Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus
The south-east Asian and sub-Saharan African populations are the most susceptible to hepatocellular carcinoma (HCC). We aimed to establish whether XRCC1, XRCC3, and XPD are associated with liver cancer in Pakistan and to examine the interaction of hepatitis B virus (HBV) or hepatitis C virus (HCV) w...
Saved in:
| Published in: | European journal of gastroenterology & hepatology Vol. 25; no. 2; p. 166 |
|---|---|
| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
England
01.02.2013
|
| Subjects: | |
| ISSN: | 1473-5687, 1473-5687 |
| Online Access: | Get more information |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Abstract | The south-east Asian and sub-Saharan African populations are the most susceptible to hepatocellular carcinoma (HCC). We aimed to establish whether XRCC1, XRCC3, and XPD are associated with liver cancer in Pakistan and to examine the interaction of hepatitis B virus (HBV) or hepatitis C virus (HCV) with repaired genes in the occurrence of liver cancer.
We enrolled 74 healthy individuals, 75 had either HBV or HCV, and 50 were HCC patients. The characteristic information of all the study participants were collected through a standard interviewer-administered questionnaire. The PCR-RFLP was used to identify the genotype of the patients.
The results of our study indicated that the patients infected with HBV or HCV had a four or three-fold greater risk of developing liver cancer. Patients older than 55 years of age had a significantly higher risk of developing cancer compared with younger patients. The homozygous wild types Arg/Arg for 280 and Thr/Thr for 241 were more frequent in the controls than in the cases. The allelic frequency of mutant 280His and 399Gln was more pronounced among HCC cases than the controls or the HBV-infected patients.
The frequency of the XPD gene in the controls was in Hardy-Weinberg equilibrium, indicating that the gene played a protective role in the Pakistani population. XRCC1 or XRCC3 was associated with liver cancer in the Pakistani population; however, the XPD gene played a vital role in the repair of DNA damage. |
|---|---|
| AbstractList | The south-east Asian and sub-Saharan African populations are the most susceptible to hepatocellular carcinoma (HCC). We aimed to establish whether XRCC1, XRCC3, and XPD are associated with liver cancer in Pakistan and to examine the interaction of hepatitis B virus (HBV) or hepatitis C virus (HCV) with repaired genes in the occurrence of liver cancer.
We enrolled 74 healthy individuals, 75 had either HBV or HCV, and 50 were HCC patients. The characteristic information of all the study participants were collected through a standard interviewer-administered questionnaire. The PCR-RFLP was used to identify the genotype of the patients.
The results of our study indicated that the patients infected with HBV or HCV had a four or three-fold greater risk of developing liver cancer. Patients older than 55 years of age had a significantly higher risk of developing cancer compared with younger patients. The homozygous wild types Arg/Arg for 280 and Thr/Thr for 241 were more frequent in the controls than in the cases. The allelic frequency of mutant 280His and 399Gln was more pronounced among HCC cases than the controls or the HBV-infected patients.
