Long noncoding RNA TUG1 alleviates extracellular matrix accumulation via mediating microRNA-377 targeting of PPARγ in diabetic nephropathy

Long noncoding RNA taurine-upregulated gene 1 (lncRNA TUG1) has been reported to play a key role in the progression of diabetic nephropathy (DN). However, the role of lncRNA TUG1 in the regulation of diabetic nephropathy remains largely unknown. The aim of the present study is to identify the regula...

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Bibliographic Details
Published in:	Biochemical and biophysical research communications Vol. 484; no. 3; pp. 598 - 604
Main Authors:	Duan, Li-Jun, Ding, Min, Hou, Li-Jun, Cui, Yuan-Tao, Li, Chun-Jun, Yu, De-Min
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 11.03.2017
Subjects:	Animals Cells, Cultured Diabetic Nephropathies - metabolism Diabetic Nephropathies - pathology diabetic nephropathy Extracellular matrix Extracellular Matrix - metabolism Extracellular Matrix - pathology Long noncoding RNA Mesangial cell Mesangial Cells - metabolism Mesangial Cells - pathology Mice Mice, Inbred C57BL MicroRNAs - metabolism miRNA-377 PPAR gamma - metabolism PPARγ RNA, Long Noncoding - metabolism TUG1 Mesangial cell Extracellular matrix Long noncoding RNA TUG1 PPARγ diabetic nephropathy miRNA-377
ISSN:	0006-291X, 1090-2104, 1090-2104
Online Access:	Get full text
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