_20230224 crossref_primary_10_1007_s10495_024_01997_8 crossref_primary_10_1007_s11010_024_04983_5 crossref_primary_10_1038_s41598_022_17510_7 crossref_primary_10_1002_prm2_12090 crossref_primary_10_3390_biology14030253 crossref_primary_10_1016_j_biopha_2023_115419 crossref_primary_10_3390_antiox13030298 crossref_primary_10_1186_s12985_024_02462_3 crossref_primary_10_3389_fimmu_2022_877634 crossref_primary_10_1016_j_bcp_2022_115241 crossref_primary_10_1186_s12951_024_02808_7 crossref_primary_10_1038_s41420_023_01407_z crossref_primary_10_3892_ijmm_2024_5480 crossref_primary_10_3389_fimmu_2025_1604652 crossref_primary_10_3892_or_2022_8430 crossref_primary_10_3389_fvets_2025_1611661 crossref_primary_10_1007_s12672_024_01573_1 crossref_primary_10_1016_j_cellimm_2023_104774 crossref_primary_10_1038_s41419_023_05716_0 crossref_primary_10_3389_fphar_2024_1474285 crossref_primary_10_3748_wjg_v29_i4_616 crossref_primary_10_1016_j_ejmech_2022_114861 crossref_primary_10_1016_j_lfs_2024_123279 crossref_primary_10_1038_s41392_024_01769_5 crossref_primary_10_1016_j_biopha_2023_115251 crossref_primary_10_1016_j_biopha_2024_116227 crossref_primary_10_1007_s11684_023_0992_z crossref_primary_10_1038_s41418_022_00941_0 crossref_primary_10_1016_j_intimp_2025_114683 crossref_primary_10_1186_s40164_023_00427_w crossref_primary_10_1002_ctm2_70253 crossref_primary_10_1002_mco2_70116 crossref_primary_10_1038_s41420_024_02116_x crossref_primary_10_1002_mco2_70349 crossref_primary_10_1016_j_bbcan_2025_189400 crossref_primary_10_2147_JIR_S347955 crossref_primary_10_3389_fendo_2022_991178 crossref_primary_10_1016_j_bbcan_2022_188797 crossref_primary_10_1080_17425247_2024_2379937 crossref_primary_10_1038_s41401_025_01548_0 crossref_primary_10_1016_j_critrevonc_2025_104907 crossref_primary_10_3389_fimmu_2025_1534926 crossref_primary_10_3389_fimmu_2023_1255443 crossref_primary_10_1186_s12894_024_01472_1 crossref_primary_10_1186_s12935_023_03207_y crossref_primary_10_1016_j_critrevonc_2024_104349 crossref_primary_10_1016_j_cej_2024_156050 crossref_primary_10_1016_j_biopha_2022_113711 crossref_primary_10_1186_s13046_023_02925_5 crossref_primary_10_3389_fimmu_2023_1120519 crossref_primary_10_1111_jcmm_18524 crossref_primary_10_1038_s41420_025_02415_x crossref_primary_10_3389_fcell_2025_1522873 |
| Cites_doi | 10.1007/s11010-015-2412-4 10.1016/j.cyto.2017.05.024 10.3389/fimmu.2019.01253 10.1038/35074122 10.3389/fimmu.2018.00014 10.4049/jimmunol.181.4.2446 10.1016/j.cell.2013.12.010 10.1038/nchembio.2238 10.1016/j.cell.2019.06.014 10.1074/jbc.M104516200 10.1038/nature14344 10.1016/S1535-6108(03)00050-3 10.1016/j.chembiol.2008.02.010 10.1016/S0891-5849(02)01360-6 10.7554/eLife.02523 10.1038/ni1576 10.1038/s41467-018-06487-5 10.1111/1759-7714.13207 10.1038/nature23007 10.1021/acschembio.5b00245 10.1007/s00005-014-0293-y 10.1158/0008-5472.CAN-19-0596 10.1101/cshperspect.a028480 10.1158/0008-5472.CAN-12-1187 10.1038/ni.2523 10.1016/j.bmcl.2012.01.035 10.1021/ja411006a 10.3389/fimmu.2018.00847 10.1161/CIRCULATIONAHA.117.030423 10.1146/annurev-immunol-031210-101324 10.3892/ijmm.2013.1563 10.1053/j.gastro.2017.06.017 10.1016/j.canlet.2015.07.044 10.1073/pnas.1922600117 10.1016/j.canlet.2011.09.031 10.3389/fonc.2015.00131 10.1038/s41419-019-1897-2 10.1016/j.cell.2012.03.042 10.1002/ijc.28311 10.1158/0008-5472.CAN-10-3232 10.1038/nature14468 10.1038/sj.leu.2402238 10.1038/s41586-018-0597-x |
| ContentType | Journal Article |
| Copyright | 2021 Society for Leukocyte Biology 2021 Society for Leukocyte Biology. |
| Copyright_xml | – notice: 2021 Society for Leukocyte Biology – notice: 2021 Society for Leukocyte Biology. |
| DBID | AAYXX CITATION 7QL 7T5 7T7 7U9 8FD C1K FR3 H94 M7N P64 7X8 |
| DOI | 10.1002/JLB.3MA1220-815RRR |
| DatabaseName | CrossRef Bacteriology Abstracts (Microbiology B) Immunology Abstracts Industrial and Applied Microbiology Abstracts (Microbiology A) Virology and AIDS Abstracts Technology Research Database Environmental Sciences and Pollution Management Engineering Research Database AIDS and Cancer Research Abstracts Algology Mycology and Protozoology Abstracts (Microbiology C) Biotechnology and BioEngineering Abstracts MEDLINE - Academic |