The frequency of the XPD gene in the controls was in Hardy-Weinberg equilibrium, indicating that the gene played a protective role in the Pakistani population. XRCC1 or XRCC3 was associated with liver cancer in the Pakistani population; however, the XPD gene played a vital role in the repair of DNA damage. The south-east Asian and sub-Saharan African populations are the most susceptible to hepatocellular carcinoma (HCC). We aimed to establish whether XRCC1, XRCC3, and XPD are associated with liver cancer in Pakistan and to examine the interaction of hepatitis B virus (HBV) or hepatitis C virus (HCV) with repaired genes in the occurrence of liver cancer.OBJECTIVEThe south-east Asian and sub-Saharan African populations are the most susceptible to hepatocellular carcinoma (HCC). We aimed to establish whether XRCC1, XRCC3, and XPD are associated with liver cancer in Pakistan and to examine the interaction of hepatitis B virus (HBV) or hepatitis C virus (HCV) with repaired genes in the occurrence of liver cancer.We enrolled 74 healthy individuals, 75 had either HBV or HCV, and 50 were HCC patients. The characteristic information of all the study participants were collected through a standard interviewer-administered questionnaire. The PCR-RFLP was used to identify the genotype of the patients.MATERIALS AND METHODSWe enrolled 74 healthy individuals, 75 had either HBV or HCV, and 50 were HCC patients. The characteristic information of all the study participants were collected through a standard interviewer-administered questionnaire. The PCR-RFLP was used to identify the genotype of the patients.The results of our study indicated that the patients infected with HBV or HCV had a four or three-fold greater risk of developing liver cancer. Patients older than 55 years of age had a significantly higher risk of developing cancer compared with younger patients. The homozygous wild types Arg/Arg for 280 and Thr/Thr for 241 were more frequent in the controls than in the cases. The allelic frequency of mutant 280His and 399Gln was more pronounced among HCC cases than the controls or the HBV-infected patients.RESULTSThe results of our study indicated that the patients infected with HBV or HCV had a four or three-fold greater risk of developing liver cancer. Patients older than 55 years of age had a significantly higher risk of developing cancer compared with younger patients. The homozygous wild types Arg/Arg for 280 and Thr/Thr for 241 were more frequent in the controls than in the cases. The allelic frequency of mutant 280His and 399Gln was more pronounced among HCC cases than the controls or the HBV-infected patients.The frequency of the XPD gene in the controls was in Hardy-Weinberg equilibrium, indicating that the gene played a protective role in the Pakistani population. XRCC1 or XRCC3 was associated with liver cancer in the Pakistani population; however, the XPD gene played a vital role in the repair of DNA damage.CONCLUSIONThe frequency of the XPD gene in the controls was in Hardy-Weinberg equilibrium, indicating that the gene played a protective role in the Pakistani population. XRCC1 or XRCC3 was associated with liver cancer in the Pakistani population; however, the XPD gene played a vital role in the repair of DNA damage. |
| Author | Khan, Abrar ul Haq Ali, Muhammad Aslam, Muhammad A Shaikh, Rehan S Sayyed, Ali H Amin, Farah Gulnaz, Asma |
