Targeting IGF Perturbs Global Replication through Ribonucleotide Reductase Dysfunction

Inhibition of IGF receptor (IGF1R) delays repair of radiation-induced DNA double-strand breaks (DSB), prompting us to investigate whether IGF1R influences endogenous DNA damage. Here we demonstrate that IGF1R inhibition generates endogenous DNA lesions protected by 53BP1 bodies, indicating under-rep...

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Bibliographic Details
Published in:	Cancer research (Chicago, Ill.) Vol. 81; no. 8; p. 2128
Main Authors:	Rieunier, Guillaume, Wu, Xiaoning, Harris, Letitia E, Mills, Jack V, Nandakumar, Ashwin, Colling, Laura, Seraia, Elena, Hatch, Stephanie B, Ebner, Daniel V, Folkes, Lisa K, Weyer-Czernilofsky, Ulrike, Bogenrieder, Thomas, Ryan, Anderson J, Macaulay, Valentine M
Format:	Journal Article
Language:	English
Published:	United States 15.04.2021
Subjects:	Animals Antibodies, Monoclonal, Humanized - pharmacology Ataxia Telangiectasia Mutated Proteins - genetics Cell Line, Tumor Checkpoint Kinase 1 - metabolism Deoxyribonucleosides - metabolism DNA Breaks, Double-Stranded DNA Damage DNA Repair DNA Replication Down-Regulation Fibroblasts Heterografts Histones - metabolism Humans MAP Kinase Signaling System MCF-7 Cells Mice Mitogen-Activated Protein Kinase Kinases - metabolism Mutation Orphan Nuclear Receptors - metabolism Proto-Oncogene Proteins c-akt - metabolism Proto-Oncogene Proteins c-jun - metabolism Receptor, IGF Type 1 - antagonists & inhibitors Receptor, IGF Type 1 - metabolism Ribonucleoside Diphosphate Reductase - metabolism Ribonucleotide Reductases - metabolism S Phase Cell Cycle Checkpoints Spheroids, Cellular
ISSN:	1538-7445, 1538-7445
Online Access:	Get more information
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