GTAC enables parallel genotyping of multiple genomic loci with chromatin accessibility profiling in single cells

Understanding clonal evolution and cancer development requires experimental approaches for characterizing the consequences of somatic mutations on gene regulation. However, no methods currently exist that efficiently link high-content chromatin accessibility with high-confidence genotyping in single...

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Bibliographic Details
Published in:	Cell stem cell Vol. 30; no. 5; p. 722
Main Authors:	Turkalj, Sven, Jakobsen, Niels Asger, Groom, Angus, Metzner, Marlen, Riva, Simone G, Gür, E Ravza, Usukhbayar, Batchimeg, Salazar, Mirian Angulo, Hentges, Lance D, Mickute, Gerda, Clark, Kevin, Sopp, Paul, Davies, James O J, Hughes, Jim R, Vyas, Paresh
Format:	Journal Article
Language:	English
Published:	United States 04.05.2023
Subjects:	Chromatin Gene Expression Regulation Genomics Genotype Humans Leukemia, Myeloid, Acute Transposases - genetics Transposases - metabolism leukemia stem cells single-cell ATAC-seq acute myeloid leukemia chromatin accessibility epigenomics single-cell technologies cancer evolution somatic mutation clonal tracking tumor heterogeneity
ISSN:	1875-9777, 1875-9777
Online Access:	Get more information
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