Strategies to enhance drug delivery to solid tumors by harnessing the EPR effects and alternative targeting mechanisms

[Display omitted] The Enhanced Permeability and Retention (EPR) effect has been recognized as the central paradigm in tumor-targeted delivery in the last decades. In the wake of this concept, nanotechnologies have reached phenomenal levels in research. However, clinical tumors display a poor manifes...

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Bibliographic Details
Published in:	Advanced drug delivery reviews Vol. 188; p. 114449
Main Authors:	Zi, Yixuan, Yang, Kaiyun, He, Jianhua, Wu, Zimei, Liu, Jianping, Zhang, Wenli
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01.09.2022
Subjects:	Antineoplastic Agents Clinical translation Drug Delivery Systems - methods EPR effect Humans independent of EPR effect Nanomedicine Nanomedicine - methods Nanoparticles Neoplasms - therapy Permeability Preclinical models Transendothelial pathway Tumor Microenvironment Clinical translation Transendothelial pathway independent of EPR effect Nanomedicine Preclinical models EPR effect
ISSN:	0169-409X, 1872-8294, 1872-8294
Online Access:	Get full text
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