Synchronous Endometrial and Ovarian Carcinomas: Evidence of Clonality

Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian tumors (SEOs) clinically behave as independent primary tumors rather than a single advanced-stage carcinoma. We used 18 SEOs to investigate t...

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Vydáno v:JNCI : Journal of the National Cancer Institute Ročník 108; číslo 6; s. djv428
Hlavní autoři: Anglesio, Michael S, Wang, Yi Kan, Maassen, Madlen, Horlings, Hugo M, Bashashati, Ali, Senz, Janine, Mackenzie, Robertson, Grewal, Diljot S, Li-Chang, Hector, Karnezis, Anthony N, Sheffield, Brandon S, McConechy, Melissa K, Kommoss, Friedrich, Taran, Florin A, Staebler, Annette, Shah, Sohrab P, Wallwiener, Diethelm, Brucker, Sara, Gilks, C Blake, Kommoss, Stefan, Huntsman, David G
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.06.2016
Témata:
Adult
Aged
Carcinoma, Endometrioid - genetics
Carcinoma, Endometrioid - pathology
Carcinoma, Ovarian Epithelial
Clone Cells
DNA, Neoplasm - analysis
Endometrial Neoplasms - genetics
Endometrial Neoplasms - pathology
Exome
Female
Humans
Middle Aged
Neoplasm Grading
Neoplasm Staging
Neoplasms, Glandular and Epithelial - genetics
Neoplasms, Glandular and Epithelial - pathology
Neoplasms, Multiple Primary - genetics
Neoplasms, Multiple Primary - pathology
Ovarian Neoplasms - genetics
Ovarian Neoplasms - pathology
Sample Size
Sequence Analysis, DNA - methods
ISSN:1460-2105
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Shrnutí:Many women with ovarian endometrioid carcinoma present with concurrent endometrial carcinoma. Organ-confined and low-grade synchronous endometrial and ovarian tumors (SEOs) clinically behave as independent primary tumors rather than a single advanced-stage carcinoma. We used 18 SEOs to investigate the ancestral relationship between the endometrial and ovarian components. Based on both targeted and exome sequencing, 17 of 18 patient cases of simultaneous cancer of the endometrium and ovary from our series showed evidence of a clonal relationship, ie, primary tumor and metastasis. Eleven patient cases fulfilled clinicopathological criteria that would lead to classification as independent endometrial and ovarian primary carcinomas, including being of FIGO stage T1a/1A, with organ-restricted growth and without surface involvement; 10 of 11 of these cases showed evidence of clonality. Our observations suggest that the disseminating cells amongst SEOs are restricted to physically accessible and microenvironment-compatible sites yet remain indolent, without the capacity for further dissemination.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1460-2105
DOI:10.1093/jnci/djv428