Role of small interfering RNA (siRNA) in targeting ocular neovascularization: A review

Ocular neovascularization (NV) plays a central role in the pathogenesis of various ocular diseases including diabetic retinopathy, age-related macular degeneration, retinoblastoma, retinitis pigmentosa and may lead to loss of vision if not controlled in time. Several clinical trials elucidate the ce...

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Bibliographic Details
Published in:	Experimental eye research Vol. 202; p. 108329
Main Authors:	Supe, Shibani, Upadhya, Archana, Singh, Kavita
Format:	Journal Article
Language:	English
Published:	England Elsevier Ltd 01.01.2021
Subjects:	Cationic polymer Diabetic Retinopathy - genetics Eye - blood supply Genetic Therapy - methods Humans Liposomes Neovascularization, Pathologic - therapy Ocular cular siRNA delivery Ocular neovascularization (NV) Polyplexes, Lipoplexes, siRNA formulations, Diabetic retinopathy, Age-related macular degeneration, Patents on siRNA against ocular NV, Clinical trials RNA Interference RNA, Small Interfering - genetics Small interfering RNA (siRNA) Vascular endothelial growth factor (VEGF) Vascular Endothelial Growth Factor A - genetics Ocular cular siRNA delivery Ethylene glycol PubChem CID: 9033 PubChem CID: 24847767 Vascular endothelial growth factor (VEGF) PubChem CID: 174 PEG2000 DSPE Ocular neovascularization (NV) Small interfering RNA (siRNA) Poly-l-lysine PubChem CID: 447078 lysine PubChem CID: 21896651 Polyethylenimine 1, 2-distearoyl-sn-glycero-3-phosphoethanolamine Cationic polymer PubChem CID: 162282 PubChem CID 5962 Liposomes Polyplexes, Lipoplexes, siRNA formulations, Diabetic retinopathy, Age-related macular degeneration, Patents on siRNA against ocular NV, Clinical trials Chitosan PubChem CID 406952 Hyaluronic acid
ISSN:	0014-4835, 1096-0007, 1096-0007
Online Access:	Get full text
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