| Author_xml | – sequence: 1 givenname: Asma surname: Gulnaz fullname: Gulnaz, Asma organization: Institute of Molecular Biology & Biotechnology, Bahauddin Zakariya University, Multan, Pakistan – sequence: 2 givenname: Ali H surname: Sayyed fullname: Sayyed, Ali H – sequence: 3 givenname: Farah surname: Amin fullname: Amin, Farah – sequence: 4 givenname: Abrar ul Haq surname: Khan fullname: Khan, Abrar ul Haq – sequence: 5 givenname: Muhammad A surname: Aslam fullname: Aslam, Muhammad A – sequence: 6 givenname: Rehan S surname: Shaikh fullname: Shaikh, Rehan S – sequence: 7 givenname: Muhammad surname: Ali fullname: Ali, Muhammad |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/23044807$$D View this record in MEDLINE/PubMed |
| BookMark | eNpNkFtLxDAQhYMoXlb_gUgefXA1k7RN91HrFRRFFHxbpsnUjbZNTVplf4d_2F0v4NMZDh9nDmeLrba-JcZ2QRyCmOijm7OLQ1EKUKRkrtIJap2usE1ItBqnWa5X_90bbCvGFyFAK9DrbEMqkSS50Jvs8zhGbxz2zrfcV_zpvijg4FvUAcfW8qe7U_5MLfXO8M7X88aHbuZiwz9cP1sQ3LUmEEayPLj4ugyZUYe9N1TXQ42BGwzGtb5BXpLBIdKS6Wf0w7neRX7y_arg7y4McZutVVhH2vnVEXs8P3soLsfXtxdXxfH12Kg0S8eVlKrEksDmVlU6wUkKBFJZqCgFYWyupVKQYZlkFuzCqKTRBJALzDIkOWL7P7ld8G8DxX7auLhsjS35IU5BapWkeTaRC3TvFx3Khuy0C67BMJ_-DSm_APyueM0 |
| CitedBy_id | crossref_primary_10_1007_s13277_013_1451_2 crossref_primary_10_1007_s13277_013_0973_y crossref_primary_10_4251_wjgo_v16_i4_1596 crossref_primary_10_1007_s12032_014_0356_2 crossref_primary_10_4254_wjh_v8_i10_485 crossref_primary_10_1097_MD_0000000000000330 crossref_primary_10_1007_s13277_013_0899_4 crossref_primary_10_1002_jmv_27217 crossref_primary_10_1016_j_humgen_2023_201165 crossref_primary_10_1111_jcmm_12896 crossref_primary_10_5812_hepatmon_35106 crossref_primary_10_1007_s13277_013_0841_9 crossref_primary_10_1007_s13277_012_0625_7 crossref_primary_10_1002_cam4_538 crossref_primary_10_1177_1533033821990046 crossref_primary_10_3892_etm_2015_2421 crossref_primary_10_1002_jcb_29335 crossref_primary_10_1002_jmv_25873 crossref_primary_10_1007_s13277_013_1435_2 crossref_primary_10_1007_s13277_013_0765_4 crossref_primary_10_3389_fmicb_2018_00663 crossref_primary_10_1371_journal_pone_0206853 |
| ContentType | Journal Article |
| DBID | CGR CUY CVF ECM EIF NPM 7X8 |
| DOI | 10.1097/MEG.0b013e328359a775 |
| DatabaseName | Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed MEDLINE - Academic |
| DatabaseTitle | MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) MEDLINE - Academic |
| DatabaseTitleList | MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | no_fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1473-5687 |
| ExternalDocumentID | 23044807 |
| Genre | Journal Article |
| GroupedDBID | --- .-D .Z2 0R~ 4Q1 4Q2 4Q3 53G 5GY 5VS 6PF 71W 8L- AAAAV AAHPQ AAIQE AAMTA AARTV AASCR AAUEB AAWTL AAYEP ABASU ABBUW ABDIG ABJNI ABOCM ABVCZ ABXVJ ABZAD ACCJW ACDDN ACEWG ACGFO ACGFS ACILI ACWDW ACWRI ACXJB ACXNZ ADFPA ADGGA ADHPY ADNKB AE3 AE6 AEETU AENEX AFDTB AFSOK AFUWQ AGINI AHQNM AHVBC AINUH AJCLO AJIOK AJNWD AJNYG AJZMW AKCTQ ALKUP ALMA_UNASSIGNED_HOLDINGS ALMTX AMJPA AMKUR AMNEI AOHHW AWKKM BQLVK BS7 C45 CAG CGR COF CS3 CUY CVF DIWNM DUNZO E.X EBS ECM EEVPB EIF EJD EX3 F5P FCALG FL- GNXGY GQDEL H0~ HLJTE HZ~ IKREB IN~ IPNFZ JF9 JG8 JK3 JK8 K8S KD2 L-C N9A NPM N~M O9- OAG OAH OCUKA ODA OJAPA OLG OLW OPUJH ORVUJ OUVQU OVD OVDNE OVOZU OWU OWV OWW OWX OWY OWZ OXXIT P-K P2P R58 RIG RLZ S4R S4S T8P TEORI TSPGW V2I VVN W3M WOQ WOW X3V X3W XXN XYM YFH ZFV ZZMQN 7X8 ABPXF ACBKD ACDOF ADKSD |
| ID | FETCH-LOGICAL-c3565-f223babe1d8d3f74a951e123d1fe510cd8723316ab46d1d0cdf2c7e1180a66ae2 |
| IEDL.DBID | 7X8 |
| ISICitedReferencesCount | 29 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000312794400007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1473-5687 |
