Therapeutic Implications of Detecting MAPK-Activating Alterations in Cutaneous and Unknown Primary Melanomas

Cutaneous and unknown primary melanomas frequently harbor alterations that activate the MAPK pathway. Whether MAPK driver detection beyond BRAF V600 is clinically relevant in the checkpoint inhibitor era is unknown. Patients with melanoma were prospectively offered tumor sequencing of 341-468 genes....

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Vydáno v:	Clinical cancer research Ročník 27; číslo 8; s. 2226
Hlavní autoři:	Shoushtari, Alexander N, Chatila, Walid K, Arora, Arshi, Sanchez-Vega, Francisco, Kantheti, Havish S, Rojas Zamalloa, Jorge A, Krieger, Penina, Callahan, Margaret K, Betof Warner, Allison, Postow, Michael A, Momtaz, Parisa, Nair, Suresh, Ariyan, Charlotte E, Barker, Christopher A, Brady, Mary Susan, Coit, Daniel G, Rosen, Neal, Chapman, Paul B, Busam, Klaus J, Solit, David B, Panageas, Katherine S, Wolchok, Jedd D, Schultz, Nikolaus
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 15.04.2021
Témata:	Adolescent Adult Aged Aged, 80 and over Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Child Drug Resistance, Neoplasm - genetics Female Gain of Function Mutation Humans Immune Checkpoint Inhibitors - pharmacology Immune Checkpoint Inhibitors - therapeutic use Ipilimumab - pharmacology Ipilimumab - therapeutic use Kaplan-Meier Estimate Male MAP Kinase Signaling System - genetics Melanoma - drug therapy Melanoma - genetics Melanoma - mortality Melanoma - secondary Middle Aged Mitogen-Activated Protein Kinases - genetics Neoplasms, Unknown Primary - drug therapy Neoplasms, Unknown Primary - genetics Neoplasms, Unknown Primary - immunology Neoplasms, Unknown Primary - mortality Nivolumab - pharmacology Nivolumab - therapeutic use Prognosis Programmed Cell Death 1 Receptor - antagonists & inhibitors Prospective Studies Retrospective Studies Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - immunology Skin Neoplasms - mortality Time Factors Treatment Outcome Young Adult
ISSN:	1557-3265, 1557-3265
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