Pharmacogenetics of tuberculosis treatment toxicity and effectiveness in a large Brazilian cohort

Genetic polymorphisms have been associated with risk of antituberculosis treatment toxicity. We characterized associations with adverse events and treatment failure/recurrence among adults treated for tuberculosis in Brazil. Participants were followed in Regional Prospective Observational Research i...

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Veröffentlicht in:	Pharmacogenetics and genomics Jg. 35; H. 2; S. 55
Hauptverfasser:	Amorim, Gustavo, Jaworski, James, Yang, Jing, Cordeiro-Santos, Marcelo, Kritski, Afrânio L, Figueiredo, Marina C, Turner, Megan, Andrade, Bruno B, Velez Edwards, Digna R, Santos, Adalberto R, Rolla, Valeria C, Sterling, Timothy R, Haas, David W
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 01.02.2025
Schlagworte:	Adult Antitubercular Agents - adverse effects Antitubercular Agents - therapeutic use Arylamine N-Acetyltransferase - genetics Brazil Cohort Studies Female Glutathione Transferase - genetics Humans Liver-Specific Organic Anion Transporter 1 Male Middle Aged Pharmacogenetics Polymorphism, Single Nucleotide Pregnane X Receptor Prospective Studies Treatment Outcome Tuberculosis - drug therapy Tuberculosis - genetics Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - genetics Brazil
ISSN:	1744-6880, 1744-6880
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