Case series of omalizumab for allergic bronchopulmonary aspergillosis in cystic fibrosis patients
Summary Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first‐line therapy, but relapse and adverse effects commonly occur. Case reports have suggested the efficacy of the anti‐IgE recombinant humanized monoclonal an...
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| Published in: | Pediatric pulmonology Vol. 52; no. 2; pp. 190 - 197 |
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| Main Authors: | , , , , , , , , , , |
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01.02.2017
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| ISSN: | 8755-6863, 1099-0496, 1099-0496 |
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| Abstract | Summary
Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first‐line therapy, but relapse and adverse effects commonly occur. Case reports have suggested the efficacy of the anti‐IgE recombinant humanized monoclonal antibody omalizumab. A retrospective multicenter observational French study retrieved 32 CF patients (11 children and 21 adults) who have received omalizumab for more than 3 months in the context of ABPA. Clinical characteristics, concomitant medications (inhaled and oral corticosteroids, antifungal drugs), lung function, body mass index (BMI), and serum IgE were compared at the start and during the first year of omalizumab therapy. Omalizumab‐related adverse effects and costs were also evaluated. No significant difference with omalizumab could be demonstrated with regard to lung function, BMI, or the number of patients receiving oral corticosteroids. At the time of initiation of omalizumab, 56% of patients were receiving oral corticosteroids. Five patients were able to discontinue corticosteroids during follow‐up and nine patients were able to reduce their daily dose. A total of 78% of the patients had received antifungal therapy at the time of the initiation of omalizumab. Treatment tolerance was good (12.5% of patients experienced side effects). The median cost of omalizumab treatment was €3,620 per patient per month. Omalizumab may represent a steroid‐sparing therapy in CF patients with ABPA. A randomized‐controlled trial is urgently required to provide higher level of evidence regarding the efficacy and cost‐effectiveness of omalizumab in CF patients with ABPA. Pediatr Pulmonol. 2017;52:190–197. © 2016 Wiley Periodicals, Inc. |
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| AbstractList | Summary Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first-line therapy, but relapse and adverse effects commonly occur. Case reports have suggested the efficacy of the anti-IgE recombinant humanized monoclonal antibody omalizumab. A retrospective multicenter observational French study retrieved 32 CF patients (11 children and 21 adults) who have received omalizumab for more than 3 months in the context of ABPA. Clinical characteristics, concomitant medications (inhaled and oral corticosteroids, antifungal drugs), lung function, body mass index (BMI), and serum IgE were compared at the start and during the first year of omalizumab therapy. Omalizumab-related adverse effects and costs were also evaluated. No significant difference with omalizumab could be demonstrated with regard to lung function, BMI, or the number of patients receiving oral corticosteroids. At the time of initiation of omalizumab, 56% of patients were receiving oral corticosteroids. Five patients were able to discontinue corticosteroids during follow-up and nine patients were able to reduce their daily dose. A total of 78% of the patients had received antifungal therapy at the time of the initiation of omalizumab. Treatment tolerance was good (12.5% of patients experienced side effects). The median cost of omalizumab treatment was [euro]3,620 per patient per month. Omalizumab may represent a steroid-sparing therapy in CF patients with ABPA. A randomized-controlled trial is urgently required to provide higher level of evidence regarding the efficacy and cost-effectiveness of omalizumab in CF patients with ABPA. Pediatr Pulmonol. 2017;52:190-197. © 2016 Wiley Periodicals, Inc. Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first-line therapy, but relapse and adverse effects commonly occur. Case reports have suggested the efficacy of the anti-IgE recombinant humanized monoclonal antibody omalizumab. A retrospective multicenter observational French study retrieved 32 CF patients (11 children and 21 adults) who have received omalizumab for more than 3 months in the context of ABPA. Clinical characteristics, concomitant medications (inhaled and oral corticosteroids, antifungal drugs), lung function, body mass index (BMI), and serum IgE were compared at the start and during the first year of omalizumab therapy. Omalizumab-related adverse effects and costs were also evaluated. No significant difference with omalizumab could be demonstrated with regard to lung function, BMI, or the number of patients receiving oral corticosteroids. At the time of initiation of omalizumab, 56% of patients were receiving oral corticosteroids. Five patients were able to discontinue corticosteroids during follow-up and nine patients were able to reduce their daily dose. A total of 78% of the patients had received antifungal therapy at the time of the initiation of omalizumab. Treatment tolerance was good (12.5% of patients experienced side effects). The median cost of omalizumab treatment was €3,620 per patient per month. Omalizumab may represent a steroid-sparing therapy in CF patients with ABPA. A randomized-controlled trial is urgently required to provide higher level of evidence regarding the efficacy and cost-effectiveness of omalizumab in CF patients with ABPA. Pediatr Pulmonol. 2017;52:190-197. © 2016 Wiley Periodicals, Inc.Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first-line therapy, but relapse and adverse effects commonly occur. Case reports have suggested the efficacy of the anti-IgE recombinant humanized monoclonal antibody omalizumab. A retrospective multicenter observational French study retrieved 32 CF patients (11 children and 21 adults) who have received omalizumab for more than 3 months in the context of ABPA. Clinical characteristics, concomitant medications (inhaled and oral corticosteroids, antifungal drugs), lung function, body mass index (BMI), and serum IgE were compared at the start and during the first year of omalizumab therapy. Omalizumab-related adverse effects and costs were also evaluated. No significant difference with omalizumab could be demonstrated with regard to lung function, BMI, or the number of patients receiving oral corticosteroids. At the time of initiation of omalizumab, 56% of patients were receiving oral corticosteroids. Five patients were able to discontinue corticosteroids during follow-up and nine patients were able to reduce their daily dose. A total of 78% of the patients had received antifungal therapy at the time of the initiation of omalizumab. Treatment tolerance was good (12.5% of patients experienced side effects). The median cost of omalizumab treatment was €3,620 per patient per month. Omalizumab may represent a steroid-sparing therapy in CF patients with ABPA. A randomized-controlled trial is urgently required to provide higher level of evidence regarding the efficacy and cost-effectiveness of omalizumab in CF patients with ABPA. Pediatr Pulmonol. 2017;52:190-197. © 2016 Wiley Periodicals, Inc. Summary Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first‐line therapy, but relapse and adverse effects commonly occur. Case reports have suggested the efficacy of the anti‐IgE recombinant humanized monoclonal antibody omalizumab. A retrospective multicenter observational French study retrieved 32 CF patients (11 children and 21 adults) who have received omalizumab for more than 3 months in the context of ABPA. Clinical characteristics, concomitant medications (inhaled and oral corticosteroids, antifungal drugs), lung function, body mass index (BMI), and serum IgE were compared at the start and during the first year of omalizumab therapy. Omalizumab‐related adverse effects and costs were also evaluated. No significant difference with omalizumab could be demonstrated with regard to lung function, BMI, or the number of patients receiving oral corticosteroids. At the time of initiation of omalizumab, 56% of patients were receiving oral corticosteroids. Five patients were able to discontinue corticosteroids during follow‐up and nine patients were able to reduce their daily dose. A total of 78% of the patients had received antifungal therapy at the time of the initiation of omalizumab. Treatment tolerance was good (12.5% of patients experienced side effects). The median cost of omalizumab treatment was €3,620 per patient per month. Omalizumab may represent a steroid‐sparing therapy in CF patients with ABPA. A randomized‐controlled trial is urgently required to provide higher level of evidence regarding the efficacy and cost‐effectiveness of omalizumab in CF patients with ABPA. Pediatr Pulmonol. 