| DatabaseTitle | CrossRef Virology and AIDS Abstracts Technology Research Database Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) AIDS and Cancer Research Abstracts Immunology Abstracts Engineering Research Database Industrial and Applied Microbiology Abstracts (Microbiology A) Biotechnology and BioEngineering Abstracts Environmental Sciences and Pollution Management MEDLINE - Academic |
| DatabaseTitleList | Virology and AIDS Abstracts CrossRef MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Anatomy & Physiology Biology |
| EISSN | 1938-3673 |
| EndPage | 314 |
| ExternalDocumentID | 10_1002_JLB_3MA1220_815RRR JLB10982 |
| Genre | reviewArticle |
| GroupedDBID | --- .GJ 0R~ 0VX 18M 1OB 1OC 29K 2WC 33P 4.4 53G 5GY 5RE 5WD AABZA AACZT AAHHS AAPGJ AAPXW AARHZ AASGY AAUAY AAVAP AAWDT AAXRX AAZKR ABCUV ABDFA ABEFU ABEJV ABJNI ABLJU ABMNT ABNHQ ABPQP ABPTD ABWST ABXVV ACAHQ ACCFJ ACCZN ACFRR ACGFO ACGFS ACPOU ACPRK ACUTJ ACXBN ACXQS ACZBC ADBBV ADIPN ADKYN ADOZA ADQBN ADVEK ADVOB ADXAS ADZMN AEEZP AENEX AEQDE AFFNX AFGWE AFRAH AFYAG AGMDO AGQXC AHMMS AI. AIURR AIWBW AJAOE AJBDE AJEEA ALMA_UNASSIGNED_HOLDINGS ALUQN AMYDB ANFBD APJGH ATGXG AVNTJ BCRHZ C45 CS3 D-I DCZOG DRFUL DRSTM DU5 E3Z EBS EJD EMOBN F5P F9R GX1 H13 HZ~ K-O KOP L7B LATKE LEEKS LUTES LYRES O9- OBOKY OCZFY OJZSN OK1 OPAEJ OVD OWPYF P2P P2W RHI RJQFR ROL ROX SJN SUPJJ TCN TEORI TMA TR2 TSL VH1 W8F WOHZO WOQ YHG ZGI ZXP ZZTAW AAMMB AAYXX ABGNP ABVGC ABXZS ADGKP ADNBA AEFGJ AGXDD AIDQK AIDYY AJBYB AJNCP ALXQX CITATION 7QL 7T5 7T7 7U9 8FD AGORE C1K FR3 H94 M7N P64 7X8 |
| ID | FETCH-LOGICAL-c3572-6cd13cadd36270250636a31e8260c2e1c40cde73d6c96eaa6c0eef3dfeaa924c3 |
| IEDL.DBID | DRFUL |
| ISICitedReferencesCount | 114 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000678130500010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0741-5400 1938-3673 |
| IngestDate | Sun Sep 28 09:07:03 EDT 2025 Fri Sep 12 16:40:45 EDT 2025 Tue Nov 18 22:13:39 EST 2025 Sat Nov 29 01:45:08 EST 2025 Wed Jan 22 16:28:36 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| License | https://academic.oup.com/pages/standard-publication-reuse-rights |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3572-6cd13cadd36270250636a31e8260c2e1c40cde73d6c96eaa6c0eef3dfeaa924c3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| PQID | 3248801294 |
| PQPubID | 2046249 |
| PageCount | 14 |
| ParticipantIDs | proquest_miscellaneous_2555972905 proquest_journals_3248801294 crossref_citationtrail_10_1002_JLB_3MA1220_815RRR crossref_primary_10_1002_JLB_3MA1220_815RRR wiley_primary_10_1002_JLB_3MA1220_815RRR_JLB10982 |
| PublicationCentury | 2000 |
| PublicationDate | August 2021 |
| PublicationDateYYYYMMDD | 2021-08-01 |
| PublicationDate_xml | – month: 08 year: 2021 text: August 2021 |
| PublicationDecade | 2020 |
| PublicationPlace | Bethesda |
| PublicationPlace_xml | – name: Bethesda |
| PublicationTitle | Journal of leukocyte biology |
| PublicationYear | 2021 |
| Publisher | Oxford University Press |
| Publisher_xml | – name: Oxford University Press |
| References | 2018; 562 2015; 5 2015; 523 2019; 11 2015; 520 2019; 10 2019; 79 2013; 126 2015; 10 2008; 9 2008; 15 2015; 405 2017; 153 2016; 380 2014; 62 2012; 149 2014; 136 2014; 156 2003; 34 2008; 181 2001; 276 2012; 72 2001; 410 2017; 97 2018; 9 2001; 61 2013; 14 2014; 3 2011; 71 2017; 13 2018; 137 2013; 133 2003; 3 2020; 117 2001; 15 2012; 314 2011; 29 2012; 22 2019; 178 2014; 33 2017; 547 Jiang (2023032108483600900_) 2015; 520 Nakajima (2023032108483600900_) 2001; 61 Gout (2023032108483600900_) 2001; 15 Moreno (2023032108483600900_) 2008; 181 Kagan (2023032108483600900_) 2017; 13 Mikami (2023032108483600900_) 2020; 117 Alspach (2023032108483600900_) 2019; 11 Lüth (2023032108483600900_) 2011; 71 Dixon (2023032108483600900_) 2015; 10 Shankaran (2023032108483600900_) 2001; 410 Showalter (2023032108483600900_) 2017; 97 Dixon (2023032108483600900_) 2014; 3 Troyano (2023032108483600900_) 2001; 276 Wang (2023032108483600900_) 2019; 10 Viswanathan (2023032108483600900_) 2017; 547 Durgeau (2023032108483600900_) 2018; 9 Mittrücker (2023032108483600900_) 2014; 62 Yant (2023032108483600900_) 2003; 34 