Increase in mechanical load and pro-fibrotic stimulation leads to fibrotic and hypertrophic remodeling in porcine living myocardial slices

Heart failure (HF) is a growing global health concern, driven by factors such as increased mechanical load of the heart muscle tissue. This pathogenic condition is the result of remodeling processes, partially mediated by the cytokine transforming growth factor β (TGF- β1), with progressive depositi...

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Bibliographic Details
Published in:	Scientific reports Vol. 15; no. 1; pp. 41180 - 14
Main Authors:	Bentele, Marco, Linke, Sophie, Neumüller, Susanne, Korte, Andrea, Gietz, Anika, Just, Annette, Stucki-Koch, Angelika, Pfanne, Angelika, Liu, Junqing, Zhao, Jiahao, Schwennen, Cornelia, Homann, Christian, Visscher, Christian, Pflaum, Michael, Wiegmann, Bettina, Bär, Christian, Weber, Natalie, Fiedler, Jan, Thum, Thomas
Format:	Journal Article
Language:	English
Published:	London Nature Publishing Group UK 21.11.2025 Nature Publishing Group Nature Portfolio
Subjects:	(up to 6): Cardiovascular diseases 631/443/592/1540 631/443/592/75 692/4019 Animals Cardiac muscle Cell culture Collagen Collagen - metabolism Congestive heart failure Disease Models, Animal Extracellular matrix Extracellular Matrix - metabolism Fibroblast activation Fibroblasts Fibrosis Global health Heart failure Heart Failure - metabolism Heart Failure - pathology Heart Failure - physiopathology Heart Ventricles - metabolism Heart Ventricles - pathology Hogs Humanities and Social Sciences Hypertension Hypertrophy Living myocardial slices Mechanical properties MicroRNAs - genetics MicroRNAs - metabolism multidisciplinary Muscle contraction Myocardium Myocardium - metabolism Myocardium - pathology Peptides Physiology Proteins Public health Science Science (multidisciplinary) Stress, Mechanical Swine TGF-β stimulation Transforming Growth Factor beta1 - metabolism Transforming Growth Factor beta1 - pharmacology Transforming growth factor-b Transforming growth factor-b1 Ventricular Remodeling Living myocardial slices Fibroblast activation Cardiovascular diseases Fibrosis TGF-β stimulation Hypertrophy (up to 6): Cardiovascular diseases
ISSN:	2045-2322, 2045-2322
Online Access:	Get full text
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