2017;52:190–197. © 2016 Wiley Periodicals, Inc. Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first-line therapy, but relapse and adverse effects commonly occur. Case reports have suggested the efficacy of the anti-IgE recombinant humanized monoclonal antibody omalizumab. A retrospective multicenter observational French study retrieved 32 CF patients (11 children and 21 adults) who have received omalizumab for more than 3 months in the context of ABPA. Clinical characteristics, concomitant medications (inhaled and oral corticosteroids, antifungal drugs), lung function, body mass index (BMI), and serum IgE were compared at the start and during the first year of omalizumab therapy. Omalizumab-related adverse effects and costs were also evaluated. No significant difference with omalizumab could be demonstrated with regard to lung function, BMI, or the number of patients receiving oral corticosteroids. At the time of initiation of omalizumab, 56% of patients were receiving oral corticosteroids. Five patients were able to discontinue corticosteroids during follow-up and nine patients were able to reduce their daily dose. A total of 78% of the patients had received antifungal therapy at the time of the initiation of omalizumab. Treatment tolerance was good (12.5% of patients experienced side effects). The median cost of omalizumab treatment was €3,620 per patient per month. Omalizumab may represent a steroid-sparing therapy in CF patients with ABPA. A randomized-controlled trial is urgently required to provide higher level of evidence regarding the efficacy and cost-effectiveness of omalizumab in CF patients with ABPA. Pediatr Pulmonol. 2017;52:190-197. © 2016 Wiley Periodicals, Inc. |
| Author | Hubert, Dominique Auzou, Lila Murris‐Espin, Marlène Burgel, Pierre‐Régis Durieu, Isabelle Nové‐Josserand, Raphaële Grard, Soazic Mammar, Benyebka Reix, Philippe Brémont, François Mely, Laurent |
| Author_xml | – sequence: 1 givenname: Raphaële surname: Nové‐Josserand fullname: Nové‐Josserand, Raphaële email: raphaele.nove-josserand@chu-lyon.fr organization: University Center Hospital Lyon‐Sud – sequence: 2 givenname: Soazic surname: Grard fullname: Grard, Soazic organization: University Center Hospital Lyon‐Sud – sequence: 3 givenname: Lila surname: Auzou fullname: Auzou, Lila organization: Cochin Hospital, AP‐HP – sequence: 4 givenname: Philippe surname: Reix fullname: Reix, Philippe organization: University Center Hospital‐HFME – sequence: 5 givenname: Marlène surname: Murris‐Espin fullname: Murris‐Espin, Marlène organization: Rangueil‐Larrey University Hospital – sequence: 6 givenname: François surname: Brémont fullname: Brémont, François organization: University Center Hospital‐CF Pediatric Center – sequence: 7 givenname: Benyebka surname: Mammar fullname: Mammar, Benyebka organization: Center Hospital‐Pneumology Unit – sequence: 8 givenname: Laurent surname: Mely fullname: Mely, Laurent organization: Hospital Renée Sabran – sequence: 9 givenname: Dominique surname: Hubert fullname: Hubert, Dominique organization: Cochin Hospital, AP‐HP – sequence: 10 givenname: Isabelle surname: Durieu fullname: Durieu, Isabelle organization: University Center Hospital Lyon‐Sud – sequence: 11 givenname: Pierre‐Régis surname: Burgel fullname: Burgel, Pierre‐Régis organization: Sorbonne Paris Cité |
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| Cites_doi | 10.1513/pats.200908-086AL 10.1002/ppul.21002 10.1378/chest.115.2.364 10.1111/j.1398-9995.2009.02147.x 10.3109/13693786.2010.503665 10.1128/AAC.05077-11 10.1016/j.jcf.2005.05.019 10.1080/02770900902849871 10.1034/j.1399-3003.2000.016003464.x 10.1016/j.prrv.2012.11.004 10.1002/ppul.22937 10.1086/376525 10.1002/ppul.20907 10.1136/thoraxjnl-2012-201869 10.1067/mai.2003.1388 10.1111/j.1398-9995.2010.02522.x 10.1111/j.1398-9995.2011.02599.x 10.1007/s40265-013-0085-4 10.1136/thx.2004.035519 10.1002/ppul.20804 10.1177/1753465814547517 |
