How can scanned proton beam treatment planning for low‐grade glioma cope with increased distal RBE and locally increased radiosensitivity for late MR‐detected brain lesions?

A novel risk model has recently been proposed for the occurrence of late contrast‐enhancing brain lesions (CEBLs) after proton irradiation of low‐grade glioma (LGG) patients. It predicts a strong dependence on dose‐weighted linear‐energy transfer (LETd effect) and an increased radiosensitivity of th...

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