| IngestDate | Sun Nov 09 11:49:03 EST 2025 Wed Feb 19 01:55:46 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c3565-f223babe1d8d3f74a951e123d1fe510cd8723316ab46d1d0cdf2c7e1180a66ae2 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| PMID | 23044807 |
| PQID | 1273458692 |
| PQPubID | 23479 |
| ParticipantIDs | proquest_miscellaneous_1273458692 pubmed_primary_23044807 |
| PublicationCentury | 2000 |
| PublicationDate | 2013-Feb 20130201 |
| PublicationDateYYYYMMDD | 2013-02-01 |
| PublicationDate_xml | – month: 02 year: 2013 text: 2013-Feb |
| PublicationDecade | 2010 |
| PublicationPlace | England |
| PublicationPlace_xml | – name: England |
| PublicationTitle | European journal of gastroenterology & hepatology |
| PublicationTitleAlternate | Eur J Gastroenterol Hepatol |
| PublicationYear | 2013 |
| SSID | ssj0017317 |
| Score | 2.174909 |
| Snippet | The south-east Asian and sub-Saharan African populations are the most susceptible to hepatocellular carcinoma (HCC). We aimed to establish whether XRCC1,... |
| SourceID | proquest pubmed |
| SourceType | Aggregation Database Index Database |
| StartPage | 166 |
| SubjectTerms | Adolescent Adult Anthropometry - methods Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - virology Case-Control Studies Child DNA Repair - genetics DNA, Neoplasm - genetics DNA-Binding Proteins - genetics Female Gene Frequency Genetic Predisposition to Disease Hepatitis B, Chronic - complications Hepatitis C, Chronic - complications Humans Liver Neoplasms - genetics Liver Neoplasms - virology Male Middle Aged Phenotype Polymorphism, Genetic Polymorphism, Restriction Fragment Length Risk Factors Sex Factors Smoking - adverse effects X-ray Repair Cross Complementing Protein 1 Xeroderma Pigmentosum Group D Protein - genetics Young Adult |
| Title | Association of XRCC1, XRCC3, and XPD genetic polymorphism with an increased risk of hepatocellular carcinoma because of the hepatitis B and C virus |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/23044807 https://www.proquest.com/docview/1273458692 |
| Volume | 25 |
| WOSCitedRecordID | wos000312794400007&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1bS8MwFA7qRHzxfpk3Ivi4MntL2ifRuemDG0NU-lbS5gQHrp2rG_g7_MOe03XMF0HwpYWSpmnOSfKdO2MXAgU0Ccq3fBCXKKB4vqWEASvUxodUaUeWEXIvD7LXC6Io7FcKt6Jyq5zvieVGrfOUdORNm_Kw-IEInavRu0VVo8i6WpXQWGY1F6EMuXTJaGFFkG5Zcdf2pGv5IpDz0LlQNrvtu7kOkDKOhUpK_3eQWR42nc3_DnOLbVQwk1_P-GKbLUG2w9a6lSF9l339IAvPDY8eWy27Ud7cBleZ5lH_liNzUYwjH-Vvn8McKTIohpw0t9iCDzICnAVoTu7p1MkrHm0fOZkCyLeVp1SmKMuHiiMF1aQAaoN4c9aOcinxm_JTLT4djCfFHnvutJ9a91ZVn8FKXcSBlkFokagEbB1o10hPIVoDPAm1bQCXeqoD6biuLVTiCW1rfGCcVAIlnVNCKHD22UqWZ3DIOMLCUBjsw3FCT2ovCAMUnUF6IIRJhK6z8_l0x8j_9Ccqg3xSxIsJr7ODGc3i0SxRR0wKbwqZP_rD28ds3SkrXZCnygmrGVz9cMpW0ylOx_isZCy89vrdb0fN18Y |
| linkProvider | ProQuest |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Association+of+XRCC1%2C+XRCC3%2C+and+XPD+genetic+polymorphism+with+an+increased+risk+of+hepatocellular+carcinoma+because+of+the+hepatitis+B+and+C+virus&rft.jtitle=European+journal+of+gastroenterology+%26+hepatology&rft.au=Gulnaz%2C+Asma&rft.au=Sayyed%2C+Ali+H&rft.au=Amin%2C+Farah&rft.au=Khan%2C+Abrar+ul+Haq&rft.date=2013-02-01&rft.eissn=1473-5687&rft.volume=25&rft.issue=2&rft.spage=166&rft_id=info:doi/10.1097%2FMEG.0b013e328359a775&rft_id=info%3Apmid%2F23044807&rft_id=info%3Apmid%2F23044807&rft.externalDocID=23044807 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1473-5687&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1473-5687&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1473-5687&client=summon |