An Efficient and Safe Herpes Simplex Virus Type 1 Amplicon Vector for Transcriptionally Targeted Therapy of Human Hepatocellular Carcinomas

Our previous studies have shown that transgene expression could be targeted to proliferating cells when cell cycle transcriptional regulatory elements were incorporated into herpes simplex virus type 1 (HSV-1) amplicon backbone vectors. In the study reported here, we further demonstrated the transcr...

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Bibliographic Details
Published in:	Molecular therapy Vol. 15; no. 6; pp. 1129 - 1136
Main Authors:	Lam, Paula YP, Sia, Kian Chuan, Khong, Jenn H, Geest, Bart De, Lim, Kar S, Ho, Ivy AW, Wang, Grace Y, Miao, Lv, Huynh, H, Hui, Kam M
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2007 Elsevier Limited
Subjects:	alpha 1-Antitrypsin - genetics alpha-Fetoproteins - genetics Animals Apolipoproteins Apolipoproteins E - genetics Binding sites Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Carcinoma, Hepatocellular - therapy CCAAT-Binding Factor - genetics Cell cycle Cell Line Cell Line, Tumor Female Gene Amplification Gene therapy Genetic Therapy - methods Genetic Vectors - genetics HeLa Cells Hepatectomy Herpes viruses Herpesvirus 1, Human - genetics Humans Immunoblotting Liver cancer Liver Neoplasms - genetics Liver Neoplasms - pathology Liver Neoplasms - therapy Luciferases - genetics Luciferases - metabolism Mice Mice, Inbred BALB C Mice, SCID Microscopy, Fluorescence Proteins Recombinant Fusion Proteins - genetics Recombinant Fusion Proteins - metabolism Transcription factors Transcription, Genetic - genetics Tumors Vectors (Biology) Xenograft Model Antitumor Assays - methods Singapore
ISSN:	1525-0016, 1525-0024, 1525-0024
Online Access:	Get full text
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