A Subset of Colorectal Cancers with Cross-Sensitivity to Olaparib and Oxaliplatin

Defects in the homologous recombination (HR) repair pathway are of clinical interest due to sensitivity of HR-deficient cells to PARP inhibitors. We were interested in defining PARP vulnerability in patients with metastatic colorectal cancer (mCRC) carrying and mutations who display poor prognosis,...

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Bibliographic Details
Published in:	Clinical cancer research Vol. 26; no. 6; p. 1372
Main Authors:	Arena, Sabrina, Corti, Giorgio, Durinikova, Erika, Montone, Monica, Reilly, Nicole M, Russo, Mariangela, Lorenzato, Annalisa, Arcella, Pamela, Lazzari, Luca, Rospo, Giuseppe, Pagani, Massimiliano, Cancelliere, Carlotta, Negrino, Carola, Isella, Claudio, Bartolini, Alice, Cassingena, Andrea, Amatu, Alessio, Mauri, Gianluca, Sartore-Bianchi, Andrea, Mittica, Gloria, Medico, Enzo, Marsoni, Silvia, Linnebacher, Michael, Abrignani, Sergio, Siena, Salvatore, Di Nicolantonio, Federica, Bardelli, Alberto
Format:	Journal Article
Language:	English
Published:	United States 15.03.2020
Subjects:	Animals Antineoplastic Agents - pharmacology Cell Line, Tumor Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - metabolism Colorectal Neoplasms - pathology Drug Resistance, Neoplasm Gene Expression Regulation, Neoplastic Humans Mice Mice, Inbred NOD Mice, SCID Mutation Oxaliplatin - pharmacology Phthalazines - pharmacology Piperazines - pharmacology Poly(ADP-ribose) Polymerase Inhibitors - pharmacology Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins p21(ras) - genetics Recombinational DNA Repair Treatment Outcome Xenograft Model Antitumor Assays
ISSN:	1557-3265, 1557-3265
Online Access:	Get more information
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