Kim (2023032108483600900_) 2018; 9 Dixon (2023032108483600900_) 2012; 149 Germain (2023032108483600900_) 2012; 22 Yarilina (2023032108483600900_) 2008; 9 Yang (2023032108483600900_) 2014; 156 Dolma (2023032108483600900_) 2003; 3 Castro (2023032108483600900_) 2018; 9 Zhou (2023032108483600900_) 2017; 153 Vredevoogd (2023032108483600900_) 2019; 178 Lee (2023032108483600900_) 2013; 133 Song (2023032108483600900_) 2019; 79 Li (2023032108483600900_) 2012; 314 Schott (2023032108483600900_) 2015; 5 Yang (2023032108483600900_) 2008; 15 Linher-Melville (2023032108483600900_) 2015; 405 Camicia (2023032108483600900_) 2013; 126 Motaghed (2023032108483600900_) 2014; 33 Sun (2023032108483600900_) 2016; 380 McKinney (2023032108483600900_) 2015; 523 Piaszyk-Borychowska (2023032108483600900_) 2019; 10 Mucida (2023032108483600900_) 2013; 14 Bi (2023032108483600900_) 2019; 10 Zhang (2023032108483600900_) 2018; 137 Peng (2023032108483600900_) 2012; 72 Skouta (2023032108483600900_) 2014; 136 Vesely (2023032108483600900_) 2011; 29 Song (2023032108483600900_) 2018; 562 |
| References_xml | – volume: 9 start-page: 14 year: 2018 article-title: Recent advances in targeting CD8 T‐cell immunity for more effective cancer immunotherapy publication-title: Front Immunol – volume: 10 start-page: 1604 year: 2015 end-page: 1609 article-title: Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death publication-title: ACS Chem Biol – volume: 97 start-page: 123 year: 2017 end-page: 132 article-title: Cytokines in immunogenic cell death: applications for cancer immunotherapy publication-title: Cytokine – volume: 10 start-page: 682 year: 2019 article-title: Metadherin enhances vulnerability of cancer cells to ferroptosis publication-title: Cell Death Dis – volume: 5 start-page: 131 year: 2015 article-title: Oncogenic RAS mutants confer resistance of RMS13 rhabdomyosarcoma cells to oxidative stress‐induced ferroptotic cell death publication-title: Front Oncol – volume: 136 start-page: 4551 year: 2014 end-page: 4556 article-title: Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models publication-title: J Am Chem Soc – volume: 79 start-page: 3737 year: 2019 end-page: 3748 article-title: Low‐dose IFNγ induces tumor cell stemness in tumor microenvironment of non‐small cell lung cancer publication-title: Cancer Res – volume: 181 start-page: 2446 year: 2008 end-page: 2454 article-title: IFN‐gamma‐producing human invariant NKT cells promote tumor‐associated antigen‐specific cytotoxic T cell responses publication-title: J Immunol – volume: 314 start-page: 213 year: 2012 end-page: 222 article-title: Interferon‐γ induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon‐regulatory factor‐1 (IRF‐1) publication-title: Cancer Lett – volume: 562 start-page: 423 year: 2018 end-page: 428 article-title: IRE1α‐XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity publication-title: Nature – volume: 117 start-page: 12258 year: 2020 end-page: 12268 article-title: Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation publication-title: Proc Natl Acad Sci U S A – volume: 71 start-page: 3763 year: 2011 end-page: 3771 article-title: Chronic inflammatory IFN‐γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis publication-title: Cancer Res – volume: 62 start-page: 449 year: 2014 end-page: 458 article-title: Heterogeneity in the differentiation and function of CD8 T cells publication-title: Arch Immunol Ther Exp (Warsz) – volume: 380 start-page: 205 year: 2016 end-page: 215 article-title: Tumor microenvironment and cancer therapy resistance publication-title: Cancer Lett – volume: 547 start-page: 453 year: 2017 end-page: 457 article-title: Dependency of a therapy‐resistant state of cancer cells on a lipid peroxidase pathway publication-title: Nature – volume: 126 start-page: 1969 year: 2013 end-page: 1980 article-title: BAL1/ARTD9 represses the anti‐proliferative and pro‐apoptotic IFNγ‐STAT1‐IRF1‐p53 axis in diffuse large B‐cell lymphoma publication-title: J Cell Sci – volume: 13 start-page: 81 year: 2017 end-page: 90 article-title: Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis publication-title: Nat Chem Biol – volume: 10 start-page: 1253 