Rational design of DNA vaccines for the induction of human papillomavirus type 16 E6- and E7-specific cytotoxic T-cell responses

Many DNA vaccine candidates have been developed for the treatment of human papillomavirus type 16 (HPV16)-induced malignancies. Most of these vaccines consist of a fusion of E7 with a "carrier-protein" that functions to increase the potency of the vaccine. The nature of these carrier-prote...

Full description

Saved in:

Bibliographic Details
Published in:	Human gene therapy Vol. 23; no. 12; p. 1301
Main Authors:	Oosterhuis, Koen, Aleyd, Esil, Vrijland, Kim, Schumacher, Ton N, Haanen, John B
Format:	Journal Article
Language:	English
Published:	United States 01.12.2012
Subjects:	Animals CD4-Positive T-Lymphocytes - immunology Cell Line Drug Design Endoplasmic Reticulum - metabolism Female Human papillomavirus 16 - immunology Humans Male Mice Mice, Inbred C57BL Oncogene Proteins, Viral - genetics Oncogene Proteins, Viral - immunology Papillomavirus E7 Proteins - genetics Papillomavirus E7 Proteins - immunology Papillomavirus Infections - prevention & control Papillomavirus Vaccines - genetics Papillomavirus Vaccines - immunology Recombinant Proteins - genetics Recombinant Proteins - immunology Repressor Proteins - genetics Repressor Proteins - immunology T-Lymphocytes, Cytotoxic - immunology Uterine Cervical Neoplasms - prevention & control Uterine Cervical Neoplasms - virology Vaccines, DNA - genetics Vaccines, DNA - immunology
ISSN:	1557-7422, 1557-7422
Online Access:	Get more information
Tags:	Add Tag No Tags, Be the first to tag this record!

Be the first to leave a comment!