The Irrelevance of In Vitro Dissolution in Setting Product Specifications for Drugs Like Dextromethorphan That are Subject to Lysosomal Trapping

The purpose of the present study was to develop a physiologically based pharmacokinetic model for dextromethorphan (DEX) and its metabolites in extensive and poor metabolizers. The model was used to study the influence of dissolution rates on the sensitivity of maximum plasma concentration and area...

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Vydáno v:	Journal of pharmaceutical sciences Ročník 108; číslo 1; s. 268
Hlavní autoři:	Bolger, Michael B, Macwan, Joyce S, Sarfraz, Muhammad, Almukainzi, May, Löbenberg, Raimar
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 01.01.2019
Témata:	Absorption, Physiological Area Under Curve Caco-2 Cells Computer Simulation Cytochrome P-450 CYP3A - genetics Dextromethorphan - blood Dextromethorphan - chemistry Enterocytes - metabolism Humans Lysosomes - metabolism Metabolic Clearance Rate - genetics Models, Biological Permeability Polymorphism, Genetic Solubility Therapeutic Equivalency dissolution rate absorption computational ADME CYP enzymes pharmacokinetics metabolite kinetics metabolism genetic polymorphisms bioequivalence
ISSN:	1520-6017, 1520-6017
On-line přístup:	Zjistit podrobnosti o přístupu
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