year: 2019 article-title: Signal integration of IFN‐I and IFN‐II with TLR4 involves sequential recruitment of STAT1‐complexes and NFκB to enhance pro‐inflammatory transcription publication-title: Front Immunol – volume: 410 start-page: 1107 year: 2001 end-page: 1111 article-title: IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity publication-title: Nature – volume: 34 start-page: 496 year: 2003 end-page: 502 article-title: The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults publication-title: Free Radic Biol Med – volume: 22 start-page: 3571 year: 2012 end-page: 3574 article-title: Identification of a selective small molecule inhibitor of breast cancer stem cells publication-title: Bioorg Med Chem Lett – volume: 14 start-page: 281 year: 2013 end-page: 289 article-title: Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II‐restricted cytotoxic T lymphocytes publication-title: Nat Immunol – volume: 9 start-page: 4184 year: 2018 article-title: GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections publication-title: Nat Commun – volume: 10 start-page: 2225 year: 2019 end-page: 2235 article-title: CD137 ligand feedback upregulates PD‐L1 expression on lung cancer via T cell production of IFN‐γ publication-title: Thorac Cancer – volume: 137 start-page: 1934 year: 2018 end-page: 1948 article-title: Inhibition of JAK‐STAT signaling suppresses pathogenic immune responses in medium and large vessel vasculitis publication-title: Circulation – volume: 3 start-page: 285 year: 2003 end-page: 296 article-title: Identification of genotype‐selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells publication-title: Cancer Cell – volume: 11 year: 2019 article-title: Interferon γ and its important roles in promoting and inhibiting spontaneous and therapeutic cancer immunity publication-title: Cold Spring Harb Perspect Biol – volume: 3 year: 2014 article-title: Pharmacological inhibition of cystine‐glutamate exchange induces endoplasmic reticulum stress and ferroptosis publication-title: Elife – volume: 523 start-page: 612 year: 2015 end-page: 616 article-title: T‐cell exhaustion, co‐stimulation and clinical outcome in autoimmunity and infection publication-title: Nature – volume: 178 start-page: 585 year: 2019 end-page: 599.e15 article-title: Augmenting immunotherapy impact by lowering tumor TNF cytotoxicity threshold publication-title: Cell – volume: 15 start-page: 234 year: 2008 end-page: 245 article-title: Synthetic lethal screening identifies compounds activating iron‐dependent, nonapoptotic cell death in oncogenic‐RAS‐harboring cancer cells publication-title: Chem Biol – volume: 149 start-page: 1060 year: 2012 end-page: 1072 article-title: Ferroptosis: an iron‐dependent form of nonapoptotic cell death publication-title: Cell – volume: 9 start-page: 847 year: 2018 article-title: Interferon‐gamma at the crossroads of tumor immune surveillance or evasion publication-title: Front Immunol – volume: 520 start-page: 57 year: 2015 end-page: 62 article-title: Ferroptosis as a p53‐mediated activity during tumour suppression publication-title: Nature – volume: 405 start-page: 205 year: 2015 end-page: 221 article-title: Signal transducer and activator of transcription 3 and 5 regulate system Xc and redox balance in human breast cancer cells publication-title: Mol Cell Biochem – volume: 156 start-page: 317 year: 2014 end-page: 331 article-title: Regulation of ferroptotic cancer cell death by GPX4 publication-title: Cell – volume: 29 start-page: 235 year: 2011 end-page: 271 article-title: Natural innate and adaptive immunity to cancer publication-title: Annu Rev Immunol – volume: 153 start-page: 1107 year: 2017 end-page: 1119.e10 article-title: Antibodies against immune checkpoint molecules restore functions of tumor‐infiltrating T cells in hepatocellular carcinomas publication-title: Gastroenterology – volume: 33 start-page: 8 year: 2014 end-page: 16 article-title: Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells publication-title: Int J Mol Med – volume: 133 start-page: 2895 year: 2013 end-page: 2902 article-title: Serum interferon gamma level predicts recurrence in hepatocellular carcinoma