Extracellular vesicles for drug delivery

Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous mechanism for intercellular communication. Since the discovery that EVs are capable of functionally transferring biological information, the potential use of EVs as drug delivery vehicles has gained consider...

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Vydáno v:Advanced drug delivery reviews Ročník 106; číslo Pt A; s. 148 - 156
Hlavní autoři: Vader, Pieter, Mol, Emma A., Pasterkamp, Gerard, Schiffelers, Raymond M.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Netherlands Elsevier B.V 15.11.2016
Témata:
Animals
biodistribution
Drug Carriers - metabolism
drug delivery
Drug Delivery Systems - methods
exosomes
Extracellular vesicles
Extracellular Vesicles - metabolism
Humans
isolation
microvesicles
nanomedicine
targeting
biodistribution
targeting
exosomes
Extracellular vesicles
nanomedicine
isolation
microvesicles
drug delivery
ISSN:0169-409X, 1872-8294, 1872-8294
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Shrnutí:Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous mechanism for intercellular communication. Since the discovery that EVs are capable of functionally transferring biological information, the potential use of EVs as drug delivery vehicles has gained considerable scientific interest. EVs may have multiple advantages over currently available drug delivery vehicles, such as their ability to overcome natural barriers, their intrinsic cell targeting properties, and stability in the circulation. However, therapeutic applications of EVs as drug delivery systems have been limited due to a lack of methods for scalable EV isolation and efficient drug loading. Furthermore, in order to achieve targeted drug delivery, their intrinsic cell targeting properties should be tuned through EV engineering. Here, we review and discuss recent progress and remaining challenges in the development of EVs as drug delivery vehicles. [Display omitted]
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ISSN:0169-409X
1872-8294
1872-8294
DOI:10.1016/j.addr.2016.02.006