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| Keywords | corticosteroids Aspergillus fumigatus allergic bronchopulmonary aspergillosis (ABPA) immunoglobulin E IgE cystic fibrosis |
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| References | 2009; 44 2010; 65 2009; 46 2010; 48 2013; 14 2000; 16 2013; 49 2013; 73 2005; 4 2003; 37 2011; 66 2009; 102 2008; 43 2012; 17 2007; 62 2014; 8 1999; 115 2012; 56 2012; 67 2003; 111 2010; 7 2013; 9 e_1_2_5_15_1 e_1_2_5_14_1 e_1_2_5_17_1 e_1_2_5_25_1 e_1_2_5_9_1 e_1_2_5_16_1 e_1_2_5_8_1 e_1_2_5_11_1 e_1_2_5_10_1 e_1_2_5_24_1 e_1_2_5_6_1 e_1_2_5_13_1 e_1_2_5_21_1 e_1_2_5_5_1 e_1_2_5_12_1 e_1_2_5_22_1 e_1_2_5_4_1 e_1_2_5_3_1 e_1_2_5_2_1 e_1_2_5_18_1 Elmallah MK (e_1_2_5_19_1) 2012; 17 Jat KR (e_1_2_5_23_1) 2013; 9 e_1_2_5_20_1 Glackin L (e_1_2_5_7_1) 2009; 102 |
| References_xml | – volume: 111 start-page: 952 year: 2003 end-page: 957 article-title: Anti‐inflammatory effect of itraconazole in stable allergic bronchopulmonary aspergillosis: a randomized controlled trial publication-title: J Allergy Clin Immunol – volume: 67 start-page: 754 year: 2012 end-page: 756 article-title: Clinical management and outcome of refractory asthma in the UK from the British Thoracic Society Difficult Asthma Registry publication-title: Thorax – volume: 8 start-page: 141 year: 2014 end-page: 149 article-title: Omalizumab: a new treatment option for allergic bronchopulmonary aspergillosis in patients with cystic fibrosis publication-title: Ther Adv Respir Dis – volume: 102 start-page: 29 year: 2009 article-title: Voriconazole in the treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis publication-title: Ir Med J – volume: 14 start-page: 22 year: 2013 end-page: 24 article-title: Omalizumab in the management of steroid dependent allergic bronchopulmonary aspergillosis (ABPA) complicating cystic fibrosis publication-title: Paediatr Respir Rev – volume: 48 start-page: S32 year: 2010 end-page: S36 article-title: Characteristics and consequences of airway colonization by filamentous fungi in 201 adult patients with cystic fibrosis in France publication-title: Med Mycol – volume: 115 start-page: 364 year: 1999 end-page: 370 article-title: Allergic bronchopulmonary aspergillosis in cystic fibrosis: role of atopy and response to itraconazole publication-title: Chest – volume: 66 start-page: 1254 year: 2011 end-page: 1256 article-title: Allergic bronchopulmonary aspergillosis and omalizumab publication-title: Allergy – volume: 9 start-page: CD010288 year: 2013 article-title: Anti‐IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis publication-title: Cochrane Database Syst Rev – volume: 17 start-page: 88 year: 2012 end-page: 92 article-title: Management of patients with cystic fibrosis and allergic bronchopulmonary aspergillosis using anti‐immunoglobulin e therapy (omalizumab) publication-title: J Pediatr Pharmacol Ther – volume: 62 start-page: 276 year: 2007 end-page: 277 article-title: Successful treatment of allergic bronchopulmonary aspergillosis with recombinant anti‐IgE antibody publication-title: Thorax – volume: 66 start-page: 671 year: 2011 end-page: 678 article-title: Persistency of response to omalizumab therapy in severe allergic (IgE‐mediated) asthma publication-title: Allergy – volume: 56 start-page: 869 year: 2012 end-page: 874 article-title: High prevalence of azole‐resistant in adults with cystic fibrosis exposed to itraconazole publication-title: Antimicrob Agents Chemother – volume: 7 start-page: 237 year: 2010 end-page: 244 article-title: Allergic bronchopulmonary aspergillosis publication-title: Proc Am Thorac Soc – volume: 44 start-page: 516 year: 2009 article-title: Omalizumab for treatment of ABPA exacerbations in CF patients publication-title: Pediatr Pulmonol – volume: 4 start-page: 215 year: 2005 end-page: 220 article-title: Voriconazole therapy in children with cystic fibrosis publication-title: J Cyst Fibros – volume: 49 start-page: 503 year: 2013 end-page: 507 article-title: Omalizumab therapy for allergic bronchopulmonary aspergillosis in children with cystic fibrosis: a synthesis of published evidence publication-title: Pediatr Pulmonol – volume: 16 start-page: 464 year: 2000 