patients after curative treatments publication-title: Int J Cancer – volume: 72 start-page: 5209 year: 2012 end-page: 5218 article-title: PD‐1 blockade enhances T‐cell migration to tumors by elevating IFN‐γ inducible chemokines publication-title: Cancer Res – volume: 276 start-page: 47107 year: 2001 end-page: 47115 article-title: Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U‐937 human promonocytic cells. The role of intracellular oxidation publication-title: J Biol Chem – volume: 61 start-page: 3399 year: 2001 end-page: 3405 article-title: A role of interferon‐gamma (IFN‐gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN‐gamma‐deficient mice publication-title: Cancer Res – volume: 15 start-page: 1633 year: 2001 end-page: 1640 article-title: Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)‐ cystine transporter: a new action for an old drug publication-title: Leukemia – volume: 9 start-page: 378 year: 2008 end-page: 387 article-title: TNF activates an IRF1‐dependent autocrine loop leading to sustained expression of chemokines and STAT1‐dependent type I interferon‐response genes publication-title: Nat Immunol – volume: 405 start-page: 205 year: 2015 ident: 2023032108483600900_ article-title: Signal transducer and activator of transcription 3 and 5 regulate system Xc− and redox balance in human breast cancer cells publication-title: Mol Cell Biochem doi: 10.1007/s11010-015-2412-4 – volume: 97 start-page: 123 year: 2017 ident: 2023032108483600900_ article-title: Cytokines in immunogenic cell death: applications for cancer immunotherapy publication-title: Cytokine doi: 10.1016/j.cyto.2017.05.024 – volume: 10 start-page: 1253 year: 2019 ident: 2023032108483600900_ article-title: Signal integration of IFN-I and IFN-II with TLR4 involves sequential recruitment of STAT1-complexes and NFκB to enhance pro-inflammatory transcription publication-title: Front Immunol doi: 10.3389/fimmu.2019.01253 – volume: 410 start-page: 1107 year: 2001 ident: 2023032108483600900_ article-title: IFNgamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity publication-title: Nature doi: 10.1038/35074122 – volume: 9 start-page: 14 year: 2018 ident: 2023032108483600900_ article-title: Recent advances in targeting CD8 T-cell immunity for more effective cancer immunotherapy publication-title: Front Immunol doi: 10.3389/fimmu.2018.00014 – volume: 181 start-page: 2446 year: 2008 ident: 2023032108483600900_ article-title: IFN-gamma-producing human invariant NKT cells promote tumor-associated antigen-specific cytotoxic T cell responses publication-title: J Immunol doi: 10.4049/jimmunol.181.4.2446 – volume: 156 start-page: 317 year: 2014 ident: 2023032108483600900_ article-title: Regulation of ferroptotic cancer cell death by GPX4 publication-title: Cell doi: 10.1016/j.cell.2013.12.010 – volume: 13 start-page: 81 year: 2017 ident: 2023032108483600900_ article-title: Oxidized arachidonic and adrenic PEs navigate cells to ferroptosis publication-title: Nat Chem Biol doi: 10.1038/nchembio.2238 – volume: 178 start-page: 585 year: 2019 ident: 2023032108483600900_ article-title: Augmenting immunotherapy impact by lowering tumor TNF cytotoxicity threshold publication-title: Cell doi: 10.1016/j.cell.2019.06.014 – volume: 276 start-page: 47107 year: 2001 ident: 2023032108483600900_ article-title: Effect of glutathione depletion on antitumor drug toxicity (apoptosis and necrosis) in U-937 human promonocytic cells. The role of intracellular oxidation publication-title: J Biol Chem doi: 10.1074/jbc.M104516200 – volume: 520 start-page: 57 year: 2015 ident: 2023032108483600900_ article-title: Ferroptosis as a p53-mediated activity during tumour suppression publication-title: Nature doi: 10.1038/nature14344 – volume: 3 start-page: 285 year: 2003 ident: 2023032108483600900_ article-title: Identification of genotype-selective antitumor agents using synthetic lethal chemical screening in engineered human tumor cells publication-title: Cancer Cell doi: 10.1016/S1535-6108(03)00050-3 – volume: 15 start-page: 234 year: 2008 ident: 2023032108483600900_ article-title: Synthetic lethal screening identifies compounds activating iron-dependent, nonapoptotic