DNA double-strand break repair within heterochromatic regions

DNA DSBs (double-strand breaks) represent a critical lesion for a cell, with misrepair being potentially as harmful as lack of repair. In mammalian cells, DSBs are predominantly repaired by non-homologous end-joining or homologous recombination. The kinetics of repair of DSBs can differ widely, and...

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Bibliographic Details
Published in:Biochemical Society transactions Vol. 40; no. 1; p. 173
Main Authors: Murray, Johanne M, Stiff, Tom, Jeggo, Penny A
Format: Journal Article
Language:English
Published: England 01.02.2012
Subjects:
Animals
Ataxia Telangiectasia Mutated Proteins
Cell Cycle Proteins - metabolism
Chromatin Assembly and Disassembly
DNA Breaks, Double-Stranded
DNA Helicases - metabolism
DNA Repair
DNA-Binding Proteins - metabolism
Euchromatin - metabolism
Heterochromatin - metabolism
Histones - metabolism
Humans
Mi-2 Nucleosome Remodeling and Deacetylase Complex
Phosphorylation
Protein-Serine-Threonine Kinases - metabolism
Repressor Proteins - metabolism
Tripartite Motif-Containing Protein 28
Tumor Suppressor Proteins - metabolism
ISSN:1470-8752, 1470-8752
Online Access:Get more information
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Summary:DNA DSBs (double-strand breaks) represent a critical lesion for a cell, with misrepair being potentially as harmful as lack of repair. In mammalian cells, DSBs are predominantly repaired by non-homologous end-joining or homologous recombination. The kinetics of repair of DSBs can differ widely, and recent studies have shown that the higher-order chromatin structure can dramatically affect the pathway utilized, the rate of repair and the genetic factors required for repair. Studies of the repair of DSBs arising within heterochromatic DNA regions have provided insight into the constraints that higher-order chromatin structure poses on repair and the processing that is uniquely required for the repair of such DSBs. In the present paper, we provide an overview of our current understanding of the process of heterochromatic DSB repair in mammalian cells and consider the evolutionary conservation of the processes.
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ISSN:1470-8752
1470-8752
DOI:10.1042/BST20110631