Venetoclax plus gilteritinib is effective in preclinical models of FLT3-mutant BCL11B-a lineage-ambiguous leukemia

Aberrant activation of BCL11B (BCL11B-a) defines a subtype of lineage-ambiguous leukemias with T-lymphoid and myeloid features, co-occurring activating FLT3 mutations, and a stem/progenitor immunophenotype and gene expression profile. Similar to other lineage-ambiguous leukemias, optimal treatment i...

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Veröffentlicht in:	Blood Jg. 146; H. 19; S. 2350
Hauptverfasser:	Montefiori, Lindsey E, Iacobucci, Ilaria, Gao, Qingsong, Moore, Jamila, Wright, William C, Wei, Huimei, Baviskar, Pradyumna, Sona, Surbhi, Jin, Hongjian, Budhraja, Amit, Lott, Josi, Tatarata, Qi Zhang, Cheng, Zhongshan, Khan, Tanya, Backhaus Wagner, Emily A, Johnson, Melissa, Mehr, Cyrus M, Freeman, Burgess, Janke, Laura, Haferlach, Torsten, Geeleher, Paul, Mead, Paul E, Konopleva, Marina, Opferman, Joseph T, Mullighan, Charles G
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 06.11.2025
Schlagworte:	Aniline Compounds - administration & dosage Aniline Compounds - pharmacology Animals Antineoplastic Combined Chemotherapy Protocols - pharmacology Antineoplastic Combined Chemotherapy Protocols - therapeutic use Bridged Bicyclo Compounds, Heterocyclic - administration & dosage Bridged Bicyclo Compounds, Heterocyclic - pharmacology Cell Line, Tumor Female fms-Like Tyrosine Kinase 3 - antagonists & inhibitors fms-Like Tyrosine Kinase 3 - genetics Humans Leukemia - drug therapy Leukemia - genetics Leukemia - pathology Mice Mutation Proto-Oncogene Proteins c-bcl-2 - genetics Pyrazines - administration & dosage Pyrazines - pharmacology Sulfonamides - administration & dosage Sulfonamides - pharmacology Xenograft Model Antitumor Assays
ISSN:	1528-0020, 1528-0020
Online-Zugang:	Weitere Angaben
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