Latency delay of visual evoked potential is a real measurement of demyelination in a rat model of optic neuritis

To investigate the relationship between size of demyelinated lesion, extent of axonal loss, and degree of latency delay of visual evoked potentials (VEPs) in a rat model of experimental demyelination. Lysolecithin 1% (0.4 or 0.8 μL) was microinjected into an optic nerve of each of 14 rats 2 mm poste...

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Bibliographic Details
Published in:	Investigative ophthalmology & visual science Vol. 52; no. 9; p. 6911
Main Authors:	You, Yuyi, Klistorner, Alexander, Thie, Johnson, Graham, Stuart L
Format:	Journal Article
Language:	English
Published:	United States 29.08.2011
Subjects:	Animals Axons - pathology Demyelinating Diseases - pathology Demyelinating Diseases - physiopathology Disease Models, Animal Disease Progression Electroretinography Evoked Potentials, Visual - physiology Lysophosphatidylcholines - toxicity Male Microinjections Optic Nerve - pathology Optic Nerve - physiopathology Optic Neuritis - chemically induced Optic Neuritis - pathology Optic Neuritis - physiopathology Rats Rats, Sprague-Dawley Severity of Illness Index
ISSN:	1552-5783, 1552-5783
Online Access:	Get more information
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