Monitoring hospital wastewaters for their probable genotoxicity

Hospitals' effluents contain a considerable amount of chemicals. Considering the significant volume of wastewater discharged by hospitals, the presence of these chemicals represents a real threat to the environment and human health. Thus, the aim of this study was to evaluate the in vivo and in...

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Published in:Journal of water and health Vol. 18; no. 1; pp. 1 - 7
Main Authors: Beltifa, Asma, Alibi, Sana, Mansour, Hedi Ben
Format: Journal Article
Language:English
Published: England IWA Publishing 01.02.2020
Subjects:
Access
Albinism
Animals
Biocompatibility
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA Damage
DNA fragmentation
Effluents
Environmental Monitoring - methods
Genetic testing
Genotoxicity
Hospital wastes
Hospitals
Humans
In vivo methods and tests
Laboratories
Liver
Medical wastes
Mice
Monitoring
Organic chemistry
Pharmaceuticals
Salmonella
Telemedicine
Toxicology
Waste Water - chemistry
Wastewater discharges
Wastewater treatment
Water Pollutants, Chemical - analysis
Water Pollutants, Chemical - toxicity
Tunisia
ISSN:1477-8920, 1996-7829
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Abstract Hospitals' effluents contain a considerable amount of chemicals. Considering the significant volume of wastewater discharged by hospitals, the presence of these chemicals represents a real threat to the environment and human health. Thus, the aim of this study was to evaluate the in vivo and in vitro genotoxicities of three wastewater effluents collected from Tunisian hospitals. The liver of Swiss albino male mice, previously treated with different doses of the hospital wastewaters, was used as a model to detect DNA fragmentation. Our results showed all the hospital effluents caused significant qualitative and quantitative hazards in hepatic DNA. The wastewater collected from Sfax hospital exhibited the highest genotoxic effect, which may be explained by the presence in this effluent of some toxic micropolluants. There was a significant increase in genotoxicity, proportionally to the concentration of effluent. However, the vitotox assay did not show any significant genotoxicity on Salmonella typhimurium TA104 in the presence or absence of microsomal fraction S9. The ratio gentox/cytox was lower than the threshold 1.5. This study assessed the toxicological risk issued from Tunisian hospital wastewaters, which is potentially very harmful, and it has been pointed out that wastewater treatment requires special attention.
AbstractList Hospitals' effluents contain a considerable amount of chemicals. Considering the significant volume of wastewater discharged by hospitals, the presence of these chemicals represents a real threat to the environment and human health. Thus, the aim of this study was to evaluate the in vivo and in vitro genotoxicities of three wastewater effluents collected from Tunisian hospitals. The liver of Swiss albino male mice, previously treated with different doses of the hospital wastewaters, was used as a model to detect DNA fragmentation. Our results showed all the hospital effluents caused significant qualitative and quantitative hazards in hepatic DNA. The wastewater collected from Sfax hospital exhibited the highest genotoxic effect, which may be explained by the presence in this effluent of some toxic micropolluants. There was a significant increase in genotoxicity, proportionally to the concentration of effluent. However, the vitotox assay did not show any significant genotoxicity on Salmonella typhimurium TA104 in the presence or absence of microsomal fraction S9. The ratio gentox/cytox was lower than the threshold 1.5. This study assessed the toxicological risk issued from Tunisian hospital wastewaters, which is potentially very harmful, and it has been pointed out that wastewater treatment requires special attention.Hospitals' effluents contain a considerable amount of chemicals. Considering the significant volume of wastewater discharged by hospitals, the presence of these chemicals represents a real threat to the environment and human health. Thus, the aim of this study was to evaluate the in vivo and in vitro genotoxicities of three wastewater effluents collected from Tunisian hospitals. The liver of Swiss albino male mice, previously treated with different doses of the hospital wastewaters, was used as a model to detect DNA fragmentation. Our results showed all the hospital effluents caused significant qualitative and quantitative hazards in hepatic DNA. The wastewater collected from Sfax hospital exhibited the highest genotoxic effect, which may be explained by the presence in this effluent of some toxic micropolluants. There was a significant increase in genotoxicity, proportionally to the concentration of effluent. However, the vitotox assay did not show any significant genotoxicity on Salmonella typhimurium TA104 in the presence or absence of microsomal fraction S9. The ratio gentox/cytox was lower than the threshold 1.5. This study assessed the toxicological risk issued from Tunisian hospital wastewaters, which is potentially very harmful, and it has been pointed out that wastewater treatment requires special attention.
Hospitals' effluents contain a considerable amount of chemicals. Considering the significant volume of wastewater discharged by hospitals, the presence of these chemicals represents a real threat to the environment and human health. Thus, the aim of this study was to evaluate the in vivo and in vitro genotoxicities of three wastewater effluents collected from Tunisian hospitals. The liver of Swiss albino male mice, previously treated with different doses of the hospital wastewaters, was used as a model to detect DNA fragmentation. Our results showed all the hospital effluents caused significant qualitative and quantitative hazards in hepatic DNA. The wastewater collected from Sfax hospital exhibited the highest genotoxic effect, which may be explained by the presence in this effluent of some toxic micropolluants. There was a significant increase in genotoxicity, proportionally to the concentration of effluent. However, the vitotox assay did not show any significant genotoxicity on Salmonella typhimurium TA104 in the presence or absence of microsomal fraction S9. The ratio gentox/cytox was lower than the threshold 1.5. This study assessed the toxicological risk issued from Tunisian hospital wastewaters, which is potentially very harmful, and it has been pointed out that wastewater treatment requires special attention.
Author Alibi, Sana
Mansour, Hedi Ben
Beltifa, Asma
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/32129181$$D View this record in MEDLINE/PubMed
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Snippet Hospitals' effluents contain a considerable amount of chemicals. Considering the significant volume of wastewater discharged by hospitals, the presence of...
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StartPage 1
SubjectTerms Access
Albinism
Animals
Biocompatibility
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA Damage
DNA fragmentation
Effluents
Environmental Monitoring - methods
Genetic testing
Genotoxicity
Hospital wastes
Hospitals
Humans
In vivo methods and tests
Laboratories
Liver
Medical wastes
Mice
Monitoring
Organic chemistry
Pharmaceuticals
Salmonella
Telemedicine
Toxicology
Waste Water - chemistry
Wastewater discharges
Wastewater treatment
Water Pollutants, Chemical - analysis
Water Pollutants, Chemical - toxicity
Title Monitoring hospital wastewaters for their probable genotoxicity
URI https://www.ncbi.nlm.nih.gov/pubmed/32129181
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Volume 18
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