end-page: 471 article-title: Allergic bronchopulmonary aspergillosis in cystic fibrosis publication-title: Eur Respir J – volume: 65 start-page: 134 year: 2010 end-page: 135 article-title: Steroid dependency despite omalizumab treatment of ABPA in cystic fibrosis publication-title: Allergy – volume: 37 start-page: S225 year: 2003 end-page: S264 article-title: Allergic bronchopulmonary aspergillosis in cystic fibrosis‐state of the art: cystic Fibrosis Foundation Consensus Conference publication-title: Clin Infect Dis – volume: 73 start-page: 1197 year: 2013 end-page: 1212 article-title: Omalizumab: a review of its use in patients with severe persistent allergic asthma publication-title: Drugs – volume: 43 start-page: 1249 year: 2008 end-page: 1251 article-title: Treatment of allergic bronchopulmonary aspergillosis (ABPA) in CF with anti‐IgE antibody (omalizumab) publication-title: Pediatr Pulmonol – volume: 46 start-page: 445 year: 2009 end-page: 447 article-title: Resolution of corticosteroid‐induced diabetes in allergic bronchopulmonary aspergillosis with omalizumab therapy: a novel approach publication-title: J Asthma – volume: 43 start-page: 607 year: 2008 end-page: 610 article-title: Steroid‐sparing effect of omalizumab for allergic bronchopulmonary aspergillosis and cystic fibrosis publication-title: Pediatr Pulmonol – ident: e_1_2_5_13_1 doi: 10.1513/pats.200908-086AL – ident: e_1_2_5_18_1 doi: 10.1002/ppul.21002 – ident: e_1_2_5_6_1 doi: 10.1378/chest.115.2.364 – ident: e_1_2_5_22_1 doi: 10.1111/j.1398-9995.2009.02147.x – ident: e_1_2_5_2_1 doi: 10.3109/13693786.2010.503665 – ident: e_1_2_5_9_1 doi: 10.1128/AAC.05077-11 – ident: e_1_2_5_5_1 doi: 10.1016/j.jcf.2005.05.019 – ident: e_1_2_5_17_1 doi: 10.1080/02770900902849871 – ident: e_1_2_5_4_1 doi: 10.1034/j.1399-3003.2000.016003464.x – ident: e_1_2_5_20_1 doi: 10.1016/j.prrv.2012.11.004 – volume: 9 start-page: CD010288 year: 2013 ident: e_1_2_5_23_1 article-title: Anti‐IgE therapy for allergic bronchopulmonary aspergillosis in people with cystic fibrosis publication-title: Cochrane Database Syst Rev – volume: 102 start-page: 29 year: 2009 ident: e_1_2_5_7_1 article-title: Voriconazole in the treatment of allergic bronchopulmonary aspergillosis in cystic fibrosis publication-title: Ir Med J – volume: 17 start-page: 88 year: 2012 ident: e_1_2_5_19_1 article-title: Management of patients with cystic fibrosis and allergic bronchopulmonary aspergillosis using anti‐immunoglobulin e therapy (omalizumab) publication-title: J Pediatr Pharmacol Ther – ident: e_1_2_5_25_1 doi: 10.1002/ppul.22937 – ident: e_1_2_5_3_1 doi: 10.1086/376525 – ident: e_1_2_5_15_1 doi: 10.1002/ppul.20907 – ident: e_1_2_5_11_1 doi: 10.1136/thoraxjnl-2012-201869 – ident: e_1_2_5_8_1 doi: 10.1067/mai.2003.1388 – ident: e_1_2_5_24_1 doi: 10.1111/j.1398-9995.2010.02522.x – ident: e_1_2_5_12_1 doi: 10.1111/j.1398-9995.2011.02599.x – ident: e_1_2_5_10_1 doi: 10.1007/s40265-013-0085-4 – ident: e_1_2_5_14_1 doi: 10.1136/thx.2004.035519 – ident: e_1_2_5_16_1 doi: 10.1002/ppul.20804 – ident: e_1_2_5_21_1 doi: 10.1177/1753465814547517 |
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Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first‐line therapy,... Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first-line therapy, but... Summary Allergic bronchopulmonary aspergillosis (ABPA) affects up to 15% of patients with cystic fibrosis (CF). Corticosteroids are used as first-line therapy,... |
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| SubjectTerms | Adolescent Adrenal Cortex Hormones - therapeutic use Adult allergic bronchopulmonary aspergillosis (ABPA) Anti-Allergic Agents - therapeutic use Antifungal Agents - therapeutic use Aspergillosis, Allergic Bronchopulmonary - complications Aspergillosis, Allergic Bronchopulmonary - drug therapy Aspergillosis, Allergic Bronchopulmonary - immunology Aspergillus fumigatus Child corticosteroids cystic fibrosis Cystic Fibrosis - complications Drug Therapy, Combination Female Humans IgE immunoglobulin E Immunoglobulin E - immunology Male Middle Aged Omalizumab - therapeutic use Retrospective Studies Young Adult |
| Title | Case series of omalizumab for allergic bronchopulmonary aspergillosis in cystic fibrosis patients |
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