cell death in oncogenic-RAS-harboring cancer cells publication-title: Chem Biol doi: 10.1016/j.chembiol.2008.02.010 – volume: 34 start-page: 496 year: 2003 ident: 2023032108483600900_ article-title: The selenoprotein GPX4 is essential for mouse development and protects from radiation and oxidative damage insults publication-title: Free Radic Biol Med doi: 10.1016/S0891-5849(02)01360-6 – volume: 3 start-page: e02523 year: 2014 ident: 2023032108483600900_ article-title: Pharmacological inhibition of cystine-glutamate exchange induces endoplasmic reticulum stress and ferroptosis publication-title: Elife doi: 10.7554/eLife.02523 – volume: 9 start-page: 378 year: 2008 ident: 2023032108483600900_ article-title: TNF activates an IRF1-dependent autocrine loop leading to sustained expression of chemokines and STAT1-dependent type I interferon-response genes publication-title: Nat Immunol doi: 10.1038/ni1576 – volume: 9 start-page: 4184 year: 2018 ident: 2023032108483600900_ article-title: GABAergic signaling linked to autophagy enhances host protection against intracellular bacterial infections publication-title: Nat Commun doi: 10.1038/s41467-018-06487-5 – volume: 10 start-page: 2225 year: 2019 ident: 2023032108483600900_ article-title: CD137 ligand feedback upregulates PD-L1 expression on lung cancer via T cell production of IFN-γ publication-title: Thorac Cancer doi: 10.1111/1759-7714.13207 – volume: 547 start-page: 453 year: 2017 ident: 2023032108483600900_ article-title: Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway publication-title: Nature doi: 10.1038/nature23007 – volume: 10 start-page: 1604 year: 2015 ident: 2023032108483600900_ article-title: Human haploid cell genetics reveals roles for lipid metabolism genes in nonapoptotic cell death publication-title: ACS Chem Biol doi: 10.1021/acschembio.5b00245 – volume: 62 start-page: 449 year: 2014 ident: 2023032108483600900_ article-title: Heterogeneity in the differentiation and function of CD8+ T cells publication-title: Arch Immunol Ther Exp (Warsz) doi: 10.1007/s00005-014-0293-y – volume: 79 start-page: 3737 year: 2019 ident: 2023032108483600900_ article-title: Low-dose IFNγ induces tumor cell stemness in tumor microenvironment of non-small cell lung cancer publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-19-0596 – volume: 11 start-page: a028480 year: 2019 ident: 2023032108483600900_ article-title: Interferon γ and its important roles in promoting and inhibiting spontaneous and therapeutic cancer immunity publication-title: Cold Spring Harb Perspect Biol doi: 10.1101/cshperspect.a028480 – volume: 72 start-page: 5209 year: 2012 ident: 2023032108483600900_ article-title: PD-1 blockade enhances T-cell migration to tumors by elevating IFN-γ inducible chemokines publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-12-1187 – volume: 14 start-page: 281 year: 2013 ident: 2023032108483600900_ article-title: Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes publication-title: Nat Immunol doi: 10.1038/ni.2523 – volume: 22 start-page: 3571 year: 2012 ident: 2023032108483600900_ article-title: Identification of a selective small molecule inhibitor of breast cancer stem cells publication-title: Bioorg Med Chem Lett doi: 10.1016/j.bmcl.2012.01.035 – volume: 136 start-page: 4551 year: 2014 ident: 2023032108483600900_ article-title: Ferrostatins inhibit oxidative lipid damage and cell death in diverse disease models publication-title: J Am Chem Soc doi: 10.1021/ja411006a – volume: 9 start-page: 847 year: 2018 ident: 2023032108483600900_ article-title: Interferon-gamma at the crossroads of tumor immune surveillance or evasion publication-title: Front Immunol doi: 10.3389/fimmu.2018.00847 – volume: 126 start-page: 1969 year: 2013 ident: 2023032108483600900_ article-title: BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFNγ-STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma publication-title: J Cell Sci – volume: 137 start-page: 1934 year: 2018 ident: 2023032108483600900_ article-title: Inhibition of JAK-STAT signaling suppresses pathogenic immune responses in medium and large vessel vasculitis publication-title: Circulation doi: 