LC–MS/MS analysis of metformin, saxagliptin and 5‐hydroxy saxagliptin in human plasma and its pharmacokinetic study with a fixed‐dose formulation in healthy Indian subjects

A specific and rapid liquid chromatography–tandem mass spectrometry method is proposed for the simultaneous determination of metformin (MET), saxagliptin (SAXA) and its active metabolite, 5‐hydroxy saxagliptin (5‐OH SAXA) in human plasma. Sample preparation was accomplished from 50 μL plasma sample...

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Bibliographic Details
Published in:	Biomedical chromatography Vol. 31; no. 3; pp. np - n/a
Main Authors:	Shah, Priyanka A., Shah, Jaivik V., Sanyal, Mallika, Shrivastav, Pranav S.
Format:	Journal Article
Language:	English
Published:	England 01.03.2017
Subjects:	5‐hydroxy saxagliptin Adamantane - analogs & derivatives Adamantane - blood Chromatography, Liquid - methods Dipeptides - blood human plasma Humans ion‐pair solid phase extraction LC–MS/MS metformin Metformin - blood Reproducibility of Results saxagliptin Solid Phase Extraction Tandem Mass Spectrometry - methods LC-MS/MS metformin saxagliptin 5-hydroxy saxagliptin ion-pair solid phase extraction human plasma
ISSN:	0269-3879, 1099-0801, 1099-0801
Online Access:	Get full text
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