11β-HSD1 Inhibitors for the Treatment of Type 2 Diabetes and Cardiovascular Disease

Inhibition of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) has been proposed as a novel therapeutic target for the treatment of type 2 diabetes mellitus. Over 170 new compounds targeting 11β-HSD1 have been developed. This article reviews the current published literature on compounds...

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Bibliographic Details
Published in:	Drugs (New York, N.Y.) Vol. 73; no. 13; pp. 1385 - 1393
Main Authors:	Anderson, Anna, Walker, Brian R.
Format:	Journal Article
Language:	English
Published:	Cham Springer International Publishing 01.09.2013 Adis International
Subjects:	11-beta-Hydroxysteroid Dehydrogenase Type 1 - antagonists & inhibitors 11-beta-Hydroxysteroid Dehydrogenase Type 1 - metabolism Animals Antihypertensive Agents - adverse effects Antihypertensive Agents - pharmacology Antihypertensive Agents - therapeutic use Biological and medical sciences Cardiovascular Diseases - drug therapy Cardiovascular Diseases - enzymology Cardiovascular Diseases - immunology Diabetes Mellitus, Type 2 - drug therapy Diabetes Mellitus, Type 2 - enzymology Diabetes Mellitus, Type 2 - immunology Diabetes. Impaired glucose tolerance Drugs, Investigational - adverse effects Drugs, Investigational - pharmacology Drugs, Investigational - therapeutic use Endocrine pancreas. Apud cells (diseases) Endocrinopathies Enzyme Inhibitors - adverse effects Enzyme Inhibitors - pharmacology Enzyme Inhibitors - therapeutic use Etiopathogenesis. Screening. Investigations. Target tissue resistance Humans Hypoglycemic Agents - adverse effects Hypoglycemic Agents - pharmacology Hypoglycemic Agents - therapeutic use Hypolipidemic Agents - adverse effects Hypolipidemic Agents - pharmacology Hypolipidemic Agents - therapeutic use Immunity, Innate - drug effects Internal Medicine Leading Article Medical sciences Medicine Medicine & Public Health Metabolic Syndrome - drug therapy Metabolic Syndrome - enzymology Metabolic Syndrome - immunology Molecular Targeted Therapy - adverse effects Pharmacology/Toxicology Pharmacotherapy DHEA Carbenoxolone Glycyrrhetinic Acid Glycaemic Control Cortisol Endocrinopathy Type 2 diabetes Treatment Enzyme 11β-Hydroxysteroid dehydrogenase Metabolic diseases Cardiovascular disease Inhibitor Oxidoreductases Review
ISSN:	0012-6667, 1179-1950, 1179-1950
Online Access:	Get full text
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