An evaluation of "I, Pancreas" algorithm performance in silico

The objective of this study was to investigate the performance of a newly proposed insulin titrating algorithm to achieve tight glycemic control in the critically ill. A simulation environment with 10 critically ill virtual subjects was employed to evaluate the "I, Pancreas" algorithm prop...

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Published in:Journal of diabetes science and technology Vol. 3; no. 4; p. 857
Main Authors: Wilinska, Malgorzata E, Nodale, Marianna
Format: Journal Article
Language:English
Published: United States 01.07.2009
Subjects:
Algorithms
Blood Glucose - drug effects
Computer Simulation
Critical Illness
Diabetes Mellitus - drug therapy
Humans
Insulin - administration & dosage
Insulin - therapeutic use
ISSN:1932-2968, 1932-3107
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Abstract The objective of this study was to investigate the performance of a newly proposed insulin titrating algorithm to achieve tight glycemic control in the critically ill. A simulation environment with 10 critically ill virtual subjects was employed to evaluate the "I, Pancreas" algorithm proposed by Braithwaite et al. and described in an article in this issue of Journal of Diabetes Science and Technology. The algorithm was coded in MATLAB and was "plugged in" to a simulation environment to provide glucose control in a 48-hour-long simulated study. Mean blood glucose was 6.5 +/- 0.4 mmol/liter (118 +/- 7.8 mg/dl), percentage of time spent in the target glucose range was 38% (32-44%), and the hyperglycemic index was 0.6 (0.4 -1.0) mmol/liter [11.1 (7.7-18.1) mg/dl]. A single episode of mild hypoglycemia at 3.8 mmol/liter (69 mg/dl) was observed during 480 hours of glucose control. In this initial in silico evaluation, the "I, Pancreas" algorithm provided a safe control of glucose in the simulated study and achieved tight glycemic control 38% of the time.
AbstractList The objective of this study was to investigate the performance of a newly proposed insulin titrating algorithm to achieve tight glycemic control in the critically ill. A simulation environment with 10 critically ill virtual subjects was employed to evaluate the "I, Pancreas" algorithm proposed by Braithwaite et al. and described in an article in this issue of Journal of Diabetes Science and Technology. The algorithm was coded in MATLAB and was "plugged in" to a simulation environment to provide glucose control in a 48-hour-long simulated study. Mean blood glucose was 6.5 +/- 0.4 mmol/liter (118 +/- 7.8 mg/dl), percentage of time spent in the target glucose range was 38% (32-44%), and the hyperglycemic index was 0.6 (0.4 -1.0) mmol/liter [11.1 (7.7-18.1) mg/dl]. A single episode of mild hypoglycemia at 3.8 mmol/liter (69 mg/dl) was observed during 480 hours of glucose control. In this initial in silico evaluation, the "I, Pancreas" algorithm provided a safe control of glucose in the simulated study and achieved tight glycemic control 38% of the time.
The objective of this study was to investigate the performance of a newly proposed insulin titrating algorithm to achieve tight glycemic control in the critically ill.BACKGROUNDThe objective of this study was to investigate the performance of a newly proposed insulin titrating algorithm to achieve tight glycemic control in the critically ill.A simulation environment with 10 critically ill virtual subjects was employed to evaluate the "I, Pancreas" algorithm proposed by Braithwaite et al. and described in an article in this issue of Journal of Diabetes Science and Technology. The algorithm was coded in MATLAB and was "plugged in" to a simulation environment to provide glucose control in a 48-hour-long simulated study.METHODSA simulation environment with 10 critically ill virtual subjects was employed to evaluate the "I, Pancreas" algorithm proposed by Braithwaite et al. and described in an article in this issue of Journal of Diabetes Science and Technology. The algorithm was coded in MATLAB and was "plugged in" to a simulation environment to provide glucose control in a 48-hour-long simulated study.Mean blood glucose was 6.5 +/- 0.4 mmol/liter (118 +/- 7.8 mg/dl), percentage of time spent in the target glucose range was 38% (32-44%), and the hyperglycemic index was 0.6 (0.4 -1.0) mmol/liter [11.1 (7.7-18.1) mg/dl]. A single episode of mild hypoglycemia at 3.8 mmol/liter (69 mg/dl) was observed during 480 hours of glucose control.RESULTSMean blood glucose was 6.5 +/- 0.4 mmol/liter (118 +/- 7.8 mg/dl), percentage of time spent in the target glucose range was 38% (32-44%), and the hyperglycemic index was 0.6 (0.4 -1.0) mmol/liter [11.1 (7.7-18.1) mg/dl]. A single episode of mild hypoglycemia at 3.8 mmol/liter (69 mg/dl) was observed during 480 hours of glucose control.In this initial in silico evaluation, the "I, Pancreas" algorithm provided a safe control of glucose in the simulated study and achieved tight glycemic control 38% of the time.CONCLUSIONIn this initial in silico evaluation, the "I, Pancreas" algorithm provided a safe control of glucose in the simulated study and achieved tight glycemic control 38% of the time.
Author Wilinska, Malgorzata E
Nodale, Marianna
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CitedBy_id crossref_primary_10_1186_cc13921
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SubjectTerms Algorithms
Blood Glucose - drug effects
Computer Simulation
Critical Illness
Diabetes Mellitus - drug therapy
Humans
Insulin - administration & dosage
Insulin - therapeutic use
Title An evaluation of "I, Pancreas" algorithm performance in silico
URI https://www.ncbi.nlm.nih.gov/pubmed/20144335
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