10.1161/CIRCULATIONAHA.117.030423 – volume: 29 start-page: 235 year: 2011 ident: 2023032108483600900_ article-title: Natural innate and adaptive immunity to cancer publication-title: Annu Rev Immunol doi: 10.1146/annurev-immunol-031210-101324 – volume: 33 start-page: 8 year: 2014 ident: 2023032108483600900_ article-title: Thymoquinone regulates gene expression levels in the estrogen metabolic and interferon pathways in MCF7 breast cancer cells publication-title: Int J Mol Med doi: 10.3892/ijmm.2013.1563 – volume: 61 start-page: 3399 year: 2001 ident: 2023032108483600900_ article-title: A role of interferon-gamma (IFN-gamma) in tumor immunity: T cells with the capacity to reject tumor cells are generated but fail to migrate to tumor sites in IFN-gamma-deficient mice publication-title: Cancer Res – volume: 153 start-page: 1107 year: 2017 ident: 2023032108483600900_ article-title: Antibodies against immune checkpoint molecules restore functions of tumor-infiltrating T cells in hepatocellular carcinomas publication-title: Gastroenterology doi: 10.1053/j.gastro.2017.06.017 – volume: 380 start-page: 205 year: 2016 ident: 2023032108483600900_ article-title: Tumor microenvironment and cancer therapy resistance publication-title: Cancer Lett doi: 10.1016/j.canlet.2015.07.044 – volume: 117 start-page: 12258 year: 2020 ident: 2023032108483600900_ article-title: Epigenetic conversion of conventional T cells into regulatory T cells by CD28 signal deprivation publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1922600117 – volume: 314 start-page: 213 year: 2012 ident: 2023032108483600900_ article-title: Interferon-γ induces autophagy with growth inhibition and cell death in human hepatocellular carcinoma (HCC) cells through interferon-regulatory factor-1 (IRF-1) publication-title: Cancer Lett doi: 10.1016/j.canlet.2011.09.031 – volume: 5 start-page: 131 year: 2015 ident: 2023032108483600900_ article-title: Oncogenic RAS mutants confer resistance of RMS13 rhabdomyosarcoma cells to oxidative stress-induced ferroptotic cell death publication-title: Front Oncol doi: 10.3389/fonc.2015.00131 – volume: 10 start-page: 682 year: 2019 ident: 2023032108483600900_ article-title: Metadherin enhances vulnerability of cancer cells to ferroptosis publication-title: Cell Death Dis doi: 10.1038/s41419-019-1897-2 – volume: 149 start-page: 1060 year: 2012 ident: 2023032108483600900_ article-title: Ferroptosis: an iron-dependent form of nonapoptotic cell death publication-title: Cell doi: 10.1016/j.cell.2012.03.042 – volume: 133 start-page: 2895 year: 2013 ident: 2023032108483600900_ article-title: Serum interferon gamma level predicts recurrence in hepatocellular carcinoma patients after curative treatments publication-title: Int J Cancer doi: 10.1002/ijc.28311 – volume: 71 start-page: 3763 year: 2011 ident: 2023032108483600900_ article-title: Chronic inflammatory IFN-γ signaling suppresses hepatocarcinogenesis in mice by sensitizing hepatocytes for apoptosis publication-title: Cancer Res doi: 10.1158/0008-5472.CAN-10-3232 – volume: 523 start-page: 612 year: 2015 ident: 2023032108483600900_ article-title: T-cell exhaustion, co-stimulation and clinical outcome in autoimmunity and infection publication-title: Nature doi: 10.1038/nature14468 – volume: 15 start-page: 1633 year: 2001 ident: 2023032108483600900_ article-title: Sulfasalazine, a potent suppressor of lymphoma growth by inhibition of the x(c)- cystine transporter: a new action for an old drug publication-title: Leukemia doi: 10.1038/sj.leu.2402238 – volume: 562 start-page: 423 year: 2018 ident: 2023032108483600900_ article-title: IRE1α-XBP1 controls T cell function in ovarian cancer by regulating mitochondrial activity publication-title: Nature doi: 10.1038/s41586-018-0597-x |
| SSID | ssj0003260 |
| Score | 2.6322432 |
| SecondaryResourceType | review_article |
| Snippet | IFNγ released from CD8+ T cells or natural killer cells plays a crucial role in antitumor host immunity. Several studies have found that IFNγ is involved in... |
| SourceID | proquest crossref wiley |
| SourceType | Aggregation Database Enrichment Source Index Database Publisher |
| StartPage | 301 |
