How can scanned proton beam treatment planning for low‐grade glioma cope with increased distal RBE and locally increased radiosensitivity for late MR‐detected brain lesions?

A novel risk model has recently been proposed for the occurrence of late contrast‐enhancing brain lesions (CEBLs) after proton irradiation of low‐grade glioma (LGG) patients. It predicts a strong dependence on dose‐weighted linear‐energy transfer (LETd effect) and an increased radiosensitivity of th...

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Bibliographic Details
Published in:	Medical physics (Lancaster) Vol. 48; no. 4; pp. 1497 - 1507
Main Authors:	Bauer, Julia, Bahn, Emanuel, Harrabi, Semi, Herfarth, Klaus, Debus, Jürgen, Alber, Markus
Format:	Journal Article
Language:	English
Published:	United States 01.04.2021
Subjects:	Brain - diagnostic imaging Glioma - diagnostic imaging Glioma - radiotherapy Humans low‐grade glioma treatment proton relative biological effectiveness Proton Therapy proton treatment planning Protons Radiation Tolerance radiation‐induced brain injury Radiotherapy Planning, Computer-Assisted Relative Biological Effectiveness Retrospective Studies radiation-induced brain injury proton therapy low-grade glioma treatment proton relative biological effectiveness proton treatment planning
ISSN:	0094-2405, 2473-4209, 2473-4209
Online Access:	Get full text
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