| SubjectTerms | Apoptosis Cancer Cancer therapies CD8 antigen Cell cycle cell ferroptosis Cell proliferation Ferroptosis G1 phase Glutathione Hepatocellular carcinoma IFNγ JAK/STAT pathway Lipid peroxidation Lipids Liver cancer Lymphocytes Lymphocytes T Membrane potential mRNA Natural killer cells Peroxidation Reactive oxygen species system xc Transforming growth factor-b1 Tumor cell lines γ-Interferon |
| Title | IFNγ‐mediated repression of system xc− drives vulnerability to induced ferroptosis in hepatocellular carcinoma cells |
| URI | https://onlinelibrary.wiley.com/doi/abs/10.1002%2FJLB.3MA1220-815RRR https://www.proquest.com/docview/3248801294 https://www.proquest.com/docview/2555972905 |
| Volume | 110 |
| WOSCitedRecordID | wos000678130500010&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVWIB databaseName: Wiley Online Library Full Collection 2020 customDbUrl: eissn: 1938-3673 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0003260 issn: 0741-5400 databaseCode: DRFUL dateStart: 19970101 isFulltext: true titleUrlDefault: https://onlinelibrary.wiley.com providerName: Wiley-Blackwell |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NatwwEB6STQu9NE3S0m1-UKD0Utzox7bs4ybpkpZkKUsDezOyLJNAYgfbG7q3HnssfZW8Rx8iT9KR7N20FEIpuRnZssVoRjOfPPoG4HWufUmZER66E-r5iqFJBRwnRKV-LjKZR1y7YhNyNIomk_jTEhzOz8K0_BCLDTdrGW69tgau0nrvjjT04_H-O3EyYBzxT8SC8Xi8DCscFdjvwcrheHh6vFiRMUShLR0ns4kAtDs8g-_Z-_stfzqou6jz99jVOZ_h6sMM-xk87YJPMmi1ZQ2WTLEOG4MCgffljLwhLh3U7bOvw-O2SuVsA2YfhqOfN7dfv7tTJhihkmqePluQMictGTT5om-__SBZZXlsyfX0wtJZu8zbGWlKgtAflSgjuamq8qop6_Ma28gZesOmtH8PbDos0bayUVFeKmKb6udwOnz_-eDI6yo2eFoEknuhzpjQuGSiW5Q2ugpFqAQziGGo5oZpn-rMSJGFOg6NUqGmxqBK5HiNQFCLF9ArysK8BJIaqnLUoiBMccpiRF4p-ojMCF_JnEreBzafpkR3dOa2qsZF0hIx8wQlnXSSTlpJ9-Htos9VS-Zx79Nb89lPOsOuE4w_I-vUY78Pu4vbaJJWLKow5bROEKUhTOMxDXCQThf-4Wu2idE44q_-o88mPOE218YlJm5Br6mmZhse6evmvK52YFlOop3OKH4Bk6EP8A |
| linkProvider | Wiley-Blackwell |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1fT9RAEJ_AodEXEdB4iromxhdT2T_9-3gqF9DjYi6Q8LbZ224jCbSk7RHvzUceCV-F78GH4JMwu-0dEBNjDG_NtttuZmd25red_Q3A-0z7EWVGeOhOqOcrhiYVcJwQNfYzkUZZzLUrNhENh_H-fvJjATZnZ2Eafoj5hpu1DLdeWwO3G9IbN6yh3wafP4mdHuMIgGIWjEajRVjyUZ-CDix9HfX3BvMlGWMU2vBxMpsJQNvTM_iejT_fctdD3YSdt4NX5336y_c07qfwpA0_Sa_RlxVYMPkqrPVyhN5HU_KBuIRQt9O-Cg-bOpXTNZhu94eXF1e_z9w5E4xRSTlLoM1JkZGGDpr80len5yQtLZMtOZkcWkJrl3s7JXVBEPyjGqUkM2VZHNdFdVBhG_mJ_rAu7P8DmxBLtK1tlBdHitim6hns9Td3v2x5bc0GT4sg4l6oUyY0LproGCMbX4UiVIIZRDFUc8O0T3VqIpGGOgmNUqGmxqBSZHiNUFCL59DJi9y8ADI2VGWoR0E4xjlLEHuN0UukRvgqymjEu8Bm8yR1S2hu62ocyoaKmUuUtGwlLRtJd-HjvM9xQ-fx16fXZ9MvW9OuJEagsXXrid-Fd_PbaJRWLCo3xaSSiNMQqPGEBjhIpwz_8DXbxGgS85f_0ectPNra3RnIwfbw-yt4zG3mjUtTXIdOXU7Ma3igT-qDqnzT2sY1a_MS-A |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV3NbtQwEB6VFhAXfloQCwWMhLigtP7J73GhjSgsq2pFpd4sr2OLSm2ySrIVe-PIEfEqvAcP0Sdh7GS3ICSEELfIiRNrPOOZzxl_A_DM6jChzIgA3QkNQsXQpCKOE6KmoRVFYlOufbGJZDxOj4-zwzXYX56F6fghVhtuzjL8eu0M3MwKu3vJGvpm9HJHvBsyjgAoZdFkMrkCG2GUxWifG3uT_Gi0WpIxRqEdHydzmQC0Pz2D79n9_S2_eqjLsPPn4NV7n_zWfxr3bbjZh59k2OnLHVgz5SZsDUuE3mcL8pz4hFC_074J17o6lYstWBzk4-_fLj598edMMEYl9TKBtiSVJR0dNPmoLz5_JUXtmGzJ-fzUEVr73NsFaSuC4B_VqCDW1HU1a6vmpME28gH9YVu5_wcuIZZoV9uorM4UcU3NXTjK99-_eh30NRsCLaKEB7EumNC4aKJjTFx8FYtYCWYQxVDNDdMh1YVJRBHrLDZKxZoag0ph8RqhoBb3YL2sSnMfyNRQZVGPoniKc5Yh9pqilyiMCFViacIHwJbzJHVPaO7qapzKjoqZS5S07CUtO0kP4MWqz6yj8_jj09vL6Ze9aTcSI9DUufUsHMDT1W00SicWVZpq3kjEaQjUeEYjHKRXhr_4mmtiNEv5g3_o8wSuH-7lcnQwfvsQbnCXeOOzFLdhva3n5hFc1eftSVM_7k3jB9tKEnM |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=IFN%CE%B3-mediated+repression+of+system+xc%E2%88%92+drives+vulnerability+to+induced+ferroptosis+in+hepatocellular+carcinoma+cells&rft.jtitle=Journal+of+leukocyte+biology&rft.au=Kong%2C+Rui&rft.au=Wang%2C+Nan&rft.au=Han%2C+Wei&rft.au=Bao%2C+Wen&rft.date=2021-08-01&rft.issn=0741-5400&rft.eissn=1938-3673&rft.volume=110&rft.issue=2&rft.spage=301&rft.epage=314&rft_id=info:doi/10.1002%2FJLB.3MA1220-815RRR&rft.externalDBID=n%2Fa&rft.externalDocID=10_1002_JLB_3MA1220_815RRR |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0741-5400&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0741-5400&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0741-5400&client=summon |